{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:04:05Z","timestamp":1780621445339,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"grants from National Natural Science Foundation of China","award":["No. 82170894"],"award-info":[{"award-number":["No. 82170894"]}]},{"name":"Program of Shanghai Science and Technology Committee","award":["21S11901100"],"award-info":[{"award-number":["21S11901100"]}]},{"name":"the Research Physician Project of Shanghai Tenth People's Hospital","award":["2023YJXYSA014"],"award-info":[{"award-number":["2023YJXYSA014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Geriatr"],"DOI":"10.1186\/s12877-026-07519-2","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:48:20Z","timestamp":1776930500000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["24-hour urinary creatinine as a predictor of lumbar spine bone mineral density change after one-year of zoledronic acid treatment in older postmenopausal women with osteoporosis: a cohort study"],"prefix":"10.1186","volume":"26","author":[{"given":"Jiangping","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"issue":"10169","key":"7519_CR1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","volume":"393","author":"JE Compston","year":"2019","unstructured":"Compston JE, McClung MR, Leslie WD. Osteoporosis. Lancet. 2019;393(10169):364\u201376.","journal-title":"Lancet"},{"issue":"1","key":"7519_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-018-0480-2","volume":"13","author":"TP Ho-Le","year":"2018","unstructured":"Ho-Le TP, Pham HM, Center JR, Eisman JA, Nguyen HT, Nguyen TV. Prediction of changes in bone mineral density in the elderly: contribution of \u201costeogenomic profile.\u201d Arch Osteoporos. 2018;13(1):68.","journal-title":"Arch Osteoporos"},{"issue":"8","key":"7519_CR3","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.21106","volume":"4","author":"L Wang","year":"2021","unstructured":"Wang L, Yu W, Yin X, et al. Prevalence of osteoporosis and fracture in China: the China osteoporosis prevalence study. JAMA Netw Open. 2021;4(8):e2121106. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.21106.","journal-title":"JAMA Netw Open"},{"issue":"18","key":"7519_CR4","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1056\/NEJMoa067312","volume":"356","author":"DM Black","year":"2007","unstructured":"Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007;356(18):1809\u201322.","journal-title":"N Engl J Med"},{"issue":"18","key":"7519_CR5","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1056\/NEJMoa1204061","volume":"367","author":"S Boonen","year":"2012","unstructured":"Boonen S, Reginster JY, Kaufman JM, Lippuner K, Zanchetta J, Langdahl B, et al. Fracture risk and zoledronic acid therapy in men with osteoporosis. N Engl J Med. 2012;367(18):1714\u201323.","journal-title":"N Engl J Med"},{"issue":"9","key":"7519_CR6","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.4065\/83.9.1032","volume":"83","author":"MT Drake","year":"2008","unstructured":"Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc. 2008;83(9):1032\u201345.","journal-title":"Mayo Clin Proc"},{"issue":"11","key":"7519_CR7","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1093\/annonc\/mds169","volume":"23","author":"P Hadji","year":"2012","unstructured":"Hadji P, Coleman R, Gnant M, Green J. The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis. Ann Oncol. 2012;23(11):2782\u201390.","journal-title":"Ann Oncol"},{"issue":"4","key":"7519_CR8","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00432-014-1853-6","volume":"141","author":"TI Gabbert","year":"2015","unstructured":"Gabbert TI, Hoffmeister B, Felsenberg D. Risk factors influencing the duration of treatment with bisphosphonates until occurrence of an osteonecrosis of the jaw in 963 cancer patients. J Cancer Res Clin Oncol. 2015;141(4):749\u201358.","journal-title":"J Cancer Res Clin Oncol"},{"key":"7519_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70243","author":"B Ozcan","year":"2025","unstructured":"Ozcan B, Ceylan S, Ozcan M, et al. Understanding the impact of multimorbidity, medications and frailty on zoledronic acid efficacy in treating osteoporosis among older adults. Br J Clin Pharmacol. 