{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:25:36Z","timestamp":1777425936100,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"crossref","award":["BMBF 01GL1805"],"award-info":[{"award-number":["BMBF 01GL1805"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The coronavirus disease 2019 (COVID-19) pandemic is a threat to ongoing clinical trials necessitating regular face-to-face, in-person meetings, particularly in participants with a high risk of complications. Guidance on how to handle and safely continue such trials is lacking. Chronically ill elderly individuals require\u2014in addition to protection from infection\u2014regular physical exercise and social contact to remain healthy. Solutions on how to handle these conflicting necessities are needed.<\/jats:p>\n                <jats:p>The ENTAIER-randomised controlled trial was investigating the influence of mindful movements on fall risk, fear of falling, mobility, balance, life quality, and other outcomes. The study population was planned to comprise of 550 chronically ill elderly individuals with a high risk of falling. The movements were regularly performed in coached groups over 6\u2009months. After the trial began, COVID-19 lockdowns stopped all in-person meetings, and it was expected that the limitations of this pandemic would continue for a long term. Therefore, the exercise programme, which involved complex movements and was typically conducted face-to-face in groups, had to be substituted by a telemedicine programme within a short timeframe. The objectives, therefore, were to identify challenges and tasks that could to be resolved and steps that could to be taken to achieve high-quality, efficacy, safety, and enable human encounter and motivation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We proceeded with four steps: 1) A literature review on the quality and feasibility issues of telemedicine in general, and specifically, in exercise training in elderly individuals. 2) Participation in two international telemedicine task forces on integrative medicine, particularly, mind\u2013body medicine. 3) Interviews with study therapists, (for practical purposes, eurythmy therapists and Tai Chi teachers are summarized here as therapists) personnel, and international experts on providing mindful movement exercises and other physiotherapies via live telecommunication technology, and with scientists and patient representatives. 4) Final evaluation by the core trial team and subsequent planning and implementation of changes in the trial organisation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Various tasks and challenges were identified: for the technical equipment for therapists and patients; for the ability of therapists and trial participants to adequately manage the technology and telemedicine intervention; the reservations and concerns about the technology among therapists and participants; safety and data protection in using the technology; and study design. The two major options found on how to continue the trial in the COVID-19 situation were a complete switch to telemedicine and a partial switch in the form of risk management implemented into the former design.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The management of an ongoing clinical trial in a national or international crisis with a minimum of available time and extra financial resources, alongside with two checklists on steps and procedures for trial continuation and telemedicine implementation, may be informative for other researchers or healthcare providers faced with similar challenges and making similar decisions in the current situation or similar future scenarios.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trail registration<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.drks.de\">www.drks.de<\/jats:ext-link>. DRKS00016609. Registered July 30, 2019.