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It includes five domains: locomotion, vitality, cognition, psychological well-being, and sensory function. This study aimed to examine the associations between IC domains and common geriatric syndromes in hospitalized older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective observational study, 245 patients aged\u2009\u2265\u200960 years who underwent comprehensive geriatric assessment were included. IC was evaluated across five domains using standard tools: gait speed, self-reported sensory deficits, Standardized Mini-Mental State Examination (S-MMSE), Euro Quality of Life 5 Domain (EuroQOL-5D) and Mini Nutritional Assessment. The IC score ranges from 0 to 5, with higher scores indicating better intrinsic capacity, and a score\u2009\u2264\u20092 representing moderate\u2013severe decline. Geriatric syndromes assessed were frailty, probable sarcopenia, falls, urinary incontinence, and functional impairments in Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL). Logistic regression models identified predictive IC domains, adjusting for age, sex, polypharmacy, and comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nearly 60% of participants had moderate to severe IC decline (score\u2009\u2264\u20092). Vitality and locomotor impairments were the most common. Cognitive and vitality impairments were strongly associated with both ADL and IADL disability (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while locomotor and vitality impairments predicted probable sarcopenia and frailty (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Cognitive impairment was linked to a nearly six-fold increased fall risk (OR\u2009=\u20095.86, 95% CI: 2.51\u201313.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The models showed good discrimination, with an area under the curve value of 0.723 for falls and 0.854 for ADL disability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IC impairments, particularly in cognition, vitality, and locomotion, are prevalent and predictive of major geriatric syndromes in hospitalized older adults. Routine IC assessment may help identify at-risk individuals and inform targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12877-025-06697-9","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:53:05Z","timestamp":1764071585000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cumulative effect of intrinsic capacity domains on geriatric syndromes and functionality in older inpatients"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-0351","authenticated-orcid":false,"given":"Nagihan S\u00f6zen","family":"Gencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4570-3071","authenticated-orcid":false,"given":"Sibel","family":"\u00c7avdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6447-2352","authenticated-orcid":false,"given":"Fatma Ozge","family":"Kayhan Ko\u00e7ak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-832X","authenticated-orcid":false,"given":"Fatma","family":"Erol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-3786","authenticated-orcid":false,"given":"Sumru","family":"Savas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"6697_CR1","unstructured":"Organization WH. 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Proc Nutr Soc. 2023;82(1):39\u201346.","journal-title":"Proc Nutr Soc"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-025-06697-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-025-06697-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-025-06697-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:04:25Z","timestamp":1764075865000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgeriatr.biomedcentral.com\/articles\/10.1186\/s12877-025-06697-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6697"],"URL":"https:\/\/doi.org\/10.1186\/s12877-025-06697-9","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"6 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research protocol was conducted in accordance with the Helsinki declaration and was approved by Ege University Medical Research Ethical Committee (Ethics committee decision no:24\u2009\u2212\u200910.IT\/45 date: 23\/10\/2024).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"In accordance with institutional policies and ethical standards, informed consent is routinely obtained from all patients hospitalized in the internal medicine inpatient clinic where this study was conducted. Patients, or their legal guardians when appropriate, were informed that their medical information could be used for research purposes. Those who declined informed their physician, and this decision was documented in the medical chart. Patients who did not provide consent were excluded from the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"949"}}