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Data were collected through a cohort involving 946 community-dwelling older people aged\u2009\u2265\u200960 with chronic musculoskeletal pain in Hong Kong. Selected independent variables were categorized into physical, psychological, and social domains. Physical variables included age, sex, body mass index (BMI), pain severity score, number of pain regions, the most painful site, and the number of comorbidities. Psychological variables included depression level measured using the 9-question Patient Health Questionnaire (PHQ-9), and anxiety level measured using the Generalized Anxiety Disorder Assessment (GAD-7). Social variables included living, marital, and social welfare recipient\u2019s status. The dependent variables comprised the index scores and the five dimensions of the EQ-5D descriptive system. Ordinal least squares (OLS) model and logistic regression model were used for data analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the participants was 67.1 (SD\u2009=\u20095.1), with 77.6% being female. Higher pain severity scores (beta (\u03b2) coefficient =-0.044,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), depression scores (\u03b2=-0.007,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher anxiety scores (\u03b2=-0.01,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) were associated with lower EQ-5D index scores. Specifically, knee pain (\u03b2=-0.061,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) was significantly associated with lower EQ-5D index scores. Participants with higher pain severity and depression scores were more likely to report problems in most EQ-5D dimensions. Participants with anxiety primarily faced challenges related to mood, and those with knee pain were more likely to have problems with mobility and daily activities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among the selected determinants in our study, pain intensity, depression, anxiety, and knee pain were identified as key determinants associated with reduced HRQoL in older Chinese people with chronic musculoskeletal pain. Each of these determinants showed distinct associations with different dimensions of the EQ-5D, potentially informed resource allocation and the development of targeted interventions to improve the overall HRQoL of this specific population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12877-024-04669-z","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T13:02:29Z","timestamp":1706706149000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Determinants of health-related quality of life in older people with chronic musculoskeletal pain: a cross-sectional study"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6740-0051","authenticated-orcid":false,"given":"Hugo Pak-Yiu","family":"Fong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Yue-Kwan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Kwan-Wa","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3098-8673","authenticated-orcid":false,"given":"Hermione Hin-Man","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-6385","authenticated-orcid":false,"given":"Samuel Yeung-Shan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-7773","authenticated-orcid":false,"given":"Regina Wing-Shan","family":"Sit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"issue":"12","key":"4669_CR1","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.7326\/0003-4819-135-12-200112180-00007","volume":"135","author":"SG Leveille","year":"2001","unstructured":"Leveille SG, Ling S, Hochberg MC, et al. 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