{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:02:46Z","timestamp":1791388966454,"version":"4.3.3"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12879-019-3960-0","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T10:24:26Z","timestamp":1556533466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-6525","authenticated-orcid":false,"given":"S. C.","family":"Ibeneme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Omeje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Myezwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salome Nwaelom","family":"Ezeofor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Anieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Irem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaka Obiageli","family":"Nnamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortune Elochukwu","family":"Ezenwankwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. C.","family":"Ibeneme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"issue":"1","key":"3960_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/2052-8426-2-20","volume":"2","author":"NW Cummins","year":"2014","unstructured":"Cummins NW, Badley AD. Making sense of how HIV kills infected CD4 T cells: implications for HIV cure. Mol Cell Ther. 2014;2(1):20.","journal-title":"Mol Cell Ther"},{"key":"3960_CR2","volume-title":"Global health estimates 2015: deaths by cause, age, sex, by country and by region, 2000\u20132015","author":"World Health Organization","year":"2016","unstructured":"World Health Organization. Global health estimates 2015: deaths by cause, age, sex, by country and by region, 2000\u20132015. Geneva: World Health Organization; 2016."},{"key":"3960_CR3","unstructured":"UNAIDS. Data Book. Joint United Nations Programme on HIV\/AIDS (UNAIDS). Geneva. 2017.\u00a0 http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/20170720_Data_book_2017_en.pdf ."},{"key":"3960_CR4","unstructured":"Federal Republic of Nigeria- National HIV and AIDS Strategic Framework 2017-2021. https:\/\/www.childrenandaids.org\/sites\/default\/files\/2017-11\/NATIONAL-HIV-AND-AIDS-STRATEGIC-FRAMEWORK.pdf ."},{"issue":"9903","key":"3960_CR5","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1016\/S0140-6736(13)61809-7","volume":"382","author":"SG Deeks","year":"2013","unstructured":"Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet. 2013;382(9903):1525\u201333.","journal-title":"Lancet"},{"issue":"2","key":"3960_CR6","first-page":"12","volume":"22","author":"L Highleyman","year":"2010","unstructured":"Highleyman L. Inflammation, immune activation, and HIV. BETA. 2010;22(2):12\u201326.","journal-title":"BETA"},{"issue":"9","key":"3960_CR7","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1056\/NEJMoa1507198","volume":"373","author":"Temprano ANRS 12136 Study Group","year":"2015","unstructured":"Temprano ANRS 12136 Study Group. A trial of early antiretrovirals and isoniazid preventive therapy in Africa. N Engl J Med. 2015;373(9):808\u201322.","journal-title":"N Engl J Med"},{"issue":"9","key":"3960_CR8","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1056\/NEJMoa1600693","volume":"375","author":"MS Cohen","year":"2016","unstructured":"Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole SV. Antiretroviral therapy for the prevention of HIV-1 transmission. N Engl J Med. 2016;375(9):830\u20139.","journal-title":"N Engl J Med"},{"issue":"4","key":"3960_CR9","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nm0402-319","volume":"8","author":"Zvi Grossman","year":"2002","unstructured":"Grossman Z, Meier-Schellersheim M, Sousa AE, Victorino RMM, Paul WE. CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause? Nature Medicine. 2002;8(4):319\u201323. https:\/\/doi.org\/10.1038\/nm0402-319 .","journal-title":"Nature Medicine"},{"issue":"1","key":"3960_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/QAI.0000000000001014","volume":"73","author":"JL Marcus","year":"2016","unstructured":"Marcus JL, Chao CR, Leyden WA, Xu L, Quesenberry CP Jr, Klein DB, Towner WJ, Horberg MA, Silverberg MJ. Narrowing the gap in life expectancy between HIV-infected and HIV-uninfected individuals with access to care. J Acquir Immune Defic Syndr (1999). 