2025. https:\/\/doi.org\/10.1002\/bcp.70243.","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"7519_CR10","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1002\/jcsm.13090","volume":"13","author":"L Wang","year":"2022","unstructured":"Wang L, Yin L, Yang M, Cheng X. Muscle composition and the imminent mortality risk after hip fracture. J Cachexia Sarcopenia Muscle. 2022;13(6):2752\u20133.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"7519_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/jcsm.12359","volume":"10","author":"M Papageorgiou","year":"2019","unstructured":"Papageorgiou M, Sathyapalan T, Schutte R. Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women. J Cachexia Sarcopenia Muscle. 2019;10(1):131\u20139.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"7519_CR12","doi-asserted-by":"crossref","unstructured":"Herrmann M, Engelke K, Ebert R, Muller-Deubert S, Rudert M, Ziouti F et al. Interactions between Muscle and Bone-Where Physics Meets Biology. Biomolecules. 2020;10(3),432.","DOI":"10.3390\/biom10030432"},{"key":"7519_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1287972","volume":"14","author":"Z Zhao","year":"2023","unstructured":"Zhao Z, Yan K, Guan Q, Guo Q, Zhao C. Mechanism and physical activities in bone-skeletal muscle crosstalk. Front Endocrinol (Lausanne). 2023;14:1287972. https:\/\/doi.org\/10.3389\/fendo.2023.1287972.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"7519_CR14","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/ajcn\/37.3.478","volume":"37","author":"SB Heymsfield","year":"1983","unstructured":"Heymsfield SB, Arteaga C, McManus C, Smith J, Moffitt S. Measurement of muscle mass in humans: validity of the 24-hour urinary creatinine method. Am J Clin Nutr. 1983;37(3):478\u201394.","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"7519_CR15","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1002\/jcsm.12969","volume":"13","author":"D Groothof","year":"2022","unstructured":"Groothof D, Post A, Polinder-Bos HA, Erler NS, Flores-Guerrero JL, Kootstra-Ros JE, et al. Muscle mass and estimates of renal function: a longitudinal cohort study. J Cachexia Sarcopenia Muscle. 2022;13(4):2031\u201343.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"7519_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.metabol.2019.06.010","volume":"98","author":"S Christakos","year":"2019","unstructured":"Christakos S, Li S, De La Cruz J, Bikle DD. New developments in our understanding of vitamin metabolism, action and treatment. Metabolism. 2019;98:112\u201320.","journal-title":"Metabolism"},{"issue":"10","key":"7519_CR17","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/ki.2011.207","volume":"80","author":"R Agarwal","year":"2011","unstructured":"Agarwal R, Hynson JE, Hecht TJ, Light RP, Sinha AD. Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate. Kidney Int. 2011;80(10):1073\u20139.","journal-title":"Kidney Int"},{"issue":"10329","key":"7519_CR18","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/S0140-6736(21)02646-5","volume":"399","author":"IR Reid","year":"2022","unstructured":"Reid IR, Billington EO. Drug therapy for osteoporosis in older adults. Lancet. 2022;399(10329):1080\u201392.","journal-title":"Lancet"},{"issue":"14","key":"7519_CR19","first-page":"1671","volume":"26","author":"Chinese Society of Osteoporosis and Bone Mineral Research","year":"2023","unstructured":"Chinese Society of Osteoporosis and Bone Mineral Research. Guidelines for the diagnosis and treatment of primary osteoporosis (2022). Chin Gen Pract. 2023;26(14):1671\u201391.","journal-title":"Chin Gen Pract"},{"issue":"4","key":"7519_CR20","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/BF01774016","volume":"5","author":"CC Gluer","year":"1995","unstructured":"Gluer CC, Blake G, Lu Y, Blunt BA, Jergas M, Genant HK. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int. 1995;5(4):262\u201370.","journal-title":"Osteoporos Int"},{"issue":"4","key":"7519_CR21","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/ecco-jcc\/jjaa194","volume":"15","author":"C Danny","year":"2021","unstructured":"Danny C, Nina P, Maria B, Raphael PL, Neetima J, Anna W, et al. Development of a Simple, Serum Biomarker-based Model Predictive of the Need for Early Biologic Therapy in Crohn\u2019s Disease. J Crohns Colitis. 