{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:32:04Z","timestamp":1768307524481,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Oslo University Hospital"},{"DOI":"10.13039\/501100012446","name":"Akershus University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12879-016-2148-0","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T13:40:48Z","timestamp":1483623648000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Thymus activity measured by T-cell receptor excision circles in patients with different severities of respiratory syncytial virus infection"],"prefix":"10.1186","volume":"17","author":[{"given":"Kiran Aftab","family":"Gul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonje","family":"Sonerud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans O.","family":"Fj\u00e6rli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Nakstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore Gunnar","family":"Abrahamsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S.","family":"Inchley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"2148_CR1","first-page":"S1","volume":"96 Suppl B","author":"BJ Law","year":"2002","unstructured":"Law BJ, Carbonell-Estrany X, Simoes EA. An update on respiratory syncytial virus epidemiology: a developed country perspective. Respir Med. 2002;96 Suppl B:S1\u20137.","journal-title":"Respir Med"},{"issue":"6","key":"2148_CR2","first-page":"543","volume":"140","author":"WP Glezen","year":"1986","unstructured":"Glezen WP, Taber LH, Frank AL, Kasel JA. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child. 1986;140(6):543\u20136.","journal-title":"Am J Dis Child"},{"issue":"1","key":"2148_CR3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2431-4-25","volume":"4","author":"HO Fjaerli","year":"2004","unstructured":"Fjaerli HO, Farstad T, Bratlid D. Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993-2000: a population-based retrospective study. BMC Pediatr. 2004;4(1):25.","journal-title":"BMC Pediatr"},{"issue":"6712","key":"2148_CR4","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/25374","volume":"396","author":"DC Douek","year":"1998","unstructured":"Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396(6712):690\u20135.","journal-title":"Nature"},{"issue":"11","key":"2148_CR5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s001090100271","volume":"79","author":"MD Hazenberg","year":"2001","unstructured":"Hazenberg MD, Verschuren MC, Hamann D, Miedema F, van Dongen JJ. T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J Mol Med (Berl). 2001;79(11):631\u201340.","journal-title":"J Mol Med (Berl)"},{"issue":"1","key":"2148_CR6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s10875-006-7519-7","volume":"26","author":"MV Arellano","year":"2006","unstructured":"Arellano MV, Ordonez A, Ruiz-Mateos E, Leal-Noval SR, Molina-Pinelo S, Hernandez A, Vallejo A, Hinojosa R, Leal M. Thymic function-related markers within the thymus and peripheral blood: Are they comparable? J Clin Immunol. 2006;26(1):96\u2013100.","journal-title":"J Clin Immunol"},{"key":"2148_CR7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-59745-395-0_12","volume":"380","author":"ML Dion","year":"2007","unstructured":"Dion ML, Sekaly RP, Cheynier R. Estimating thymic function through quantification of T-cell receptor excision circles. Methods Mol Biol. 2007;380:197\u2013213.","journal-title":"Methods Mol Biol"},{"key":"2148_CR8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1749-6632.2011.06346.x","volume":"1246","author":"JM Puck","year":"2011","unstructured":"Puck JM. The case for newborn screening for severe combined immunodeficiency and related disorders. Ann N Y Acad Sci. 2011;1246:108\u201317.","journal-title":"Ann N Y Acad Sci"},{"key":"2148_CR9","doi-asserted-by":"crossref","unstructured":"Machnes-Maayan D1 LA, Katz U, Mishali D, Vardi A, Simon AJ, Somech R. Insight into normal thymic activity by assessment of peripheral blood samples. Immunol Res. 2015;61(3)198\u2013205.","DOI":"10.1007\/s12026-014-8558-4"},{"key":"2148_CR10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12879-015-0878-z","volume":"15","author":"CS Inchley","year":"2015","unstructured":"Inchley CS, Sonerud T, Fjaerli HO, Nakstad B. Nasal mucosal microRNA expression in children with respiratory syncytial virus infection. BMC Infect Dis. 2015;15:150.","journal-title":"BMC Infect Dis"},{"issue":"6","key":"2148_CR11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.79.6.939","volume":"79","author":"DI Lowell","year":"1987","unstructured":"Lowell DI, Lister G, Von KH, McCarthy P. Wheezing in infants: the response to epinephrine. Pediatrics. 1987;79(6):939\u201345.","journal-title":"Pediatrics"},{"issue":"2","key":"2148_CR12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0732-8893(93)90003-P","volume":"16","author":"MA Olsen","year":"1993","unstructured":"Olsen MA, Shuck KM, Sambol AR. Evaluation of Abbott TestPack RSV for the diagnosis of respiratory syncytial virus infections. Diagn Microbiol Infect Dis. 1993;16(2):105\u20139.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"10","key":"2148_CR13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/gm384","volume":"4","author":"MN Cruickshank","year":"2012","unstructured":"Cruickshank MN, Pitt J, Craig JM. Going back to the future with Guthrie-powered epigenome-wide association studies. Genome Med. 2012;4(10):83.","journal-title":"Genome Med"},{"issue":"4","key":"2148_CR14","first-page":"514","volume":"34","author":"J Lingman Framme","year":"2014","unstructured":"Lingman Framme J, Borte S, von Dobeln U, Hammarstrom L, Oskarsdottir S. Retrospective analysis of TREC based newborn screening results and clinical phenotypes in infants with the 22q11 deletion syndrome. J Clin Immunol. 