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The aim was to investigate the association between global cognitive function and gait speed in a representative sample of very old people, and whether the association was affected by dementia, and walking aid use.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Method<\/jats:title>\n<jats:p>This cross-sectional study included 1317 participants, mean age 89.4\u2009years, and 68% women, from the Ume\u00e585+\/Gerontological Regional Database. Self-paced gait speed was measured over 2.4\u2009m, with or without walking aids, and global cognitive function with the Mini-Mental State Examination\u00a0(MMSE). The association between cognition and gait speed was analyzed using multiple linear regression and stratified according to dementia. The influence of missing gait speed values was explored using multiple imputation. An interaction analysis was performed to investigate the influence of walking aid use.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In comprehensively adjusted analyses, MMSE associated with gait speed (unstandardized \u03b2 (\u03b2) 0.011\u2009m\/s, 95% Confidence Interval [CI]\u2009=\u20090.009, 0.013, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in the total sample. No association was found in people with dementia (\u03b2 0.003\u2009m\/s, 95%CI\u2009=\u20090.000, 0.006, <jats:italic>p<\/jats:italic>\u2009=\u20090.058), until missing gait speed values were compensated for by multiple imputation (\u03b2 0.007\u2009m\/s, 95% [CI]\u2009=\u20090.002, 0.011, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). In interaction analysis the use of walking aids attenuated the association between cognition and gait speed (\u03b2 \u2212\u20090.019\u2009m\/s, 95%CI\u2009=\u2009\u2212\u20090.024, \u2212\u20090.013, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Global cognitive function appears to associate with gait speed in very old people. However, in people with dementia selection bias was indicated since unless missing gait speed values were accounted for no association was observed. Walking aid use attenuated cognitive load, which may not apply to walking in daily activities, and requires further investigation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12877-020-1433-3","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T19:02:59Z","timestamp":1580497379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The association between cognition and gait in a representative sample of very old people \u2013 the influence of dementia and walking aid use"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2807-1295","authenticated-orcid":false,"given":"Jerry","family":"\u00d6hlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Ahlgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Folkesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngve","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Littbrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Olofsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Toots","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,31]]},"reference":[{"key":"1433_CR1","volume-title":"Department of Economic and Social Affairs","author":"United Nations","year":"2015","unstructured":"United Nations. 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If informed consent to participate was agreed, a home visit was scheduled and documented. The same information was provided to, and assent obtained from, relatives of participants with cognitive impairment. This study, including consent procedure, was approved by the Regional Ethics Review Board in Ume\u00e5 (registration nos. 99\u2013326, 05-063\u2009M, 09-178\u2009M, 2018\u2013188-32\u2009M) and the Ethics Committee of Vaasa Central Hospital (reg. Nos. 05\u201387 and 10\u201354).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"34"}}