{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:15:24Z","timestamp":1785366924753,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Korea Health Technology R&D project","award":["HR22C1734"],"award-info":[{"award-number":["HR22C1734"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Osteosarcopenia is geriatric syndrome defined as the concomitant occurrence of osteopenia\/osteoporosis, and sarcopenia. Osteosarcopenia is a relatively new concept in geriatric medicine; however, it may increase the risk of fragility fractures, several morbidities and mortalities, and socioeconomic costs. Although resistance exercises and nutritional support\u2014including protein, calcium, and vitamin D\u2014are potential non-pharmacological management procedures, evidence is still lacking. The objective of this study was therefore to evaluate the effect of combined resistance exercise and nutritional support on the quality and quantity of bone and muscle in postmenopausal females with osteosarcopenia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This research proposal presents the protocol for a prospective, single-center, single-blinded, two-armed randomized controlled trial. Thirty-four participants with osteosarcopenia will be recruited and randomly divided into intervention and control groups; both groups will receive nutritional supplements (protein, 40 g; vitamin D, 1600 IU; calcium, 600 mg) daily. The intervention group will undergo 24 weeks of resistance exercise of increasing intensity, achieved through a three-phase step-up process. The primary outcomes will be the changes in skeletal muscle index and bone marrow density of the lumbar spine and femoral neck between the baseline and end of intervention (24 weeks). The secondary outcomes will be the body composition, whole body phase angle, physical function assessment, quality of life, psychological assessment, and bone turnover markers of participants, surveyed at multiple time points.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>This randomized controlled trial may reveal the effect of resistance exercise and nutritional support on older postmenopausal women with osteosarcopenia. The results will provide evidence for developing proper non-pharmacological management guidelines for postmenopausal women.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinical Research Information Service of Republic of Korea, KCT0008291, Registered on 16 March 2023, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/cris.nih.go.kr\/cris\/search\/detailSearch.do\/25262\">https:\/\/cris.nih.go.kr\/cris\/search\/detailSearch.do\/25262<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12877-024-04667-1","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T02:02:33Z","timestamp":1705456953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of resistance training and nutritional support on osteosarcopenia in older, community-dwelling postmenopausal Korean females (ERTO-K study): a study protocol"],"prefix":"10.1186","volume":"24","author":[{"given":"Byung Chan","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Won","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"issue":"10","key":"4667_CR1","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1007\/s00198-017-4151-8","volume":"28","author":"HP Hirschfeld","year":"2017","unstructured":"Hirschfeld HP, Kinsella R, Duque G. Osteosarcopenia: where bone, muscle, and fat collide. Osteoporos Int. 2017;28(10):2781\u201390.","journal-title":"Osteoporos Int"},{"issue":"6","key":"4667_CR2","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/BF01622200","volume":"4","author":"JA Kanis","year":"1994","unstructured":"Kanis JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report .WHO Study Group. Osteoporosis Int. 1994;4(6):368\u201381.","journal-title":"Osteoporosis Int"},{"issue":"8","key":"4667_CR3","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.jamda.2016.06.001","volume":"17","author":"L Cao","year":"2016","unstructured":"Cao L, Morley JE. Sarcopenia Is Recognized as an Independent Condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) Code. J Am Med Direct Assoc. 