2021;15(4):583\u201393.","journal-title":"J Crohns Colitis"},{"issue":"3","key":"7519_CR22","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/bjs.9736","volume":"102","author":"GS Collins","year":"2015","unstructured":"Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): the TRIPOD Statement. Br J Surg. 2015;102(3):148\u201358.","journal-title":"Br J Surg"},{"issue":"1","key":"7519_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00198-012-2057-z","volume":"24","author":"S Verschueren","year":"2013","unstructured":"Verschueren S, Gielen E, O\u2019Neill TW, Pye SR, Adams JE, Ward KA, et al. Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men. Osteoporos Int. 2013;24(1):87\u201398.","journal-title":"Osteoporos Int"},{"issue":"9","key":"7519_CR24","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1002\/jbmr.3458","volume":"33","author":"D Chalhoub","year":"2018","unstructured":"Chalhoub D, Boudreau R, Greenspan S, Newman AB, Zmuda J, Frank-Wilson AW, et al. Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men. J Bone Miner Res. 2018;33(9):1612\u201321.","journal-title":"J Bone Miner Res"},{"issue":"2","key":"7519_CR25","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00198-015-3241-8","volume":"27","author":"H He","year":"2016","unstructured":"He H, Liu Y, Tian Q, Papasian CJ, Hu T, Deng HW. Relationship of sarcopenia and body composition with osteoporosis. Osteoporos Int. 2016;27(2):473\u201382.","journal-title":"Osteoporos Int"},{"key":"7519_CR26","doi-asserted-by":"crossref","unstructured":"Ge J, Zeng J, Ma H, Sun S, Zhao Z, Jing Y et al. A New Index Based on Serum Creatinine and Cystatin C Can Predict the Risks of Sarcopenia, Falls and Fractures in Old Patients with Low Bone Mineral Density. Nutrients. 2022;14(23):5020.","DOI":"10.3390\/nu14235020"},{"issue":"12","key":"7519_CR27","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1172\/JCI118722","volume":"97","author":"GA Rodan","year":"1996","unstructured":"Rodan GA, Fleisch HA. Bisphosphonates: mechanisms of action. J Clin Invest. 1996;97(12):2692\u20136.","journal-title":"J Clin Invest"},{"issue":"12","key":"7519_CR28","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00228-001-0411-8","volume":"57","author":"S Cremers","year":"2002","unstructured":"Cremers S, Sparidans R, den Hamdy HJ, Vermeij N, Papapoulos P. A pharmacokinetic and pharmacodynamic model for intravenous bisphosphonate (pamidronate) in osteoporosis. Eur J Clin Pharmacol. 2002;57(12):883\u201390.","journal-title":"Eur J Clin Pharmacol"},{"issue":"3","key":"7519_CR29","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/jcsm.12289","volume":"9","author":"HC Chiu","year":"2018","unstructured":"Chiu HC, Chiu CY, Yang RS, Chan DC, Liu SH, Chiang CK. Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin-3 down-regulation. J Cachexia Sarcopenia Muscle. 2018;9(3):585\u2013602.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"7519_CR30","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1002\/jcsm.13335","volume":"14","author":"L Slade","year":"2023","unstructured":"Slade L, Bollen SE, Bass JJ, Phillips BE, Smith K, Wilkinson DJ, et al. Bisphosphonates attenuate age-related muscle decline in Caenorhabditis elegans. J Cachexia Sarcopenia Muscle. 2023;14(6):2613\u201322.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"7519_CR31","doi-asserted-by":"publisher","first-page":"3711","DOI":"10.2147\/DDDT.S328858","volume":"15","author":"CF Huang","year":"2021","unstructured":"Huang CF, Shiao MS, Mao TY. Retrospective study of the effects of zoledronic acid on muscle mass in osteoporosis patients. Drug Des Devel Ther. 2021;15:3711\u20135.","journal-title":"Drug Des Devel Ther"},{"issue":"4","key":"7519_CR32","doi-asserted-by":"publisher","first-page":"420","DOI":"10.14283\/jfa.2022.54","volume":"11","author":"NS Haeri","year":"2022","unstructured":"Haeri NS, Perera S, Greenspan SL. Does zoledronic acid improve appendicular lean mass in older women with osteoporosis? A sub-analysis of a randomized clinical trial. J Frailty Aging. 