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Chronic diseases, chest CT, laboratory tests, and other data were collected within the first 48\u2009h of hospitalization. Outcomes were progression to severe respiratory failure with the need of mechanical ventilation (SRF\/MV) and death.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean age was 72.7\u2009\u00b1\u20099.2\u2009years, and 63.2% were men. SRF\/MV occurred in 16.9% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and death occurred in 8%. In the adjusted regression analyses, lung involvement over 50% [odds ratio (OR): 3.09 (1.03\u20139.28; 0.043)], C-reactive protein (CRP)\u2009&gt;\u200980\u2009ng\/mL [OR: 2.97 (0.99\u20138.93; 0.052)], Vitamin D\u2009&lt;\u200940\u2009ng\/mL [OR: 6.41 (1.21\u201333.88; 0.029)], and hemoglobin &lt;\u200912\u2009g\/mL [OR: 3.32 (1.20\u20139.20; 0.020)] were independent predictors for SFR\/MV, while chronic atrial fibrillation [OR: 26.72 (3.87\u2013184.11; 0.001)], cancer history [OR:8.32 (1.28\u201353.91; 0.026)] and IL-6\u2009&gt;\u200940\u2009pg\/mL [OR:10.01 (1.66\u201360.13; 0.012)] were independent predictors of death.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In hospitalized older adults with COVID-19, tomographic pulmonary involvement &gt;\u200950%, anemia, vitamin D below 40\u2009ng\/mL, and CRP above 80\u2009mg\/L were independent risk factors for progression to SRF\/MV. The presence of chronic atrial fibrillation, previous cancer, IL-6\u2009&gt;\u200940\u2009pg\/mL, and anemia were independent predictors of death.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12877-022-02776-3","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T04:25:44Z","timestamp":1645071944000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic diseases, chest computed tomography, and laboratory tests as predictors of severe respiratory failure and death in elderly Brazilian patients hospitalized with COVID-19: a prospective cohort study"],"prefix":"10.1186","volume":"22","author":[{"given":"Alberto Frisoli","family":"Junior","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Tavares","family":"Paes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliene","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Carlos","family":"Campos Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila Jean Mc Neill","family":"Ingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"2776_CR1","doi-asserted-by":"publisher","unstructured":"CDC COVID-19 Response Team. 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