2016;17(8):675\u20137.","journal-title":"J Am Med Direct Assoc"},{"key":"4667_CR4","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.bone.2015.04.016","volume":"80","author":"MH Edwards","year":"2015","unstructured":"Edwards MH, Dennison EM, Aihie Sayer A, Fielding R, Cooper C. Osteoporosis and sarcopenia in older age. Bone. 2015;80:126\u201330.","journal-title":"Bone"},{"issue":"4","key":"4667_CR5","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.3346\/jkms.2018.33.e27","volume":"33","author":"JI Yoo","year":"2018","unstructured":"Yoo JI, Kim H, Ha YC, Kwon HB, Koo KH. Osteosarcopenia in Patients with Hip Fracture Is Related with High Mortality. J Korean Med Sci. 2018;33(4):e27.","journal-title":"J Korean Med Sci"},{"issue":"4","key":"4667_CR6","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jamda.2014.10.018","volume":"16","author":"YR Huo","year":"2015","unstructured":"Huo YR, Suriyaarachchi P, Gomez F, Curcio CL, Boersma D, Muir SW, Montero-Odasso M, Gunawardene P, Demontiero O, Duque G. Phenotype of osteosarcopenia in older individuals with a history of falling. J Am Med Direct Assoc. 2015;16(4):290\u20135.","journal-title":"J Am Med Direct Assoc"},{"issue":"2","key":"4667_CR7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s11914-014-0204-5","volume":"12","author":"CM Girgis","year":"2014","unstructured":"Girgis CM, Mokbel N, Digirolamo DJ. Therapies for musculoskeletal disease: can we treat two birds with one stone? Curr Osteoporos Rep. 2014;12(2):142\u201353.","journal-title":"Curr Osteoporos Rep"},{"issue":"3","key":"4667_CR8","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00198-013-2523-2","volume":"25","author":"LM Giangregorio","year":"2014","unstructured":"Giangregorio LM, Papaioannou A, Macintyre NJ, Ashe MC, Heinonen A, Shipp K, Wark J, McGill S, Keller H, Jain R, et al. Too Fit To Fracture: exercise recommendations for individuals with osteoporosis or osteoporotic vertebral fracture. Osteoporos Int. 2014;25(3):821\u201335.","journal-title":"Osteoporos Int"},{"key":"4667_CR9","first-page":"Cd000333","volume":"7","author":"TE Howe","year":"2011","unstructured":"Howe TE, Shea B, Dawson LJ, Downie F, Murray A, Ross C, Harbour RT, Caldwell LM, Creed G. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev. 2011;7:Cd000333.","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"4667_CR10","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1002\/jcsm.12483","volume":"10","author":"J Bauer","year":"2019","unstructured":"Bauer J, Morley JE, Schols A, Ferrucci L, Cruz-Jentoft AJ, Dent E, Baracos VE, Crawford JA, Doehner W, Heymsfield SB, et al. Sarcopenia: A Time for Action. An SCWD Position Paper. J Cachexia Sarcopenia Muscle. 2019;10(5):956\u201361.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"4667_CR11","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","volume":"21","author":"LK Chen","year":"2020","unstructured":"Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, et al. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Direct Assoc. 2020;21(3):300-307.e302.","journal-title":"J Am Med Direct Assoc"},{"issue":"10","key":"4667_CR12","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1007\/s12603-018-1139-9","volume":"22","author":"E Dent","year":"2018","unstructured":"Dent E, Morley JE, Cruz-Jentoft AJ, Arai H, Kritchevsky SB, Guralnik J, Bauer JM, Pahor M, Clark BC, Cesari M, et al. International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management. J Nutr Health Aging. 2018;22(10):1148\u201361.","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"4667_CR13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/rheumatology\/keaa755","volume":"60","author":"MA Clynes","year":"2021","unstructured":"Clynes MA, Gregson CL, Bruy\u00e8re O, Cooper C, Dennison EM. Osteosarcopenia: where osteoporosis and sarcopenia collide. Rheumatology (Oxford, England). 2021;60(2):529\u201337.","journal-title":"Rheumatology (Oxford, England)"},{"key":"4667_CR14","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.2147\/CIA.S225618","volume":"14","author":"T Lichtenberg","year":"2019","unstructured":"Lichtenberg T, von Stengel S, Sieber C, Kemmler W. The Favorable effects of a high-intensity resistance training on sarcopenia in older community-dwelling men with osteosarcopenia: the randomized controlled FrOST study. Clin Interventions Aging. 2019;14:2173\u201386.","journal-title":"Clin Interventions Aging"},{"key":"4667_CR15","doi-asserted-by":"crossref","unstructured":"Kemmler W, Kohl M, Jakob F, Engelke K, von Stengel S. Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study. Nutrients. 