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12877-021-02232-8","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T11:42:39Z","timestamp":1620042159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Addressing COVID-19 challenges in a randomised controlled trial on exercise interventions in a high-risk population"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-5944","authenticated-orcid":false,"given":"G. S.","family":"Kienle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Werthmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Grotejohann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hundhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Schmoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ch","family":"Stumpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Voigt-Radloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"2232_CR1","unstructured":"WHO. Rolling updates on coronavirus disease (COVID-19). Published 2020. Accessed 01 Sep 2020."},{"key":"2232_CR2","unstructured":"McIntosh K, Hirsch M, Bloom A. Coronavirus disease 2019 (COVID-19): Clinical features. \u00a92020 UpToDate, Inc. Wolters Kluwer. Published 2020. Accessed 29 June 2020."},{"key":"2232_CR3","unstructured":"Cohen P, Blau J, Elmore J, Kunins G. Coronavirus disease 2019 (COVID-19): Outpatient management in adults. \u00a92020 UpToDate, Inc. Wolters Kluwer. Published 2020. Accessed 29 June 2020."},{"key":"2232_CR4","unstructured":"Centers for Disease Control and Prevention: Checklist for Older Adults. Published 08-05-2020. Accessed 01 Sep 2020."},{"issue":"4","key":"2232_CR5","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3855\/jidc.12684","volume":"14","author":"MN Aung","year":"2020","unstructured":"Aung MN, Yuasa M, Koyanagi Y, Aung TNN, Moolphate S, Matsumoto H, et al. Sustainable health promotion for the seniors during COVID-19 outbreak: a lesson from Tokyo. J Infect Dev Ctries. 2020;14(4):328\u201331. https:\/\/doi.org\/10.3855\/jidc.12684.","journal-title":"J Infect Dev Ctries"},{"issue":"3","key":"2232_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.encep.2020.04.005","volume":"46","author":"A Chevance","year":"2020","unstructured":"Chevance A, Gourion D, Hoertel N, Llorca PM, Thomas P, Bocher R, et al. Ensuring mental health care during the SARS-CoV-2 epidemic in France: a narrative review. Encephale. 2020;46(3):193\u2013201. https:\/\/doi.org\/10.1016\/j.encep.2020.04.005.","journal-title":"Encephale."},{"key":"2232_CR7","unstructured":"Guidance on the management of clinical trials during the COVID-19 (coronavirus) pandemic. Published 28 April 2020. Accessed 01 Sep 2020."},{"key":"2232_CR8","unstructured":"Committee for Human Medicinal Products (CHMP).\u00a0Points to consider on implications of Coronavirus disease (COVID-19) on methodological aspects of ongoing clinical trials. EMA\/158330\/2020 Rev. 1.\u00a0Published\u00a026 June 2020. Accessed 17 Sep\u00a02020."},{"issue":"5","key":"2232_CR9","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/S1470-2045(20)30226-6","volume":"21","author":"BHR de Paula","year":"2020","unstructured":"de Paula BHR, Araujo I, Bandeira L, Barreto N, Doherty GJ. Recommendations from national regulatory agencies for ongoing cancer trials during the COVID-19 pandemic. Lancet Oncol. 2020;21(5):624\u20137. https:\/\/doi.org\/10.1016\/S1470-2045(20)30226-6.","journal-title":"Lancet Oncol"},{"issue":"1","key":"2232_CR10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12877-020-1503-6","volume":"20","author":"GS Kienle","year":"2020","unstructured":"Kienle GS, Werthmann PG, Grotejohann B, Kaier K, Steinbrenner I, Voigt-Radloff S, et al. A multi-centre, parallel-group, randomised controlled trial to assess the efficacy and safety of eurythmy therapy and tai chi in comparison with standard care in chronically ill elderly patients with increased risk of falling (ENTAiER): a trial protocol. BMC Geriatr. 2020;20(1):108. https:\/\/doi.org\/10.1186\/s12877-020-1503-6.","journal-title":"BMC Geriatr"},{"key":"2232_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jclinepi.2020.10.007","volume":"130","author":"C Garritty","year":"2021","unstructured":"Garritty C, Gartlehner G, Nussbaumer-Streit B, King VJ, Hamel C, Kamel C, et al. Cochrane rapid reviews methods group offers evidence-informed guidance to conduct rapid reviews. J Clin Epidemiol. 