{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:02:15Z","timestamp":1789783335181,"version":"4.0.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12879-016-1382-9","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T01:14:01Z","timestamp":1455498841000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fusarium ramigenum, a novel human opportunist in a patient with common variable immunodeficiency and cellular immune defects: case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Ruxandra V.","family":"Moroti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriu","family":"Gheorghita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M. S.","family":"Al-Hatmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Sybren","family":"de Hoog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"1382_CR1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/1469-0691.12409","volume":"20","author":"M Nucci","year":"2014","unstructured":"Nucci M, Marr KA, Vehreschild MJ, de Souza CA, Velasco E, Cappellano P, et al. Improvement in the outcome of invasive fusariosis in the last decade. Clin Microbiol Infect. 2014;20:580\u20135.","journal-title":"Clin Microbiol Infect"},{"key":"1382_CR2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/CMR.00014-07","volume":"20","author":"M Nucci","year":"2007","unstructured":"Nucci M, Anaissie E. Fusarium infections in immunocompromised patients. Clin Microbiol Rev. 2007;20:695\u2013704.","journal-title":"Clin Microbiol Rev"},{"key":"1382_CR3","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s10096-013-1924-7","volume":"32","author":"J Guarro","year":"2013","unstructured":"Guarro J. Fusariosis, a complex infection caused by a high diversity of fungal species refractory to treatment. Eur J Clin Microbiol Infect Dis. 2013;32:1491\u2013500.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"1382_CR4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/myc.12212","volume":"57","author":"DL Horn","year":"2014","unstructured":"Horn DL, Freifeld AG, Schuster MG, Azie NE, Franks B, Kauffman CA. Treatment and outcomes of invasive fusariosis: review of 65 cases from the PATH Alliance(\u00ae) registry. Mycoses. 2014;57:652\u20138.","journal-title":"Mycoses"},{"key":"1382_CR5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1684\/ecn.2009.0150","volume":"20","author":"C Popa","year":"2009","unstructured":"Popa C, Barrera P, Joosten LA, van Riel PL, Kullberg BJ, van der Meer JW, et al. Cytokine production from stimulated whole blood cultures in rheumatoid arthritis patients treated with various TNF blocking agents. Eur Cytokine Netw. 2009;20:88\u201393.","journal-title":"Eur Cytokine Netw"},{"key":"1382_CR6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","volume":"11","author":"L Romani","year":"2011","unstructured":"Romani L. Immunity to fungal infections. Nat Rev Immunol. 2011;11:275\u201388.","journal-title":"Nat Rev Immunol"},{"key":"1382_CR7","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1128\/IAI.01089-13","volume":"82","author":"H Yamamoto","year":"2014","unstructured":"Yamamoto H, Nakamura Y, Sato K, Takahashi Y, Nomura T, Miyasaka T, et al. Defect of CARD9 leads to impaired accumulation of gamma interferon-producing memory phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans. Infect Immun. 2014;82:1606\u201315.","journal-title":"Infect Immun"},{"key":"1382_CR8","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s10875-014-0053-0","volume":"34","author":"FN Varzaneh","year":"2014","unstructured":"Varzaneh FN, Keller B, Unger S, Aghamohammadi A, Warnatz K, Rezaei N. Cytokines in common variable immunodeficiency as signs of immune dysregulation and potential therapeutic targets - a review of the current knowledge. J Clin Immunol. 2014;34:524\u201343.","journal-title":"J Clin Immunol"},{"key":"1382_CR9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.clim.2011.07.004","volume":"141","author":"S Assen van","year":"2011","unstructured":"van Assen S, de Haan A, Holvast A, Horst G, Gorter L, Westra J, et al. Cell-mediated immune responses to inactivated trivalent influenza-vaccination are decreased in patients with common variable immunodeficiency. Clin Immunol. 2011;141:161\u20138.","journal-title":"Clin Immunol"},{"key":"1382_CR10","doi-asserted-by":"crossref","unstructured":"Barbosa RR, Silva SP, Silva SL, Melo AC, Pedro E, Barbosa MP, et al. Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation. PLoS ONE 6(8): e22848. doi: 10.1371\/journal.pone.0022848 .","DOI":"10.1371\/journal.pone.0022848"},{"key":"1382_CR11","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.4049\/jimmunol.178.6.3932","volume":"178","author":"A Giovannetti","year":"2007","unstructured":"Giovannetti A, Pierdominici M, Mazzetta F, Marziali M, Renzi C, Mileo AM, et al. Unravelling the complexity of T cell abnormalities in common variable immunodeficiency. J Immunol. 2007;178:3932\u201343.","journal-title":"J Immunol"},{"key":"1382_CR12","first-page":"244","volume":"20","author":"N Rezaei","year":"2010","unstructured":"Rezaei N, Aghamohammadi A, Nourizadeh M, Kardar GA, Pourpak Z, Zare A, et al. Cytokine production by activated T cells in common variable immunodeficiency. J Investig Allergol Clin Immunol. 2010;20:244\u201351.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"1382_CR13","first-page":"160","volume":"22","author":"M Oraei","year":"2012","unstructured":"Oraei M, Aghamohammadi A, Rezaei N, Bidad K, Gheflati Z, Amirkhani A, et al. Naive CD4+ T cells and recent thymic emigrants in common variable immunodeficiency. J Investig Allergol Clin Immunol. 2012;22:160\u20137.","journal-title":"J Investig Allergol Clin Immunol"},{"key":"1382_CR14","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0248-8663(03)00189-9","volume":"24","author":"C Bloch-Michel","year":"2003","unstructured":"Bloch-Michel C, Viallard JF, Blanco P, Liferman F, Neau D, Moreau JF, et al. Common variable immunodeficiency: 17 observations in the adult. Rev Med Interne. 2003;24:640\u201350.","journal-title":"Rev Med Interne"},{"key":"1382_CR15","volume-title":"Atlas of Clinical Fungi","author":"GS Hoog de","year":"2011","unstructured":"de Hoog GS, Guarro J, Gene J, Figueras MJ. Atlas of Clinical Fungi. 3rd ed. Utrecht, the Netherlands: Centraalbureau voor Schimmelcultures; 2011.","edition":"3"},{"key":"1382_CR16","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2307\/3761403","volume":"90","author":"HI Nirenberg","year":"1998","unstructured":"Nirenberg HI, O\u2019Donnell K. New Fusarium species and combinations within the Gibberella fujikuroi species complex. Mycologia. 1998;90:434\u201358.","journal-title":"Mycologia"},{"key":"1382_CR17","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1080\/19440040903573040","volume":"27","author":"A Moretti","year":"2010","unstructured":"Moretti A, Ferracane L, Somma S, Ricci V, Mul\u00e8 G, Susca A, et al. Identification, mycotoxin risk and pathogenicity of Fusarium species associated to fig endosepsis in Apulia. Food Addit Contam. 2010;27:718\u201328.","journal-title":"Food Addit Contam"},{"key":"1382_CR18","first-page":"1068","volume":"70","author":"AM Al-Hatmi","year":"2015","unstructured":"Al-Hatmi AM, van Diepeningen AD, Curfs-Breuker I, de Hoog GS, Meis JF. Specific antifungal susceptibility profiles of opportunists in the Fusarium fujikuroi complex. J Antimicrob Chemother. 2015;70:1068\u201371.","journal-title":"J Antimicrob Chemother"},{"key":"1382_CR19","doi-asserted-by":"crossref","unstructured":"Espinel-Ingroff A, Colombo AL, Cordoba S, Dufresne PJ, Fuller J, Ghannoum M, et al. An international evaluation of MIC distributions and ECV definition for Fusarium species identified by molecular methods for the CLSI broth microdilution method. Antimicrob Agents Chemother\u00a02016;60(2):1079-84","DOI":"10.1128\/AAC.02456-15"},{"key":"1382_CR20","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1128\/AAC.00286-10","volume":"54","author":"O Lortholary","year":"2010","unstructured":"Lortholary O, Obenga G, Biswas P, Caillot D, Chachaty E, Bienvenu AL, et al. International retrospective analysis of 73 cases of invasive fusariosis treated with voriconazole. Antimicrob Agents Chemother. 2010;54:4446\u201350.","journal-title":"Antimicrob Agents Chemother"},{"key":"1382_CR21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/1469-0691.12465","volume":"20","author":"AM Tortorano","year":"2014","unstructured":"Tortorano AM, Richardson M, Roilides E, van Diepeningen A, Caira M, Munoz P, et al. ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others. Clin Microbiol Infect. 2014;20:27\u201346.","journal-title":"Clin Microbiol Infect"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-016-1382-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T12:05:19Z","timestamp":1600171519000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1471-2334\/16\/79"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,15]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1382"],"URL":"https:\/\/doi.org\/10.1186\/s12879-016-1382-9","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,15]]},"article-number":"79"}}