{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:04:37Z","timestamp":1774267477976,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:00:00Z","timestamp":1525305600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004919","name":"King Abdulaziz City for Science and Technology","doi-asserted-by":"publisher","award":["ARP-28-112"],"award-info":[{"award-number":["ARP-28-112"]}],"id":[{"id":"10.13039\/501100004919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12879-018-3114-9","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T12:15:39Z","timestamp":1525349739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Clonal diversity and genetic profiling of antibiotic resistance among multidrug\/carbapenem-resistant Klebsiella pneumoniae isolates from a tertiary care hospital in Saudi Arabia"],"prefix":"10.1186","volume":"18","author":[{"given":"Taher uz","family":"Zaman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Alrodayyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Albladi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Aldrees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Ismail","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameera","family":"Aljohani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan H.","family":"Balkhy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"issue":"11","key":"3114_CR1","doi-asserted-by":"publisher","first-page":"1000 e1001","DOI":"10.1016\/j.cmi.2015.06.016","volume":"21","author":"B Hasan","year":"2015","unstructured":"Hasan B, Olsen B, Alam A, Akter L, Melhus A. Dissemination of the multidrug-resistant extended-spectrum beta-lactamase-producing Escherichia coli O25b-ST131 clone and the role of house crow (Corvus splendens) foraging on hospital waste in Bangladesh. Clin Microbiol Infect. 2015;21(11):1000 e1001\u20134.","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"3114_CR2","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1093\/jac\/dkp327","volume":"64","author":"A Endimiani","year":"2009","unstructured":"Endimiani A, Depasquale JM, Forero S, Perez F, Hujer AM, Roberts-Pollack D, Fiorella PD, Pickens N, Kitchel B, Casiano-Colon AE, et al. Emergence of blaKPC-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system. J Antimicrob Chemother. 2009;64(5):1102\u201310.","journal-title":"J Antimicrob Chemother"},{"issue":"12","key":"3114_CR3","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S1473-3099(10)70276-0","volume":"10","author":"AM Hammerum","year":"2010","unstructured":"Hammerum AM, Toleman MA, Hansen F, Kristensen B, Lester CH, Walsh TR, Fuursted K. Global spread of New Delhi metallo-beta-lactamase 1. Lancet Infect Dis. 2010;10(12):829\u201330.","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"3114_CR4","doi-asserted-by":"publisher","first-page":"e1130","DOI":"10.1016\/j.ijid.2013.06.016","volume":"17","author":"A Shibl","year":"2013","unstructured":"Shibl A, Al-Agamy M, Memish Z, Senok A, Khader SA, Assiri A. The emergence of OXA-48- and NDM-1-positive Klebsiella pneumoniae in Riyadh, Saudi Arabia. Int J Infect Dis. 2013;17(12):e1130\u20133.","journal-title":"Int J Infect Dis"},{"issue":"5","key":"3114_CR5","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/j.1574-6976.2011.00268.x","volume":"35","author":"N Woodford","year":"2011","unstructured":"Woodford N, Turton JF, Livermore DM. Multiresistant gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. FEMS Microbiol Rev. 2011;35(5):736\u201355.","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"3114_CR6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1089\/mdr.2011.0011","volume":"17","author":"AF Tawfik","year":"2011","unstructured":"Tawfik AF, Alswailem AM, Shibl AM, Al-Agamy MH. Prevalence and genetic characteristics of TEM, SHV, and CTX-M in clinical Klebsiella pneumoniae isolates from Saudi Arabia. Microb Drug Resist. 