{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:48:30Z","timestamp":1791823710778,"version":"4.3.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-026-05110-y","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:15:32Z","timestamp":1784196932000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of lncRNA DARS-AS1 in colorectal cancer and its regulatory effect on tumor progression"],"prefix":"10.1186","volume":"26","author":[{"given":"Qiaoyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"2","key":"5110_CR1","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s10555-023-10158-3","volume":"43","author":"R Abedizadeh","year":"2024","unstructured":"Abedizadeh R, Majidi F, Khorasani HR, Abedi H, Sabour D. Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments. Cancer Metastasis Rev. 2024;43(2):729\u201353.","journal-title":"Cancer Metastasis Rev"},{"issue":"1","key":"5110_CR2","doi-asserted-by":"publisher","first-page":"10238","DOI":"10.1038\/s41598-020-66652-z","volume":"10","author":"T Yamano","year":"2020","unstructured":"Yamano T, Yamauchi S, Igeta M, Takenaka Y, Song J, Kimura K, et al. Combination of preoperative tumour markers and lymphovascular invasion with TNM staging as a cost and labour efficient subtyping of colorectal cancer. Sci Rep. 2020;10(1):10238.","journal-title":"Sci Rep"},{"key":"5110_CR3","doi-asserted-by":"crossref","unstructured":"Mou F, Sun Q, Ye Z. Advances in the combination of immunotherapy and radiotherapy for microsatellite-stable metastatic colorectal cancer. Curr Proteomics. 2025;22(5):100049.","DOI":"10.1016\/j.curpro.2025.100049"},{"key":"5110_CR4","doi-asserted-by":"publisher","first-page":"149433","DOI":"10.1016\/j.gene.2025.149433","volume":"955","author":"MJ Saadh","year":"2025","unstructured":"Saadh MJ, Allela OQB, Kareem RA, Baldaniya L, Ballal S, Vashishth R, et al. Prognostic gene expression profile of colorectal cancer. Gene. 2025;955:149433.","journal-title":"Gene"},{"key":"5110_CR5","doi-asserted-by":"crossref","unstructured":"Lulli M, Napoli C, Landini I, Mini E, Lapucci A. Role of Non-Coding RNAs in Colorectal Cancer: Focus on Long Non-Coding RNAs. Int J Mol Sci. 2022;23(21):13431.","DOI":"10.3390\/ijms232113431"},{"issue":"1","key":"5110_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2174\/0109298665248028231122064831","volume":"31","author":"Z Xu","year":"2024","unstructured":"Xu Z, Yu Y, Ni H, Sun W, Kuang Y. LINC01836 Promotes Colorectal Cancer Progression and Functions as ceRNA to Target SLC17A9 by Sponging miR-1226-3p. Protein Pept Lett. 2024;31(1):43\u201360.","journal-title":"Protein Pept Lett"},{"issue":"6","key":"5110_CR7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.2174\/0109298665297110240611115010","volume":"31","author":"H Ge","year":"2024","unstructured":"Ge H, Yan Y, Wang H, Bian J, Deng Z, Su X, et al. Circular RNA hsa_circ_0005939 Regulates UHRF1BP1L Expression by Targeting miR-4693-3p to Promote Colorectal Cancer Progression. Protein Pept Lett. 2024;31(6):437\u201346.","journal-title":"Protein Pept Lett"},{"key":"5110_CR8","doi-asserted-by":"publisher","first-page":"e150923221164","DOI":"10.2174\/1874467217666230915125622","volume":"17","author":"Y Ruan","year":"2024","unstructured":"Ruan Y, Lu G, Yu Y, Luo Y, Wu H, Shen Y, et al. PF-04449913 Inhibits Proliferation and Metastasis of Colorectal Cancer Cells by Down-regulating MMP9 Expression through the ERK\/p65 Pathway. Curr Mol Pharmacol. 