{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:53:42Z","timestamp":1774968822934,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100018731","name":"Jiangsu Hengrui Medicine","doi-asserted-by":"publisher","award":["No. H202139"],"award-info":[{"award-number":["No. H202139"]}],"id":[{"id":"10.13039\/100018731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"DOI":"10.1186\/s12877-024-05371-w","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T22:05:46Z","timestamp":1726783546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serotonin syndrome caused by escitalopram in Parkinson\u2019s disease psychosis: a case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Shan\u2019mei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linghe","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"issue":"11","key":"5371_CR1","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1056\/NEJMra041867","volume":"352","author":"EW Boyer","year":"2005","unstructured":"Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005;352(11):1112\u201320.","journal-title":"N Engl J Med"},{"issue":"9","key":"5371_CR2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/qjmed\/hcg109","volume":"96","author":"EJ Dunkley","year":"2003","unstructured":"Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003;96(9):635\u201342.","journal-title":"QJM"},{"key":"5371_CR3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev-pathmechdis-031521-034145","volume":"18","author":"H Ye","year":"2023","unstructured":"Ye H, Robak LA, Yu M, Cykowski M, Shulman JM. Genetics and pathogenesis of Parkinson\u2019s syndrome. Annu Rev Pathol. 2023;18:95\u2013121.","journal-title":"Annu Rev Pathol"},{"issue":"11","key":"5371_CR4","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3949\/ccjm.83a.15129","volume":"83","author":"RZ Wang","year":"2016","unstructured":"Wang RZ, Vashistha V, Kaur S, Houchens NW. Serotonin syndrome: preventing, recognizing, and treating it. Clevel Clin J Med. 2016;83(11):810\u20137.","journal-title":"Clevel Clin J Med"},{"issue":"2","key":"5371_CR5","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/bcpt.13912","volume":"133","author":"N Mikkelsen","year":"2023","unstructured":"Mikkelsen N, Damkier P, Pedersen SA. Serotonin syndrome-A focused review. Basic Clin Pharmacol Toxicol. 2023;133(2):124\u20139.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"5371_CR6","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1177\/026988119901300111","volume":"13","author":"PK Gillman","year":"1999","unstructured":"Gillman PK. The serotonin syndrome and its treatment. J Psychopharmacol. 1999;13(1):100\u20139.","journal-title":"J Psychopharmacol"},{"issue":"1","key":"5371_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/nrneurol.2009.196","volume":"6","author":"WF Abdo","year":"2010","unstructured":"Abdo WF, van de Warrenburg BP, Burn DJ, Quinn NP, Bloem BR. The clinical approach to movement disorders. Nat Rev Neurol. 2010;6(1):29\u201337.","journal-title":"Nat Rev Neurol"},{"issue":"Pt 11","key":"5371_CR8","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1093\/brain\/aws023","volume":"135","author":"RC Helmich","year":"2012","unstructured":"Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR. Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain. 2012;135(Pt 11):3206\u201326.","journal-title":"Brain"},{"key":"5371_CR9","doi-asserted-by":"publisher","first-page":"g1626","DOI":"10.1136\/bmj.g1626","volume":"348","author":"NA Buckley","year":"2014","unstructured":"Buckley NA, Dawson AH, Isbister GK. Serotonin syndrome. BMJ. 2014;348:g1626.","journal-title":"BMJ"},{"issue":"7","key":"5371_CR10","first-page":"161","volume":"47","author":"SH Evans","year":"2017","unstructured":"Evans SH, Cameron MW, Burton JM. Hypertonia. Curr Probl Pediatr Adolesc Health Care. 2017;47(7):161\u20136.","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"issue":"1","key":"5371_CR11","doi-asserted-by":"publisher","first-page":"e13957","DOI":"10.1111\/apha.13957","volume":"238","author":"A Monte","year":"2023","unstructured":"Monte A, Magris R, Nardello F, Bombieri F, Zamparo P. Muscle shape changes in Parkinson\u2019s disease impair function during rapid contractions. Acta Physiol (Oxf). 