{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:38:46Z","timestamp":1788817126600,"version":"build-2803163510"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2020YFC2005403\uff0c2020YFC2005406"],"award-info":[{"award-number":["2020YFC2005403\uff0c2020YFC2005406"]}]},{"name":"2021 Capital General medicine Research Project","award":["21QK08"],"award-info":[{"award-number":["21QK08"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To investigate the clinical features and risk factors of bloodstream infections in the older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This was a prospective cohort multicenter study. According to the inclusion and exclusion criteria, older adults with suspected bloodstream infections from December 2020 to June 2023 were included in the analysis of the clinical features of older adults bloodstream infections.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 338 older adultswith suspected bloodstream infections were included, of which 141 were diagnosed with bloodstream infections. The proportion of gram-negative bacteria (47.5%) was close to that of gram-positive bacteria (46.1%), while the proportion of gram-negative bacteria was slightly higher.The common clinical manifestations of bloodstream infection were fever (75.2%), decreased level of consciousness (24.8%), chills (14.2%), shock (12.1%), etc.Multivariate regression analysis showed high procalcitonin levels at admission (OR\u2009=\u20092.008, 95%CI 1.258\u20133.206, <jats:italic>P<\/jats:italic>\u2009=\u20090.003) and heart rate\u2009&gt;\u200990 beats\/min (OR\u2009=\u20092.104, 95%CI 1.302-3.400). <jats:italic>P<\/jats:italic>\u2009=\u20090.002), arterial partial blood pressure of carbon dioxide\u2009&lt;\u200932 mmHg (OR\u2009=\u20091.922, 95%CI 1.025\u20133.601, <jats:italic>P<\/jats:italic>\u2009=\u20090.042), and coronary heart disease (OR\u2009=\u20091.909, 95%CI 1.134\u20133.213), <jats:italic>P<\/jats:italic>\u2009=\u20090.015) were independent risk factors for bloodstream infection in the older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The proportion of gram-negative and gram-positive bacteria in bloodstream infections in older adults was similar. The common clinical features of bloodstream infection in the older adults are fever and a decreased level of consciousness, and there was no significant difference in systemic clinical manifestations between bloodstream infection and non-bloodstream infection. High procalcitonin (PCT) level, heart rate\u2009&gt;\u200990 beats\/min, arterial partial pressure of carbon dioxide (PaCO2)\u2009&lt;\u200932 mmHg, and underlying coronary heart disease were independent risk factors for bloodstream infection in older adults.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12877-025-05934-5","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T08:01:48Z","timestamp":1748678508000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical features and risk factors of older adults with bloodstream infection"],"prefix":"10.1186","volume":"25","author":[{"given":"Mengxi","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yachan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"5934_CR1","unstructured":"1. Shanghai Society of Microbiology Clinical Microbiology Committee, Shanghai Medical Association Laboratory Medicine Branch, Shanghai Medical Association Critical Care branch. Expert consensus on clinical test pathway of bloodstream infection. Chin J Clin Infect Dis. 2022;40(8):457\u2013475."},{"key":"5934_CR2","doi-asserted-by":"crossref","unstructured":"2. Laupland K B, Pasquill K, Steele L, et al. Burden of bloodstream infection in older persons: a population-based study. BMC Geriatr. 2021;21(1):31.","DOI":"10.1186\/s12877-020-01984-z"},{"key":"5934_CR3","doi-asserted-by":"crossref","unstructured":"3. Leibovici-Weissman Y, Tau N, Yahav D. Bloodstream infections in the elderly: what is the real goal?. Aging Clin Exp Res. 2021;33(4):1101\u20131112.","DOI":"10.1007\/s40520-019-01337-w"},{"key":"5934_CR4","doi-asserted-by":"crossref","unstructured":"4. Yang X, Zeng J, Yu X, et al. PCT, IL-6, and IL-10 facilitate early diagnosis and pathogen classifications in bloodstream infection. 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Clinical Profile, Prognostic Factors, and Outcome Prediction in Hospitalized Patients With Bloodstream Infection: Results From a 10-Year Prospective Multicenter Study. Front Med (Lausanne). 2021;8:629671.","DOI":"10.3389\/fmed.2021.629671"},{"key":"5934_CR9","doi-asserted-by":"crossref","unstructured":"9. Wu H N, Yuan E Y, Li W B, et al. Microbiological and Clinical Characteristics of Bloodstream Infections in General Intensive Care Unit: A Retrospective Study. Front Med (Lausanne). 2022;9:876207.","DOI":"10.3389\/fmed.2022.876207"},{"key":"5934_CR10","doi-asserted-by":"crossref","unstructured":"10. Caterino J M, Kline D M, Leininger R, et al. Nonspecific Symptoms Lack Diagnostic Accuracy for Infection in Older Patients in the Emergency Department. J Am Geriatr Soc. 2019;67(3):484\u2013492.","DOI":"10.1111\/jgs.15679"},{"key":"5934_CR11","doi-asserted-by":"crossref","unstructured":"11. Rieck K M, Pagali S, Miller D M. Delirium in hospitalized older adults. 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Written and oral informed consent was obtained from all participants to publish the results of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"397"}}