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Whether and how the HIV duration impact the symptom distress among middle-aged and older PLWH has not been explored clearly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The patients with HIV-infected aged more than 40\u00a0years old were included from seven designated medical institutions of seven regions in China. Outcome was the score of symptom distress. We used the multiple regression model to calculate adjusted Coefficient of Regression (\u03b2) with 95% CI in this study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 210 participants (mean age 50.8\u00a0years; 71.0% male; 68.1% at asymptomatic stage) in the study, the median number of symptoms was 5. Of all symptoms reported, the most distressed symptoms were sleep disturbance (33.33%), followed by memory loss (31.90%), fatigue (26.67%), slow reactions (22.86%), and vision blur (21.90%). All participants were divided into four groups according to HIV duration, and the median of total score of symptom ditress among all participants was 0.1(0.0,0.9). Difference of total scores and clusters\u2019 scores of symptom distress among four HIV duration groups were statistically significant. 51 participants with 6\u201310\u00a0years HIV duration were more likely to be higher level of education, at asymptomatic stage and have higher CD4\u2009+\u2009T cell count. After adjustment for gender, age, race, education, marital status, employment, family income, region, stage of disease and CD4\u2009+\u2009T cell count, the score of symptom distress among participants with 6\u201310\u00a0years HIV duration had was higher with the extension of HIV duration. Specially in physical symptoms and psychological symptoms,participants with 6\u201310\u00a0years HIV duration reported the persisting worse burdensome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>HIV duration with 6\u201310 yearsmay be a key period that the medical team needs to pay special attention to among middle-aged and elderly PLWH. There is a need to provide medical and psychosocial services targeting middle-aged and elderly PLWH according to their changing symptom distress.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov: ChiCTR2100046225. Registered 11 May 2021.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12877-022-03411-x","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T03:14:23Z","timestamp":1662347663000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between HIV duration and symptom distress among middle-aged and elderly people with HIV-infected in China: a cross-sectional study"],"prefix":"10.1186","volume":"22","author":[{"given":"Meilian","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"3411_CR1","unstructured":"Global health sector strategy on HIV: 2016\u20132021 [https:\/\/www.who.int\/publications\/i\/item\/WHO-HIV-2016.05]"},{"key":"3411_CR2","unstructured":"World Health Organization. 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