2024;17:e150923221164.","journal-title":"Curr Mol Pharmacol"},{"key":"5110_CR9","doi-asserted-by":"publisher","first-page":"e18761429283717","DOI":"10.2174\/0118761429283717231222104730","volume":"17","author":"M Li","year":"2024","unstructured":"Li M, Fan J, Hu M, Xu J, He Z, Zeng J. Quercetin Enhances 5-fluorouracil Sensitivity by Regulating the Autophagic Flux and Inducing Drp-1 Mediated Mitochondrial Fragmentation in Colorectal Cancer Cells. Curr Mol Pharmacol. 2024;17:e18761429283717.","journal-title":"Curr Mol Pharmacol"},{"issue":"4","key":"5110_CR10","doi-asserted-by":"publisher","first-page":"340","DOI":"10.2174\/0118744710331660250127115004","volume":"18","author":"E Bahadoran","year":"2025","unstructured":"Bahadoran E, Zafari Y, Homaei A, Jalilvand M, Moghbelinejad S. Role of the p53\/miR-34a\/SIRT1 Feedback Loop in Metformin-induced Radiosensitivity of Colorectal Cancer Cells. Curr Radiopharmaceuticals. 2025;18(4):340\u201351.","journal-title":"Curr Radiopharmaceuticals"},{"key":"5110_CR11","doi-asserted-by":"publisher","first-page":"148566","DOI":"10.1016\/j.gene.2024.148566","volume":"923","author":"Q Dang","year":"2024","unstructured":"Dang Q. LncRNA DARS-AS1 in human cancers: A comprehensive review of its potency as a biomarker and therapeutic target. Gene. 2024;923:148566.","journal-title":"Gene"},{"issue":"3","key":"5110_CR12","doi-asserted-by":"publisher","first-page":"571","DOI":"10.7150\/ijms.90611","volume":"21","author":"J Shu","year":"2024","unstructured":"Shu J, Xia K, Luo H, Wang Y. DARS-AS1: A Vital Oncogenic LncRNA Regulator with Potential for Cancer Prognosis and Therapy. Int J Med Sci. 2024;21(3):571\u201382.","journal-title":"Int J Med Sci"},{"issue":"1","key":"5110_CR13","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1515\/med-2022-0583","volume":"17","author":"C Du","year":"2022","unstructured":"Du C, Han X, Zhang Y, Guo F, Yuan H, Wang F, et al. DARS-AS1 modulates cell proliferation and migration of gastric cancer cells by regulating miR-330-3p\/NAT10 axis. Open Med (Warsaw Poland). 2022;17(1):2036\u201345.","journal-title":"Open Med (Warsaw Poland)"},{"issue":"1","key":"5110_CR14","doi-asserted-by":"publisher","first-page":"8217","DOI":"10.1080\/21655979.2021.1982272","volume":"12","author":"Y Feng","year":"2021","unstructured":"Feng Y, Wei G, Zhang L, Zhou H, Wang W, Guo P, et al. LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis. Bioengineered. 2021;12(1):8217\u201332.","journal-title":"Bioengineered"},{"key":"5110_CR15","doi-asserted-by":"publisher","first-page":"126147","DOI":"10.1016\/j.ijbiomac.2023.126147","volume":"250","author":"X Liu","year":"2023","unstructured":"Liu X, Zhang G, Yu T, Liu J, Chai X, Yin D, et al. CL4-modified exosomes deliver lncRNA DARS-AS1 siRNA to suppress triple-negative breast cancer progression and attenuate doxorubicin resistance by inhibiting autophagy. Int J Biol Macromol. 2023;250:126147.","journal-title":"Int J Biol Macromol"},{"key":"5110_CR16","doi-asserted-by":"publisher","first-page":"4660217","DOI":"10.1155\/2022\/4660217","volume":"2022","author":"Y Xue","year":"2022","unstructured":"Xue Y, Liu H, Nie G, Ren X. lncRNA DARS-AS1 Promoted Osteosarcoma Progression through Regulating miR-532-3p\/CCR7. Dis Markers. 2022;2022:4660217.","journal-title":"Dis Markers"},{"issue":"1","key":"5110_CR17","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1080\/15476286.2022.2079889","volume":"19","author":"W Shen","year":"2022","unstructured":"Shen W, Zhu M, Wang Q, Zhou X, Wang J, Wang T, et al. DARS-AS1 recruits METTL3\/METTL14 to bind and enhance DARS mRNA m(6)A modification and translation for cytoprotective autophagy in cervical cancer. RNA Biol. 2022;19(1):751\u201363.","journal-title":"RNA Biol"},{"issue":"4","key":"5110_CR18","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/kjm2.12323","volume":"37","author":"XL