2020;12(8):2341.","DOI":"10.3390\/nu12082341"},{"key":"4667_CR16","doi-asserted-by":"publisher","first-page":"571","DOI":"10.2147\/CIA.S299867","volume":"16","author":"W Kemmler","year":"2021","unstructured":"Kemmler W, Schoene D, Kohl M, von Stengel S. Changes in Body Composition and Cardiometabolic Health After Detraining in Older Men with Osteosarcopenia: 6-Month Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST) Study. Clin Interventions Aging. 2021;16:571\u201382.","journal-title":"Clin Interventions Aging"},{"key":"4667_CR17","doi-asserted-by":"publisher","first-page":"e7586","DOI":"10.1136\/bmj.e7586","volume":"346","author":"A-W Chan","year":"2013","unstructured":"Chan A-W, Tetzlaff JM, G\u00f8tzsche PC, Altman DG, Mann H, Berlin JA, Dickersin K, Hr\u00f3bjartsson A, Schulz KF, Parulekar WR, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013;346:e7586.","journal-title":"BMJ"},{"issue":"8","key":"4667_CR18","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","volume":"9","author":"JA Kanis","year":"1994","unstructured":"Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Mineral Res. 1994;9(8):1137\u201341.","journal-title":"J Bone Mineral Res"},{"issue":"5","key":"4667_CR19","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1002\/jor.22823","volume":"33","author":"JM Wilkinson","year":"2015","unstructured":"Wilkinson JM, Morris RM, Martin-Fernandez MA, Pozo JM, Frangi AF, Maheson M, Yang L. Use of high resolution dual-energy x-ray absorptiometry-region free analysis (DXA-RFA) to detect local periprosthetic bone remodeling events. J Orthop Res. 2015;33(5):712\u20136.","journal-title":"J Orthop Res"},{"issue":"8","key":"4667_CR20","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.jamda.2013.05.021","volume":"14","author":"J Bauer","year":"2013","unstructured":"Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, Phillips S, Sieber C, Stehle P, Teta D, et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Direct Assoc. 2013;14(8):542\u201359.","journal-title":"J Am Med Direct Assoc"},{"issue":"3","key":"4667_CR21","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/mus.25557","volume":"56","author":"J Steele","year":"2017","unstructured":"Steele J, Fisher J, Giessing J, Gentil P. Clarity in reporting terminology and definitions of set endpoints in resistance training. Muscle & nerve. 2017;56(3):368\u201374.","journal-title":"Muscle & nerve"},{"issue":"9","key":"4667_CR22","first-page":"782","volume":"13","author":"MJ Kaiser","year":"2009","unstructured":"Kaiser MJ, Bauer JM, Ramsch C, Uter W, Guigoz Y, Cederholm T, Thomas DR, Anthony P, Charlton KE, Maggio M, et al. Validation of the Mini Nutritional Assessment short-form (MNA\u00ae-SF): A practical tool for identification of nutritional status. JNHA. 2009;13(9):782.","journal-title":"JNHA"},{"issue":"6","key":"4667_CR23","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1136\/bjsports-2017-097608","volume":"52","author":"RW Morton","year":"2018","unstructured":"Morton RW, Murphy KT, McKellar SR, Schoenfeld BJ, Henselmans M, Helms E, Aragon AA, Devries MC, Banfield L, Krieger JW, et al. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018;52(6):376\u201384.","journal-title":"Br J Sports Med"},{"key":"4667_CR24","doi-asserted-by":"crossref","unstructured":"Campa F, Toselli S, Mazzilli M, Gobbo LA, Coratella G. Assessment of Body composition in athletes: a narrative review of available methods with special reference to quantitative and qualitative bioimpedance analysis. Nutrients. 2021;13(5):1620.","DOI":"10.3390\/nu13051620"},{"issue":"1","key":"4667_CR25","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/jcsm.12860","volume":"13","author":"Y Akamatsu","year":"2022","unstructured":"Akamatsu Y, Kusakabe T, Arai H, Yamamoto Y, Nakao K, Ikeue K, Ishihara Y, Tagami T, Yasoda A, Ishii K, et al. Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality. J Cachexia Sarcopenia Muscle. 2022;13(1):180\u20139.