{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:58:46Z","timestamp":1793890726496,"version":"4.8.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T00:00:00Z","timestamp":1639785600000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Leipzig"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osteoporotic vertebral compression fractures (VCFs) are common. An increase in mortality associated with osteoporotic VCFs has been well documented. The purpose of this study was to assess the impact of time to surgery on 1-year survival in patients with osteoporotic vertebral compression fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a retrospective cohort study with prospective mortality follow-up,\n                      <jats:bold>c<\/jats:bold>\n                      onsecutive patients aged \u2265 60\u2009years who had operative treatment of a low-energy fracture of a thoracolumbar vertebra and had undergone surgical stabilization between January 2015 and December 2018 were identified from our institutional database. By chart review, additional information on hospitalization time, comorbidities (expressed as ASA - American Society of Anesthesiologists Scale), complications and revision surgery was obtained. Time-to-surgery was defined as the time between admission and surgery. Mortality data was assessed by contacting the patients by phone, mail or the national social insurance database.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred sixty patients (mean age 78\u2009years, SD 7\u2009years, range, 60 to 93; 172 female) were available for final analysis. Mean follow-up was 40\u2009months (range, 12 to 68\u2009months). Fifty-nine patients (22.7%) had died at final follow-up and 27\/260 patients (10.4%) had died within 1 year after the surgery. Time-to-surgery was not different for patients who died within 1 year after the surgery and those who survived (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.501). In-hospital complications were seen in 40\/260 (15.4%) patients. Time-to-surgery showed a strong correlation with hospitalization time (Pearson\u2019s\n                      <jats:italic>r\u2009=<\/jats:italic>\n                      \u00a0.614,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), but only a very weak correlation with the time spent in hospital after the surgery (Pearson\u2019s\n                      <jats:italic>r\u2009=<\/jats:italic>\n                      \u00a0.146,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In contrast to patients with proximal femur factures, time-to-surgery had no significant effect on one-year mortality in geriatric patients with osteoporotic vertebral compression fractures. Treatment decisions for these fractures in the elderly should be individualized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12877-021-02682-0","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T04:02:39Z","timestamp":1639800159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Does time-to-surgery affect mortality in patients with acute osteoporotic vertebral compression fractures?"],"prefix":"10.1186","volume":"21","author":[{"given":"Christian","family":"Pfeifle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Kohut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Sven","family":"Jarvers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich J.","family":"Spiegl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph-Eckhard","family":"Heyde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Osterhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,18]]},"reference":[{"key":"2682_CR1","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17:1726\u201333. https:\/\/doi.org\/10.1007\/s00198-006-0172-4.","journal-title":"Osteoporos Int"},{"key":"2682_CR2","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/BOR.0000000000000064","volume":"26","author":"WD Leslie","year":"2014","unstructured":"Leslie WD, Morin SN. Osteoporosis epidemiology 2013: implications for diagnosis, risk assessment, and treatment. Curr Opin Rheumatol. 2014;26:440\u20136. https:\/\/doi.org\/10.1097\/BOR.0000000000000064.","journal-title":"Curr Opin Rheumatol"},{"key":"2682_CR3","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1359\/jbmr.2003.18.7.1254","volume":"18","author":"T Jalava","year":"2003","unstructured":"Jalava T, Sarna S, Pylkk\u00e4nen L, Mawer B, Kanis JA, Selby P, et al. Association between vertebral fracture and increased mortality in osteoporotic patients. J Bone Miner Res. 2003;18:1254\u201360. https:\/\/doi.org\/10.1359\/jbmr.2003.18.7.1254.","journal-title":"J Bone Miner Res"},{"key":"2682_CR4","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s00198-003-1490-4","volume":"15","author":"O Johnell","year":"2004","unstructured":"Johnell O, Kanis JA, Od\u00e9n A, Sernbo I, Redlund-Johnell I, Petterson C, et al. Mortality after osteoporotic fractures. Osteoporos Int. 2004;15:38\u201342. https:\/\/doi.org\/10.1007\/s00198-003-1490-4.","journal-title":"Osteoporos Int"},{"key":"2682_CR5","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1097\/BRS.0000000000000992","volume":"40","author":"AA Edidin","year":"2015","unstructured":"Edidin AA, Ong KL, Lau E, Kurtz SM. Morbidity and mortality after vertebral fractures: comparison of vertebral augmentation and nonoperative Management in the Medicare Population. Spine. 2015;40:1228\u201341. https:\/\/doi.org\/10.1097\/BRS.0000000000000992.","journal-title":"Spine"},{"key":"2682_CR6","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1007\/s11999-010-1279-7","volume":"468","author":"JM Zampini","year":"2010","unstructured":"Zampini JM, White AP, McGuire KJ. Comparison of 5766 vertebral compression fractures treated with or without Kyphoplasty. Clin Orthop Relat Res. 2010;468:1773\u201380. https:\/\/doi.org\/10.1007\/s11999-010-1279-7.","journal-title":"Clin Orthop Relat Res"},{"key":"2682_CR7","doi-asserted-by":"publisher","first-page":"E1266","DOI":"10.1097\/BRS.0b013e31820a0b3f","volume":"36","author":"MC Gerling","year":"2011","unstructured":"Gerling MC, Eubanks JD, Patel R, Whang PG, Bohlman HH, Ahn NU. Cement augmentation of refractory osteoporotic vertebral compression fractures: survivorship analysis. Spine. 