{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:55:08Z","timestamp":1787856908584,"version":"build-2784847793"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371801 and 81071348"],"award-info":[{"award-number":["81371801 and 81071348"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Guangzhou Key Laboratory for Blood Safety","award":["201509010009"],"award-info":[{"award-number":["201509010009"]}]},{"name":"the Guangzhou Pearl River S and T Nova Program","award":["201506010075"],"award-info":[{"award-number":["201506010075"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12879-016-1834-2","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T21:14:59Z","timestamp":1474319699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence of hepatitis B surface antigen (HBsAg) in a blood donor population born prior to and after implementation of universal HBV vaccination in Shenzhen, China"],"prefix":"10.1186","volume":"16","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baocheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Allain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"1834_CR1","doi-asserted-by":"publisher","first-page":"6550","DOI":"10.1016\/j.vaccine.2009.08.048","volume":"27","author":"X Liang","year":"2009","unstructured":"Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, et al. Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine. 2009;27:6550\u20137.","journal-title":"Vaccine"},{"key":"1834_CR2","first-page":"777","volume":"49","author":"X Shao","year":"2015","unstructured":"Shao X, Wu C, Wang F, Liang J, Xie X, Zhu Q, et al. Seroepidemiological analysis of hepatitis B among children aged 1\u201314 in 3 counties of Guangdong province in 2013. Zhonghua Yu Fang Yi Xue Za Zhi. 2015;49:777\u201381.","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"1834_CR3","doi-asserted-by":"publisher","first-page":"7842","DOI":"10.3748\/wjg.v21.i25.7842","volume":"21","author":"P Huang","year":"2015","unstructured":"Huang P, Zhu LG, Zhu YF, Yue M, Su J, Zhu FC, et al. Seroepidemiology of hepatitis B virus infection and impact of vaccination. World J Gastroenterol. 2015;21:7842\u201350.","journal-title":"World J Gastroenterol"},{"key":"1834_CR4","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1046\/j.1537-2995.2003.00424.x","volume":"43","author":"R Biswas","year":"2003","unstructured":"Biswas R, Tabor E, Hsia CC, Wright DJ, Laycock ME, Fiebig EW, et al. Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection. Transfusion. 2003;43:788\u201398.","journal-title":"Transfusion"},{"key":"1834_CR5","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.jhep.2008.07.014","volume":"49","author":"G Raimondo","year":"2008","unstructured":"Raimondo G, Allain JP, Brunetto MR, Buendia MA, Chen DS, Colombo M, et al. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol. 2008;49:652\u20137.","journal-title":"J Hepatol"},{"key":"1834_CR6","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1002\/hep.21413","volume":"44","author":"E Brojer","year":"2006","unstructured":"Brojer E, Grabarczyk P, Liszewski G, Mikulska M, Allain JP, Letowska M, et al. Characterization of HBV DNA+\/HBsAg- blood donors in Poland identified by triplex NAT. Hepatology. 2006;44:1666\u201374.","journal-title":"Hepatology"},{"key":"1834_CR7","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.jhep.2015.06.016","volume":"63","author":"M Spreafico","year":"2015","unstructured":"Spreafico M, Berzuini A, Foglieni B, Candotti D, Raffaele L, Guarnori I, et al. Poor efficacy of nucleic acid testing in identifying occult HBV infection and consequences for safety of blood supply in Italy. J Hepatol. 2015;63:1068\u201376.","journal-title":"J Hepatol"},{"key":"1834_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00430-014-0373-y","volume":"204","author":"WH Gerlich","year":"2015","unstructured":"Gerlich WH. Prophylactic vaccination against hepatitis B: achievements, challenges and perspectives. Med Microbiol Immunol. 2015;204:39\u201355.","journal-title":"Med Microbiol Immunol"},{"key":"1834_CR9","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.jhep.2012.05.021","volume":"57","author":"YH Ni","year":"2012","unstructured":"Ni YH, Chang MH, Wu JF, Hsu HY, Chen HL, Chen DS. Minimization of hepatitis B infection by a 25-year universal vaccination program. J Hepatol. 