{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:46:10Z","timestamp":1778186770204,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81170370"],"award-info":[{"award-number":["No.81170370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81601797"],"award-info":[{"award-number":["No.81601797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Scientific Research Program","award":["No.JCYJ20170412143551332, JCYJ20170307153714512, JCYJ20170307153919735, JCYJ20170307153425389"],"award-info":[{"award-number":["No.JCYJ20170412143551332, JCYJ20170307153714512, JCYJ20170307153919735, JCYJ20170307153425389"]}]},{"name":"Shenzhen Health and Family Planning Commission","award":["No.SZFZ2017063, SZXJ2017032, SZFZ2017036, No.201601058"],"award-info":[{"award-number":["No.SZFZ2017063, SZXJ2017032, SZFZ2017036, No.201601058"]}]},{"name":"provincial medical funds of Guangdong","award":["No.B2017019, 2014A031313718, A2018163"],"award-info":[{"award-number":["No.B2017019, 2014A031313718, A2018163"]}]},{"name":"the Shenzhen Nanshan District Scientific Research Program of the People\u2019s Republic of China","award":["No.2016010, No.2017013, No.2017015, No.2017026, No.2017027"],"award-info":[{"award-number":["No.2016010, No.2017013, No.2017015, No.2017026, No.2017027"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12879-019-3779-8","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T14:06:11Z","timestamp":1550585171000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Staphylococcus aureus with an erm-mediated constitutive macrolide-lincosamide-streptogramin B resistance phenotype has reduced susceptibility to the new ketolide, solithromycin"],"prefix":"10.1186","volume":"19","author":[{"given":"Weiming","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangjian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duoyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-2064","authenticated-orcid":false,"given":"Zhijian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,19]]},"reference":[{"issue":"Suppl 1","key":"3779_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/infdis\/jiw402","volume":"215","author":"E Geisinger","year":"2017","unstructured":"Geisinger E, Isberg RR. Interplay between antibiotic resistance and virulence during disease promoted by multidrug-resistant bacteria. J Infect Dis. 2017;215(Suppl 1):9\u201317.","journal-title":"J Infect Dis"},{"key":"3779_CR2","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1128\/AAC.39.3.577","volume":"39","author":"B Weisblum","year":"1995","unstructured":"Weisblum B. Erythromycin resistance by ribosome modification. Antimicrob Agents Chemother. 1995;39:577\u201385.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.nmni.2015.05.003","volume":"7","author":"C Bouchiat","year":"2015","unstructured":"Bouchiat C, El-Zeenni N, Chakrakodi B, Nagaraj S, Arakere G, Etienne J. Epidemiology of Staphylococcus aureus in Bangalore, India: emergence of the ST217 clone and high rate of resistance to erythromycin and ciprofloxacin in the community. New Microbes New Infect. 2015;7:15\u201320.","journal-title":"New Microbes New Infect"},{"key":"3779_CR4","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1093\/jac\/49.4.611","volume":"49","author":"FJ Schmitz","year":"2002","unstructured":"Schmitz FJ, Petridou J, Jagusch H, Astfalk N, Scheuring S, Schwarz S. Molecular characterization of ketolide-resistant erm(A)-carrying Staphylococcus aureus isolates selected in vitro by telithromycin, ABT-773, quinupristin and clindamycin. J Antimicrob Chemother. 2002;49:611\u20137.","journal-title":"J Antimicrob Chemother"},{"key":"3779_CR5","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.molcel.2013.10.013","volume":"52","author":"P Gupta","year":"2013","unstructured":"Gupta P, Kannan K, Mankin AS, V\u00e1zquez-Laslop N. Regulation of gene expression by macrolide-induced ribosomal frameshifting. Mol Cell. 2013;52:629\u201342.","journal-title":"Mol Cell"},{"key":"3779_CR6","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1007\/s40265-016-0667-z","volume":"76","author":"GG Zhanel","year":"2016","unstructured":"Zhanel GG, Hartel E, Adam H, Zelenitsky S, Zhanel MA, Golden A, Schweizer F, Gorityala B, Lagac\u00e9-Wiens PR, Walkty AJ, Gin AS, Hoban DJ, Lynch JP, Karlowsky JA. Solithromycin: a novel fluoroketolide for the treatment of community-acquired bacterial pneumonia. Drugs. 2016;76:1737\u201357.","journal-title":"Drugs"},{"key":"3779_CR7","doi-asserted-by":"publisher","first-page":"3662","DOI":"10.1128\/AAC.00185-16","volume":"60","author":"DJ Farrell","year":"2016","unstructured":"Farrell DJ, Flamm RK, Sader HS, Jones RN. Results from the Solithromycin international surveillance program (2014). Antimicrob Agents Chemother. 2016;60:3662\u20138.