2016;73(1):39.","journal-title":"J Acquir Immune Defic Syndr (1999)"},{"key":"3960_CR11","unstructured":"Reust CE. Common adverse effects of antiretroviral therapy for HIV disease. Am Fam Physician. 2011;83(12):1143\u2013451.\u00a0"},{"issue":"5","key":"3960_CR12","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/COH.0b013e328356682a","volume":"7","author":"FJ Lee","year":"2012","unstructured":"Lee FJ, Carr A. Tolerability of HIV integrase inhibitors. Curr Opin HIV AIDS. 2012;7(5):422\u20138.","journal-title":"Curr Opin HIV AIDS"},{"issue":"2","key":"3960_CR13","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1513\/AnnalsATS.201606-492OC","volume":"15","author":"MR Gingo","year":"2018","unstructured":"Gingo MR, Nouraie M, Kessinger CJ, Greenblatt RM, Huang L, Kleerup EC, Kingsley L, McMahon DK, Morris A. Decreased lung function and all-cause mortality in HIV-infected individuals. Ann Am Thorac Soc. 2018;15(2):192\u20139.","journal-title":"Ann Am Thorac Soc"},{"issue":"10","key":"3960_CR14","doi-asserted-by":"publisher","first-page":"e203","DOI":"10.1371\/journal.pmed.0050203","volume":"5","author":"LH Kuller","year":"2008","unstructured":"Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC, Ledergerber B, Lundgren J, Neuhaus J, Nixon D, Paton NI. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med. 2008;5(10):e203.","journal-title":"PLoS Med"},{"issue":"8","key":"3960_CR15","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1128\/JVI.01844-08","volume":"83","author":"AR Stacey","year":"2009","unstructured":"Stacey AR, Norris PJ, Qin L, Haygreen EA, Taylor E, Heitman J, Lebedeva M, DeCamp A, Li D, Grove D, Self SG. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol. 2009;83(8):3719\u201333.","journal-title":"J Virol"},{"issue":"4","key":"3960_CR16","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1586\/eri.11.21","volume":"9","author":"SD Lawn","year":"2011","unstructured":"Lawn SD, Meintjes G. Pathogenesis and prevention of immune reconstitution disease during antiretroviral therapy. Expert Rev Anti-Infect Ther. 2011;9(4):415\u201330.","journal-title":"Expert Rev Anti-Infect Ther"},{"issue":"3","key":"3960_CR17","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3390\/v11030200","volume":"11","author":"Sonia Zicari","year":"2019","unstructured":"Zicari S, Sessa L, Cotugno N, Ruggiero A, Morrocchi E, Concato C, Rocca S, Zangari P, Manno EC, Palma P. Immune Activation, Inflammation, and Non-AIDS Co-Morbidities in HIV-Infected Patients under Long-Term ART. Viruses. 2019;11(3):200.","journal-title":"Viruses"},{"issue":"1","key":"3960_CR18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/QAI.0000000000001320","volume":"75","author":"BJ Macatangay","year":"2017","unstructured":"Macatangay BJ, Yang M, Sun X, Morton J, De VG, Little S, Hogan C, Rinaldo CR. Brief Report: Changes in Levels of Inflammation After Antiretroviral Treatment During Early HIV Infection in AIDS Clinical Trials Group Study A5217. J Acquir Immune Defic Syndr (1999). 2017;75(1):137\u201341.","journal-title":"J Acquir Immune Defic Syndr (1999)"},{"issue":"1","key":"3960_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2332\/allergolint.09-OA-0126","volume":"59","author":"T Shirai","year":"2010","unstructured":"Shirai T, Suda T, Inui N, Chida K. Correlation between peripheral blood T-cell profiles and clinical and inflammatory parameters in stable COPD. Allergol Int. 2010;59(1):75\u201382.","journal-title":"Allergol Int"},{"issue":"4","key":"3960_CR20","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/clpt.2009.255","volume":"87","author":"MF O'Connor","year":"2010","unstructured":"O'Connor MF, Irwin MR. Links between behavioral factors and inflammation. Clin Pharmacol Ther. 2010;87(4):479\u201382.","journal-title":"Clin Pharmacol Ther"},{"issue":"Suppl_1","key":"3960_CR21","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1093\/gerona\/glu057","volume":"69","author":"C Franceschi","year":"2014","unstructured":"Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol Ser A Biol Sci Med Sci. 2014;69(Suppl_1):S4\u20139.","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"key":"3960_CR22","first-page":"619","volume-title":"Chronic Kidney Disease in the Aging Human Immunodeficiency Virus-Infected Population","author":"JB Kopp","year":"2017","unstructured":"Kopp JB. Chronic Kidney Disease in the Aging Human Immunodeficiency Virus-Infected Population; 2017. p. 619\u201321."