2021;130:13\u201322. https:\/\/doi.org\/10.1016\/j.jclinepi.2020.10.007.","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"2232_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000217","volume":"7","author":"D Moher","year":"2010","unstructured":"Moher D, Schulz KF, Simera I, Altman DG. Guidance for developers of health research reporting guidelines. PLoS Med. 2010;7(2):e1000217. https:\/\/doi.org\/10.1371\/journal.pmed.1000217.","journal-title":"PLoS Med"},{"key":"2232_CR13","volume-title":"Qualitative research practice. A guide for social science students and researchers","author":"JLJ Ritchie","year":"2003","unstructured":"Ritchie JLJ. Qualitative research practice. A guide for social science students and researchers. London: Sage; 2003."},{"key":"2232_CR14","volume-title":"Qualitative research and evaluation methods","author":"MQ Patton","year":"2002","unstructured":"Patton MQ. Qualitative research and evaluation methods. Thousand Oaks: Sage; 2002."},{"issue":"19","key":"2232_CR15","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1136\/bjsports-2020-102650","volume":"54","author":"HP Dijkstra","year":"2020","unstructured":"Dijkstra HP, Ergen E, Holtzhausen L, Beasley I, Alonso JM, Geertsema L, et al. Remote assessment in sport and exercise medicine (SEM): a narrative review and teleSEM solutions for and beyond the COVID-19 pandemic. Br J Sports Med. 2020;54(19):1162\u20137. https:\/\/doi.org\/10.1136\/bjsports-2020-102650.","journal-title":"Br J Sports Med"},{"issue":"8","key":"2232_CR16","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1093\/ptj\/pzaa089","volume":"100","author":"A Middleton","year":"2020","unstructured":"Middleton A, Simpson KN, Bettger JP, Bowden MG. COVID-19 pandemic and beyond: considerations and costs of Telehealth exercise programs for older adults with functional impairments living at home-lessons learned from a pilot case study. Phys Ther. 2020;100(8):1278\u201388. https:\/\/doi.org\/10.1093\/ptj\/pzaa089.","journal-title":"Phys Ther"},{"issue":"3","key":"2232_CR17","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3233\/JPD-202109","volume":"10","author":"ER Dorsey","year":"2020","unstructured":"Dorsey ER, Okun MS, Bloem BR. Care, convenience, comfort, confidentiality, and contagion: the 5 C\u2019s that will shape the future of telemedicine. J Parkinsons Dis. 2020;10(3):893\u20137. https:\/\/doi.org\/10.3233\/JPD-202109.","journal-title":"J Parkinsons Dis"},{"issue":"10227","key":"2232_CR18","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/S0140-6736(20)30424-4","volume":"395","author":"ER Dorsey","year":"2020","unstructured":"Dorsey ER, Topol EJ. Telemedicine 2020 and the next decade. Lancet. 2020;395(10227):859. https:\/\/doi.org\/10.1016\/S0140-6736(20)30424-4.","journal-title":"Lancet."},{"key":"2232_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.physio.2019.06.006","volume":"107","author":"M Nelson","year":"2020","unstructured":"Nelson M, Bourke M, Crossley K, Russell T. Telerehabilitation is non-inferior to usual care following total hip replacement - a randomized controlled non-inferiority trial. Physiotherapy. 2020;107:19\u201327. https:\/\/doi.org\/10.1016\/j.physio.2019.06.006.","journal-title":"Physiotherapy."},{"issue":"2","key":"2232_CR20","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1017\/S0266462320000021","volume":"36","author":"M Hosseiniravandi","year":"2020","unstructured":"Hosseiniravandi M, Kahlaee AH, Karim H, Ghamkhar L, Safdari R. Home-based telerehabilitation software systems for remote supervising: a systematic review. Int J Technol Assess Health Care. 2020;36(2):113\u201325. https:\/\/doi.org\/10.1017\/S0266462320000021.","journal-title":"Int J Technol Assess Health Care"},{"issue":"1","key":"2232_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/nur.21922","volume":"42","author":"M Ortiz-Pina","year":"2019","unstructured":"Ortiz-Pina M, Salas-Farina Z, Mora-Traverso M, et al. A home-based tele-rehabilitation protocol for patients with hip fracture called @ctivehip. Res Nurs Health. 2019;42(1):29\u201338. https:\/\/doi.org\/10.1002\/nur.21922.","journal-title":"Res Nurs Health"},{"issue":"1","key":"2232_CR22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1093\/ageing\/afx146","volume":"47","author":"P Bernocchi","year":"2018","unstructured":"Bernocchi P, Vitacca M, La Rovere MT, et al. Home-based telerehabilitation in older patients with chronic obstructive pulmonary disease and heart failure: a randomised controlled trial. Age Ageing. 