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"4667_CR26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s11136-020-02630-2","volume":"30","author":"JI Yoo","year":"2021","unstructured":"Yoo JI, Ha YC, Kim M, Seo SH, Kim MJ, Lee GY, Seo YM, Sung C, Park KS. Translation and validation of the Korean version of the Sarcopenia Quality of Life (SarQoL-K\u00ae) questionnaire and applicability with the SARC-F screening tool. Qual Life Res. 2021;30(2):603\u201311.","journal-title":"Qual Life Res"},{"key":"4667_CR27","doi-asserted-by":"crossref","unstructured":"Ware JE Jr, Sherbourne CD. The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection. Med Care. 1992;30(6):473\u201383.","DOI":"10.1097\/00005650-199206000-00002"},{"issue":"2","key":"4667_CR28","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.comppsych.2007.08.006","volume":"49","author":"C Han","year":"2008","unstructured":"Han C, Jo SA, Kwak JH, Pae CU, Steffens D, Jo I, Park MH. Validation of the Patient Health Questionnaire-9 Korean version in the elderly population: the Ansan Geriatric study. Compr Psychiatry. 2008;49(2):218\u201323.","journal-title":"Compr Psychiatry"},{"issue":"3","key":"4667_CR29","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/gps.1664","volume":"22","author":"SA Jo","year":"2007","unstructured":"Jo SA, Park MH, Jo I, Ryu S-H, Han C. Usefulness of Beck Depression Inventory (BDI) in the Korean elderly population. Int J Geriatr Psychiatry. 2007;22(3):218\u201323.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"1","key":"4667_CR30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-2318-7-5","volume":"7","author":"I Bautmans","year":"2007","unstructured":"Bautmans I, Gorus E, Njemini R, Mets T. Handgrip performance in relation to self-perceived fatigue, physical functioning and circulating IL-6 in elderly persons without inflammation. BMC Geriatr. 2007;7(1):5.","journal-title":"BMC Geriatr"},{"issue":"3 Suppl","key":"4667_CR31","first-page":"10","volume":"14","author":"T Rantanen","year":"2002","unstructured":"Rantanen T, Avlund K, Suominen H, Schroll M, Fr\u00e4ndin K, Pertti E. Muscle strength as a predictor of onset of ADL dependence in people aged 75 years. Aging Clin Exp Res. 2002;14(3 Suppl):10\u20135.","journal-title":"Aging Clin Exp Res"},{"issue":"2","key":"4667_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.clnu.2010.09.010","volume":"30","author":"K Norman","year":"2011","unstructured":"Norman K, Stob\u00e4us N, Gonzalez MC, Schulzke JD, Pirlich M. Hand grip strength: outcome predictor and marker of nutritional status. Clin Nutr (Edinburgh, Scotland). 2011;30(2):135\u201342.","journal-title":"Clin Nutr (Edinburgh, Scotland)"},{"key":"4667_CR33","unstructured":"Miranda-Cantellops N, Tiu TK: Berg Balance Testing. In: StatPearls. Treasure Island (FL): StatPearls Publishing, Copyright \u00a9 2022, StatPearls Publishing LLC.; 2022."},{"issue":"8","key":"4667_CR34","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1093\/ptj\/77.8.812","volume":"77","author":"A Shumway-Cook","year":"1997","unstructured":"Shumway-Cook A, Baldwin M, Polissar NL, Gruber W. Predicting the probability for falls in community-dwelling older adults. Phys Ther. 1997;77(8):812\u20139.","journal-title":"Phys Ther"},{"issue":"2","key":"4667_CR35","doi-asserted-by":"publisher","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","volume":"49","author":"JM Guralnik","year":"1994","unstructured":"Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A Short Physical Performance Battery Assessing Lower Extremity Function: Association With Self-Reported Disability and Prediction of Mortality and Nursing Home Admission. J Gerontol. 1994;49(2):M85\u201394.","journal-title":"J Gerontol"},{"issue":"10","key":"4667_CR36","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s40520-018-1082-y","volume":"31","author":"F Lauretani","year":"2019","unstructured":"Lauretani F, Ticinesi A, Gionti L, Prati B, Nouvenne A, Tana C, Meschi T, Maggio M. Short-Physical Performance Battery (SPPB) score is associated with falls in older outpatients. Aging Clin Exp Res. 2019;31(10):1435\u201342.","journal-title":"Aging Clin Exp Res"},{"key":"4667_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exger.2014.01.027","volume":"53","author":"MS Fragala","year":"2014","unstructured":"Fragala MS, Fukuda DH, Stout JR, Townsend JR, Emerson NS, Boone CH, Beyer KS, Oliveira LP, Hoffman JR. Muscle quality index improves with resistance exercise training in older adults. Exp Gerontol. 2014;53:1\u20136.","journal-title":"Exp Gerontol"},{"issue":"3","key":"4667_CR38","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2114\/jpa2.28.123","volume":"28","author":"Y Takai","year":"2009","unstructured":"Takai Y, Ohta M, Akagi R, Kanehisa H, Kawakami Y, Fukunaga T. Sit-to-stand Test to Evaluate Knee Extensor Muscle Size and Strength in the Elderly: A Novel Approach. J Physiol Anthropol. 