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All patients and their families signed informed consent forms, adhering to the principle of voluntary anonymity and fairness, and the study was approved by the Ethics Committee of Chengdu Fifth People\u2019s Hospital (Ethics No: 2023-033(K)-01), and all participants provided written informed consent. This study is not a clinical trial study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of the study findings was obtained from all participants or their legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"What is already knownSarcopenia is a common condition among elderly cancer patients and is associated with declines in physical function and quality of life.Nutritional status plays a critical role in the management of sarcopenia and the maintenance of physical function in this population.Although the relationships among sarcopenia, nutritional status, physical function, and quality of life have been investigated, the underlying mechanisms remain inadequately understood.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Contribution of the paper"}},{"value":"This study presents a comprehensive path analysis that elucidates the direct and indirect relationships among sarcopenia, nutritional status, physical function, and quality of life in elderly cancer patients. The results underscore the mediating role of physical function in the link between sarcopenia and quality of life. These findings provide valuable insights into the importance of early detection and targeted interventions for sarcopenia\u2014particularly those aimed at improving nutrition and physical function\u2014to enhance quality of life in this population.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"What this paper adds"}}],"article-number":"461"}}