},{"key":"3960_CR23","doi-asserted-by":"crossref","unstructured":"Moso MA, Woolnough E, Langham F, Hoy JF, Cheng AC, Walker RG, Chrysostomou A, Woolley I, Weeraratne A, Trevillyan JM. Increasing prevalence and risk of chronic kidney disease in HIV-positive individuals: changing demographics over a six-year period. J Infect Dis. 2018;217:1013\u20135.","DOI":"10.1093\/infdis\/jix676"},{"issue":"47","key":"3960_CR24","doi-asserted-by":"publisher","first-page":"48487","DOI":"10.1074\/jbc.R400025200","volume":"279","author":"S Black","year":"2004","unstructured":"Black S, Kushner I, Samols D. C-reactive protein. J Biol Chem. 2004;279(47):48487\u201390.","journal-title":"J Biol Chem"},{"issue":"10","key":"3960_CR25","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1249\/mss.0b013e31811ece1c","volume":"39","author":"LK Stewart","year":"2007","unstructured":"Stewart LK, Flynn MG, Campbell WW, Craig BA, Robinson JP, Timmerman KL, McFarlin BK, Coen PM, Talbert E. The influence of exercise training on inflammatory cytokines and C-reactive protein. Med Sci Sports Exerc. 2007;39(10):1714\u20139.","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"3960_CR26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/QCO.0000000000000325","volume":"30","author":"EF Attia","year":"2017","unstructured":"Attia EF, Miller RF, Ferrand RA. Bronchiectasis and other chronic lung diseases in adolescents living with HIV. Curr Opin Infect Dis. 2017;30(1):21\u201330.","journal-title":"Curr Opin Infect Dis"},{"key":"3960_CR27","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1164\/ajrccm.160.2.9812020","volume":"160","author":"M Saetta","year":"1999","unstructured":"Saetta M, Baraldo S, Corbino L, Turato G, Braccioni F, Rea F, Cavallesco G, Tropeano G, Mapp CE, Maestrelli P, et al. CD8+VE cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160:711\u20137.","journal-title":"Am J Respir Crit Care Med"},{"key":"3960_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1136\/thx.2005.042200","volume":"61","author":"VM Pinto-Plata","year":"2006","unstructured":"Pinto-Plata VM, Mullerova H, Toso JF, Feudjo-Tepie M, Soriano JB, Vessey RS, Celli BR. C-reactive protein in patients with COPD, control smokers and non-smokers. Thorax. 2006;61:23\u20138.","journal-title":"Thorax"},{"key":"3960_CR29","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1093\/ije\/dyl082","volume":"35","author":"DD Sin","year":"2006","unstructured":"Sin DD, Man SF. Commentary: fuelling the fire\u2013systemic inflammation and development of lung disease in the general community. Int J Epidemiol. 2006;35:1008\u201310.","journal-title":"Int J Epidemiol"},{"issue":"1\u20133","key":"3960_CR30","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0014-2999(01)01320-6","volume":"429","author":"W MacNee","year":"2001","unstructured":"MacNee W. Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol. 2001;429(1\u20133):195\u2013207.","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"3960_CR31","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.bcp.2012.05.005","volume":"84","author":"IT Lee","year":"2012","unstructured":"Lee IT, Yang CM. Role of NADPH oxidase\/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol. 2012;84(5):581\u201390.","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"3960_CR32","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.autrev.2012.06.007","volume":"12","author":"LA Perandini","year":"2012","unstructured":"Perandini LA, de S\u00e1-Pinto AL, Roschel H, Benatti FB, Lima FR, Bonf\u00e1 E, Gualano B. Exercise as a therapeutic tool to counteract inflammation and clinical symptoms in autoimmune rheumatic diseases. Autoimmun Rev. 2012;12(2):218\u201324.","journal-title":"Autoimmun Rev"},{"key":"3960_CR33","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/00001648-200209000-00012","volume":"1","author":"ES Ford","year":"2002","unstructured":"Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive protein among US adults. Epidemiology. 