{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:28:35Z","timestamp":1787020115309,"version":"build-2736575974"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T00:00:00Z","timestamp":1691193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T00:00:00Z","timestamp":1691193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["16AM0080"],"award-info":[{"award-number":["16AM0080"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delirium is a clinical condition characterised by acute and fluctuating deterioration of the cognitive state, generally secondary to an acute pathology. Delirium is associated with negative outcomes in older adults, such as longer hospitalisations, higher mortality, and short and medium-term institutionalisation. Randomised clinical trials have shown that delirium is preventable through non-pharmacological prevention measures, decreasing its incidence by 30\u201350%. These interventions include promoting physical activity, facilitating the use of glasses and hearing aids, cognitive stimulation, and providing frequent reorientation of time and space, among others. These measures are currently seldom applied in hospitals in Chile and around the world for reasons including the heavy workload of clinical staff, the lack of trained personnel, and in general the absence of a systematic implementation processes.<\/jats:p>\n                    <jats:p>We developed a software called PREVEDEL, which includes non-pharmacological strategies such as cognitive stimulation, early mobilisation, orientation, and pain assessment. We propose a randomised clinical trial to evaluate whether cognitive stimulation guided by PREVEDEL software prevents delirium status (full\/subsyndromal delirium) in hospitalised older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A randomised controlled trial, with parallel, multicentre groups. We will recruite patients 65\u00a0years or older who have been hospitalised for less than 48\u00a0h in the general ward or the intermediate care units of four hospitals in Santiago, Chile. The participants in the intervention group will use a tablet with cognitive stimulation software for delirium prevention for five continuous days versus the control group who will use the tablet without the software.<\/jats:p>\n                    <jats:p>We will evaluate the incidence, duration, density of delirium, subsyndromal delirium with the Confusion Assessment Method, cognitive with the Montreal Cognitive Assessment, and functional status with the Functional Independence Measure at discharge. Moreover, we will evaluate the adherence to prevention measures, as well as demographic variables of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The use of cognitive PREVEDEL software could increase and improve the implementation of non-pharmacological prevention measures for delirium in hospitalised older adults, thus reducing its incidence and contributing to patients and health professionals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>NCT05108207 ClinicalTrials.gov. Registered 4 November 2021.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12877-023-04189-2","type":"journal-article","created":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T06:01:52Z","timestamp":1691215312000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Software-guided (PREVEDEL) cognitive stimulation to prevent delirium in hospitalised older adults: study protocol"],"prefix":"10.1186","volume":"23","author":[{"given":"Maricel","family":"Garrido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Salech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Jara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ignacio","family":"Far\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Ponce","family":"de la Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2123-6082","authenticated-orcid":false,"given":"Eduardo","family":"Tobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,5]]},"reference":[{"issue":"9920","key":"4189_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","volume":"383","author":"SK Inouye","year":"2014","unstructured":"Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet (London, England). 2014;383(9920):911\u201322. https:\/\/doi.org\/10.1016\/S0140-6736(13)60688-1.","journal-title":"Lancet (London, England)"},{"issue":"1","key":"4189_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1056\/NEJMoa1112923","volume":"367","author":"JS Saczynski","year":"2012","unstructured":"Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, Inouye SK, et al. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012;367(1):30\u20139.","journal-title":"N Engl J Med"},{"issue":"4","key":"4189_CR3","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0034-7094(12)70146-0","volume":"62","author":"D Veiga","year":"2012","unstructured":"Veiga D, Luis C, Parente D, Fernandes V, Botelho M, Santos P, et al. Postoperative delirium in intensive care patients: risk factors and outcome. 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Alzheimer\u2019s dementia (Amsterdam, Netherlands). 2016;7:1\u201310. https:\/\/doi.org\/10.1016\/j.dadm.2016.11.002.","journal-title":"Alzheimer's dementia (Amsterdam, Netherlands)"},{"issue":"6","key":"4189_CR6","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1192\/bjp.bp.113.139865","volume":"205","author":"D Meagher","year":"2014","unstructured":"Meagher D, O\u2019Regan N, Ryan D, Connolly W, Boland E, O\u2019Caoimhe R, Timmons S. Frequency of delirium and subsyndromal delirium in an adult acute hospital population. British Journal of Psychiatry. 2014;205(6):478\u201385. https:\/\/doi.org\/10.1192\/bjp.bp.113.139865. Epub 2014 Oct 30. PMID: 25359923. 3, 4,6,12,13,15, 22.","journal-title":"British Journal of Psychiatry"},{"key":"4189_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0123090","volume":"10","author":"I Abraha","year":"2015","unstructured":"Abraha I, et al. 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The study adhered to the Declaration of Helsinki.The informed consent written will be given by the patient himself and obtained by one of the main investigators.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"472"}}