{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:10:44Z","timestamp":1762542644158,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["5D43TW006589"],"award-info":[{"award-number":["5D43TW006589"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["525 004022012","222956933302"],"award-info":[{"award-number":["525 004022012","222956933302"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R21AI124171"],"award-info":[{"award-number":["1R21AI124171"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12879-017-2281-4","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T02:05:38Z","timestamp":1488247538000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Screening of TNF\u03b1, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study"],"prefix":"10.1186","volume":"17","author":[{"given":"Ang\u00e9lica","family":"Mera-Ram\u00edrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenifer","family":"Orobio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Adelaida","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Gallego-Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"issue":"1","key":"2281_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1590\/S0100-879X1998000100020","volume":"31","author":"A Ribeiro-De-Jesus","year":"1998","unstructured":"Ribeiro-De-Jesus A, Almeida RP, Lessa H, Bacellar O, Carvalho EM. Cytokine profile and pathology in human leishmaniasis. Braz J Med Biol Res. 1998;31(1):143\u20138.","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"2281_CR2","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/infdis\/168.3.709","volume":"168","author":"KA Weigle","year":"1993","unstructured":"Weigle KA, Santrich C, Martinez F, Valderrama L, Saravia NG. Epidemiology of cutaneous leishmaniasis in Colombia: environmental and behavioral risk factors for infection, clinical manifestations, and pathogenicity. J Infect Dis. 1993;168(3):709\u201314.","journal-title":"J Infect Dis"},{"issue":"3","key":"2281_CR3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4269\/ajtmh.1995.53.273","volume":"53","author":"EM Carvalho","year":"1995","unstructured":"Carvalho EM, Correia Filho D, Bacellar O, Almeida RP, Lessa H, Rocha H. Characterization of the immune response in subjects with self-healing cutaneous leishmaniasis. Am J Trop Med Hyg. 1995;53(3):273\u20137.","journal-title":"Am J Trop Med Hyg"},{"issue":"11","key":"2281_CR4","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nri933","volume":"2","author":"D Sacks","year":"2002","unstructured":"Sacks D, Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol. 2002;2(11):845\u201358.","journal-title":"Nat Rev Immunol"},{"issue":"Suppl 1","key":"2281_CR5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1590\/S0074-02761988000500006","volume":"83","author":"P Scott","year":"1988","unstructured":"Scott P, Natovitz P, Coffman RL, Pearce E, Sher A. CD4+ T cell subsets in experimental cutaneous leishmaniasis. Mem Inst Oswaldo Cruz. 1988;83 Suppl 1:256\u20139.","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"12","key":"2281_CR6","doi-asserted-by":"publisher","first-page":"6734","DOI":"10.1128\/IAI.70.12.6734-6740.2002","volume":"70","author":"O Bacellar","year":"2002","unstructured":"Bacellar O, Lessa H, Schriefer A, Machado P, Ribeiro de Jesus A, Dutra WO, Gollob KJ, Carvalho EM. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect Immun. 2002;70(12):6734\u201340.","journal-title":"Infect Immun"},{"issue":"2","key":"2281_CR7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1590\/S0074-02761996000200019","volume":"91","author":"AM Da-Cruz","year":"1996","unstructured":"Da-Cruz AM, de Oliveira MP, De Luca PM, Mendonca SC, Coutinho SG. Tumor necrosis factor-alpha in human american tegumentary leishmaniasis. Mem Inst Oswaldo Cruz. 1996;91(2):225\u20139.","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"6","key":"2281_CR8","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.humimm.2009.01.007","volume":"70","author":"LR Castellano","year":"2009","unstructured":"Castellano LR, Filho DC, Argiro L, Dessein H, Prata A, Dessein A, Rodrigues V. Th1\/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-gamma production. Hum Immunol. 2009;70(6):383\u201390.","journal-title":"Hum Immunol"},{"issue":"5","key":"2281_CR9","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1128\/IAI.01513-08","volume":"77","author":"A Maurer-Cecchini","year":"2009","unstructured":"Maurer-Cecchini A, Decuypere S, Chappuis F, Alexandrenne C, De Doncker S, Boelaert M, Dujardin JC, Loutan L, Dayer JM, Tulliano G, et al. Immunological determinants of clinical outcome in Peruvian patients with tegumentary leishmaniasis treated with pentavalent antimonials. Infect Immun. 