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Written informed consent was obtained from all individuals enrolled into the study by trained surveillance officers upon interview. Surveillance officers approached adult patients directly to obtain consent. Parents, legal guardians or primary care giver were approached for cases who were minors; in addition, where a minor was old enough to understand, assent was obtained.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Halima Dawood has received honoraria\/travel grants from Pfizer-South Africa, MSD329 South Africa and Mylan-South Africa. Anne von Gottberg has previously received grants from the US Centers for Disease Control and Prevention and Pfizer-South Africa. All other authors declare that they have no commercial or other association that may pose a conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"276"}}