2011;17(3):383\u20138.","journal-title":"Microb Drug Resist"},{"key":"3114_CR7","first-page":"M100","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: Twentieth Informational Supplement","author":"CLSI: Clinical and Laboratory Standards Institute","year":"2010","unstructured":"CLSI: Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twentieth Informational Supplement; 2010. p. M100\u2013S20."},{"key":"3114_CR8","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ijid.2014.05.021","volume":"28","author":"T Uz Zaman","year":"2014","unstructured":"Uz Zaman T, Aldrees M, Al Johani SM, Alrodayyan M, Aldughashem FA, Balkhy HH. Multi-drug carbapenem-resistant Klebsiella pneumoniae infection carrying the OXA-48 gene and showing variations in outer membrane protein 36 causing an outbreak in a tertiary care hospital in Riyadh, Saudi Arabia. Int J Infect Dis. 2014;28:186\u201392.","journal-title":"Int J Infect Dis"},{"issue":"4","key":"3114_CR9","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1128\/AAC.05961-11","volume":"56","author":"P Nordmann","year":"2012","unstructured":"Nordmann P, Boulanger AE, Poirel L. NDM-4 metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli. Antimicrob Agents Chemother. 2012;56(4):2184\u20136.","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"3114_CR10","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1093\/molbev\/msm092","volume":"24","author":"K Tamura","year":"2007","unstructured":"Tamura K, Dudley J, Nei M, Kumar S. MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol Biol Evol. 2007;24(8):1596\u20139.","journal-title":"Mol Biol Evol"},{"issue":"2","key":"3114_CR11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4161\/viru.22718","volume":"4","author":"AS Shon","year":"2013","unstructured":"Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107\u201318.","journal-title":"Virulence"},{"issue":"12","key":"3114_CR12","doi-asserted-by":"publisher","first-page":"4377","DOI":"10.1128\/JCM.02316-14","volume":"52","author":"F Compain","year":"2014","unstructured":"Compain F, Babosan A, Brisse S, Genel N, Audo J, Ailloud F, Kassis-Chikhani N, Arlet G, Decre D. Multiplex PCR for detection of seven virulence factors and K1\/K2 capsular serotypes of Klebsiella pneumoniae. J Clin Microbiol. 2014;52(12):4377\u201380.","journal-title":"J Clin Microbiol"},{"issue":"8","key":"3114_CR13","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.1128\/JCM.43.8.4178-4182.2005","volume":"43","author":"L Diancourt","year":"2005","unstructured":"Diancourt L, Passet V, Verhoef J, Grimont PA, Brisse S. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol. 2005;43(8):4178\u201382.","journal-title":"J Clin Microbiol"},{"issue":"5","key":"3114_CR14","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2144\/000113370","volume":"48","author":"W Deng","year":"2010","unstructured":"Deng W, Maust BS, Nickle DC, Learn GH, Liu Y, Heath L, Kosakovsky Pond SL, Mullins JI. DIVEIN: a web server to analyze phylogenies, sequence divergence, diversity, and informative sites. BioTechniques. 2010;48(5):405\u20138.","journal-title":"BioTechniques"},{"issue":"5","key":"3114_CR15","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1128\/JB.186.5.1518-1530.2004","volume":"186","author":"EJ Feil","year":"2004","unstructured":"Feil EJ, Li BC, Aanensen DM, Hanage WP, Spratt BG. eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data. J Bacteriol. 2004;186(5):1518\u201330.","journal-title":"J Bacteriol"},{"issue":"2","key":"3114_CR16","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/molbev\/msj030","volume":"23","author":"DH Huson","year":"2006","unstructured":"Huson DH, Bryant D. Application of phylogenetic networks in evolutionary studies. Mol Biol Evol. 2006;23(2):254\u201367.","journal-title":"Mol Biol Evol"},{"issue":"6","key":"3114_CR17","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1128\/AAC.02050-13","volume":"58","author":"HM Zowawi","year":"2014","unstructured":"Zowawi HM, Sartor AL, Balkhy HH, Walsh TR, Al Johani SM, AlJindan RY, Alfaresi M, Ibrahim E, Al-Jardani A, Al-Abri S, et al. Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf cooperation council: dominance of OXA-48 and NDM producers. Antimicrob Agents Chemother. 2014;58(6):3085\u201390.","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"3114_CR18","doi-asserted-by":"publisher","first-page":"e0131372","DOI":"10.1371\/journal.pone.0131372","volume":"10","author":"A Sonnevend","year":"2015","unstructured":"Sonnevend A, Ghazawi AA, Hashmey R, Jamal W, Rotimi VO, Shibl AM, Al-Jardani A, Al-Abri SS, Tariq WU, Weber S, et al. Characterization of Carbapenem-resistant Enterobacteriaceae with high rate of autochthonous transmission in the Arabian peninsula. PLoS One. 2015;10(6):e0131372.","journal-title":"PLoS One"},{"issue":"9","key":"3114_CR19","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S1473-3099(13)70190-7","volume":"13","author":"LS Munoz-Price","year":"2013","unstructured":"Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, Cornaglia G, Garau J, Gniadkowski M, Hayden MK, et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013;13(9):785\u201396.","journal-title":"Lancet Infect Dis"},{"key":"3114_CR20","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.meegid.2015.01.010","volume":"31","author":"A Barguigua","year":"2015","unstructured":"Barguigua A, Zerouali K, Katfy K, El Otmani F, Timinouni M, Elmdaghri N. Occurrence of OXA-48 and NDM-1 carbapenemase-producing Klebsiella pneumoniae in a Moroccan university hospital in Casablanca, Morocco. Infect Genet Evol. 2015;31:142\u20138.","journal-title":"Infect Genet Evol"},{"issue":"7","key":"3114_CR21","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1093\/jac\/dks121","volume":"67","author":"L Poirel","year":"2012","unstructured":"Poirel L, Potron A, Nordmann P. OXA-48 carbapenemases: the phantom menace. J Antimicrob Chemother. 2012;67(7):1597\u2013606.","journal-title":"J Antimicrob Chemother"},{"issue":"9","key":"3114_CR22","doi-asserted-by":"publisher","first-page":"5223","DOI":"10.1128\/AAC.00236-16","volume":"60","author":"D Mantilla-Calderon","year":"2016","unstructured":"Mantilla-Calderon D, Jumat MR, Wang T, Ganesan P, Al-Jassim N, Hong PY. Isolation and characterization of NDM-positive Escherichia coli from municipal wastewater in Jeddah Saudi Arabia. Antimicrob Agents Chemother. 2016;60(9):5223\u201331.","journal-title":"Antimicrob Agents Chemother"},{"key":"3114_CR23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ijid.2015.03.002","volume":"34","author":"S Bastian","year":"2015","unstructured":"Bastian S, Nordmann P, Creton E, Malpote E, Thiery G, Martino F, Breurec S, Dortet L. First case of NDM-1 producing Klebsiella pneumoniae in Caribbean islands. Int J Infect Dis. 2015;34:53\u20134.","journal-title":"Int J Infect Dis"},{"issue":"11","key":"3114_CR24","doi-asserted-by":"publisher","first-page":"5403","DOI":"10.1128\/AAC.00585-11","volume":"55","author":"L Poirel","year":"2011","unstructured":"Poirel L, Dortet L, Bernabeu S, Nordmann P. Genetic features of blaNDM-1-positive Enterobacteriaceae. Antimicrob Agents Chemother. 2011;55(11):5403\u20137.","journal-title":"Antimicrob Agents Chemother"},{"issue":"Pt 9","key":"3114_CR25","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1099\/jmm.0.008094-0","volume":"58","author":"XD Wang","year":"2009","unstructured":"Wang XD, Cai JC, Zhou HW, Zhang R, Chen GX. Reduced susceptibility to carbapenems in Klebsiella pneumoniae clinical isolates associated with plasmid-mediated beta-lactamase production and OmpK36 porin deficiency. J Med Microbiol. 