2009;77(5):2022\u20139.","journal-title":"Infect Immun"},{"issue":"9","key":"2281_CR10","doi-asserted-by":"publisher","first-page":"6139","DOI":"10.4049\/jimmunol.180.9.6139","volume":"180","author":"A Salhi","year":"2008","unstructured":"Salhi A, Rodrigues Jr V, Santoro F, Dessein H, Romano A, Castellano LR, Sertorio M, Rafati S, Chevillard C, Prata A, et al. Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis. J Immunol. 2008;180(9):6139\u201348.","journal-title":"J Immunol"},{"issue":"3","key":"2281_CR11","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/j.1365-2249.2007.03436.x","volume":"149","author":"A Gomes-Silva","year":"2007","unstructured":"Gomes-Silva A, de Cassia Bittar R, Dos Santos Nogueira R, Amato VS, da Silva Mattos M, Oliveira-Neto MP, Coutinho SG, Da-Cruz AM. Can interferon-gamma and interleukin-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection? Clin Exp Immunol. 2007;149(3):440\u20134.","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"2281_CR12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"S Akira","year":"2004","unstructured":"Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4(7):499\u2013511.","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"2281_CR13","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1128\/IAI.72.4.1920-1928.2004","volume":"72","author":"P Kropf","year":"2004","unstructured":"Kropf P, Freudenberg MA, Modolell M, Price HP, Herath S, Antoniazi S, Galanos C, Smith DF, Muller I. Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun. 2004;72(4):1920\u20138.","journal-title":"Infect Immun"},{"issue":"1","key":"2281_CR14","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1189\/jlb.1003484","volume":"76","author":"P Kropf","year":"2004","unstructured":"Kropf P, Freudenberg N, Kalis C, Modolell M, Herath S, Galanos C, Freudenberg M, Muller I. Infection of C57BL\/10ScCr and C57BL\/10ScNCr mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication. J Leukoc Biol. 2004;76(1):48\u201357.","journal-title":"J Leukoc Biol"},{"issue":"6","key":"2281_CR15","doi-asserted-by":"publisher","first-page":"3988","DOI":"10.4049\/jimmunol.179.6.3988","volume":"179","author":"FL Ribeiro-Gomes","year":"2007","unstructured":"Ribeiro-Gomes FL, Moniz-De-Souza MC, Alexandre-Moreira MS, Dias WB, Lopes MF, Nunes MP, Lungarella G, Dosreis GA. Neutrophils activate macrophages for intracellular killing of Leishmania major through recruitment of TLR4 by neutrophil elastase. J Immunol. 2007;179(6):3988\u201394.","journal-title":"J Immunol"},{"issue":"5","key":"2281_CR16","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1128\/IAI.01528-07","volume":"76","author":"SM Whitaker","year":"2008","unstructured":"Whitaker SM, Colmenares M, Pestana KG, Mcmahon-Pratt D. Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4. Infect Immun. 2008;76(5):2149\u201356.","journal-title":"Infect Immun"},{"issue":"7","key":"2281_CR17","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1128\/IAI.01388-10","volume":"79","author":"C Gallego","year":"2011","unstructured":"Gallego C, Golenbock D, Gomez MA, Saravia NG. Toll-Like Receptors Participate in Macrophage Activation and Intracellular Control of Leishmania (Viannia) panamensis. Infect Immun. 2011;79(7):2871\u20139.","journal-title":"Infect Immun"},{"issue":"2","key":"2281_CR18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0169-4758(98)01355-6","volume":"15","author":"JM Blackwell","year":"1999","unstructured":"Blackwell JM. Tumour necrosis factor alpha and mucocutaneous leishmaniasis. Parasitol Today. 1999;15(2):73\u20135.","journal-title":"Parasitol Today"},{"issue":"5","key":"2281_CR19","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1084\/jem.182.5.1259","volume":"182","author":"M Cabrera","year":"1995","unstructured":"Cabrera M, Shaw MA, Sharples C, Williams H, Castes M, Convit J, Blackwell JM. Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. J Exp Med. 1995;182(5):1259\u201364.","journal-title":"J Exp Med"},{"issue":"2","key":"2281_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/76048","volume":"25","author":"NC Arbour","year":"2000","unstructured":"Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000;25(2):187\u201391.","journal-title":"Nat Genet"},{"issue":"11","key":"2281_CR21","doi-asserted-by":"publisher","first-page":"6398","DOI":"10.1128\/IAI.68.11.6398-6401.2000","volume":"68","author":"E Lorenz","year":"2000","unstructured":"Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun. 2000;68(11):6398\u2013401.","journal-title":"Infect Immun"},{"issue":"1","key":"2281_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1073\/pnas.0506803102","volume":"103","author":"FP Mockenhaupt","year":"2006","unstructured":"Mockenhaupt FP, Cramer JP, Hamann L, Stegemann MS, Eckert J, Oh NR, Otchwemah RN, Dietz E, Ehrhardt S, Schroder NW, et al. Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci U S A. 2006;103(1):177\u201382.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2281_CR23","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.micinf.2010.10.018","volume":"13","author":"S Ajdary","year":"2011","unstructured":"Ajdary S, Ghamilouie MM, Alimohammadian MH, Riazi-Rad F, Pakzad SR. Toll-like receptor 4 polymorphisms predispose to cutaneous leishmaniasis. Microbes Infect. 2011;13(3):226\u201331.","journal-title":"Microbes Infect"},{"issue":"5","key":"2281_CR24","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1046\/j.1365-3083.2000.00724.x","volume":"51","author":"F Bosque","year":"2000","unstructured":"Bosque F, Saravia NG, Valderrama L, Milon G. Distinct innate and acquired immune responses to Leishmania in putative susceptible and resistant human populations endemically exposed to L. (Viannia) panamensis infection. Scand J Immunol. 2000;51(5):533\u201341.","journal-title":"Scand J Immunol"},{"issue":"3","key":"2281_CR25","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S1413-8670(11)70181-7","volume":"15","author":"DD Paskulin","year":"2011","unstructured":"Paskulin DD, Fallavena PR, Paludo FJ, Borges TJ, Picanco JB, Dias FS, Alho CS. TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness. Braz J Infect Dis. 2011;15(3):231\u20138.","journal-title":"Braz J Infect Dis"},{"issue":"12","key":"2281_CR26","doi-asserted-by":"publisher","first-page":"10795","DOI":"10.1007\/s11033-012-1973-5","volume":"39","author":"M Rasouli","year":"2012","unstructured":"Rasouli M, Keshavarz M, Kalani M, Moravej A, Kiany S, Badiee P. Toll-like receptor 4 (TLR4) polymorphisms in Iranian patients with visceral leishmaniasis. Mol Biol Rep. 2012;39(12):10795\u2013802.","journal-title":"Mol Biol Rep"},{"issue":"3\u20134","key":"2281_CR27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.cyto.2006.07.016","volume":"35","author":"E Kamali-Sarvestani","year":"2006","unstructured":"Kamali-Sarvestani E, Rasouli M, Mortazavi H, Gharesi-Fard B. Cytokine gene polymorphisms and susceptibility to cutaneous leishmaniasis in Iranian patients. Cytokine. 2006;35(3\u20134):159\u201365.","journal-title":"Cytokine"},{"issue":"7","key":"2281_CR28","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","volume":"94","author":"AG Wilson","year":"1997","unstructured":"Wilson AG, Symons JA, McDowell TL, Mcdevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A. 1997;94(7):3195\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2281_CR29","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/S1473-3099(05)70023-2","volume":"5","author":"NW Schroder","year":"2005","unstructured":"Schroder NW, Schumann RR. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis. 2005;5(3):156\u201364.","journal-title":"Lancet Infect Dis"},{"issue":"9","key":"2281_CR30","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1001\/archinte.162.9.1028","volume":"162","author":"E Lorenz","year":"2002","unstructured":"Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med. 2002;162(9):1028\u201332.","journal-title":"Arch Intern Med"},{"issue":"10","key":"2281_CR31","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1086\/344893","volume":"186","author":"DM Agnese","year":"2002","unstructured":"Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE, Lowry SF. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis. 2002;186(10):1522\u20135.","journal-title":"J Infect Dis"},{"issue":"1","key":"2281_CR32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1590\/S0074-02762008000100004","volume":"103","author":"G Zafra","year":"2008","unstructured":"Zafra G, Florez O, Morillo CA, Echeverria LE, Martin J, Gonzalez CI. Polymorphisms of toll-like receptor 2 and 4 genes in Chagas disease. Mem Inst Oswaldo Cruz. 2008;103(1):27\u201330.","journal-title":"Mem Inst Oswaldo Cruz"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-017-2281-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-017-2281-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-017-2281-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T11:16:31Z","timestamp":1589454991000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-017-2281-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2281"],"URL":"https:\/\/doi.org\/10.1186\/s12879-017-2281-4","relation":{},"ISSN":["1471-2334"],"issn-type":[{"type":"electronic","value":"1471-2334"}],"subject":[],"published":{"date-parts":[[2017,2,28]]},"assertion":[{"value":"15 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"177"}}