{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:25:48Z","timestamp":1757625948470,"version":"3.44.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"PRIN 2020"},{"name":"European Union - NextGenerationEU - AGE-It Spoke 3"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"DOI":"10.1186\/s12877-025-06280-2","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T09:48:32Z","timestamp":1755942512000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Syncope is associated with multidimensional frailty in older adults"],"prefix":"10.1186","volume":"25","author":[{"given":"Francesco","family":"Curcio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria","family":"Chiappetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Medio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Pacilio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Alessio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Trotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Abete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Liguori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Sasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cacciatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Galizia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Abete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"GIMSI (Italian Multidisciplinary Group for the Study of Syncope)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"issue":"5","key":"6280_CR1","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.jamda.2009.09.015","volume":"11","author":"RJJ Gobbens","year":"2010","unstructured":"Gobbens RJJ, Luijkx KG, Wijnen-Sponselee MT, et al. In search of an integral conceptual definition of frailty: opinions of experts. J Am Med Dir Assoc. 2010;11(5):338\u201343.","journal-title":"J Am Med Dir Assoc"},{"issue":"3","key":"6280_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cger.2017.02.002","volume":"33","author":"M Cesari","year":"2017","unstructured":"Cesari M, Calvani R, Marzetti E. Frailty in older persons. Clin Geriatr Med. 2017;33(3):293\u2013303.","journal-title":"Clin Geriatr Med"},{"key":"6280_CR3","doi-asserted-by":"crossref","unstructured":"Veronese N, Custodero C, Cella A et al. Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis. Ageing Res Rev 202;72:101498.","DOI":"10.1016\/j.arr.2021.101498"},{"issue":"21","key":"6280_CR4","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","volume":"39","author":"M Brignole","year":"2018","unstructured":"Brignole M, Moya A, de Lange FJ, et al. ESC guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39(21):1883\u2013948.","journal-title":"Eur Heart J"},{"issue":"4","key":"6280_CR5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.pcad.2012.11.006","volume":"55","author":"RA Kenny","year":"2013","unstructured":"Kenny RA, Bhangu J, King-Kallimanis BL. Epidemiology of syncope\/collapse in younger and older Western patient populations. Prog Cardiovasc Dis. 2013;55(4):357\u201363.","journal-title":"Prog Cardiovasc Dis"},{"issue":"12","key":"6280_CR6","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1056\/NEJMoa012407","volume":"347","author":"ES Soteriades","year":"2002","unstructured":"Soteriades ES, Evans JC, Larson MG, et al. Incidence and prognosis of syncope. N Engl J Med. 2002;347(12):878\u201385.","journal-title":"N Engl J Med"},{"issue":"216","key":"6280_CR7","first-page":"45","volume":"55","author":"LA Lipsitz","year":"1985","unstructured":"Lipsitz LA, Wei JY, Rowe JW. Syncope in an elderly, institutionalised population: prevalence, incidence, and associated risk. Q J Med. 1985;55(216):45\u201354.","journal-title":"Q J Med"},{"issue":"2","key":"6280_CR8","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afad245","volume":"53","author":"S Jansen","year":"2024","unstructured":"Jansen S, van der Velde N. Syncope in older adults: challenges, approach and treatment. Age Ageing. 2024;53(2): afad245.","journal-title":"Age Ageing"},{"key":"6280_CR9","doi-asserted-by":"crossref","unstructured":"Folstein MF, Folstein SE, McHugh PR. \"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12(3):189\u201398.","DOI":"10.1016\/0022-3956(75)90026-6"},{"issue":"1","key":"6280_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1017\/S1041610291000480","volume":"3","author":"JI Sheikh","year":"1991","unstructured":"Sheikh JI, Yesavage JA, Brooks JO, et al. Proposed factor structure of the geriatric depression scale. Int Psychogeriatr. 