{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:38:07Z","timestamp":1792787887250,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":86,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Joint Fund of the National Natural Science Foundation of China","award":["U23A20483"],"award-info":[{"award-number":["U23A20483"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902839"],"award-info":[{"award-number":["81902839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Gastroenterol"],"DOI":"10.1186\/s12876-026-05114-8","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:34:40Z","timestamp":1784039680000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of bilirubin reduction rate after percutaneous transhepatic cholangiographic drainage with major complications in hilar cholangiocarcinoma"],"prefix":"10.1186","volume":"26","author":[{"given":"Tong","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyi","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"issue":"2","key":"5114_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrclinonc.2017.157","volume":"15","author":"SI Ilyas","year":"2018","unstructured":"Ilyas SI, Khan SA, Hallemeier CL, Kelley RK, Gores GJ. Cholangiocarcinoma - evolving concepts and therapeutic strategies. Nat Rev Clin Oncol. 2018;15(2):95\u2013111.","journal-title":"Nat Rev Clin Oncol"},{"issue":"5","key":"5114_CR2","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.surg.2019.01.010","volume":"165","author":"LC Franken","year":"2019","unstructured":"Franken LC, Schreuder AM, Roos E, van Dieren S, Busch OR, Besselink MG, et al. Morbidity and mortality after major liver resection in patients with perihilar cholangiocarcinoma: a systematic review and meta-analysis. Surgery. 2019;165(5):918\u201328.","journal-title":"Surgery"},{"key":"5114_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092119","author":"RJ Ellis","year":"2022","unstructured":"Ellis RJ, Soares KC, Jarnagin WR. Preoperative management of perihilar cholangiocarcinoma. Cancers (Basel). 2022. https:\/\/doi.org\/10.3390\/cancers14092119.","journal-title":"Cancers (Basel)"},{"key":"5114_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.108897","volume":"125","author":"A Mehrabi","year":"2020","unstructured":"Mehrabi A, Khajeh E, Ghamarnejad O, Nikdad M, Chang DH, B\u00fcchler MW, et al. Meta-analysis of the efficacy of preoperative biliary drainage in patients undergoing liver resection for perihilar cholangiocarcinoma. Eur J Radiol. 2020;125:108897.","journal-title":"Eur J Radiol"},{"issue":"4","key":"5114_CR5","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.jvir.2016.12.1218","volume":"28","author":"A Al Mahjoub","year":"2017","unstructured":"Al Mahjoub A, Menahem B, Fohlen A, Dupont B, Alves A, Launoy G, et al. Preoperative biliary drainage in patients with resectable perihilar cholangiocarcinoma: is percutaneous transhepatic biliary drainage safer and more effective than endoscopic biliary drainage? A meta-analysis. J Vasc Interv Radiol. 2017;28(4):576\u201382.","journal-title":"J Vasc Interv Radiol"},{"issue":"2","key":"5114_CR6","doi-asserted-by":"publisher","first-page":"E203","DOI":"10.1055\/a-0990-9114","volume":"8","author":"Y Ba","year":"2020","unstructured":"Ba Y, Yue P, Leung JW, Wang H, Lin Y, Bai B, et al. Percutaneous transhepatic biliary drainage may be the preferred preoperative drainage method in hilar cholangiocarcinoma. Endosc Int Open. 2020;8(2):E203-e210.","journal-title":"Endosc Int Open"},{"issue":"4","key":"5114_CR7","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00423-016-1427-y","volume":"401","author":"Y Kishi","year":"2016","unstructured":"Kishi Y, Shimada K, Nara S, Esaki M, Kosuge T. The type of preoperative biliary drainage predicts short-term outcome after major hepatectomy. Langenbecks Arch Surg. 2016;401(4):503\u201311.","journal-title":"Langenbecks Arch Surg"},{"issue":"1","key":"5114_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07385-0","volume":"20","author":"WH She","year":"2020","unstructured":"She WH, Cheung TT, Ma KW, Tsang SHY, Dai WC, Chan ACY, et al. Defining the optimal bilirubin level before hepatectomy for hilar cholangiocarcinoma. BMC Cancer. 