{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:37:39Z","timestamp":1792787859126,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"unconditioned grant from Gilead Sciences srl"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12879-018-3591-x","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T08:55:40Z","timestamp":1545209740000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cytomegalovirus, Epstein-Barr virus and human herpesvirus 8 salivary shedding in HIV positive men who have sex with men with controlled and uncontrolled plasma HIV viremia: a 24-month longitudinal study"],"prefix":"10.1186","volume":"18","author":[{"given":"Monica","family":"Basso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Andreis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Scaggiante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Franchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Zago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela","family":"Biasolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Del Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Mengoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Sarmati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Andreoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Pal\u00f9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio Giuseppe","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"3591_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.cell.2009.06.036","volume":"138","author":"HW Virgin","year":"2009","unstructured":"Virgin HW, Wherry EJ, Ahmed R. Redefining chronic viral infection. Cell. 2009;138:30\u201350.","journal-title":"Cell"},{"key":"3591_CR2","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.3389\/fmicb.2017.02521","volume":"8","author":"ME Cruz-Mu\u00f1oz","year":"2018","unstructured":"Cruz-Mu\u00f1oz ME, Fuentes-Panan\u00e1 EM. Beta and Gamma human herpesviruses: agonistic and antagonistic interactions with the host immune system. Front Microbiol. 2018;8:2521.","journal-title":"Front Microbiol"},{"key":"3591_CR3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/ncpneuro0401","volume":"3","author":"DH Gilden","year":"2007","unstructured":"Gilden DH, Mahalingam R, Cohrs RJ, Tyler KL. Herpesvirus infections of the nervous system. Nat Clin Pract Neurol. 2007;3:82\u201394.","journal-title":"Nat Clin Pract Neurol"},{"key":"3591_CR4","first-page":"63","volume":"325","author":"C Sinzger","year":"2008","unstructured":"Sinzger C, Digel M, Jahn G. Cytomegalovirus cell tropism. Curr Top Microbiol Immunol. 2008;325:63\u201383.","journal-title":"Curr Top Microbiol Immunol"},{"key":"3591_CR5","doi-asserted-by":"crossref","unstructured":"Hau PM, Tsao SW. Epstein-Barr virus hijacks DNA damage response transducers to orchestrate its life cycle. Viruses. 2017;9.","DOI":"10.3390\/v9110341"},{"key":"3591_CR6","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1097\/QCO.0000000000000409","volume":"3","author":"G Haidar","year":"2017","unstructured":"Haidar G, Singh N. Viral infections in solid organ transplant recipients: novel updates and a review of the classics. Curr Opin Infect Dis. 2017;3:579\u201388.","journal-title":"Curr Opin Infect Dis"},{"key":"3591_CR7","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/nrc.2016.92","volume":"16","author":"LS Young","year":"2016","unstructured":"Young LS, Yap LF, Murray PG. Epstein-Barr virus: more than 50 years old and still providing surprises. Nat Rev Cancer. 2016;16:789\u2013802.","journal-title":"Nat Rev Cancer"},{"key":"3591_CR8","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1093\/neuonc\/nor227","volume":"14","author":"K Dziurzynski","year":"2012","unstructured":"Dziurzynski K, Chang SM, Heimberger AB, Kalejta RF, McGregor Dallas SR, Smit M, et al. Consensus on the role of human cytomegalovirus in glioblastoma. Neuro-Oncology. 