1991;3(1):23\u20138.","journal-title":"Int Psychogeriatr"},{"issue":"5","key":"6280_CR11","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/j.1532-5415.1968.tb02103.x","volume":"16","author":"BS Linn","year":"1968","unstructured":"Linn BS, Linn MW, Gurel L. Cumulative illness rating scale. J Am Geriatr Soc. 1968;16(5):622\u20136.","journal-title":"J Am Geriatr Soc"},{"key":"6280_CR12","doi-asserted-by":"crossref","unstructured":"Katz S, Ford AB, Moskowitz RW et al. Studies of illness in the aged. The index of ADL; a standardized measure of biological and psychological functions. JAMA 1963;185(12):914\u20139.","DOI":"10.1001\/jama.1963.03060120024016"},{"issue":"3","key":"6280_CR13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","volume":"9","author":"MP Lawton","year":"1969","unstructured":"Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179\u201386.","journal-title":"Gerontologist"},{"issue":"9","key":"6280_CR14","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1111\/j.1532-5415.2010.03016.x","volume":"58","author":"MJ Kaiser","year":"2010","unstructured":"Kaiser MJ, Bauer JM, R\u00e4msch C, et al. Frequency of malnutrition in older adults: a multinational perspective using the mini nutritional assessment. J Am Geriatr Soc. 2010;58(9):1734\u20138.","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"6280_CR15","doi-asserted-by":"publisher","first-page":"P239","DOI":"10.1093\/geronj\/45.6.P239","volume":"45","author":"ME Tinetti","year":"1990","unstructured":"Tinetti ME, Richman D, Powell L. Falls efficacy as a measure of fear of falling. J Gerontol. 1990;45(6):P239-43.","journal-title":"J Gerontol"},{"issue":"1","key":"6280_CR16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40621-017-0110-2","volume":"4","author":"TJ Mielenz","year":"2017","unstructured":"Mielenz TJ, Durbin LL, Cisewski JA, et al. Select physical performance measures and driving outcomes in older adults. Inj Epidemiol. 2017;4(1):14.","journal-title":"Inj Epidemiol"},{"issue":"3","key":"6280_CR17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.archger.2010.01.011","volume":"51","author":"F Mazzella","year":"2010","unstructured":"Mazzella F, Cacciatore F, Galizia G, et al. Social support and long-term mortality in the elderly: role of comorbidity. Arch Gerontol Geriatr. 2010;51(3):323\u20138.","journal-title":"Arch Gerontol Geriatr"},{"issue":"2","key":"6280_CR18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","volume":"21","author":"R Freeman","year":"2011","unstructured":"Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21(2):69\u201372.","journal-title":"Clin Auton Res"},{"issue":"5","key":"6280_CR19","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s40520-017-0793-9","volume":"29","author":"P Abete","year":"2017","unstructured":"Abete P, Basile C, Bulli G, et al. The Italian version of the \u201cfrailty index\u201d based on deficits in health: a validation study. Aging Clin Exp Res. 2017;29(5):913\u201326.","journal-title":"Aging Clin Exp Res"},{"issue":"1","key":"6280_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01788-1","volume":"20","author":"I Liguori","year":"2020","unstructured":"Liguori I, Russo G, Bulli G, et al. Validation of \u201c(fr)AGILE\u201d: a quick tool to identify multidimensional frailty in the elderly. BMC Geriatr. 2020;20(1): 375.","journal-title":"BMC Geriatr"},{"issue":"1","key":"6280_CR21","first-page":"1","volume":"1","author":"CB Begg","year":"1986","unstructured":"Begg CB. Statistical methods in medical diagnosis. Crit Rev Med Inform. 1986;1(1):1\u201322.","journal-title":"Crit Rev Med Inform"},{"key":"6280_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102919","volume":"237","author":"T Hatoum","year":"2022","unstructured":"Hatoum T, Sheldon RS. Syncope and the aging patient: navigating the challenges. Auton Neurosci. 2022;237: 102919.","journal-title":"Auton Neurosci"},{"key":"6280_CR23","doi-asserted-by":"crossref","unstructured":"Lipsitz LA. Altered blood pressure homeostasis in advancing age: clinical and research implications. J Gerontol 1989;44(6):M179\u201383.na","DOI":"10.1093\/geronj\/44.6.M179"},{"key":"6280_CR24","doi-asserted-by":"crossref","unstructured":"Bauer JH. Age-related changes in the renin-aldosterone system. Physiological effect and clinical implication. Drugs Aging 1993;3(3):238\u201345.","DOI":"10.2165\/00002512-199303030-00005"},{"issue":"2","key":"6280_CR25","doi-asserted-by":"publisher","first-page":"182","DOI":"10.12809\/hkmj176945","volume":"24","author":"CW Wong","year":"2018","unstructured":"Wong CW. Complexity of syncope in elderly people: a comprehensive geriatric approach. Hong Kong Med J. 2018;24(2):182\u201390.","journal-title":"Hong Kong Med J"},{"issue":"1","key":"6280_CR26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/agm2.12240","volume":"6","author":"K Bandhu","year":"2023","unstructured":"Bandhu K, Rao A, Nehra A, et al. Recurrent syncope in long survivors and its association with geriatric syndromes. Aging Med. 2023;6(1):49\u201355.","journal-title":"Aging Med"},{"issue":"1","key":"6280_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijcard.2010.10.055","volume":"155","author":"VK Marrison","year":"2012","unstructured":"Marrison VK, Fletcher A, Parry SW. The older patient with syncope: practicalities and controversies. Int J Cardiol. 2012;155(1):9\u201313.","journal-title":"Int J Cardiol"},{"issue":"5","key":"6280_CR28","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.jamda.2019.01.149","volume":"20","author":"A Ceccofiglio","year":"2019","unstructured":"Ceccofiglio A, Mussi C, Rafanelli M, et al. Increasing prevalence of orthostatic hypotension as a cause of syncope with advancing age and multimorbidity. J Am Med Dir Assoc. 