2020;20(1):914.","journal-title":"BMC Cancer"},{"key":"5114_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8040458","author":"KM Wronka","year":"2019","unstructured":"Wronka KM, Gr\u0105t M, Stypu\u0142kowski J, Bik E, Patkowski W, Krawczyk M, et al. Relevance of preoperative hyperbilirubinemia in patients undergoing hepatobiliary resection for hilar cholangiocarcinoma. J Clin Med. 2019. https:\/\/doi.org\/10.3390\/jcm8040458.","journal-title":"J Clin Med"},{"issue":"12","key":"5114_CR10","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1245\/s10434-010-1168-z","volume":"17","author":"S Grandadam","year":"2010","unstructured":"Grandadam S, Compagnon P, Arnaud A, Olivi\u00e9 D, Malledant Y, Meunier B, et al. Role of preoperative optimization of the liver for resection in patients with hilar cholangiocarcinoma type III. Ann Surg Oncol. 2010;17(12):3155\u201361.","journal-title":"Ann Surg Oncol"},{"issue":"41","key":"5114_CR11","doi-asserted-by":"publisher","first-page":"5206","DOI":"10.3748\/wjg.15.5206","volume":"15","author":"HM Tsai","year":"2009","unstructured":"Tsai HM, Chuang CH, Lin XZ, Chen CY. Factors relating to the short term effectiveness of percutaneous biliary drainage for hilar cholangiocarcinoma. World J Gastroenterol. 2009;15(41):5206\u201310.","journal-title":"World J Gastroenterol"},{"issue":"12","key":"5114_CR12","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1055\/s-0034-1392559","volume":"47","author":"JK Wiggers","year":"2015","unstructured":"Wiggers JK, Groot Koerkamp B, Coelen RJ, Rauws EA, Schattner MA, Nio CY, et al. Preoperative biliary drainage in perihilar cholangiocarcinoma: identifying patients who require percutaneous drainage after failed endoscopic drainage. Endoscopy. 2015;47(12):1124\u201331.","journal-title":"Endoscopy"},{"key":"5114_CR13","doi-asserted-by":"crossref","unstructured":"Pang YY. The Brisbane 2000 terminology of liver anatomy and resections. HPB 2000; 2:333\u201339. HPB. 2002, 4(2):99; author reply 99\u2013100.","DOI":"10.1080\/136518202760378489"},{"issue":"2","key":"5114_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205\u201313.","journal-title":"Ann Surg"},{"issue":"6","key":"5114_CR15","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1200\/JCO.2014.57.9151","volume":"33","author":"PJ Johnson","year":"2015","unstructured":"Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, et al. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol. 2015;33(6):550\u20138.","journal-title":"J Clin Oncol"},{"issue":"4","key":"5114_CR16","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/jgh.13608","volume":"32","author":"PH Liu","year":"2017","unstructured":"Liu PH, Hsu CY, Hsia CY, Lee YH, Chiou YY, Huang YH, et al. ALBI and PALBI grade predict survival for HCC across treatment modalities and BCLC stages in the MELD era. J Gastroenterol Hepatol. 2017;32(4):879\u201386.","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"5114_CR17","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1053\/jhep.2001.22172","volume":"33","author":"PS Kamath","year":"2001","unstructured":"Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, et al. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001;33(2):464\u201370.","journal-title":"Hepatology"},{"issue":"2","key":"5114_CR18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1080\/13651820801992666","volume":"10","author":"Y Nimura","year":"2008","unstructured":"Nimura Y. Preoperative biliary drainage before resection for cholangiocarcinoma (Pro). HPB (Oxford). 2008;10(2):130\u20133.","journal-title":"HPB (Oxford)"},{"key":"5114_CR19","doi-asserted-by":"crossref","unstructured":"Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM et al. Surgery for cholangiocarcinoma. Liver Int. 2019, 39 Suppl 1(Suppl Suppl 1):143\u2013155.","DOI":"10.1111\/liv.14089"},{"issue":"2","key":"5114_CR20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/SLA.0b013e31826f4b0e","volume":"257","author":"C Iacono","year":"2013","unstructured":"Iacono C, Ruzzenente A, Campagnaro T, Bortolasi L, Valdegamberi A, Guglielmi A. Role of preoperative biliary drainage in jaundiced patients who are candidates for pancreatoduodenectomy or hepatic resection: highlights and drawbacks. Ann Surg. 2013;257(2):191\u2013204.","journal-title":"Ann Surg"},{"issue":"2","key":"5114_CR21","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jamcollsurg.2016.03.035","volume":"223","author":"JK Wiggers","year":"2016","unstructured":"Wiggers JK, Groot Koerkamp B, Cieslak