{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:04:30Z","timestamp":1770962670140,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"DOI":"10.1186\/s12877-025-06290-0","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:21:31Z","timestamp":1754896891000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An atypical case of Creutzfeldt-Jakob disease mimicking frontotemporal dementia: genotypic influence and clinical implications"],"prefix":"10.1186","volume":"25","author":[{"given":"Carlo","family":"Manco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Righi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Damiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Mignarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"De Stefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Plantone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"issue":"12","key":"6290_CR1","first-page":"1343","volume":"93","author":"D Plantone","year":"2022","unstructured":"Plantone D, Locci S, Bergantini L, Manco C, Cortese R, Meocci M, et al. Brain neuronal and glial damage during acute COVID-19 infection in absence of clinical neurological manifestations. J Neurol Neurosurg Psychiatry. 2022;93(12):1343\u20138.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6290_CR2","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","volume":"134","author":"K Rascovsky","year":"2011","unstructured":"Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011;134:2456\u201377. https:\/\/pubmed.ncbi.nlm.nih.gov\/21810890\/.","journal-title":"Brain"},{"issue":"8","key":"6290_CR3","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1136\/jnnp.2003.020198","volume":"75","author":"EA Croes","year":"2004","unstructured":"Croes EA, Theuns J, Houwing-Duistermaat JJ, Dermaut B, Sleegers K, Roks G, et al. Octapeptide repeat insertions in the prion protein gene and early onset dementia. J Neurol Neurosurg Psychiatry. 2004;75(8):1166\u201370. https:\/\/pubmed.ncbi.nlm.nih.gov\/15258222\/.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6290_CR4","doi-asserted-by":"crossref","unstructured":"Lin X, Xu Y, Zhen Z, Xiao K, Chen X, Yang J et al. Case report: genetic Creutzfeldt-Jakob disease with a G114V mutation and one octapeptide repeat deletion as a mimic of frontotemporal dementia. Front Neurol. 2022; 13. https:\/\/pubmed.ncbi.nlm.nih.gov\/35812092\/","DOI":"10.3389\/fneur.2022.888309"},{"issue":"3","key":"6290_CR5","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/cge.14354","volume":"104","author":"H Nan","year":"2023","unstructured":"Nan H, Liu L, Chen Z, Chu M, Li J, Jing D, et al. Octapeptide repeat alteration mutations of the prion protein gene in clinically diagnosed Alzheimer\u2019s disease and frontotemporal dementia. Clin Genet. 2023;104(3):350\u20135.","journal-title":"Clin Genet"},{"issue":"3","key":"6290_CR6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S1474-4422(20)30477-4","volume":"20","author":"P Hermann","year":"2021","unstructured":"Hermann P, Appleby B, Brandel JP, Caughey B, Collins S, Geschwind MD, et al. Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease. Lancet Neurol. 2021;20(3):235\u201346.","journal-title":"Lancet Neurol"},{"issue":"1","key":"6290_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41572-024-00497-y","volume":"10","author":"I Zerr","year":"2024","unstructured":"Zerr I, Ladogana A, Mead S, Hermann P, Forloni G, Appleby BS. Creutzfeldt-Jakob disease and other prion diseases. Nat Rev Dis Primers. 2024;10(1):14.","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"6290_CR8","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s00415-023-11962-1","volume":"271","author":"R Manara","year":"2024","unstructured":"Manara R, Fragiacomo F, Ladogana A, Vaianella L, Camporese G, Zorzi G, et al. MRI abnormalities in Creutzfeldt-Jakob disease and other rapidly progressive dementia. J Neurol. 2024;271(1):300\u20139. https:\/\/pubmed.ncbi.nlm.nih.gov\/37698615\/.","journal-title":"J Neurol"},{"key":"6290_CR9","unstructured":"Diagnostic Criteria| Creutzfeldt-Jakob Disease. Classic (CJD)| Prion Disease| CDC https:\/\/www.cdc.gov\/prions\/cjd\/diagnostic-criteria.html"},{"key":"6290_CR10","unstructured":"Brain Segmentation Software - Quantib Neurodegenerative. (ND). https:\/\/www.quantib.com\/solutions\/quantib-nd"},{"issue":"1","key":"6290_CR11","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00441-022-03715-9","volume":"392","author":"SM Da Silva Correia","year":"2023","unstructured":"Da Silva Correia SM, Schmitz M, Fischer A, Hermann P, Zerr I. Role of different Recombinant PrP substrates in the diagnostic accuracy of the CSF RT-QuIC assay in Creutzfeldt-Jakob disease. Cell Tissue Res. 2023;392(1):301\u20136. https:\/\/doi.org\/10.1007\/s00441-022-03715-9. https:\/\/link.springer.com\/article\/.","journal-title":"Cell Tissue Res"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-025-06290-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-025-06290-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-025-06290-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T20:15:08Z","timestamp":1757362508000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/s12877-025-06290-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6290"],"URL":"https:\/\/doi.org\/10.1186\/s12877-025-06290-0","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The data collection and publication were approved with a favorable opinion by the Regional Ethics Committee for Clinical Trials of the Tuscany Region (Italy) under Protocol Number 24397.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient signed the consent form approved by the ethics committee for the collection and publication of the clinical data presented in this scientific article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"613"}}