{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:37:00Z","timestamp":1789799820601,"version":"4.0.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12879-018-3602-y","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T23:40:27Z","timestamp":1545867627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Is primary meningococcal arthritis in children more frequent than we expect? Two pediatric case reports revealed by molecular test"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-1694","authenticated-orcid":false,"given":"S.","family":"Ricci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Montemaggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nieddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Serranti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Indolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Moriondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Azzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"3602_CR1","doi-asserted-by":"publisher","unstructured":"Barahona M, Catalan J, Sato Y, Hinzpeter J. Primary meningococcal type C arthritis: a case report and literature review. Case Rep Orthop. 2017;2017:4696014. \n                    https:\/\/doi.org\/10.1155\/2017\/4696014\n                    \n                  .","DOI":"10.1155\/2017\/4696014"},{"issue":"1","key":"3602_CR2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12941-018-0268-7.","volume":"17","author":"D O'Sullivan","year":"2018","unstructured":"O'Sullivan D, Linnane B, Mostyn A, Jonathan N, Lenihan M, O'Connell NH, Dunne CP. Detection of Neisseria meningitidis in a paediatric patient with septic arthritis using multiplexed diagnostic PCR targeting meningitis\/encephalitis (ME). Ann Clin Microbiol Antimicrob. 2018;17(1):14. \n                    https:\/\/doi.org\/10.1186\/s12941-018-0268-7.","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"5","key":"3602_CR3","doi-asserted-by":"publisher","first-page":"e2745","DOI":"10.1097\/MD.0000000000002745","volume":"95","author":"S Straticiuc","year":"2016","unstructured":"Straticiuc S, Ignat A, Hanganu E, Lupu VV, Ciubara AB, Cretu R. Neisseria meningitidis Serogroup C causing primary arthritis in a child: case report. Medicine (Baltimore). 2016;95(5):e2745.","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"3602_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1590\/S0325-00752011000200010","volume":"109","author":"N Sordelli","year":"2011","unstructured":"Sordelli N, Orlando N, Neyro S, Echave C, Procopio A, Fallo A, L\u00f3pez EL. Primary meningococcal arthritis in pediatrics. Report of nine cases Arch Argent Pediatr. 2011;109(2):150\u20134. \n                    https:\/\/doi.org\/10.1590\/S0325-00752011000200010\n                    \n                  .","journal-title":"Report of nine cases Arch Argent Pediatr"},{"issue":"6","key":"3602_CR5","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1179\/acb.2002.064","volume":"57","author":"E Laere De","year":"2002","unstructured":"De Laere E, Berghs B, Gordts B, Van Landuyt H. Primary meningococcal arthritis of the hip in an immunocompetent adolescent. Acta Clin Belg. 2002;57(6):345\u20138.","journal-title":"Acta Clin Belg"},{"issue":"4","key":"3602_CR6","first-page":"553","volume":"20","author":"EJ Giamarellos-Bourboulis","year":"2002","unstructured":"Giamarellos-Bourboulis EJ, Grecka P, Petrikkos GL, Toskas A, Katsilambros N. Primary meningococcal arthritis: case report and review. Clin Exp Rheumatol. 2002;20(4):553\u20134.","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"3602_CR7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0248-8663(00)00289-7","volume":"22","author":"GL Cartolano","year":"2001","unstructured":"Cartolano GL, Le Lostec Z, Ch\u00e9ron M, Boisivon A, Welker Y, Mornet P. Primary Neisseria meningitidis arthritis of the knee without meningitis: contribution of synovial fluid culture in blood-culture vial. Rev Med Interne. 2001;22(1):75\u20138.","journal-title":"Rev Med Interne"},{"issue":"6","key":"3602_CR8","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1136\/archdischild-2011-301089","volume":"97","author":"SN Faust","year":"2012","unstructured":"Faust SN, Clark J, Pallett A, Clarke NM. Managing bone and joint infection in children. Arch Dis Child. 2012;97(6):545\u201353.","journal-title":"Arch Dis Child"},{"issue":"3","key":"3602_CR9","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3201\/eid2203.150928","volume":"22","author":"C Azzari","year":"2016","unstructured":"Azzari C, Nieddu F, Moriondo M, Indolfi G, Canessa C, Ricci S, et al. Underestimation of invasive meningococcal disease in Italy. Emerg Infect Dis. 2016;22(3):469\u201375.","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"3602_CR10","first-page":"E121","volume":"56","author":"S Bosis","year":"2015","unstructured":"Bosis S, Mayer A, Esposito S. Meningococcal disease in childhood: epidemiology, clinical features and prevention. J Prev Med Hyg. 2015;56(3):E121\u20134.","journal-title":"J Prev Med Hyg"},{"key":"3602_CR11","doi-asserted-by":"publisher","first-page":"39784","DOI":"10.1038\/srep39784","volume":"6","author":"EM Dunne","year":"2016","unstructured":"Dunne EM, Mantanitobua S, Singh SP, Reyburn R, Tuivaga E, Rafai E, Tikoduadua L, Porter B, Satzke C, Strachan JE, Fox KK, Jenkins KM, Jenney A, Baro S, Mulholland EK, Kama M, Russell FM. Real-time qPCR improves meningitis pathogen detection in invasive bacterial-vaccine preventable disease surveillance in Fiji. Sci Rep. 2016;6:39784.","journal-title":"Sci Rep"},{"issue":"5","key":"3602_CR12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.jinf.2013.06.007","volume":"67","author":"E Heinsbroek","year":"2013","unstructured":"Heinsbroek E, Ladhani S, Gray S, Guiver M, Kaczmarski E, Borrow R, Ramsay M. Added value of PCR-testing for confirmation of invasive meningococcal disease in England. J Inf Secur. 