2002;1:561\u20138.","journal-title":"Epidemiology."},{"key":"3960_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001796.pub3","volume-title":"Aerobic exercise interventions for adults living with HIV\/AIDS","author":"K O'Brien","year":"2010","unstructured":"O'Brien K, Nixon S, Tynan AM, Glazier R. Aerobic exercise interventions for adults living with HIV\/AIDS; 2010."},{"issue":"3","key":"3960_CR35","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0004-9514(06)70027-7","volume":"52","author":"S Fillipas","year":"2006","unstructured":"Fillipas S, Oldmeadow LB, Bailey MJ, Cherry CL. A six-month, supervised, aerobic and resistance exercise program improves self-efficacy in people with human immunodeficiency virus: a randomised controlled trial. Aust J Physiother. 2006;52(3):185\u201390.","journal-title":"Aust J Physiother"},{"issue":"11","key":"3960_CR36","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1001\/archinte.166.11.1225","volume":"166","author":"SE Dolan","year":"2006","unstructured":"Dolan SE, Frontera W, Librizzi J, Ljungquist K, Juan S, Dorman R, Cole ME, Kanter JR, Grinspoon S. Effects of a supervised home-based aerobic and progressive resistance training regimen in women infected with human immunodeficiency virus: a randomized trial. Arch Intern Med. 2006;166(11):1225\u201331.","journal-title":"Arch Intern Med"},{"issue":"11","key":"3960_CR37","first-page":"415","volume":"5","author":"IS Yar\u2019Zever","year":"2013","unstructured":"Yar\u2019Zever IS, Abubakar U, Toriola AL, Igbokwe NU. Effects of 12 weeks cycle exercise programme on CD4 count and viral load in HIV sero-positive patients in Kano, Nigeria. J AIDS HIV Res. 2013;5(11):415\u201321.","journal-title":"J AIDS HIV Res"},{"issue":"5","key":"3960_CR38","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1161\/hc0502.103331","volume":"105","author":"A Tchernof","year":"2002","unstructured":"Tchernof A, Nolan A, Sites CK, Ades PA, Poehlman ET. Weight loss reduces C-reactive protein levels in obese postmenopausal women. Circulation. 2002;105(5):564\u20139.","journal-title":"Circulation."},{"key":"3960_CR39","unstructured":"Solis LE. The Effects of Exercise Training Intensities on Changes in Body Composition, Visceral Adipose Tissue, Adiponectin and C-Reactive Protein.\u00a0Master of Science Thesis. Department of Biology & Chemistry,\u00a0\u00a0Texas A&M International University. 2017. http:\/\/hdl.handle.net\/2152.4\/151 . Accessed Mar 2018."},{"issue":"19","key":"3960_CR40","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1161\/CIRCULATIONAHA.107.729939","volume":"116","author":"S Mora","year":"2007","unstructured":"Mora S, Cook N, Buring JE, Ridker PM, Lee IM. Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation. 2007;116(19):2110\u20138.","journal-title":"Circulation."},{"issue":"3","key":"3960_CR41","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1464-5491.2009.02679.x","volume":"26","author":"I Levinger","year":"2009","unstructured":"Levinger I, Goodman C, Peake J, Garnham A, Hare DL, Jerums G, Selig S. Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors. Diabet Med. 2009;26(3):220\u20137.","journal-title":"Diabet Med"},{"issue":"11","key":"3960_CR42","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1249\/MSS.0b013e3182644984","volume":"44","author":"MD Phillips","year":"2012","unstructured":"Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Resistance training reduces subclinical inflammation in obese, postmenopausal women. Med Sci Sports Exerc. 