2009;58(Pt 9):1196\u2013202.","journal-title":"J Med Microbiol"},{"issue":"4","key":"3114_CR26","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1128\/AAC.01275-10","volume":"55","author":"YK Tsai","year":"2011","unstructured":"Tsai YK, Fung CP, Lin JC, Chen JH, Chang FY, Chen TL, Siu LK. Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence. Antimicrob Agents Chemother. 2011;55(4):1485\u201393.","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"3114_CR27","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.1128\/AAC.01301-09","volume":"54","author":"A Garcia-Fernandez","year":"2010","unstructured":"Garcia-Fernandez A, Miriagou V, Papagiannitsis CC, Giordano A, Venditti M, Mancini C, Carattoli A. An ertapenem-resistant extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. Antimicrob Agents Chemother. 2010;54(10):4178\u201384.","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"3114_CR28","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ijantimicag.2011.03.020","volume":"38","author":"MY Lee","year":"2011","unstructured":"Lee MY, Ko KS, Kang CI, Chung DR, Peck KR, Song JH. High prevalence of CTX-M-15-producing Klebsiella pneumoniae isolates in Asian countries: diverse clones and clonal dissemination. Int J Antimicrob Agents. 2011;38(2):160\u20133.","journal-title":"Int J Antimicrob Agents"},{"issue":"7","key":"3114_CR29","doi-asserted-by":"publisher","first-page":"e0133654","DOI":"10.1371\/journal.pone.0133654","volume":"10","author":"F Al-Marzooq","year":"2015","unstructured":"Al-Marzooq F, Mohd Yusof MY, Tay ST. Molecular analysis of antibiotic resistance determinants and plasmids in Malaysian isolates of multidrug resistant Klebsiella pneumoniae. PLoS One. 2015;10(7):e0133654.","journal-title":"PLoS One"},{"issue":"4","key":"3114_CR30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.4103\/0256-4947.55306","volume":"29","author":"MH Al-Agamy","year":"2009","unstructured":"Al-Agamy MH, Shibl AM, Tawfik AF. Prevalence and molecular characterization of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in Riyadh Saudi Arabia. Ann Saudi Med. 2009;29(4):253\u20137.","journal-title":"Ann Saudi Med"},{"issue":"3","key":"3114_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1089\/mdr.2014.0123","volume":"21","author":"WY Jamal","year":"2015","unstructured":"Jamal WY, Albert MJ, Khodakhast F, Poirel L, Rotimi VO. Emergence of new sequence type OXA-48 Carbapenemase-producing Enterobacteriaceae in Kuwait. Microb Drug Resist. 2015;21(3):329\u201334.","journal-title":"Microb Drug Resist"},{"issue":"1","key":"3114_CR32","doi-asserted-by":"publisher","first-page":"e52222","DOI":"10.1371\/journal.pone.0052222","volume":"8","author":"C Zhuo","year":"2013","unstructured":"Zhuo C, Li XQ, Zong ZY, Zhong NS. Epidemic plasmid carrying Bla(CTX-M-15) in Klebsiella penumoniae in China. PLoS One. 2013;8(1):e52222.","journal-title":"PLoS One"},{"issue":"1","key":"3114_CR33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ijantimicag.2010.03.005","volume":"36","author":"A Coelho","year":"2010","unstructured":"Coelho A, Gonzalez-Lopez JJ, Miro E, Alonso-Tarres C, Mirelis B, Larrosa MN, Bartolome RM, Andreu A, Navarro F, Johnson JR, et al. Characterisation of the CTX-M-15-encoding gene in Klebsiella pneumoniae strains from the Barcelona metropolitan area: plasmid diversity and chromosomal integration. Int J Antimicrob Agents. 2010;36(1):73\u20138.","journal-title":"Int J Antimicrob Agents"},{"issue":"7","key":"3114_CR34","doi-asserted-by":"publisher","first-page":"e40360","DOI":"10.1371\/journal.pone.0040360","volume":"7","author":"XZ Huang","year":"2012","unstructured":"Huang XZ, Frye JG, Chahine MA, Glenn LM, Ake JA, Su W, Nikolich MP, Lesho EP. Characteristics of plasmids in multi-drug-resistant Enterobacteriaceae isolated during prospective surveillance of a newly opened hospital in Iraq. PLoS One. 2012;7(7):e40360.","journal-title":"PLoS One"},{"issue":"6","key":"3114_CR35","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1128\/AAC.01707-08","volume":"53","author":"A Carattoli","year":"2009","unstructured":"Carattoli A. Resistance plasmid families in Enterobacteriaceae. Antimicrob Agents Chemother. 