2012;14:246\u201355.","journal-title":"Neuro-Oncology"},{"key":"3591_CR9","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1097\/QAD.0000000000001567","volume":"31","author":"PH Gon\u00e7alves","year":"2017","unstructured":"Gon\u00e7alves PH, Uldrick TS, Yarchoan R. HIV-associated Kaposi sarcoma and related diseases. AIDS. 2017;31:1903\u201316.","journal-title":"AIDS"},{"key":"3591_CR10","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1086\/654798","volume":"51","author":"TS Uldrick","year":"2010","unstructured":"Uldrick TS, Wang V, O'Mahony D, Aleman K, Wyvill KM, Marshall V, et al. An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without multicentric Castleman disease. Clin Infect Dis. 2010;51:350\u20138.","journal-title":"Clin Infect Dis"},{"key":"3591_CR11","doi-asserted-by":"publisher","first-page":"472978","DOI":"10.1155\/2014\/472978","volume":"2014","author":"A Halenius","year":"2014","unstructured":"Halenius A, Hengel H. Human cytomegalovirus and autoimmune disease. Biomed Res Int. 2014;2014:472978.","journal-title":"Biomed Res Int"},{"key":"3591_CR12","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.4049\/jimmunol.172.2.1287","volume":"172","author":"I Kang","year":"2004","unstructured":"Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, et al. Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus. J Immunol. 2004;172:1287\u201394.","journal-title":"J Immunol"},{"key":"3591_CR13","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1056\/NEJMoa1006561","volume":"364","author":"SB Boppana","year":"2011","unstructured":"Boppana SB, Ross SA, Shimamura M, Palmer AL, Ahmed A, Michaels MG, et al. Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. N Engl J Med. 2011;364:2111\u20138.","journal-title":"N Engl J Med"},{"key":"3591_CR14","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.oraloncology.2011.06.507","volume":"47","author":"EH Pow","year":"2011","unstructured":"Pow EH, Law MY, Tsang PC, Perera RA, Kwong DL. Salivary Epstein-Barr virus DNA level in patients with nasopharyngeal carcinoma following radiotherapy. Oral Oncol. 2011;47:879\u201382.","journal-title":"Oral Oncol"},{"key":"3591_CR15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/1471-2334-11-150","volume":"11","author":"SG Parisi","year":"2011","unstructured":"Parisi SG, Cruciani M, Scaggiante R, Boldrin C, Andreis S, Dal Bello F, et al. Anal and oral human papillomavirus (HPV) infection in HIV-infected subjects in northern Italy: a longitudinal cohort study among men who have sex with men. BMC Infect Dis. 2011;11:150.","journal-title":"BMC Infect Dis"},{"key":"3591_CR16","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1097\/QAD.0000000000001589","volume":"31","author":"DP Dittmer","year":"2017","unstructured":"Dittmer DP, Tamburro K, Chen H, Lee A, Sanders MK, Wade TA, et al. Oral shedding of herpesviruses in HIV-infected patients with varying degrees of immune status. AIDS. 2017;31:2077\u201384.","journal-title":"AIDS"},{"key":"3591_CR17","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1128\/JCM.00256-06","volume":"44","author":"CS Miller","year":"2006","unstructured":"Miller CS, Berger JR, Mootoor Y, Avdiushko SA, Zhu H, Kryscio RJ. High prevalence of multiple human herpesviruses in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy. J Clin Microbiol. 2006;44:2409\u201315.","journal-title":"J Clin Microbiol"},{"key":"3591_CR18","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1590\/S0037-86822010000600003","volume":"43","author":"KS Carvalho","year":"2010","unstructured":"Carvalho KS, Silvestre Ede A, Maciel Sda S, Lira HI, Galv\u00e3o RA, Soares MJ, et al. PCR detection of multiple human herpesvirus DNA in saliva from HIV-infected individuals in Teresina, state of Piau\u00ed, Brazil. Rev Soc Bras Med Trop. 2010;43:620\u20133.","journal-title":"Rev Soc Bras Med Trop"},{"key":"3591_CR19","doi-asserted-by":"publisher","first-page":"e5277","DOI":"10.1371\/journal.pone.0005277","volume":"4","author":"MA Jacobson","year":"2009","unstructured":"Jacobson MA, Ditmer DP, Sinclair E, Martin JN, Deeks SG, Hunt P, et al. Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients. PLoS One. 2009;4:e5277.","journal-title":"PLoS One"},{"key":"3591_CR20","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1002\/jmv.24441","volume":"88","author":"R Scaggiante","year":"2016","unstructured":"Scaggiante R, Andreis S, Basso M, Franchin E, Franzetti M, Del Vecchio C, et al. Epstein-Barr and cytomegalovirus DNA salivary shedding correlate with long-term plasma HIV RNA detection in HIV-infected men who have sex with men. J Med Virol. 2016;88:1211\u201321.","journal-title":"J Med Virol"},{"key":"3591_CR21","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1097\/QAD.0000000000000243","volume":"28","author":"MT May","year":"2014","unstructured":"May MT, Gompels M, Delpech V, Porter K, Orkin C, Kegg S, et al. Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy. AIDS. 2014;28:1193\u2013202.","journal-title":"AIDS"},{"key":"3591_CR22","doi-asserted-by":"publisher","first-page":"e110749","DOI":"10.1371\/journal.pone.0110749","volume":"9","author":"LM Hofstra","year":"2014","unstructured":"Hofstra LM, Mudrikova T, Stam AJ, Otto S, Tesselaar K, Nijhuis M, et al. Residual viremia is preceding viral blips and persistent low-level viremia in treated HIV-1 patients. PLoS One. 2014;9:e110749.","journal-title":"PLoS One"},{"key":"3591_CR23","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1186\/s12879-015-1120-8","volume":"15","author":"J Young","year":"2015","unstructured":"Young J, Rickenbach M, Calmy A, Bernasconi E, Staehelin C, Schmid P, et al. Transient detectable viremia and the risk of viral rebound in patients from the Swiss HIV cohort study. BMC Infect Dis. 2015;15:382.","journal-title":"BMC Infect Dis"},{"key":"3591_CR24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1749-6632.1993.tb18343.x","volume":"694","author":"M Navazesh","year":"1993","unstructured":"Navazesh M. Methods for collecting saliva. Ann N Y Acad Sci. 1993;694:72\u20137.","journal-title":"Ann N Y Acad Sci"},{"key":"3591_CR25","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.ejpn.2016.04.002","volume":"20","author":"SG Parisi","year":"2016","unstructured":"Parisi SG, Basso M, Del Vecchio C, Andreis S, Franchin E, Bello FD, et al. Virological testing of cerebrospinal fluid in children aged less than 14 years with a suspected central nervous system infection: a retrospective study on 304 consecutive children from January 2012 to May 2015. Eur J Paediatr Neurol. 2016;20:588\u201396.","journal-title":"Eur J Paediatr Neurol"},{"key":"3591_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/jmv.10285","volume":"69","author":"MA Biasolo","year":"2003","unstructured":"Biasolo MA, Calistri A, Cesaro S, Gentile G, Mengoli C, Palu G. Case report: kinetics of Epstein-Barr virus load in a bone marrow transplant patient with no sign of lymphoproliferative disease. J Med Virol. 2003;69:220\u20132.","journal-title":"J Med Virol"},{"key":"3591_CR27","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/jmv.20149","volume":"74","author":"C Mengoli","year":"2004","unstructured":"Mengoli C, Cusinato R, Biasolo MA, Cesaro S, Parolin C, Palu G. Assessment of CMV load in solid organ transplant recipients by pp65 antigenemia and real-time quantitative DNA PCR assay: correlation with pp67 RNA detection. J Med Virol. 2004;74:78\u201384.","journal-title":"J Med Virol"},{"key":"3591_CR28","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1128\/JCM.38.5.1992-1995.2000","volume":"38","author":"IE White","year":"2000","unstructured":"White IE, Campbell TB. Quantitation of cell-free and cell-associated Kaposi\u2019s sarcoma-associated herpesvirus DNA by real-time PCR. J Clin Microb. 2000;38:1992\u20135.","journal-title":"J Clin Microb"},{"key":"3591_CR29","unstructured":"Conover WJ. Practical nonparametric statistics. 3rd ed. New York: John Wiley & Sons."},{"key":"3591_CR30","unstructured":"European AIDS Clinical Society Guidelines, Version 7.1. http:\/\/www.eacsociety.org . Accessed 12 Oct 2017."},{"key":"3591_CR31","unstructured":"European AIDS Clinical Society Guidelines, Version 9.0. http:\/\/www.eacsociety.org . Accessed 18 Jan 2018."},{"key":"3591_CR32","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/ijc.29687","volume":"138","author":"E Rohner","year":"2016","unstructured":"Rohner E, Wyss N, Heg Z, Faralli Z, Mbulaiteye SM, Novak U, et al. HIV and human herpesvirus 8 co-infection across the globe: systematic review and meta-analysis. Int J Cancer. 2016;138:45\u201354.","journal-title":"Int J Cancer"},{"key":"3591_CR33","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1146\/annurev.immunol.25.022106.141553","volume":"25","author":"AD Hislop","year":"2007","unstructured":"Hislop AD, Taylor GS, Sauce D, Rickinson AB. Cellular responses to viral infection in humans: lessons from Epstein-Barr virus. Annu Rev Immunol. 2007;25:587\u2013617.","journal-title":"Annu Rev Immunol"},{"key":"3591_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1128\/CMR.00034-08","volume":"22","author":"T Crough","year":"2009","unstructured":"Crough T, Khanna R. Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev. 2009;22:76\u201398.","journal-title":"Clin Microbiol Rev"},{"key":"3591_CR35","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1111\/hiv.12257","volume":"16","author":"S Hattab","year":"2015","unstructured":"Hattab S, Guiguet M, Carcelain G, Fourati S, Guihot A, Autran B, et al. Soluble biomarkers of immune activation and inflammation in HIV infection: impact of 2 years of effective first-line combination antiretroviral therapy. HIV Med. 2015;16:553\u201362.","journal-title":"HIV Med"},{"key":"3591_CR36","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1097\/QAD.0000000000001602","volume":"31","author":"A Agudelo-Hernandez","year":"2017","unstructured":"Agudelo-Hernandez A, Chen Y, Bullotta A, Buchanan WG, Klamar-Blain CR, Borowski L, et al. Subclinical herpesvirus shedding among HIV-1-infected men on antiretroviral therapy. AIDS. 2017;31:2085\u201394.","journal-title":"AIDS"},{"key":"3591_CR37","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/jmv.21987","volume":"83","author":"SG Parisi","year":"2011","unstructured":"Parisi SG, Boldrin C, Andreis S, Ferretto R, Fuser R, Malena M, et al. KSHV DNA viremia correlates with low CD4+ cell count in Italian males at the time of diagnosis of HIV infection. J Med Virol. 2011;83:384\u201390.","journal-title":"J Med Virol"},{"key":"3591_CR38","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1111\/j.1365-4632.2011.04992.x","volume":"52","author":"T Kuhara","year":"2013","unstructured":"Kuhara T, Watanabe D, Ishida N, Tamada Y, Matsumoto Y, Ihira M, et al. Quantitative analysis of shedding of Epstein-Barr virus in saliva from patients with connective tissue diseases: a pilot study. Int J Dermatol. 2013;52:887\u201390.","journal-title":"Int J Dermatol"},{"key":"3591_CR39","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.transproceed.2011.01.004","volume":"43","author":"M Nikoobakht","year":"2011","unstructured":"Nikoobakht M, Beitollahi J, Nikoobakht N, Aloosh M, Sahebjamee M, Rezaeidanesh M, et al. Evaluation of Epstein-Barr virus load in saliva before and after renal transplantation. Transplant Proc. 2011;43:540\u20132.","journal-title":"Transplant Proc"},{"key":"3591_CR40","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/jicd.12078","volume":"5","author":"J Shan","year":"2014","unstructured":"Shan J, Pow EH, Tsang PC, Perera RA, Kwong DL. Comparison of two laboratory extraction techniques for the detection of Epstein-Barr virus in the saliva of nasopharyngeal carcinoma patients. J Investig Clin Dent. 2014;5:104\u20138.","journal-title":"J Investig Clin Dent"},{"key":"3591_CR41","doi-asserted-by":"crossref","unstructured":"Mui UN, Haley CT, Tyring SK. Viral oncology: molecular biology and pathogenesis. J Clin Med. 2017;6.","DOI":"10.3390\/jcm6120111"},{"key":"3591_CR42","doi-asserted-by":"publisher","first-page":"e105442","DOI":"10.1371\/journal.pone.0105442","volume":"9","author":"M Masi\u00e1","year":"2014","unstructured":"Masi\u00e1 M, Robledano C, Ortiz de la Tabla V, Antequera P, Lumbreras B, Hern\u00e1ndez I, et al. Coinfection with human herpesvirus 8 is associated with persistent inflammation and immune activation in virologically suppressed HIV-infected patients. PLoS One. 2014;9:e105442.","journal-title":"PLoS One"},{"key":"3591_CR43","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1093\/cid\/cix120","volume":"64","author":"DSY Ong","year":"2017","unstructured":"Ong DSY, Bonten MJM, Spitoni C, Verduyn Lunel FM, Frencken JF, Horn J, et al. Epidemiology of multiple herpes viremia in previously immunocompetent patients with septic shock. Clin Infect Dis. 2017;64:1204\u201310.","journal-title":"Clin Infect Dis"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-018-3591-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-018-3591-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-018-3591-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T01:43:38Z","timestamp":1605663818000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-018-3591-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["3591"],"URL":"https:\/\/doi.org\/10.1186\/s12879-018-3591-x","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"4 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All participants provided informed written consent for all study procedures and for the use of their data for scientific evaluation and publication in a blinded form. This study was conducted in accordance with the Declaration of Helsinki, and it was approved by the Ethical Committee for Clinical Experimentation, Padua Province (prot. 2606-12P).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"683"}}