2012;44(11):2099\u2013110.","journal-title":"Med Sci Sports Exerc"},{"issue":"9","key":"3960_CR43","doi-asserted-by":"publisher","first-page":"e0138066","DOI":"10.1371\/journal.pone.0138066","volume":"10","author":"MG Neto","year":"2015","unstructured":"Neto MG, Concei\u00e7\u00e3o CS, Carvalho VO, Brites C. Effects of combined aerobic and resistance exercise on exercise capacity, muscle strength and quality of life in HIV-infected patients: a systematic review and meta-analysis. PLoS One. 2015;10(9):e0138066.","journal-title":"PLoS One"},{"issue":"8","key":"3960_CR44","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1080\/17461391.2016.1167962","volume":"16","author":"HR Zanetti","year":"2016","unstructured":"Zanetti HR, Cruz LG, Louren\u00e7o CL, Neves FD, Silva-Vergara ML, Mendes EL. Non-linear resistance training reduces inflammatory biomarkers in persons living with HIV: a randomized controlled trial. Eur J Sport Sci. 2016 Nov 16;16(8):1232\u20139.","journal-title":"Eur J Sport Sci"},{"issue":"12","key":"3960_CR45","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1001\/jama.295.12.1412","volume":"295","author":"S Mora","year":"2006","unstructured":"Mora S, Lee IM, Buring JE, Ridker PM. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA. 2006;295(12):1412\u20139.","journal-title":"JAMA."},{"issue":"3","key":"3960_CR46","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1177\/1559827607300283","volume":"1","author":"MG Flynn","year":"2007","unstructured":"Flynn MG, McFarlin BK, Markofski MM. The anti-inflammatory actions of exercise training. Am J Lifestyle Med. 2007;1(3):220\u201335.","journal-title":"Am J Lifestyle Med"},{"issue":"2","key":"3960_CR47","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1152\/japplphysiol.00006.2008","volume":"105","author":"CP Lambert","year":"2008","unstructured":"Lambert CP, Wright NR, Finck BN, Villareal DT. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol. 2008;105(2):473\u20138.","journal-title":"J Appl Physiol"},{"key":"3960_CR48","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S1567-7443(05)80018-3","volume":"5","author":"BK Pedersen","year":"2005","unstructured":"Pedersen BK. Natural immunity\u2013effect of exercise. Neuro Immune Biol. 2005;5:263\u201388 Elsevier.","journal-title":"Neuro Immune Biol"},{"key":"3960_CR49","first-page":"462","volume":"2","author":"A Kylasov","year":"2011","unstructured":"Kylasov A, Gavrov S. Diversity of sport: non-destructive evaluation. Enc Life Support Syst. 2011;2:462\u201391.","journal-title":"Enc Life Support Syst"},{"issue":"4","key":"3960_CR50","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1189\/jlb.0505247","volume":"78","author":"H Bruunsgaard","year":"2005","unstructured":"Bruunsgaard H. Physical activity and modulation of systemic low-level inflammation. J Leukoc Biol. 2005;78(4):819\u201335.","journal-title":"J Leukoc Biol"},{"key":"3960_CR51","doi-asserted-by":"publisher","first-page":"213","DOI":"10.4172\/2329.9096.1000213","volume":"2","author":"A Ortiz","year":"2014","unstructured":"Ortiz A. Exercise for adults living with human immunodeficiency virus infection in the era of highly active antiretroviral therapy. Int J Phys Med Rehabil. 2014;2:213. https:\/\/doi.org\/10.4172\/2329.9096.1000213 .","journal-title":"Int J Phys Med Rehabil"},{"issue":"9","key":"3960_CR52","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1503\/cmaj.1040769","volume":"172","author":"BJ Nicklas","year":"2005","unstructured":"Nicklas BJ, You T, Pahor M. Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. Can Med Assoc J. 2005;172(9):1199\u2013209.","journal-title":"Can Med Assoc J"},{"issue":"5","key":"3960_CR53","doi-asserted-by":"publisher","first-page":"E961","DOI":"10.1152\/ajpendo.00506.2005","volume":"290","author":"JM Bruun","year":"2006","unstructured":"Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab. 2006;290(5):E961\u20137.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"3960_CR54","unstructured":"Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011], The Cochrane Collaboration. Available via https:\/\/www.radioterapiaitalia.it\/wp-content\/uploads\/2017\/01\/cochrane-handbook-for-systematic-reviews-of-interventions.pdf . Accessed 14 June 2018."