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Since 2014 the ethics committee incorporates several cantons under the name Ethikkommission Nordweistschweiz (EKNZ). The trial followed good clinical practice (GCP) as well as the tenets of the Declaration of Helsinki. Key personnel had appropriate training in GCP. The trial has been registered with : NCT01408693 (, last accessed January 24th, 2018). The complete protocol is available as additional file.Eligible patients entered the informed consent process. Depending on their cognitive abilities (quantified using a mental status questionnaire), they were individually, or in the presence of a designated proxy, informed about the diagnosis, the proposed treatment and the randomised trial. Patients were only included by the surgeon on call if they consented in writing or \u2013 in the case of cognitive impairment \u2013 gave their verbal assent with written consent by a designated proxy according to the Swiss civil code (Art. 378) or a legal guardian.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Rachel Rosenthal has been an employee of F. Hoffmann-La Roche Ltd. since May 01, 2014. The present study was designed before Rachel Rosenthal joined F. Hoffmann-La Roche Ltd. and has no connection to her employment by the company. Rachel Rosenthal continues to be affiliated with the University of Basel. The other authors have no conflict of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"222"}}