2023;238(1):e13957.","journal-title":"Acta Physiol (Oxf)"},{"issue":"6","key":"5371_CR12","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1002\/mds.28022","volume":"35","author":"G Leodori","year":"2020","unstructured":"Leodori G, Belvisi D, De Bartolo MI, Fabbrini A, Costanzo M, Vial F, Conte A, Hallett M, Berardelli A. Re-emergent Tremor in Parkinson\u2019s disease: the role of the motor cortex. Mov Disord. 2020;35(6):1002\u201311.","journal-title":"Mov Disord"},{"issue":"5","key":"5371_CR13","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1136\/jnnp.67.5.646","volume":"67","author":"J Jankovic","year":"1999","unstructured":"Jankovic J, Schwartz KS, Ondo W. Re-emergent tremor of Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry. 1999;67(5):646\u201350.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"5371_CR14","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/mds.27121","volume":"33","author":"KP Bhatia","year":"2018","unstructured":"Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018;33(1):75\u201387.","journal-title":"Mov Disord"},{"issue":"1","key":"5371_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0025-7125(16)30278-4","volume":"77","author":"SN Caroff","year":"1993","unstructured":"Caroff SN, Mann SC. Neuroleptic malignant syndrome. Med Clin North Am. 1993;77(1):185\u2013202.","journal-title":"Med Clin North Am"},{"key":"5371_CR16","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.parkreldis.2020.08.031","volume":"79","author":"JH Friedman","year":"2020","unstructured":"Friedman JH. Movement disorders induced by psychiatric drugs that do not block dopamine receptors. Parkinsonism Relat Disord. 2020;79:60\u20134.","journal-title":"Parkinsonism Relat Disord"},{"issue":"6","key":"5371_CR17","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1440-1819.2008.01877.x","volume":"62","author":"B Arbaizar","year":"2008","unstructured":"Arbaizar B, G\u00f3mez-Acebo I, Llorca J. Postural induced-tremor in psychiatry. Psychiatry Clin Neurosci. 2008;62(6):638\u201345.","journal-title":"Psychiatry Clin Neurosci"},{"issue":"1","key":"5371_CR18","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1542\/peds.111.1.e89","volume":"111","author":"TD Sanger","year":"2003","unstructured":"Sanger TD, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW. Classification and definition of disorders causing hypertonia in childhood. Pediatrics. 2003;111(1):e89-97.","journal-title":"Pediatrics"},{"key":"5371_CR19","doi-asserted-by":"publisher","first-page":"113491","DOI":"10.1016\/j.expneurol.2020.113491","volume":"335","author":"F Wieters","year":"2021","unstructured":"Wieters F, Weiss Lucas C, Gruhn M, B\u00fcschges A, Fink GR, Aswendt M. Introduction to spasticity and related mouse models. Exp Neurol. 2021;335:113491.","journal-title":"Exp Neurol"},{"key":"5371_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1046\/j.1468-1331.2002.0090s1003.x","volume":"9 Suppl 1","author":"G Sheean","year":"2002","unstructured":"Sheean G. The pathophysiology of spasticity. Eur J Neurol. 2002;9 Suppl 1:3\u20139. dicussion 53-61.","journal-title":"Eur J Neurol"},{"issue":"3","key":"5371_CR21","first-page":"411","volume":"46","author":"JM Gracies","year":"2010","unstructured":"Gracies JM, Bayle N, Vinti M, Alkandari S, Vu P, Loche CM, Colas C. Five-step clinical assessment in spastic paresis. Eur J Phys Rehabil Med. 2010;46(3):411\u201321.","journal-title":"Eur J Phys Rehabil Med"},{"issue":"6","key":"5371_CR22","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2019.22360","volume":"323","author":"MJ Armstrong","year":"2020","unstructured":"Armstrong MJ, Okun MS. Diagnosis and treatment of Parkinson disease: a review. JAMA. 2020;323(6):548\u201360.","journal-title":"JAMA"},{"issue":"1","key":"5371_CR23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/bja\/85.1.129","volume":"85","author":"P Adnet","year":"2000","unstructured":"Adnet P, Lestavel P, Krivosic-Horber R. Neuroleptic malignant syndrome. Br J Anaesth. 2000;85(1):129\u201335.","journal-title":"Br J Anaesth"},{"key":"5371_CR24","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ajem.2020.06.046","volume":"43","author":"S Prakash","year":"2021","unstructured":"Prakash S. A diagnostic confusion between Serotonin syndrome and Neuroleptic malignant syndrome. Am J Emerg Med. 2021;43:272\u20133.","journal-title":"Am J Emerg Med"},{"issue":"Suppl 1","key":"5371_CR25","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/S1353-8020(02)00125-6","volume":"9","author":"Y Mizuno","year":"2003","unstructured":"Mizuno Y, Takubo H, Mizuta E, Kuno S. Malignant syndrome in Parkinson\u2019s disease: concept and review of the literature. Parkinsonism Relat Disord. 