},{"key":"3960_CR55","volume-title":"CRD\u2019s Guidance for Undertaking Reviews in Health care","author":"J Akers","year":"2009","unstructured":"Akers J, Aguiar-Ib\u00e1\u00f1ez R, Baba-Akbari SA. CRD\u2019s Guidance for Undertaking Reviews in Health care. York: Centre for Reviews and Dissemination (CRD); 2009."},{"key":"3960_CR56","volume-title":"Microsoft Excel","author":"Microsoft","year":"2013","unstructured":"Microsoft. Microsoft Excel. Redmond: Microsoft, Computer Software; 2013."},{"key":"3960_CR57","unstructured":"The physiotherapy evidence database. https:\/\/www.pedro.org.au\/ . Accessed June 2018.\u00a0"},{"issue":"7650","key":"3960_CR58","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ. Rating quality of evidence and strength of recommendations: GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924.","journal-title":"BMJ"},{"issue":"1","key":"3960_CR59","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12879-016-2095-9","volume":"17","author":"M Bonato","year":"2017","unstructured":"Bonato M, Galli L, Passeri L, Longo V, Pavei G, Bossolasco S, Bertocchi C, Cernuschi M, Balconi G, Merati G, Lazzarin A. A pilot study of brisk walking in sedentary combination antiretroviral treatment (cART)-treated patients: benefit on soluble and cell inflammatory markers. BMC Infect Dis. 2017;17(1):61.","journal-title":"BMC Infect Dis"},{"key":"3960_CR60","first-page":"2012","volume-title":"Moderate-intensity exercise improves body composition and improves physiological markers of stress in HIV-infected men. Isrn aids","author":"WD Dudgeon","year":"2012","unstructured":"Dudgeon WD, Jaggers JR, Phillips KD, Durstine JL, Burgess SE, Lyerly GW, Davis JM, Hand GA. Moderate-intensity exercise improves body composition and improves physiological markers of stress in HIV-infected men. Isrn aids; 2012. p. 2012."},{"issue":"4","key":"3960_CR61","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1139\/H10-045","volume":"35","author":"WD Dudgeon","year":"2010","unstructured":"Dudgeon WD, Phillips KD, Durstine JL, Burgess SE, Lyerly GW, Davis JM, Hand GA. Individual exercise sessions alter circulating hormones and cytokines in HIV-infected men. Appl Physiol Nutr Metab. 2010;35(4):560\u20138.","journal-title":"Appl Physiol Nutr Metab"},{"key":"3960_CR62","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cyto.2017.06.019","volume":"99","author":"RE Pedro","year":"2017","unstructured":"Pedro RE, Candido N, Guariglia DA, Melo BP, Bertolini DA, Peres SB, de Moraes SM. Exercise improves cytokine profile in HIV-infected people: a randomized clinical trial. Cytokine. 2017;99:18\u201323.","journal-title":"Cytokine."},{"issue":"3","key":"3960_CR63","first-page":"268","volume":"67","author":"R Roos","year":"2014","unstructured":"Roos R, Myezwa H, van Aswegen H, Musenge E. Effects of an education and home-based pedometer walking program on ischemic heart disease risk factors in people infected with HIV: a randomized trial. JAIDS. 2014;67(3):268\u201376.","journal-title":"JAIDS"},{"issue":"1","key":"3960_CR64","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1519\/JSC.0000000000002289","volume":"32","author":"JL Vingren","year":"2018","unstructured":"Vingren JL, Curtis JH, Levitt DE, Duplanty AA, Lee EC, McFarlin BK, Hill DW. Adding resistance training to the standard of care for inpatient substance abuse treatment in men with human immunodeficiency virus improves skeletal muscle health without altering cytokine concentrations. J Strength Cond Res. 2018;32(1):76\u201382.","journal-title":"J Strength Cond Res"},{"issue":"6","key":"3960_CR65","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1080\/09540121.2016.1263723","volume":"29","author":"A McDermott","year":"2017","unstructured":"McDermott A, Zaporojan L, McNamara P, Doherty CP, Redmond J, Forde C, Gormley J, Ega\u00f1a M, Bergin C. The effects of a 16-week aerobic exercise programme on cognitive function in people living with HIV. AIDS Care. 2017;29(6):667\u201374.","journal-title":"AIDS Care"},{"issue":"1","key":"3960_CR66","first-page":"17","volume":"16","author":"HA Aweto","year":"2016","unstructured":"Aweto HA, Aiyegbusi