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The aim of this study was to assess differences in blood pressure changes between persons with dementia receiving UV light versus vitamin D (VD) supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Post-hoc analysis of randomized controlled trial data concerning nursing home residents with dementia (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200961; 41 women, mean age 84.8\u2009years). The participants received half-body UV irradiation, twice weekly over 6\u2009months, at one standard erythema dose (UV group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) or 5600 international units of cholecalciferol once a week (VD group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939). Short-term effects were evaluated after 1\u2009month and long-term effects after 3 and 6\u2009months. Differences in blood pressure changes were assessed using linear mixed models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With the VD group as a reference, the estimated difference in mean change of systolic blood pressure was \u2212\u200926.0\u2009mmHg [95% confidence interval (CI) -39.9, \u2212\u200912.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.000] at 1\u2009month, 4.5\u2009mmHg (95% CI -6.8, 15.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.432) at 3\u2009months, and 0.1 (95% CI -14.1, 14.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.83) at 6\u2009months. The estimated difference in diastolic blood pressure was \u2212\u200910.0\u2009mmHg (95% CI -19.2, \u2212\u20090.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035) at 1\u2009month, 3.6\u2009mmHg (95% CI -4.1, 11.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.358) at 3\u2009months, and 2.7 (95% CI -6.8, 12.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.580) at 6\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UV light had only a short-term effect but not a long-term effect on blood pressure reduction compared to VD use in this sample of normotensive to mild hypertensive nursing home residents with dementia. Future studies will be needed to determine the effect of UV light in different samples of the population and especially in a population with hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12877-021-02538-7","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T06:12:28Z","timestamp":1634623948000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of ultraviolet irradiation compared to oral vitamin D supplementation on blood pressure of nursing home residents with dementia"],"prefix":"10.1186","volume":"21","author":[{"given":"Bistra I.","family":"Veleva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique A. 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Circ Res. 2019;124(7):1045\u201360.","journal-title":"Circ Res"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-021-02538-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-021-02538-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-021-02538-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T07:22:08Z","timestamp":1634628128000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/s12877-021-02538-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2538"],"URL":"https:\/\/doi.org\/10.1186\/s12877-021-02538-7","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,19]]},"assertion":[{"value":"7 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This post-hoc analysis used the data of a randomized control trial \u201cThe Effect of Ultraviolet B Irradiation Compared with Oral Vitamin D Supplementation on the Well-being of Nursing Home Residents with Dementia\u201d [\n                      \n                      ]. The study was conducted in accordance with the declaration of Helsinki, and protocol was approved by the Medical Ethical Committee of Leiden University Medical Center (Registration No P16.010) on 11 April, 2016 and was registered in the Dutch Trial Register (NL5704). Participants were recruited from three nursing homes connected to the University Network for the Care sector South Holland (UNC-ZH). Team leaders of the nursing homes sent information letters with an informed consent form to all nursing home residents and their families. An independent physician with a specialty in internal medicine was assigned to answer the questions of the participants and their families. Written informed consent was obtained from the legal representatives of all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"No individual person\u2019s data is included in the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"577"}}