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR8","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1093\/cid\/ciw490","volume":"63","author":"TM File Jr","year":"2016","unstructured":"File TM Jr, Rewerska B, Vucinic-Mihailovic V, Gonong JRV, Das AF, Keedy K, Taylor D, Sheets A, Fernandes P, Oldach D, Jamieson BD. SOLITAIRE-IV: a randomized, double-blind, multicenter study comparing the efficacy and safety of intravenous-to-oral solithromycin to intravenous-to-oral moxifloxacin for treatment of community-acquired bacterial pneumonia. Clin Infect Dis. 2016;63:1007\u201316.","journal-title":"Clin Infect Dis"},{"key":"3779_CR9","doi-asserted-by":"publisher","first-page":"959","DOI":"10.2217\/fmb.12.63","volume":"7","author":"ST Chancey","year":"2012","unstructured":"Chancey ST, Z\u00e4hner D, Stephens DS. Acquired inducible antimicrobial resistance in Gram-positive bacteria. Future Microbiol. 2012;7:959\u201378.","journal-title":"Future Microbiol"},{"key":"3779_CR10","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1017\/S0950268800051682","volume":"113","author":"N Kobayashi","year":"1994","unstructured":"Kobayashi N, Wu H, Kojima K, Taniguchi K, Urasawa S, Uehara N, Omizu Y, Kishi Y, Yagihashi A, Kurokawa I. Detection of mecA, femA, and femB genes in clinical strains of staphylococci using polymerase chain reaction. Epidemiol Infect. 1994;113:259\u201366.","journal-title":"Epidemiol Infect"},{"key":"3779_CR11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/jac\/dkn008","volume":"61","author":"EJ Yoon","year":"2008","unstructured":"Yoon EJ, Kwon AR, Min YH, Choi EC. Foggy D-shaped zone of inhibition in Staphylococcus aureus owing to a dual character of both inducible and constitutive resistance to macrolide-lincosamide-streptogramin B. J Antimicrob Chemother. 2008;61:533\u201340.","journal-title":"J Antimicrob Chemother"},{"key":"3779_CR12","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: Twenty-Sixth Informational Supplement M100-S26","author":"Clinical and Laboratory Standards Institute","year":"2016","unstructured":"Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twenty-Sixth Informational Supplement M100-S26. Wayne: CLSI; 2016."},{"key":"3779_CR13","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.1128\/AAC.00871-09","volume":"53","author":"JB Locke","year":"2009","unstructured":"Locke JB, Hilgers M, Shaw KJ. Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother. 2009;53:5265\u201374.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR14","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1128\/AAC.40.11.2562","volume":"40","author":"J Sutcliffe","year":"1996","unstructured":"Sutcliffe J, Grebe T, Tait-Kamradt A, Wondrack L. Detection of erythromycin-resistant determinants by PCR. Antimicrob Agents Chemother. 1996;40:2562\u20136.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR15","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1093\/jac\/dkh339","volume":"54","author":"L Drago","year":"2004","unstructured":"Drago L, De Vecchi E, Nicola L, Colombo A, Gismondo MR. Selection of resistance of telithromycin against Haemophilus influenzae, Moraxella catarrhalis and streptococci in comparison with macrolides. J Antimicrob Chemother. 2004;54:542\u20135.","journal-title":"J Antimicrob Chemother"},{"key":"3779_CR16","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1128\/AAC.01123-09","volume":"54","author":"P McGhee","year":"2010","unstructured":"McGhee P, Clark C, Kosowska-Shick KM, Nagai K, Dewasse B, Beachel L, Appelbaum PC. In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. Antimicrob Agents Chemother. 2010;54:230\u20138.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR17","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/jac\/dkg348","volume":"52","author":"F Walsh","year":"2003","unstructured":"Walsh F, Willcock J, Amyes S. High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae. J Antimicrob Chemother. 2003;52:345\u201353.","journal-title":"J Antimicrob Chemother"},{"key":"3779_CR18","first-page":"101","volume-title":"Programs and Abstracts of the Forty-first Interscience Conference on Antimicrobial Agents and Chemotherapy","author":"A Tait-Kamradt","year":"2001","unstructured":"Tait-Kamradt A, Reinert RR, Al-Lahham A, Low D, Sutcliffe J. High-level ketolide-resistant streptococci. In: Programs and Abstracts of the Forty-first Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago; Washington, DC: American Society for Microbiology; 2001. p. 101. Abstract C1-1813."},{"key":"3779_CR19","volume-title":"Programs and Abstracts of the 14th European Congress of Clinical Microbiology and Infectious Diseases","author":"DJ Farrell","year":"2004","unstructured":"Farrell DJ, Morrissey I, Bakker S, Felmingham D. Mutations in erm(B) associated with rare, low-level telithromycin resistance in Streptococcus pneumoniae: 3-year data from PROTEKT. In: Programs and Abstracts of the 14th European Congress of Clinical Microbiology and Infectious Diseases. Prague: European Society of Clinical Microbiology and Infectious Diseases; 2004. Abstract P1465."