2003;9(Suppl 1):S3-9.","journal-title":"Parkinsonism Relat Disord"},{"issue":"11","key":"5371_CR26","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.2169\/internalmedicine.31.1298","volume":"31","author":"Y Yamawaki","year":"1992","unstructured":"Yamawaki Y, Ogawa N. Successful treatment of levodopa-induced neuroleptic malignant syndrome (NMS) and disseminated intravascular coagulation (DIC) in a patient with Parkinson\u2019s disease. Intern Med. 1992;31(11):1298\u2013302.","journal-title":"Intern Med"},{"key":"5371_CR27","doi-asserted-by":"publisher","first-page":"1257984","DOI":"10.3389\/fpsyt.2023.1257984","volume":"14","author":"J Wu","year":"2023","unstructured":"Wu J, Yu J, Qu K, Yin J, Zhu C, Liu X. Serotonin syndrome caused by a CYP2C19-mediated interaction between low-dose escitalopram and clopidogrel: a case report. Front Psych. 2023;14:1257984.","journal-title":"Front Psych"},{"issue":"9916","key":"5371_CR28","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0140-6736(13)62106-6","volume":"383","author":"J Cummings","year":"2014","unstructured":"Cummings J, Isaacson S, Mills R, Williams H, Chi-Burris K, Corbett A, Dhall R, Ballard C. Pimavanserin for patients with Parkinson\u2019s disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet. 2014;383(9916):533\u201340.","journal-title":"Lancet"},{"issue":"10","key":"5371_CR29","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1002\/mds.23083","volume":"25","author":"P Huot","year":"2010","unstructured":"Huot P, Johnston TH, Darr T, Hazrati LN, Visanji NP, Pires D, Brotchie JM, Fox SH. Increased 5-HT2A receptors in the temporal cortex of parkinsonian patients with visual hallucinations. Mov Disord. 2010;25(10):1399\u2013408.","journal-title":"Mov Disord"},{"issue":"5","key":"5371_CR30","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1017\/S1092852916000602","volume":"21","author":"SM Stahl","year":"2016","unstructured":"Stahl SM. Parkinson\u2019s disease psychosis as a serotonin-dopamine imbalance syndrome. CNS Spectr. 2016;21(5):355\u20139.","journal-title":"CNS Spectr"},{"issue":"3933","key":"5371_CR31","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1126\/science.168.3933.849","volume":"168","author":"GM Everett","year":"1970","unstructured":"Everett GM, Borcherding JW. L-dopa: effect on concentrations of dopamine, norepinephrine, and serotonin in brains of mice. Science. 1970;168(3933):849\u201350.","journal-title":"Science"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-024-05371-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-024-05371-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-024-05371-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T22:07:59Z","timestamp":1726783679000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/s12877-024-05371-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5371"],"URL":"https:\/\/doi.org\/10.1186\/s12877-024-05371-w","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,18]]},"assertion":[{"value":"14 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The patient signed an informed consent form to receive hospital care and to authorize the use of personal health information for academic purposes. The informed consent form is archived at The Affiliated Mental Health Center of Jiangnan University. Wuxi, China, together with the medical record. The study was conducted in accordance with the Declaration of Helsinki, and was approved by the Ethics Committee of The Affiliated Mental Health Center of Jiangnan University (WXMHCIRB2023LLky007).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was obtained from the patient and her legal guardian(s) for publication of clinical information, and information has been de-identified to protect anonymity. The informed consent form is archived at The Affiliated Mental Health Center of Jiangnan University. Wuxi, China, together with the medical record.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"769"}}