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Areal bone mineral density and body fat percentage were used to define osteopenia\/osteoporosis and obesity, respectively. The criteria of the 2019 Asian Working Group for Sarcopenia were used to diagnose sarcopenia. Based on the number of these conditions, participants were divided into four groups: OSO\/0, OSO\/1, OSO\/2, and OSO\/3. Logistic regression analysis was conducted to identify associations between blood cell count-derived inflammation indices and the number of disorders with abnormal body composition.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Systemic inflammation response index (SIRI), white blood cells, neutrophil-to-lymphocyte ratio (NLR), aggregate inflammation systemic index (AISI), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) showed statistically significant differences among the four groups (<jats:italic>P\u2009&lt;<\/jats:italic>\u00a00.05). Unlike in the OSO\/0 group, in all other groups, AISI, SIRI, PLR, and NLR were significantly associated with increased likelihood of having multiple disorders with abnormal body composition after adjustment for confounders (<jats:italic>P\u2009&lt;<\/jats:italic>\u00a00.0001 for all). However, LMR showed an inverse correlation with the number of these conditions (<jats:italic>P\u2009&lt;<\/jats:italic>\u00a00.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Higher SIRI, AISI, NLR, and PLR values and lower LMR values are closely associated with OSO and its individual components\u2014osteoporosis, sarcopenia, and obesity\u2014in older adults, suggesting that the value of these indices in the evaluation of OSO warrants further investigation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12877-022-03225-x","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T08:02:54Z","timestamp":1656403374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Osteosarcopenic obesity and its components\u2014osteoporosis, sarcopenia, and obesity\u2014are associated with blood cell count-derived inflammation indices in older Chinese people"],"prefix":"10.1186","volume":"22","author":[{"given":"Yi-zhen","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-qi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-han","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun-hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"3225_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.afos.2020.12.002","volume":"7","author":"BWJ Pang","year":"2021","unstructured":"Pang BWJ, Wee SL, Chen KK, et al. 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