2009;28(3):123\u20138.","journal-title":"J Physiol Anthropol"},{"issue":"12","key":"4667_CR39","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1359\/jbmr.090526","volume":"24","author":"DC Bauer","year":"2009","unstructured":"Bauer DC, Garnero P, Harrison SL, Cauley JA, Eastell R, Ensrud KE, Orwoll E. Biochemical Markers of Bone Turnover, Hip Bone Loss, and Fracture in Older Men: The MrOS Study. J Bone Miner Res. 2009;24(12):2032\u20138.","journal-title":"J Bone Miner Res."},{"issue":"8","key":"4667_CR40","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1093\/clinchem\/47.8.1410","volume":"47","author":"R Okabe","year":"2001","unstructured":"Okabe R, Nakatsuka K, Inaba M, Miki T, Naka H, Masaki H, Moriguchi A, Nishizawa Y. Clinical Evaluation of the Elecsys \u03b2-CrossLaps Serum Assay, a New Assay for Degradation Products of Type I Collagen C-Telopeptides. Clin Chem. 2001;47(8):1410\u20134.","journal-title":"Clin Chem"},{"key":"4667_CR41","doi-asserted-by":"publisher","first-page":"110884","DOI":"10.1016\/j.exger.2020.110884","volume":"135","author":"E Banitalebi","year":"2020","unstructured":"Banitalebi E, Faramarzi M, Ghahfarokhi MM, SavariNikoo F, Soltani N, Bahramzadeh A. Osteosarcopenic obesity markers following elastic band resistance training: a randomized controlled trial. Exp Gerontol. 2020;135:110884.","journal-title":"Exp Gerontol"},{"key":"4667_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clinbiochem.2022.09.002","volume":"109\u2013110","author":"JP Brown","year":"2022","unstructured":"Brown JP, Don-Wauchope A, Douville P, Albert C, Vasikaran SD. Current use of bone turnover markers in the management of osteoporosis. Clin Biochem. 2022;109\u2013110:1\u201310.","journal-title":"Clin Biochem."},{"issue":"3","key":"4667_CR43","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s11154-022-09747-4","volume":"24","author":"F Campa","year":"2022","unstructured":"Campa F, Colognesi LA, Moro T, Paoli A, Casolo A, Santos L, Correia RR, Lemes \u00cdR, Milanez VF, Christofaro DD, et al. Effect of resistance training on bioelectrical phase angle in older adults: a systematic review with Meta-analysis of randomized controlled trials. Rev Endocr Metab Disord. 2022;24(3):439\u201349.","journal-title":"Rev Endocr Metab Disord."},{"issue":"6","key":"4667_CR44","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1001\/jamapsychiatry.2018.0572","volume":"75","author":"BR Gordon","year":"2018","unstructured":"Gordon BR, McDowell CP, Hallgren M, Meyer JD, Lyons M, Herring MP. Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials. JAMA Psychiatry. 2018;75(6):566\u201376.","journal-title":"JAMA Psychiatry"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-024-04667-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-024-04667-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-024-04667-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T22:02:33Z","timestamp":1726005753000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/s12877-024-04667-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4667"],"URL":"https:\/\/doi.org\/10.1186\/s12877-024-04667-1","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]},"assertion":[{"value":"16 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Corrected the word 'Celex core-protein' to 'Selex core-protein'","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethical validity of the trial was assessed and approved by the Institutional Review Board of Chungnam National University Hospital (CNUH 2022-12-026). In accordance with the Declaration of Helsinki and its subsequent amendments, every patient had the right to leave the study at any time, for any reason, without having to give explanations and without repercussions on his or her aftercare. Likewise, the investigating physician had the right to withdraw a patient from a study when he\/she believed it was in the patient's best interest. All participants will provide written informed consent before the trial.This work has not been previously presented or published in any form or any language.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Dr. CW Moon is receiving financial support from a Korea Health Technology R&D project for their work in this study, through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea. BC Lee, KI Kim, and KH Cho declares no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"68"}}