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A written informed consent was signed before enrollment, for participants under 18\u2009years old the informed consent was signed by their respective guardians before enrollment. There have been no live animals used or tested on in this study. Also, we used only paraffin embedded tissues and the name and characteristics of the patients have not been revealed. Confidentiality of the information was assured through handling the information by locking the document with a password, storing in a file by assigning a code number to it and omitting the name of participants. Written informed consent has been obtained from the patients.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"23"}}