2011;36:E1266\u20139. https:\/\/doi.org\/10.1097\/BRS.0b013e31820a0b3f.","journal-title":"Spine"},{"key":"2682_CR8","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1001\/jama.2017.17606","volume":"318","author":"D Pincus","year":"2017","unstructured":"Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, et al. Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA. 2017;318:1994. https:\/\/doi.org\/10.1001\/jama.2017.17606.","journal-title":"JAMA"},{"key":"2682_CR9","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00264-010-1004-x","volume":"35","author":"E Carretta","year":"2011","unstructured":"Carretta E, Bochicchio V, Rucci P, Fabbri G, Laus M, Fantini MP. Hip fracture: effectiveness of early surgery to prevent 30-day mortality. Int Orthop. 2011;35:419\u201324. https:\/\/doi.org\/10.1007\/s00264-010-1004-x.","journal-title":"Int Orthop"},{"key":"2682_CR10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/BOT.0000000000001078","volume":"32","author":"P Myers","year":"2018","unstructured":"Myers P, Laboe P, Johnson KJ, Fredericks PD, Crichlow RJ, Maar DC, et al. Patient Mortality in Geriatric Distal Femur Fractures. J Orthop Trauma. 2018;32:111\u20135. https:\/\/doi.org\/10.1097\/BOT.0000000000001078.","journal-title":"J Orthop Trauma"},{"key":"2682_CR11","doi-asserted-by":"publisher","first-page":"46S","DOI":"10.1177\/2192568217717972","volume":"8","author":"KJ Schnake","year":"2018","unstructured":"Schnake KJ, Blattert TR, Hahn P, Franck A, Hartmann F, Ullrich B, et al. Classification of osteoporotic thoracolumbar spine fractures: recommendations of the spine section of the German Society for Orthopaedics and Trauma (DGOU). Glob Spine J. 2018;8:46S\u20139S. https:\/\/doi.org\/10.1177\/2192568217717972.","journal-title":"Glob Spine J"},{"key":"2682_CR12","volume-title":"Straightforward statistics for the behavioral sciences. Brooks\/Cole Pub. Co, Pacific Grove","author":"JD Evans","year":"1996","unstructured":"Evans JD. Straightforward statistics for the behavioral sciences. Brooks\/Cole Pub. Co, Pacific Grove; 1996."},{"key":"2682_CR13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/neuros\/nyy017","volume":"84","author":"DP Beall","year":"2019","unstructured":"Beall DP, Chambers MR, Thomas S, Amburgy J, Webb JR, Goodman BS, et al. Prospective and multicenter evaluation of outcomes for quality of life and activities of daily living for balloon Kyphoplasty in the treatment of vertebral compression fractures: the EVOLVE trial. Neurosurgery. 2019;84:169\u201378. https:\/\/doi.org\/10.1093\/neuros\/nyy017.","journal-title":"Neurosurgery"},{"key":"2682_CR14","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1007\/s00198-011-1833-5","volume":"23","author":"Y-K Lee","year":"2012","unstructured":"Lee Y-K, Jang S, Jang S, Lee HJ, Park C, Ha Y-C, et al. Mortality after vertebral fracture in Korea: analysis of the National Claim Registry. Osteoporos Int. 2012;23:1859\u201365. https:\/\/doi.org\/10.1007\/s00198-011-1833-5.","journal-title":"Osteoporos Int"},{"key":"2682_CR15","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1302\/0301-620X.101B9.BJJ-2019-0295.R1","volume":"101-B","author":"S Leer-Salvesen","year":"2019","unstructured":"Leer-Salvesen S, Enges\u00e6ter LB, Dybvik E, Furnes O, Kristensen TB, Gjertsen J-E. Does time from fracture to surgery affect mortality and intraoperative medical complications for hip fracture patients?: an observational study of 73 557 patients reported to the Norwegian hip fracture register. Bone Jt J. 2019;101-B:1129\u201337. https:\/\/doi.org\/10.1302\/0301-620X.101B9.BJJ-2019-0295.R1.","journal-title":"Bone Jt J"},{"key":"2682_CR16","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1007\/s00586-016-4911-8","volume":"26","author":"M Kreinest","year":"2017","unstructured":"Kreinest M, Rillig J, Gr\u00fctzner PA, K\u00fcffer M, Tinelli M, Matschke S. Analysis of complications and perioperative data after open or percutaneous dorsal instrumentation following traumatic spinal fracture of the thoracic and lumbar spine: a retrospective cohort study including 491 patients. Eur Spine J. 2017;26:1535\u201340. https:\/\/doi.org\/10.1007\/s00586-016-4911-8.","journal-title":"Eur Spine J"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-021-02682-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-021-02682-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-021-02682-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T04:08:13Z","timestamp":1639800493000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/s12877-021-02682-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2682"],"URL":"https:\/\/doi.org\/10.1186\/s12877-021-02682-0","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"20 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol of this study was approved by the institutional ethics committee (Ethik-Kommission der Medizinischen Fakult\u00e4t der Universit\u00e4t Leipzig, reference 202\/19-ek). The study was conducted in accordance with all local regulations and followed the principles of the Helsinki declaration.Informed consent was not obtained due to the retrospective nature of the study in accordance with \u00a734 of the Saxon Hospital Act. Patients who earlier had expressed objection to the use of their data for research purposes were excluded.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"N\/AAvailability of data and materials: Anonymized grouped data available upon request from the corresponding author.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"GO is Associated Editor of BMC Musculoskeletal Disorders. The other authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"714"}}