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Acceptance and Commitment Therapy (ACT) aims to foster greater acceptance of internal events while promoting actions aligned with personal values to increase psychological flexibility in the face of challenges. The objective of this single-arm pilot, Telephone Acceptance and Commitment Therapy Intervention for Caregivers (TACTICs), was to evaluate the feasibility, acceptability, and preliminary effects of an ACT intervention on ADRD caregiver anxiety, depressive symptoms, burden, caregiver suffering, and psychological flexibility.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>ADRD caregivers \u226521\u2009years of age with a Generalized Anxiety Disorder Scale (GAD-7) score\u2009\u2265\u200910 indicative of moderate or higher symptoms of anxiety were enrolled (<jats:italic>N<\/jats:italic>\u2009=\u200915). Participants received a telephone-based ACT intervention delivered by a non-licensed, bachelor\u2019s-prepared trained interventionist over 6 weekly 1-h sessions that included engaging experiential exercises and metaphors designed to increase psychological flexibility. The following outcome measures were administered at baseline (T1), immediately post-intervention (T2), 3\u2009months post-intervention (T3), and 6\u2009months post-intervention (T4): anxiety symptoms (GAD-7; primary outcome); secondary outcomes of depressive symptoms (Patient Health Questionnaire\u20139), burden (Zarit Burden Interview), suffering (The Experience of Suffering measure), psychological flexibility\/experiential avoidance (Acceptance and Action Questionnaire-II), and coping skills (Brief COPE).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All 15 participants completed the study and 93.3% rated their overall satisfaction with their TACTICs experience as \u201ccompletely satisfied.\u201d At T2, caregivers showed large reduction in anxiety symptoms (SRM 1.42, 95% CI [0.87, 1.97], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) that were maintained at T3 and T4.<\/jats:p>\n                <jats:p>At T4, psychological suffering (SRM 0.99, 95% CI [0.41, 1.56], <jats:italic>p<\/jats:italic>\u2009=\u20090.0027) and caregiver burden (SRM 0.79, 95% CI [0.21, 1.37], <jats:italic>p<\/jats:italic>\u2009=\u20090.0113) also decreased.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Despite a small sample size, the 6-session manualized TACTICs program was effective in reducing anxiety, suggesting that non-clinically trained staff may be able to provide an effective therapeutic intervention by phone to maximize intervention scalability and reach.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Institutional Review Board (IRB) protocol #1904631305 version 05-14-2019. Recruitment began 06-14-2019 and was concluded on 12-09-2019.<\/jats:p>\n                <jats:p>Recruitment began 06-14-2019 and was concluded on 12-09-2019.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12877-021-02078-0","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T17:20:26Z","timestamp":1613582426000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Feasibility and acceptability of an acceptance and commitment therapy intervention for caregivers of adults with Alzheimer\u2019s disease and related dementias"],"prefix":"10.1186","volume":"21","author":[{"given":"Nicole R.","family":"Fowler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Judge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayler","family":"Gowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Stutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley A.","family":"Johns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"2078_CR1","unstructured":"Alzheimer\u2019s Association. 2018. 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