2009;53(6):2227\u201338.","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"3114_CR36","first-page":"553","volume":"71","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Zeng J, Liu W, Zhao F, Hu Z, Zhao C, Wang Q, Wang X, Chen H, Li H, et al. Emergence of a hypervirulent carbapenem-resistant Klebsiella pneumoniae isolate from clinical infections in China. J Inf Secur. 2015;71(5):553\u201360.","journal-title":"J Inf Secur"},{"issue":"11","key":"3114_CR37","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.3201\/eid2011.140206","volume":"20","author":"S Bialek-Davenet","year":"2014","unstructured":"Bialek-Davenet S, Criscuolo A, Ailloud F, Passet V, Jones L, Delannoy-Vieillard AS, Garin B, Le Hello S, Arlet G, Nicolas-Chanoine MH, et al. Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. Emerg Infect Dis. 2014;20(11):1812\u201320.","journal-title":"Emerg Infect Dis"},{"issue":"27","key":"3114_CR38","doi-asserted-by":"publisher","first-page":"E3574","DOI":"10.1073\/pnas.1501049112","volume":"112","author":"KE Holt","year":"2015","unstructured":"Holt KE, Wertheim H, Zadoks RN, Baker S, Whitehouse CA, Dance D, Jenney A, Connor TR, Hsu LY, Severin J, et al. Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc Natl Acad Sci U S A. 2015;112(27):E3574\u201381.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3114_CR39","doi-asserted-by":"publisher","first-page":"7612","DOI":"10.1038\/srep07612","volume":"5","author":"C Guo","year":"2015","unstructured":"Guo C, Yang X, Wu Y, Yang H, Han Y, Yang R, Hu L, Cui Y, Zhou D. MLST-based inference of genetic diversity and population structure of clinical Klebsiella pneumoniae China. Sci Rep. 2015;5:7612.","journal-title":"Sci Rep"},{"issue":"4","key":"3114_CR40","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1469-0691.2012.03805.x","volume":"19","author":"S Breurec","year":"2013","unstructured":"Breurec S, Guessennd N, Timinouni M, Le TA, Cao V, Ngandjio A, Randrianirina F, Thiberge JM, Kinana A, Dufougeray A, et al. Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258. Clin Microbiol Infect. 2013;19(4):349\u201355.","journal-title":"Clin Microbiol Infect"},{"issue":"12","key":"3114_CR41","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.tim.2014.09.003","volume":"22","author":"L Chen","year":"2014","unstructured":"Chen L, Mathema B, Chavda KD, DeLeo FR, Bonomo RA, Kreiswirth BN. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol. 2014;22(12):686\u201396.","journal-title":"Trends Microbiol"},{"issue":"1","key":"3114_CR42","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1089\/mdr.2013.0021","volume":"20","author":"D Quinones","year":"2014","unstructured":"Quinones D, Valverde A, Rodriguez-Banos M, Kobayashi N, Zayaz A, Abreu M, Canton R, del Campo R. High clonal diversity in a non-outbreak situation of clinical ESBL-producing Klebsiella pneumoniae isolates in the first national surveillance program in Cuba. Microb Drug Resist. 2014;20(1):45\u201351.","journal-title":"Microb Drug Resist"},{"issue":"11","key":"3114_CR43","doi-asserted-by":"publisher","first-page":"E509","DOI":"10.1111\/1469-0691.12275","volume":"19","author":"J Yang","year":"2013","unstructured":"Yang J, Ye L, Guo L, Zhao Q, Chen R, Luo Y, Chen Y, Tian S, Zhao J, Shen D, et al. A nosocomial outbreak of KPC-2-producing Klebsiella pneumoniae in a Chinese hospital: dissemination of ST11 and emergence of ST37, ST392 and ST395. Clin Microbiol Infect. 