2014;34(4):514\u20139.","journal-title":"J Clin Immunol"},{"key":"2148_CR15","doi-asserted-by":"crossref","unstructured":"Gul KA, Overland T, Osnes L, Baumbusch LO, Pettersen RD, Lima K, Abrahamsen TG. Neonatal Levels of T-cell Receptor Excision Circles (TREC) in Patients with 22q11.2 Deletion Syndrome and Later Disease Features. J Clin Immunol. 2015;35(4):408\u201315.","DOI":"10.1007\/s10875-015-0153-5"},{"issue":"2","key":"2148_CR16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.immuni.2004.07.016","volume":"21","author":"JH Park","year":"2004","unstructured":"Park JH, Yu Q, Erman B, Appelbaum JS, Montoya-Durango D, Grimes HL, Singer A. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity. 2004;21(2):289\u2013302.","journal-title":"Immunity"},{"issue":"1","key":"2148_CR17","first-page":"1","volume":"2","author":"VS Mahajan","year":"2005","unstructured":"Mahajan VS, Leskov IB, Chen JZ. Homeostasis of T cell diversity. Cell Mol Immunol. 2005;2(1):1\u201310.","journal-title":"Cell Mol Immunol"},{"issue":"3","key":"2148_CR18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1086\/322035","volume":"184","author":"L Bont","year":"2001","unstructured":"Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JM, Pekelharing-Berghuis M, van Diemen-Steenvoorde RA, Kimpen JL. Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity. J Infect Dis. 2001;184(3):355\u20138.","journal-title":"J Infect Dis"},{"issue":"1","key":"2148_CR19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/INF.0b013e31822dc8c1","volume":"31","author":"C Garcia","year":"2012","unstructured":"Garcia C, Soriano-Fallas A, Lozano J, Leos N, Gomez AM, Ramilo O, Mejias A. Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis. Pediatr Infect Dis J. 2012;31(1):86\u20139.","journal-title":"Pediatr Infect Dis J"},{"issue":"9183","key":"2148_CR20","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0140-6736(99)02368-5","volume":"354","author":"L Bont","year":"1999","unstructured":"Bont L, van Vught AJ, Kimpen JL. Prophylaxis against respiratory syncytial virus in premature infants. Lancet. 1999;354(9183):1003\u20134.","journal-title":"Lancet"},{"issue":"1","key":"2148_CR21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2249.2004.02512.x","volume":"137","author":"MF Roe","year":"2004","unstructured":"Roe MF, Bloxham DM, White DK, Ross-Russell RI, Tasker RT, O'Donnell DR. Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis. Clin Exp Immunol. 2004;137(1):139\u201345.","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"2148_CR22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/003655498750002349","volume":"30","author":"W Weerd De","year":"1998","unstructured":"De Weerd W, Twilhaar WN, Kimpen JL. T cell subset analysis in peripheral blood of children with RSV bronchiolitis. Scand J Infect Dis. 1998;30(1):77\u201380.","journal-title":"Scand J Infect Dis"},{"issue":"9","key":"2148_CR23","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1182\/blood.V99.9.3449","volume":"99","author":"MD Hazenberg","year":"2002","unstructured":"Hazenberg MD, Otto SA, de Pauw ES, Roelofs H, Fibbe WE, Hamann D, Miedema F. T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events. Blood. 2002;99(9):3449\u201353.","journal-title":"Blood"},{"issue":"9","key":"2148_CR24","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/infdis\/jit336","volume":"208","author":"CS Inchley","year":"2013","unstructured":"Inchley CS, Osterholt HC, Sonerud T, Fjaerli HO, Nakstad B. Downregulation of IL7R, CCR7, and TLR4 in the cord blood of children with respiratory syncytial virus disease. J Infect Dis. 2013;208(9):1431\u20135.","journal-title":"J Infect Dis"},{"issue":"7","key":"2148_CR25","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/jmv.21771","volume":"82","author":"ML Houben","year":"2010","unstructured":"Houben ML, Coenjaerts FE, Rossen JW, Belderbos ME, Hofland RW, Kimpen JL, Bont L. Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community. J Med Virol. 2010;82(7):1266\u201371.","journal-title":"J Med Virol"},{"issue":"7","key":"2148_CR26","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/infdis\/jir494","volume":"204","author":"CM Saleeby El","year":"2011","unstructured":"El Saleeby CM, Bush AJ, Harrison LM, Aitken JA, Devincenzo JP. Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis. 2011;204(7):996\u20131002.","journal-title":"J Infect Dis"},{"issue":"4","key":"2148_CR27","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/infdis\/jis721","volume":"207","author":"C Mella","year":"2013","unstructured":"Mella C, Suarez-Arrabal MC, Lopez S, Stephens J, Fernandez S, Hall MW, Ramilo O, Mejias A. Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis. 2013;207(4):564\u201373.","journal-title":"J Infect Dis"},{"issue":"5","key":"2148_CR28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ppul.10080","volume":"33","author":"RL Smyth","year":"2002","unstructured":"Smyth RL, Mobbs KJ, O'Hea U, Ashby D, Hart CA. Respiratory syncytial virus bronchiolitis: disease severity, interleukin-8, and virus genotype. Pediatr Pulmonol. 2002;33(5):339\u201346.","journal-title":"Pediatr Pulmonol"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-016-2148-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T19:04:47Z","timestamp":1658343887000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-016-2148-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,5]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2148"],"URL":"https:\/\/doi.org\/10.1186\/s12879-016-2148-0","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,5]]},"article-number":"18"}}