2022;11(4):420\u20135.","journal-title":"J Frailty Aging"},{"key":"7519_CR33","doi-asserted-by":"publisher","first-page":"101876","DOI":"10.1016\/j.eclinm.2023.101876","volume":"58","author":"GH Li","year":"2023","unstructured":"Li GH, Cheung CL, Tan KC, Kung AW, Kwok TC, Lau WC, et al. Development and validation of sex-specific hip fracture prediction models using electronic health records: a retrospective, population-based cohort study. EClinicalMedicine. 2023;58:101876.","journal-title":"EClinicalMedicine"},{"issue":"5","key":"7519_CR34","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1093\/gerona\/glz178","volume":"75","author":"MT Lam","year":"2020","unstructured":"Lam MT, Sing CW, Li GHY, Kung AWC, Tan KCB, Cheung CL. Development and validation of a risk score to predict the first hip fracture in the oldest old: a retrospective cohort study. J Gerontol A Biol Sci Med Sci. 2020;75(5):980\u20136.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"7519_CR35","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1210\/jcem.87.4.8415","volume":"87","author":"MC Hochberg","year":"2002","unstructured":"Hochberg MC, Greenspan S, Wasnich RD, Miller P, Thompson DE, Ross PD. Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. J Clin Endocrinol Metab. 2002;87(4):1586\u201392.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"7519_CR36","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/jbmr.1472","volume":"27","author":"M Austin","year":"2012","unstructured":"Austin M, Yang YC, Vittinghoff E, Adami S, Boonen S, Bauer DC, et al. Relationship between bone mineral density changes with denosumab treatment and risk reduction for vertebral and nonvertebral fractures. J Bone Min Res. 2012;27(3):687\u201393.","journal-title":"J Bone Min Res"},{"issue":"8","key":"7519_CR37","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1002\/jbmr.1644","volume":"27","author":"RM Jacques","year":"2012","unstructured":"Jacques RM, Boonen S, Cosman F, Reid IR, Bauer DC, Black DM, et al. Relationship of changes in total hip bone mineral density to vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis treated with once-yearly zoledronic acid 5\u00a0mg: the HORIZON-Pivotal Fracture Trial (PFT). J Bone Min Res. 2012;27(8):1627\u201334.","journal-title":"J Bone Min Res"},{"issue":"12","key":"7519_CR38","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1111\/jgs.16165","volume":"67","author":"S Phu","year":"2019","unstructured":"Phu S, Bani Hassan E, Vogrin S, Kirk B, Duque G. Effect of Denosumab on Falls, Muscle Strength, and Function in Community-Dwelling Older Adults. J Am Geriatr Soc. 2019;67(12):2660\u20131.","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"7519_CR39","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/jbmr.3890","volume":"35","author":"BA Hain","year":"2020","unstructured":"Hain BA, Jude B, Xu H, Smuin DM, Fox EJ, Elfar JC, et al. Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy. J Bone Min Res. 2020;35(2):368\u201381.","journal-title":"J Bone Min Res"}],"container-title":["BMC Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12877-026-07519-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-026-07519-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12877-026-07519-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:37:17Z","timestamp":1780619837000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12877-026-07519-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7519"],"URL":"https:\/\/doi.org\/10.1186\/s12877-026-07519-2","relation":{},"ISSN":["1471-2318"],"issn-type":[{"value":"1471-2318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"25 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsink and approved by the Shanghai Tenth People\u2019s Hostipal Ethics Committee (protocol code 22K177 and date of approval: 2 August 2022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors read and approved the final manuscript for publication. All personal data was released with consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"808"}}