Li","year":"2021","unstructured":"Li XL, Li SZ, Wu CX, Xing XH. miR-188-5p inhibits proliferation, migration, and invasion in gallbladder carcinoma by targeting Wnt2b and Smad2. Kaohsiung J Med Sci. 2021;37(4):294\u2013304.","journal-title":"Kaohsiung J Med Sci"},{"key":"5110_CR19","doi-asserted-by":"crossref","unstructured":"Jiang F, Liu G, Chen X, Li Q, Fang F, Shen X. Hsa_circ_0044301 Regulates Gastric Cancer Cell\u2019s Proliferation, Migration, and Invasion by Modulating the Hsa-miR-188-5p\/DAXX Axis and MAPK Pathway. Cancers. 2022;14(17):4183.","DOI":"10.3390\/cancers14174183"},{"issue":"1","key":"5110_CR20","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1186\/s12885-019-5731-0","volume":"19","author":"Y Li","year":"2019","unstructured":"Li Y, Yan X, Shi J, He Y, Xu J, Lin L, et al. Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt\/\u03b2-catenin signaling. BMC Cancer. 2019;19(1):505.","journal-title":"BMC Cancer"},{"issue":"1","key":"5110_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13578-022-00908-1","volume":"12","author":"M Si","year":"2022","unstructured":"Si M, Song Y, Wang X, Wang D, Liu X, Qu X, et al. CXCL12\/CXCR7\/\u03b2-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation. Cell bioscience. 2022;12(1):171.","journal-title":"Cell bioscience"},{"key":"5110_CR22","doi-asserted-by":"publisher","first-page":"172464","DOI":"10.1016\/j.ejphar.2019.172464","volume":"858","author":"S Yan","year":"2019","unstructured":"Yan S, Yue Y, Wang J, Li W, Sun M, Gu C, et al. LINC00668 promotes tumorigenesis and progression through sponging miR-188-5p and regulating USP47 in colorectal cancer. Eur J Pharmacol. 2019;858:172464.","journal-title":"Eur J Pharmacol"},{"key":"5110_CR23","doi-asserted-by":"crossref","unstructured":"Liao X, Li T, Yang L, Li H, Li W, Liu Y et al. Exploration of the potential molecular mechanism of magnolol in colorectal cancer treatment based on network pharmacology and molecular docking. Letters in Drug Design & Discovery. 2025;22(7):100063.","DOI":"10.1016\/j.lddd.2025.100063"},{"issue":"18","key":"5110_CR24","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.2174\/0115701808324049241108063414","volume":"21","author":"D Ipek Ceylan","year":"2024","unstructured":"Ipek Ceylan D, Ozerkan N, Emin I, Akata, Altuner EM. Exploring the Molecular Basis of Anticancer Activity in Various Mushroom Species Against Colorectal Cancer Cells. Lett Drug Des Discov. 2024;21(18):4378\u201388.","journal-title":"Lett Drug Des Discov"},{"key":"5110_CR25","doi-asserted-by":"crossref","unstructured":"Diagnosis, Treatment Guidelines For Colorectal Cancer Working Group C. Chinese Society of Clinical Oncology (CSCO) diagnosis and treatment guidelines for colorectal cancer 2018 (English version). Chinese journal of cancer research\u2009=\u2009Chung-kuo yen cheng yen chiu. 2019;31(1):117\u201334.","DOI":"10.21147\/j.issn.1000-9604.2019.01.07"},{"issue":"1","key":"5110_CR26","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12957-025-03823-0","volume":"23","author":"PC Wood","year":"2025","unstructured":"Wood PC, Zammit AP, Ferris B, Simpson FH, Burge M, Franz R, et al. Establishing high risk factors for recurrence in stage I\/II colorectal cancer: a metropolitan perspective. World J Surg Oncol. 2025;23(1):241.","journal-title":"World J Surg Oncol"},{"issue":"1","key":"5110_CR27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41698-023-00406-8","volume":"7","author":"M Zhao","year":"2023","unstructured":"Zhao M, Lau MC, Haruki K, V\u00e4yrynen JP, Gurjao C, V\u00e4yrynen SA, et al. Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data. NPJ precision Oncol. 2023;7(1):57.","journal-title":"NPJ precision Oncol"},{"issue":"5","key":"5110_CR28","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.3748\/wjg.v22.i5.1745","volume":"22","author":"G Lech","year":"2016","unstructured":"Lech G, S\u0142otwi\u0144ski R, S\u0142odkowski M, Krasnod\u0119bski IW. Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances. World J Gastroenterol. 2016;22(5):1745\u201355.","journal-title":"World J Gastroenterol"},{"issue":"5","key":"5110_CR29","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1111\/cbdd.14036","volume":"101","author":"MO Olatubosun","year":"2023","unstructured":"Olatubosun MO, Abubakar MB, Batiha GE, Malami I, Ibrahim KG, Abubakar B, et al. LncRNA SNHG15: A potential therapeutic target in the treatment of colorectal cancer. Chem Biol Drug Des. 2023;101(5):1138\u201350.","journal-title":"Chem Biol Drug Des"},{"issue":"1","key":"5110_CR30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12920-024-01862-2","volume":"17","author":"R Mao","year":"2024","unstructured":"Mao R, Xu C, Zhang Q, Wang Z, Liu Y, Peng Y, et al. Predictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression. BMC Med Genom. 2024;17(1):112.","journal-title":"BMC Med Genom"},{"key":"5110_CR31","doi-asserted-by":"publisher","first-page":"147828","DOI":"10.1016\/j.gene.2023.147828","volume":"891","author":"A Masoud","year":"2024","unstructured":"Masoud A, Mohamadynejad P. Identification of lncRNA PCAT19 as potential novel biomarker for colorectal cancer. Gene. 2024;891:147828.","journal-title":"Gene"},{"issue":"7","key":"5110_CR32","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.21873\/anticanres.17124","volume":"44","author":"M Karl\u00edkov\u00e1","year":"2024","unstructured":"Karl\u00edkov\u00e1 M, \u010curillov\u00e1 M, Pecen L, Karnos V Jr., Karnos V, Topol\u010dan O. Evaluation of Serum Cytokeratines, Thymidine Kinase, and Growth Factors as Cancer Biomarkers in Colorectal Cancer. Anticancer Res. 2024;44(7):3105\u201313.","journal-title":"Anticancer Res"},{"issue":"1","key":"5110_CR33","doi-asserted-by":"publisher","first-page":"8157","DOI":"10.1038\/s41598-023-35396-x","volume":"13","author":"J McGovern","year":"2023","unstructured":"McGovern J, Leadbitter S, Miller G, Hounat A, Kamande I, Dolan RD, et al. The relationship between heart rate variability and TNM stage, co-morbidity, systemic inflammation and survival in patients with primary operable colorectal cancer. Sci Rep. 2023;13(1):8157.","journal-title":"Sci Rep"},{"issue":"4","key":"5110_CR34","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s13304-024-01884-6","volume":"76","author":"X Niu","year":"2024","unstructured":"Niu X, Cao J. Predicting lymph node metastasis in colorectal cancer patients: development and validation of a column chart model. Updates Surg. 2024;76(4):1301\u201310.","journal-title":"Updates Surg"},{"issue":"1","key":"5110_CR35","first-page":"1","volume":"47","author":"H Wang","year":"2024","unstructured":"Wang H, Huo R, He K, Cheng L, Zhang S, Yu M, et al. Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance. Cell Oncol (Dordrecht Netherlands). 2024;47(1):1\u201317.","journal-title":"Cell Oncol (Dordrecht Netherlands)"},{"issue":"7","key":"5110_CR36","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1007\/s00535-024-02095-x","volume":"59","author":"H Inoue","year":"2024","unstructured":"Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, et al. CACNA2D1 regulates the progression and influences the microenvironment of colon cancer. J Gastroenterol. 