2013;19(11):E509\u201315.","journal-title":"Clin Microbiol Infect"},{"issue":"Pt 3","key":"3114_CR44","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1099\/00207713-51-3-915","volume":"51","author":"S Brisse","year":"2001","unstructured":"Brisse S, Verhoef J. Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping. Int J Syst Evol Microbiol. 2001;51(Pt 3):915\u201324.","journal-title":"Int J Syst Evol Microbiol"},{"issue":"10","key":"3114_CR45","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1093\/jac\/dku217","volume":"69","author":"C Ewers","year":"2014","unstructured":"Ewers C, Stamm I, Pfeifer Y, Wieler LH, Kopp PA, Schonning K, Prenger-Berninghoff E, Scheufen S, Stolle I, Gunther S, et al. Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses. J Antimicrob Chemother. 2014;69(10):2676\u201380.","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"3114_CR46","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1093\/jac\/dkt464","volume":"69","author":"J Shin","year":"2014","unstructured":"Shin J, Soo Ko K. Single origin of three plasmids bearing blaCTX-M-15 from different Klebsiella pneumoniae clones. J Antimicrob Chemother. 2014;69(4):969\u201372.","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"3114_CR47","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1093\/jac\/dkq505","volume":"66","author":"H Nazir","year":"2011","unstructured":"Nazir H, Cao S, Hasan F, Hughes D. Can phylogenetic type predict resistance development? J Antimicrob Chemother. 2011;66(4):778\u201387.","journal-title":"J Antimicrob Chemother"},{"issue":"9","key":"3114_CR48","doi-asserted-by":"publisher","first-page":"e75805","DOI":"10.1371\/journal.pone.0075805","volume":"8","author":"B Li","year":"2013","unstructured":"Li B, Hu Y, Wang Q, Yi Y, Woo PC, Jing H, Zhu B, Liu CH. Structural diversity of class 1 integrons and their associated gene cassettes in Klebsiella pneumoniae isolates from a hospital in China. PLoS One. 2013;8(9):e75805.","journal-title":"PLoS One"},{"issue":"11","key":"3114_CR49","doi-asserted-by":"publisher","first-page":"e113539","DOI":"10.1371\/journal.pone.0113539","volume":"9","author":"M Maatallah","year":"2014","unstructured":"Maatallah M, Vading M, Kabir MH, Bakhrouf A, Kalin M, Naucler P, Brisse S, Giske CG. Klebsiella variicola is a frequent cause of bloodstream infection in the Stockholm area, and associated with higher mortality compared to K. Pneumoniae. PLoS One. 2014;9(11):e113539.","journal-title":"PLoS One"},{"issue":"5","key":"3114_CR50","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/j.1574-6976.2010.00261.x","volume":"35","author":"E Skippington","year":"2011","unstructured":"Skippington E, Ragan MA. Lateral genetic transfer and the construction of genetic exchange communities. FEMS Microbiol Rev. 2011;35(5):707\u201335.","journal-title":"FEMS Microbiol Rev"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-018-3114-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-018-3114-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-018-3114-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T19:04:37Z","timestamp":1556823877000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-018-3114-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,3]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["3114"],"URL":"https:\/\/doi.org\/10.1186\/s12879-018-3114-9","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,3]]},"assertion":[{"value":"9 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"There are no human participants involved, so ethical approval and consent to participate are not needed. Aditionally, the analyzed bacterial isolates were obtained as part of routine investigations. The information presented for these isolates does not compromise the confidentiality of the patients.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"205"}}