2019;20(5):586\u20138.","journal-title":"J Am Med Dir Assoc"},{"key":"6280_CR29","doi-asserted-by":"crossref","unstructured":"Ungar A, Mussi C, Del Rosso A et al. For Italian Group for the Study of Syncope in the Elderly. Diagnosis and characteristics of syncope in older patients referred to geriatric departments. J Am Geriatr Soc 2006;54:1531e1536.","DOI":"10.1111\/j.1532-5415.2006.00891.x"},{"key":"6280_CR30","doi-asserted-by":"crossref","unstructured":"Ungar A, Mussi C, Ceccofiglio A et al. Etiology of syncope and unexplained falls in elderly adults with dementia: Syncope and Dementia (SYD) Study. J Am Geriatr Soc 2016;64:1567e1573.","DOI":"10.1111\/jgs.14225"},{"issue":"9","key":"6280_CR31","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.jamda.2018.04.018","volume":"19","author":"I Liguori","year":"2018","unstructured":"Liguori I, Russo G, Coscia V, et al. Orthostatic hypotension in the elderly: a marker of clinical frailty? J Am Med Dir Assoc. 2018;19(9):779\u201385.","journal-title":"J Am Med Dir Assoc"},{"issue":"10","key":"6280_CR32","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.33963\/KP.a2021.0138","volume":"79","author":"G Rivasi","year":"2021","unstructured":"Rivasi G, Ungar A, Moya A, et al. Syncope: new solutions for an old problem. Kardiol Pol. 2021;79(10):1068\u201378.","journal-title":"Kardiol Pol"},{"issue":"7","key":"6280_CR33","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1093\/europace\/euab024","volume":"23","author":"G Rivasi","year":"2021","unstructured":"Rivasi G, Torabi P, Secco G, et al. Age-related tilt test responses in patients with suspected reflex syncope. Europace. 2021;23(7):1100\u20135.","journal-title":"Europace"},{"issue":"1","key":"6280_CR34","doi-asserted-by":"publisher","first-page":"R3","DOI":"10.1152\/ajpregu.00031.2007","volume":"293","author":"KD Monahan","year":"2007","unstructured":"Monahan KD. Effect of aging on baroreflex function in humans. Am J Physiol Regul Integr Comp Physiol. 2007;293(1):R3-12.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"6280_CR35","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s40266-015-0263-z","volume":"32","author":"K Alagiakrishnan","year":"2015","unstructured":"Alagiakrishnan K. Current pharmacological management of hypotensive syndromes in the elderly. Drugs Aging. 2015;32(5):337\u201348.","journal-title":"Drugs Aging"},{"issue":"1","key":"6280_CR36","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1532-5415.2008.02070.x","volume":"57","author":"G Galizia","year":"2009","unstructured":"Galizia G, Abete P, Mussi C, et al. Role of early symptoms in assessment of syncope in elderly people: results from the Italian group for the study of syncope in the elderly. J Am Geriatr Soc. 2009;57(1):18\u201323.","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"6280_CR37","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3349\/ymj.2023.0455","volume":"65","author":"HK Nam","year":"2024","unstructured":"Nam HK, Chang SJ, Kim CB, et al. The association between social support, metabolic syndrome, and incidence of cardio-cerebrovascular diseases in older adults: the ARIRANG study. Yonsei Med J. 2024;65(6):363\u201370.","journal-title":"Yonsei Med J"},{"issue":"8","key":"6280_CR38","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glae145","volume":"79","author":"J Yu","year":"2024","unstructured":"Yu J, Si H, Liu Q, et al. Does social support moderate the relationship between frailty and functional ability trajectory among community-dwelling older adults? J Gerontol A Biol Sci Med Sci. 2024;79(8): glae145.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"6280_CR39","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1186\/s12877-022-03546-x","volume":"22","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Shen S, Guan H, et al. Orthostatic hypotension is associated with malnutrition diagnosed by GLIM in elderly hypertensive patients. BMC Geriatr. 2022;22(1):866.","journal-title":"BMC Geriatr"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-025-06280-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-025-06280-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-025-06280-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:25:32Z","timestamp":1757449532000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/s12877-025-06280-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6280"],"URL":"https:\/\/doi.org\/10.1186\/s12877-025-06280-2","relation":{},"ISSN":["1471-2318"],"issn-type":[{"type":"electronic","value":"1471-2318"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"assertion":[{"value":"7 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the institutional ethics committee (University of Naples Federico II\u2014Comitato Etico per le attivit\u00e0 Biomediche \u201cCarlo Romano\u201d prot. n.211\/2013) and conducted according to the ethical principles of the Declaration of Helsinki for medical research involving human subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"655"}}