},{"key":"3779_CR20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.7883\/yoken.JJID.2007.48","volume":"60","author":"Y Hirakata","year":"2007","unstructured":"Hirakata Y, Mizuta Y, Wada A, Kondoh A, Kurihara S, Izumikawa K, Seki M, Yanagihara K, Miyazaki Y, Tomono K, Kohno S. The first telithromycin-resistant Streptococcus pneumoniae isolate in Japan associated with erm(B) and mutations in 23S rRNA and riboprotein L4. Jpn J Infect Dis. 2007;60:48\u201350.","journal-title":"Jpn J Infect Dis"},{"key":"3779_CR21","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1128\/AAC.46.1.125-131.2002","volume":"46","author":"A Canu","year":"2002","unstructured":"Canu A, Malbruny B, Coquemont M, Davies TA, Appelbaum PC, Leclercq R. Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob Agents Chemother. 2002;46:125\u201331.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR22","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1128\/AAC.48.8.3169-3171.2004","volume":"48","author":"DJ Farrell","year":"2004","unstructured":"Farrell DJ, Morrissey I, Bakker S, Buckridge S, Felmingham D. In vitro activities of telithromycin, linezolid, and quinupristin\u2013dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations. Antimicrob Agents Chemother. 2004;48:3169\u201371.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR23","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1128\/AAC.44.12.3395-3401.2000","volume":"44","author":"A Tait-Kamradt","year":"2000","unstructured":"Tait-Kamradt A, Davies T, Appelbaum PC, Depardieu F, Courvalin P, Petitpas J, Wondrack L, Walker A, Jacobs MR, Sutcliffe J. Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America. Antimicrob Agents Chemother. 2000;44:3395\u2013401.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR24","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3201\/eid0909.020810","volume":"9","author":"E Perez-Trallero","year":"2003","unstructured":"Perez-Trallero E, Marimon JM, Iglesias L, Larruskain J. Fluoroquinolone and macrolide treatment failure in pneumococcal pneumonia and selection of multidrug-resistant isolates. Emerg Infect Dis. 2003;9:1159\u201362.","journal-title":"Emerg Infect Dis"},{"key":"3779_CR25","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1128\/AAC.50.3.893-898.2006","volume":"50","author":"T Bogdanovich","year":"2006","unstructured":"Bogdanovich T, Bozdogan B, Appelbaum PC. Effect of efflux on telithromycin and macrolide susceptibility in Haemophilus influenzae. Antimicrob Agents Chemother. 2006;50:893\u20138.","journal-title":"Antimicrob Agents Chemother"},{"key":"3779_CR26","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ijantimicag.2015.05.001","volume":"46","author":"B Park","year":"2015","unstructured":"Park B, Min YH. Inducible expression of erm(B) by the ketolides telithromycin and cethromycin. Int J Antimicrob Agents. 2015;46:226\u20137.","journal-title":"Int J Antimicrob Agents"},{"key":"3779_CR27","doi-asserted-by":"publisher","first-page":"9804","DOI":"10.1073\/pnas.1403586111","volume":"111","author":"S Sothiselvam","year":"2014","unstructured":"Sothiselvam S, Liu B, Han W, Ramu H, Klepacki D, Atkinson GC, Brauer A, Remm M, Tenson T, Schulten K, V\u00e1zquez-Laslop N, Mankin AS. Macrolide antibiotics allosterically predispose the ribosome for translation arrest. Proc Natl Acad Sci U S A. 2014;111:9804\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3779_CR28","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/j.1365-2958.2005.04863.x","volume":"58","author":"S Douthwaite","year":"2005","unstructured":"Douthwaite S, Jalava J, Jakobsen L. Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm. Mol Microbiol. 2005;58:613\u201322.","journal-title":"Mol Microbiol"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-3779-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-019-3779-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-3779-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T22:15:46Z","timestamp":1720995346000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-019-3779-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,19]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3779"],"URL":"https:\/\/doi.org\/10.1186\/s12879-019-3779-8","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,19]]},"assertion":[{"value":"22 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures involving human participants were performed in accordance with the ethical standards of the Shenzhen University School of Medicine and with the 1964 Helsinki declaration and its later amendments. Our study has been submitted to and approved by the Institutional Review Board of Shenzhen University School of Medicine. No formal consent is required for this type of research.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"175"}}