2018;47(1):82\u20138. https:\/\/doi.org\/10.1093\/ageing\/afx146.","journal-title":"Age Ageing"},{"issue":"3","key":"2232_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.physio.2018.04.004","volume":"104","author":"MA van Egmond","year":"2018","unstructured":"van Egmond MA, van der Schaaf M, Vredeveld T, Vollenbroek-Hutten MMR, van Berge Henegouwen MI, Klinkenbijl JHG, et al. Effectiveness of physiotherapy with telerehabilitation in surgical patients: a systematic review and meta-analysis. Physiotherapy. 2018;104(3):277\u201398. https:\/\/doi.org\/10.1016\/j.physio.2018.04.004.","journal-title":"Physiotherapy."},{"issue":"8","key":"2232_CR24","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1111\/jgs.15959","volume":"67","author":"JA Batsis","year":"2019","unstructured":"Batsis JA, DiMilia PR, Seo LM, et al. Effectiveness of ambulatory telemedicine care in older adults: a systematic review. J Am Geriatr Soc. 2019;67(8):1737\u201349. https:\/\/doi.org\/10.1111\/jgs.15959.","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"2232_CR25","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027416","volume":"9","author":"ER Ramage","year":"2019","unstructured":"Ramage ER, Fini NA, Lynch EA, Patterson A, Said CM, English C. Supervised exercise delivered via telehealth in real time to manage chronic conditions in adults: a protocol for a scoping review to inform future research in stroke survivors. BMJ Open. 2019;9(3):e027416. https:\/\/doi.org\/10.1136\/bmjopen-2018-027416.","journal-title":"BMJ Open"},{"issue":"5","key":"2232_CR26","doi-asserted-by":"publisher","DOI":"10.2196\/mhealth.9563","volume":"6","author":"J Hong","year":"2018","unstructured":"Hong J, Kong HJ, Yoon HJ. Web-based telepresence exercise program for community-dwelling elderly women with a high risk of falling: randomized controlled trial. JMIR Mhealth Uhealth. 2018;6(5):e132. https:\/\/doi.org\/10.2196\/mhealth.9563.","journal-title":"JMIR Mhealth Uhealth"},{"issue":"1\u20132","key":"2232_CR27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/1357633X18794315","volume":"26","author":"B Lai","year":"2020","unstructured":"Lai B, Bond K, Kim Y, Barstow B, Jovanov E, Bickel CS. Exploring the uptake and implementation of tele-monitored home-exercise programmes in adults with Parkinson's disease: a mixed-methods pilot study. J Telemed Telecare. 2020;26(1\u20132):53\u201363. https:\/\/doi.org\/10.1177\/1357633X18794315.","journal-title":"J Telemed Telecare"},{"issue":"1","key":"2232_CR28","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1745-6215-15-42","volume":"15","author":"M Tousignant","year":"2014","unstructured":"Tousignant M, Corriveau H, Kairy D, Berg K, Dubois MF, Gosselin S, et al. Tai chi-based exercise program provided via telerehabilitation compared to home visits in a post-stroke population who have returned home without intensive rehabilitation: study protocol for a randomized, non-inferiority clinical trial. Trials. 2014;15(1):42. https:\/\/doi.org\/10.1186\/1745-6215-15-42.","journal-title":"Trials."},{"issue":"16","key":"2232_CR29","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1056\/NEJMsr1503323","volume":"377","author":"RV Tuckson","year":"2017","unstructured":"Tuckson RV, Edmunds M, Hodgkins ML. Telehealth. N Engl J Med. 2017;377(16):1585\u201392. https:\/\/doi.org\/10.1056\/NEJMsr1503323.","journal-title":"N Engl J Med"},{"key":"2232_CR30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.nedt.2015.12.025","volume":"39","author":"CT van Houwelingen","year":"2016","unstructured":"van Houwelingen CT, Moerman AH, Ettema RG, Kort HS, Ten Cate O. Competencies required for nursing telehealth activities: a Delphi-study. Nurse Educ Today. 