2024;59(7):556\u201371.","journal-title":"J Gastroenterol"},{"issue":"4","key":"5110_CR37","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1002\/mc.23686","volume":"63","author":"J Li","year":"2024","unstructured":"Li J, Li Y, Sun X, Wei L, Guan J, Fu L, et al. Silencing lncRNA-DARS-AS1 suppresses nonsmall cell lung cancer progression by stimulating miR-302a-3p to inhibit ACAT1 expression. Mol Carcinog. 2024;63(4):757\u201371.","journal-title":"Mol Carcinog"},{"issue":"1","key":"5110_CR38","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s12010-022-04136-8","volume":"195","author":"Z Yin","year":"2023","unstructured":"Yin Z, Wang J, Li T, Ma L, Kang J, Liu G. miR-188-5p and Host MALAT1 Regulate RBE Cell Migration, Invasion, and Apoptosis via Up-regulating PSMD10 in Cholangiocarcinoma. Appl Biochem Biotechnol. 2023;195(1):655\u201371.","journal-title":"Appl Biochem Biotechnol"},{"key":"5110_CR39","doi-asserted-by":"crossref","unstructured":"Wang T, Liang D, Yang H. SNHG15 facilitated malignant behaviors of oral squamous cell carcinoma through targeting miR-188-5p\/DAAM1. Journal of oral pathology & medicine: official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2021;50(7):681\u201391.","DOI":"10.1111\/jop.13169"},{"issue":"7","key":"5110_CR40","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1007\/s10620-019-05506-9","volume":"64","author":"J Liu","year":"2019","unstructured":"Liu J, Li H, Zheng B, Sun L, Yuan Y, Xing C. Competitive Endogenous RNA (ceRNA) Regulation Network of lncRNA-miRNA-mRNA in Colorectal Carcinogenesis. Dig Dis Sci. 2019;64(7):1868\u201377.","journal-title":"Dig Dis Sci"},{"key":"5110_CR41","doi-asserted-by":"publisher","first-page":"153521","DOI":"10.1016\/j.prp.2021.153521","volume":"224","author":"H Li","year":"2021","unstructured":"Li H, Liu J, Lai Y, Huang S, Zheng L, Fan N. LINC01559 promotes colorectal cancer via sponging miR-1343-3p to modulate PARP1\/PTEN\/AKT pathway. Pathol Res Pract. 2021;224:153521.","journal-title":"Pathol Res Pract"},{"issue":"2","key":"5110_CR42","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00404-017-4405-x","volume":"296","author":"V Todorow","year":"2017","unstructured":"Todorow V, Rahmeh M, Hofmann S, Kirn V, Mahner S, Jeschke U, et al. Promotor analysis of ESR1 in endometrial cancer cell lines, endometrial and endometriotic tissue. Arch Gynecol Obstet. 2017;296(2):269\u201376.","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"5110_CR43","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41392-023-01405-8","volume":"8","author":"W Wei","year":"2023","unstructured":"Wei W, Qin B, Wen W, Zhang B, Luo H, Wang Y, et al. FBXW7\u03b2 loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth. Signal Transduct Target therapy. 2023;8(1):187.","journal-title":"Signal Transduct Target therapy"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-026-05110-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-05110-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-05110-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:04:48Z","timestamp":1791821088000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-026-05110-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5110"],"URL":"https:\/\/doi.org\/10.1186\/s12876-026-05110-y","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"21 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Shanghai Sixth People\u2032s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine before the study began. The written informed consent has been obtained from all the participants involved.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"636"}}