2013;67(5):385\u201390. \n                    https:\/\/doi.org\/10.1016\/j.jinf.2013.06.007\n                    \n                  .","journal-title":"J Inf Secur"},{"issue":"5","key":"3602_CR13","first-page":"427","volume":"73","author":"C Edge","year":"2016","unstructured":"Edge C, Waight P, Ribeiro S, Borrow R, Ramsay M, Ladhani S. Clinical diagnoses and outcomes of 4619 hospitalised cases of laboratory-confirmed invasive meningococcal disease in England: linkage analysis of multiple national databases. J Inf Secur. 2016;73(5):427\u201336.","journal-title":"J Inf Secur"},{"issue":"2","key":"3602_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/BF03256400","volume":"15","author":"K Papavasileiou","year":"2011","unstructured":"Papavasileiou K, Papavasileiou E, Tzanakaki G, Voyatzi A, Kremastinou J, et al. Acute bacterial meningitis cases diagnosed by culture and PCR in a children's hospital throughout a 9-year period (2000-2008) in Athens, Greece. Mol Diagn Ther. 2011;15(2):109\u201313.","journal-title":"Mol Diagn Ther"},{"key":"3602_CR15","unstructured":"Centers for Disease Control and Prevention. Laboratory Methods for the Diagnosis of Meningitis Caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. Second edition (2011). Chapter 10: PCR for Detection and Characterization of Bacterial Meningitis Pathogens: Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae."},{"key":"3602_CR16","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.ajem.2010.04.008","volume":"29","author":"TP Young","year":"2011","unstructured":"Young TP, Maas L, Thorp AW, Brown L. Etiology of septic arthritis in children: an update for the new millenium. Am J Emerg Med. 2011;29:899\u2013902.","journal-title":"Am J Emerg Med"},{"issue":"5","key":"3602_CR17","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1080\/00365540500388784","volume":"38","author":"E Bilavsky","year":"2006","unstructured":"Bilavsky E, Yarden-Bilavsky H, Zevit N, Amir J. Primary meningococcal arthritis in a child: case report and literature review. Scand J Infect Dis. 2006;38(5):396\u20139.","journal-title":"Scand J Infect Dis"},{"key":"3602_CR18","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1093\/milmed\/162.11.769","volume":"162","author":"M Weels","year":"1997","unstructured":"Weels M, Gibbons RB. Primary meningococcal arthritis. Case report and review of the literature. Mil Med. 1997;162:769\u201372.","journal-title":"Mil Med"},{"issue":"9","key":"3602_CR19","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1080\/21645515.2015.1051276","volume":"11","author":"M Br\u00f6ker","year":"2015","unstructured":"Br\u00f6ker M, Emonet S, Fazio C, Jacobsson S, Koliou M, Kuusi M, et al. Meningococcal serogroup Y disease in Europe: continuation of high importance in some European regions in 2013. Hum Vaccin Immunother. 2015;11(9):2281\u20136.","journal-title":"Hum Vaccin Immunother"},{"issue":"10","key":"3602_CR20","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1017\/S0950268817000929","volume":"145","author":"O S\u00e4ll","year":"2017","unstructured":"S\u00e4ll O, Stenmark B, Glim\u00e5ker M, Jacobsson S, M\u00f6lling P, Olc\u00e9n P, et al. Clinical presentation of invasive disease caused by Neisseria meningitidis serogroup Y in Sweden, 1995 to 2012. Epidemiol Infect. 2017;145(10):2137\u201343.","journal-title":"Epidemiol Infect"},{"key":"3602_CR21","doi-asserted-by":"crossref","unstructured":"Fazio C, Neri A, Renna G, Vacca P, Antonetti R, Barbui A, et al. Persistent occurrence of serogroup Y\/sequence type (ST)-23 complex invasive meningococcal disease among patients aged five to 14 years, Italy, 2007 to 2013. Euro Surveill. 2015;20(45).","DOI":"10.2807\/1560-7917.ES.2015.20.45.30061"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-018-3602-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-018-3602-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-018-3602-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T19:06:42Z","timestamp":1577387202000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-018-3602-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["3602"],"URL":"https:\/\/doi.org\/10.1186\/s12879-018-3602-y","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"19 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the local review board. A specific approval by the local ethical committee was not required because all analyses included in this study had been performed as part of the routine clinical activity. All results have been anonymized.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the guardians of the patients for the publication of this case report and any related images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare that there are no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"703"}}