2016;39:50\u201362. https:\/\/doi.org\/10.1016\/j.nedt.2015.12.025.","journal-title":"Nurse Educ Today"},{"issue":"1","key":"2232_CR31","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12245-019-0226-y","volume":"12","author":"R Sharma","year":"2019","unstructured":"Sharma R, Nachum S, Davidson KW, Nochomovitz M. It's not just FaceTime: core competencies for the medical Virtualist. Int J Emerg Med. 2019;12(1):8. https:\/\/doi.org\/10.1186\/s12245-019-0226-y.","journal-title":"Int J Emerg Med"},{"issue":"7","key":"2232_CR32","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1093\/ptj\/pzaa079","volume":"100","author":"AC Lee","year":"2020","unstructured":"Lee AC. COVID-19 and the advancement of digital physical therapist practice and telehealth. Phys Ther. 2020;100(7):1054\u20137. https:\/\/doi.org\/10.1093\/ptj\/pzaa079.","journal-title":"Phys Ther"},{"key":"2232_CR33","doi-asserted-by":"crossref","unstructured":"Nittari G, Khuman R, Baldoni S, et al. Telemedicine practice: review of the current ethical and legal challenges. Telemed J E Health. 2020;26(12):1427-37.","DOI":"10.1089\/tmj.2019.0158"},{"issue":"1","key":"2232_CR34","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12877-016-0378-z","volume":"16","author":"A Giordano","year":"2016","unstructured":"Giordano A, Bonometti GP, Vanoglio F, Paneroni M, Bernocchi P, Comini L, et al. Feasibility and cost-effectiveness of a multidisciplinary home-telehealth intervention programme to reduce falls among elderly discharged from hospital: study protocol for a randomized controlled trial. BMC Geriatr. 2016;16(1):209. https:\/\/doi.org\/10.1186\/s12877-016-0378-z.","journal-title":"BMC Geriatr"},{"issue":"12","key":"2232_CR35","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1377\/hlthaff.2018.05132","volume":"37","author":"E Shigekawa","year":"2018","unstructured":"Shigekawa E, Fix M, Corbett G, Roby DH, Coffman J. The current state of telehealth evidence: a rapid review. Health Aff (Millwood). 2018;37(12):1975\u201382. https:\/\/doi.org\/10.1377\/hlthaff.2018.05132.","journal-title":"Health Aff (Millwood)"},{"issue":"10","key":"2232_CR36","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1007\/s11606-017-4082-2","volume":"32","author":"D Chaet","year":"2017","unstructured":"Chaet D, Clearfield R, Sabin JE, Skimming K, Council on E, Judicial Affairs American Medical A. Ethical practice in telehealth and telemedicine. J Gen Intern Med. 2017;32(10):1136\u201340. https:\/\/doi.org\/10.1007\/s11606-017-4082-2.","journal-title":"J Gen Intern Med"},{"issue":"2","key":"2232_CR37","first-page":"1303","volume":"5","author":"M Edmunds","year":"2017","unstructured":"Edmunds M, Tuckson R, Lewis J, et al. An emergent research and policy framework for telehealth. EGEMS (Wash DC). 2017;5(2):1303.","journal-title":"EGEMS (Wash DC)"},{"key":"2232_CR38","unstructured":"World Confederation of Physical Therapy, International Network of Physical Therapy Regulatory Authorities: Report of the WCPT\/INPTRA Digital Physical Therapy Practice Task Force. Published 2019. Accessed 10 Aug 2020."},{"issue":"1","key":"2232_CR39","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1016\/j.jpainsymman.2020.03.019","volume":"60","author":"B Calton","year":"2020","unstructured":"Calton B, Abedini N, Fratkin M. Telemedicine in the time of coronavirus. J Pain Symptom Manag. 2020;60(1):e12\u20134. https:\/\/doi.org\/10.1016\/j.jpainsymman.2020.03.019.","journal-title":"J Pain Symptom Manag"},{"issue":"7","key":"2232_CR40","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1093\/jamia\/ocaa072","volume":"27","author":"DM Mann","year":"2020","unstructured":"Mann DM, Chen J, Chunara R, Testa PA, Nov O. COVID-19 transforms health care through telemedicine: evidence from the field. J Am Med Inform Assoc. 2020;27(7):1132\u20135. https:\/\/doi.org\/10.1093\/jamia\/ocaa072.","journal-title":"J Am Med Inform Assoc"},{"key":"2232_CR41","doi-asserted-by":"publisher","unstructured":"Ben-Arye E, Paller C, Lopez AM, et al. The Society for Integrative Oncology practice recommendations for online treatment during the COVID-19 pandemic. Support Care Cancer. 