2012;57:730\u20135.","journal-title":"J Hepatol"},{"key":"1834_CR10","doi-asserted-by":"publisher","first-page":"6266","DOI":"10.1016\/j.vaccine.2008.09.056","volume":"26","author":"AR Zanetti","year":"2008","unstructured":"Zanetti AR, Van Damme P, Shouval D. The global impact of vaccination against hepatitis B: a historical overview. Vaccine. 2008;26:6266\u201373.","journal-title":"Vaccine"},{"key":"1834_CR11","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/j.vaccine.2011.12.116","volume":"30","author":"JJ Ott","year":"2012","unstructured":"Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30:2212\u20139.","journal-title":"Vaccine"},{"key":"1834_CR12","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1111\/trf.12902","volume":"55","author":"X Zheng","year":"2014","unstructured":"Zheng X, Ye X, Du P, Zeng J, Zhu W, Yang B, et al. High prevalence of anti-hepatitis B core antigen in hepatitis B virus-vaccinated Chinese blood donors suggests insufficient protection but little threat to the blood supply. Transfusion. 2014;55:890\u20137.","journal-title":"Transfusion"},{"key":"1834_CR13","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.transci.2013.08.005","volume":"49","author":"X Ye","year":"2013","unstructured":"Ye X, Yang B, Zhu W, Zheng X, Du P, Zeng J, Li C. Six-year pilot study on nucleic acid testing for blood donations in China. Transfus Apher Sci. 2013;49:318\u201322.","journal-title":"Transfus Apher Sci"},{"key":"1834_CR14","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1128\/JCM.00145-11","volume":"49","author":"X Zheng","year":"2011","unstructured":"Zheng X, Ye X, Zhang L, Wang W, Shuai L, Wang A, et al. Characterization of occult hepatitis B virus infection from blood donors in China. J Clin Microbiol. 2011;49:1730\u20137.","journal-title":"J Clin Microbiol"},{"key":"1834_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1537-2995.2006.01146.x","volume":"47","author":"G Shang","year":"2007","unstructured":"Shang G, Seed CR, Wang F, Nie D, Farrugia A. Residual risk of transfusion-transmitted viral infections in Shenzhen, China, 2001 through 2004. Transfusion. 2007;47:529\u201339.","journal-title":"Transfusion"},{"key":"1834_CR16","doi-asserted-by":"publisher","first-page":"e692","DOI":"10.1016\/j.ijid.2012.05.1027","volume":"16","author":"J Xiao","year":"2012","unstructured":"Xiao J, Zhang J, Wu C, Shao X, Peng G, Peng Z, et al. Impact of hepatitis B vaccination among children in Guangdong Province, China. Int J Infect Dis. 2012;16:e692\u20136.","journal-title":"Int J Infect Dis"},{"key":"1834_CR17","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.3748\/wjg.v17.i31.3640","volume":"17","author":"LZ Chen","year":"2011","unstructured":"Chen LZ, Zhou WQ, Zhao SS, Liu ZY, Wen SW. A nested case-control study of maternal-neonatal transmission of hepatitis B virus in a Chinese population. World J Gastroenterol. 2011;17:3640\u20134.","journal-title":"World J Gastroenterol"},{"key":"1834_CR18","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.3748\/wjg.v9.i7.1501","volume":"9","author":"XM Li","year":"2003","unstructured":"Li XM, Yang YB, Hou HY, Shi ZJ, Shen HM, Teng BQ, et al. Interruption of HBV intrauterine transmission: a clinical study. World J Gastroenterol. 2003;9:1501\u20133.","journal-title":"World J Gastroenterol"},{"key":"1834_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1056\/NEJMoa1007644","volume":"364","author":"SL Stramer","year":"2011","unstructured":"Stramer SL, Wend U, Candotti D, Foster GA, Hollinger FB, Dodd RY, et al. Nucleic acid testing to detect HBV infection in blood donors. N Engl J Med. 2011;364:236\u201347.","journal-title":"N Engl J Med"},{"key":"1834_CR20","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1097\/MOH.0b013e32834bac10","volume":"18","author":"JP Allain","year":"2011","unstructured":"Allain JP, Cox L. Challenges in hepatitis B detection among blood donors. Curr Opin Hematol. 2011;18:461\u20136.","journal-title":"Curr Opin Hematol"},{"key":"1834_CR21","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1136\/gutjnl-2011-301281","volume":"61","author":"D Candotti","year":"2012","unstructured":"Candotti D, Lin CK, Belkhiri D, Sakuldamrongpanich T, Biswas S, Lin S, et al. Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence. Gut. 2012;61:1744\u201353.","journal-title":"Gut"},{"key":"1834_CR22","first-page":"162","volume-title":"Occult hepatitis B infection","author":"CY Li","year":"2015","unstructured":"Li CY, Fu YS, Li TT, Allain JP. Occult hepatitis B infection in the vaccinated Chinese population. In: Allain JP, Fu YS, Li CY, Raimondo G, editors. Occult hepatitis B infection. Beijing: Science Press; 2015. p. 162\u201377."},{"key":"1834_CR23","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.4161\/hv.21818","volume":"8","author":"K Han","year":"2012","unstructured":"Han K, Shao X, Zheng H, Wu C, Zhu J, Zheng X, et al. Revaccination of non- and low- responders after a standard three dose hepatitis B vaccine schedule. Hum Vaccin Immunother. 2012;8:1845\u20139.","journal-title":"Hum Vaccin Immunother"},{"key":"1834_CR24","doi-asserted-by":"publisher","first-page":"12196","DOI":"10.1128\/JVI.02127-13","volume":"87","author":"T Bian","year":"2013","unstructured":"Bian T, Yan H, Shen L, Wang F, Zhang S, Cao Y, et al. Change in hepatitis B virus large surface antigen variant prevalence 13\u00a0years after implementation of a universal vaccination program in China. J Virol. 2013;87:12196\u2013206.","journal-title":"J Virol"},{"key":"1834_CR25","doi-asserted-by":"publisher","first-page":"6091","DOI":"10.1016\/j.vaccine.2014.08.078","volume":"32","author":"L Zhang","year":"2014","unstructured":"Zhang L, Gui XE, Teter C, Zhong H, Pang Z, Ding L, et al. Effects of hepatitis B immunization on prevention of mother-to-infant transmission of hepatitis B virus and on the immune response of infants towards hepatitis B vaccine. Vaccine. 2014;32:6091\u20137.","journal-title":"Vaccine"},{"key":"1834_CR26","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1002\/hep.27650","volume":"61","author":"HY Hsu","year":"2015","unstructured":"Hsu HY, Chang MH, Ni YH, Chiang CL, Wu JF, Chen HL. Universal infant immunization and occult hepatitis B virus infection in children and adolescents: a population-based study. Hepatology. 2015;61:1183\u201391.","journal-title":"Hepatology"},{"key":"1834_CR27","doi-asserted-by":"publisher","first-page":"6613","DOI":"10.1016\/j.vaccine.2009.08.007","volume":"27","author":"JJ Lu","year":"2009","unstructured":"Lu JJ, Cheng CC, Chou SM, Hor CB, Yang YC, Wang HL. Hepatitis B immunity in adolescents and necessity for boost vaccination: 23\u00a0years after nationwide hepatitis B virus vaccination program in Taiwan. Vaccine. 2009;27:6613\u20138.","journal-title":"Vaccine"},{"key":"1834_CR28","doi-asserted-by":"publisher","unstructured":"Katoonizadeh A, Sharafkhah M, Ostovaneh MR, Norouzi A, Khoshbakht N, Mohamadkhani A, Eslami L, et al. Immune responses to hepatitis B immunization 10\u201318 years after primary vaccination: a population-based cohort study. J Viral Hepat. 2016. doi:\n                    10.1111\/jvh.12543\n                    \n                  .","DOI":"10.1111\/jvh.12543"},{"key":"1834_CR29","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1016\/j.vaccine.2016.04.013","volume":"34","author":"O Meeren Van Der","year":"2016","unstructured":"Van Der Meeren O, Behre U, Crasta P. Immunity to hepatitis B persists in adolescents 15\u201316 years of age vaccinated in infancy with three doses of hepatitis B vaccine. Vaccine. 2016;34:2745\u20139.","journal-title":"Vaccine"},{"key":"1834_CR30","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.4161\/hv.34393","volume":"10","author":"M Bagheri-Jamebozorgi","year":"2014","unstructured":"Bagheri-Jamebozorgi M, Keshavarz J, Nemati M, Mohammadi-Hossainabad S, Rezayati MT, Nejad-Ghaderi M, et al. The persistence of anti-HBs antibody and anamnestic response 20\u00a0years after primary vaccination with recombinant hepatitis B vaccine at infancy. Hum Vaccin Immunother. 2014;10:3731\u20136.","journal-title":"Hum Vaccin Immunother"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-016-1834-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-016-1834-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-016-1834-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T18:00:57Z","timestamp":1487700057000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-016-1834-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,20]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1834"],"URL":"https:\/\/doi.org\/10.1186\/s12879-016-1834-2","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,20]]},"article-number":"498"}}