KP, Doussot A, van Klaveren D, Allen PJ, et al. Postoperative mortality after liver resection for perihilar cholangiocarcinoma: development of a risk score and importance of biliary drainage of the future liver remnant. J Am Coll Surg. 2016;223(2):321-331.e321.","journal-title":"J Am Coll Surg"},{"issue":"2","key":"5114_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.asjsur.2015.04.007","volume":"39","author":"T Dumitrascu","year":"2016","unstructured":"Dumitrascu T, Brasoveanu V, Stroescu C, Ionescu M, Popescu I. Major hepatectomies for perihilar cholangiocarcinoma: predictors for clinically relevant postoperative complications using the International Study Group of Liver Surgery definitions. Asian J Surg. 2016;39(2):81\u20139.","journal-title":"Asian J Surg"},{"issue":"5","key":"5114_CR23","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1007\/s11605-014-2741-8","volume":"19","author":"N Kimura","year":"2015","unstructured":"Kimura N, Toyoki Y, Ishido K, Kudo D, Yakoshi Y, Tsutsumi S, et al. Perioperative blood transfusion as a poor prognostic factor after aggressive surgical resection for hilar cholangiocarcinoma. J Gastrointest Surg. 2015;19(5):866\u201379.","journal-title":"J Gastrointest Surg"},{"issue":"2","key":"5114_CR24","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/SLA.0b013e3181b76557","volume":"251","author":"EM Alkozai","year":"2010","unstructured":"Alkozai EM, Nijsten MW, de Jong KP, de Boer MT, Peeters PM, Slooff MJ, et al. Immediate postoperative low platelet count is associated with delayed liver function recovery after partial liver resection. Ann Surg. 2010;251(2):300\u20136.","journal-title":"Ann Surg"},{"issue":"5","key":"5114_CR25","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1182\/blood-2016-04-692665","volume":"128","author":"T Lisman","year":"2016","unstructured":"Lisman T, Porte RJ. Mechanisms of platelet-mediated liver regeneration. Blood. 2016;128(5):625\u20139.","journal-title":"Blood"},{"issue":"11","key":"5114_CR26","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.hpb.2019.01.016","volume":"21","author":"J Meyer","year":"2019","unstructured":"Meyer J, Balaphas A, Combescure C, Morel P, Gonelle-Gispert C, B\u00fchler L. Systematic review and meta-analysis of thrombocytopenia as a predictor of post-hepatectomy liver failure. HPB (Oxford). 2019;21(11):1419\u201326.","journal-title":"HPB (Oxford)"},{"key":"5114_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12186017","author":"E Gremese","year":"2023","unstructured":"Gremese E, Bruno D, Varriano V, Perniola S, Petricca L, Ferraccioli G. Serum albumin levels: a biomarker to be repurposed in different disease settings in clinical practice. J Clin Med. 2023. https:\/\/doi.org\/10.3390\/jcm12186017.","journal-title":"J Clin Med"},{"key":"5114_CR28","doi-asserted-by":"publisher","DOI":"10.1177\/17588359261417647","volume":"18","author":"Q Luo","year":"2026","unstructured":"Luo Q, Tian H, Liu Z, Chen Z, Zhang X, Qin T. Value of albumin-bilirubin grade for 90-day mortality and long-term outcomes in patients with perihilar cholangiocarcinoma: a multicenter retrospective cohort study. Ther Adv Med Oncol. 2026;18:17588359261417647.","journal-title":"Ther Adv Med Oncol"}],"container-title":["BMC Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12876-026-05114-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-05114-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12876-026-05114-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:02:34Z","timestamp":1791468154000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12876-026-05114-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5114"],"URL":"https:\/\/doi.org\/10.1186\/s12876-026-05114-8","relation":{},"ISSN":["1471-230X"],"issn-type":[{"value":"1471-230X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"assertion":[{"value":"23 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This retrospective study was approved by the Ethics Committee of Tongji Hospital (Approval No. TJ-IRB202409063) and was conducted in accordance with the Declaration of Helsinki. The requirement for informed consent to participate was waived by the Ethics Committee due to the retrospective nature of the study.","order":1,"name":"Ethics","label":"Ethics approval and\u00a0consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"621"}}