2021. https:\/\/doi.org\/10.1007\/s00520-021-06205-w.","DOI":"10.1007\/s00520-021-06205-w"},{"issue":"6","key":"2232_CR42","doi-asserted-by":"publisher","first-page":"20","DOI":"10.7453\/gahmj.2012.087","volume":"2","author":"GS Kienle","year":"2013","unstructured":"Kienle GS, Albonico HU, Baars E, Hamre HJ, Zimmermann P, Kiene H. Anthroposophic medicine: an integrative medical system originating in Europe. Glob Adv Health Med. 2013;2(6):20\u201331. https:\/\/doi.org\/10.7453\/gahmj.2012.087.","journal-title":"Glob Adv Health Med"},{"key":"2232_CR43","unstructured":"Agency EM. ICH E9 (R1) addendum on estimands and sensitivity analysis in clinical trials to the guideline on statistical principles for clinical trials. EMA\/CHMP\/ICH\/436221\/2017. Published 2017. Accessed 01 Sep 2020."},{"issue":"4","key":"2232_CR44","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/19466315.2020.1779122","volume":"12","author":"RD Meyer","year":"2020","unstructured":"Meyer RD, Ratitch B, Wolbers M, Marchenko O, Quan H, Li D, et al. Statistical issues and recommendations for clinical trials conducted during the COVID-19 pandemic. Stat Biopharm Res. 2020;12(4):399\u2013411. https:\/\/doi.org\/10.1080\/19466315.2020.1779122.","journal-title":"Stat Biopharm Res"},{"key":"2232_CR45","volume-title":"Gesundheit und Krankheit im Alter","author":"K B\u00f6hm","year":"2009","unstructured":"B\u00f6hm K, Tesch-R\u00f6mer C, Ziese T. Gesundheit und Krankheit im Alter. Berlin: Robert Koch Institut; 2009."},{"key":"2232_CR46","volume-title":"World report on ageing and health","author":"WHO","year":"2015","unstructured":"WHO. World report on ageing and health. Geneve: World Health Organization; 2015."},{"key":"2232_CR47","volume":"3","author":"M Angevaren","year":"2008","unstructured":"Angevaren M, Aufdemkampe G, Verhaar HJ, Aleman A, Vanhees L. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 2008;3:CD005381.","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"2232_CR48","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/ageing\/afu168","volume":"44","author":"KR Fox","year":"2015","unstructured":"Fox KR, Ku PW, Hillsdon M, Davis MG, Simmonds BAJ, Thompson JL, et al. Objectively assessed physical activity and lower limb function and prospective associations with mortality and newly diagnosed disease in UK older adults: an OPAL four-year follow-up study. Age Ageing. 2015;44(2):261\u20138. https:\/\/doi.org\/10.1093\/ageing\/afu168.","journal-title":"Age Ageing"},{"issue":"15","key":"2232_CR49","doi-asserted-by":"publisher","first-page":"5797","DOI":"10.1073\/pnas.1219686110","volume":"110","author":"A Steptoe","year":"2013","unstructured":"Steptoe A, Shankar A, Demakakos P, Wardle J. Social isolation, loneliness, and all-cause mortality in older men and women. Proc Natl Acad Sci U S A. 2013;110(15):5797\u2013801. https:\/\/doi.org\/10.1073\/pnas.1219686110.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2232_CR50","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1007\/s00391-012-0335-1","volume":"45","author":"MD Denkinger","year":"2012","unstructured":"Denkinger MD, Lukas A, Herbolsheimer F, Peter R, Nikolaus T. Physical activity and other health-related factors predict health care utilisation in older adults: the ActiFE Ulm study. Z Gerontol Geriatr. 2012;45(4):290\u20137. https:\/\/doi.org\/10.1007\/s00391-012-0335-1.","journal-title":"Z Gerontol Geriatr"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-021-02232-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-021-02232-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-021-02232-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T22:05:32Z","timestamp":1626818732000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/s12877-021-02232-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2232"],"URL":"https:\/\/doi.org\/10.1186\/s12877-021-02232-8","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"5 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval from the Committee of the Medical Centre \u2013 University of Freiburg (183\/19; 23.07.2019 and 13.07.2020) and the ethics committees of T\u00fcbingen for the T\u00fcbingen and Filderstadt sites (561\/2019BO1, 21.10.2019 and 12.08.2020) of Witten\/Herdecke (150\/2019, 31.07.2019 and 30.07.2020), Ulm (284\/19, 01.08.2019 and 22.07.2020), and Essen (19\u20138908-BO, 18.02.2020 and 23.07.2020) were obtained. Berlin relies on the vote from Freiburg.Written informed consent to participate in the study is obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"287"}}