AI, Ugonabo AJ, Adeyemo TA. Effects of aerobic exercise on the pulmonary functions, respiratory symptoms and psychological status of people living with HIV. J Res Health Sci. 2016;16(1):17\u201321.","journal-title":"J Res Health Sci"},{"issue":"5","key":"3960_CR67","doi-asserted-by":"publisher","first-page":"543","DOI":"10.4103\/1119-3077.141414","volume":"17","author":"CI Ezema","year":"2014","unstructured":"Ezema CI, Onwunali AA, Lamina S, Ezugwu UA, Amaeze AA, Nwankwo MJ. Effect of aerobic exercise training on cardiovascular parameters and CD4 cell count of people living with human immunodeficiency virus\/acquired immune deficiency syndrome: a randomized controlled trial. Niger J Clin Pract. 2014;17(5):543\u20138.","journal-title":"Niger J Clin Pract"},{"issue":"4","key":"3960_CR68","first-page":"511","volume":"50","author":"PT Farinatti","year":"2010","unstructured":"Farinatti PT, Borges JP, Gomes RD, Lima D, Fleck SJ. Effects of a supervised exercise program on the physical fitness and immunological function of HIV-infected patients. J Sports Med Phys Fitness. 2010;50(4):511.","journal-title":"J Sports Med Phys Fitness"},{"issue":"9","key":"3960_CR69","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1080\/09540120701796900","volume":"20","author":"GA Hand","year":"2008","unstructured":"Hand GA, Phillips KD, Dudgeon WD, William Lyerly G, Larry Durstine J, Burgess SE. Moderate intensity exercise training reverses functional aerobic impairment in HIV-infected individuals. AIDS Care. 2008;20(9):1066\u201374.","journal-title":"AIDS Care"},{"key":"3960_CR70","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2174\/1874613601509010089","volume":"9","author":"L Mangona","year":"2015","unstructured":"Mangona L, Daca T, Tchonga F, Bule O, Bhatt N, Jani I, Damasceno A, Prista A. Suppl 1: M5: effect of different types of exercise in HIV+ Mozambican women using antiretroviral therapy. Open AIDS J. 2015;9:89.","journal-title":"Open AIDS J"},{"issue":"6","key":"3960_CR71","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/00002030-200104130-00004","volume":"15","author":"BA Smith","year":"2001","unstructured":"Smith BA, Neidig JL, Nickel JT, Mitchell GL, Para MF, Fass RJ. Aerobic exercise: effects on parameters related to fatigue, dyspnea, weight and body composition in HIV-infected adults. Aids. 2001;15(6):693\u2013701.","journal-title":"Aids."},{"issue":"7","key":"3960_CR72","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1097\/00005768-199907000-00009","volume":"31","author":"FM Perna","year":"1999","unstructured":"Perna FM, LaPERRIERE AR, Klimas N, Ironson G, Perry A, Pavone J, Goldstein A, Majors P, Makemson D, Talutto C, Schneiderman N. Cardiopulmonary and CD4 cell changes in response to exercise training in early symptomatic HIV infection. Med Sci Sports Exerc. 1999;31(7):973\u20139.","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"3960_CR73","doi-asserted-by":"publisher","first-page":"47","DOI":"10.4103\/0253-7184.196886","volume":"38","author":"R Patil","year":"2017","unstructured":"Patil R, Shimpi A, Rairikar S, Shyam A, Sancheti P. Effects of fitness training on physical fitness parameters and quality of life in human immunodeficiency virus-positive Indian females. Indian J Sex Transm Dis. 2017;38(1):47.","journal-title":"Indian J Sex Transm Dis"},{"issue":"3","key":"3960_CR74","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1249\/01.mss.0000191347.73848.80","volume":"38","author":"L Terry","year":"2006","unstructured":"Terry L, Sprinz E, Stein R, Medeiros NB, Oliveira J, Ribeiro JP. Exercise training in HIV-1-infected individuals with dyslipidemia and lipodystrophy. Med Sci Sports Exerc. 2006;38(3):411\u20137.","journal-title":"Med Sci Sports Exerc"},{"key":"3960_CR75","volume-title":"The effect of exercise training on aerobic fitness, immune indices, and quality of life in HIV+ patients. Medicine & Science in Sports & Exercise","author":"WW Stringer","year":"1998","unstructured":"Stringer WW, Berezovskaya M, O'brien WA, Beck CK, Casaburi R. The effect of exercise training on aerobic fitness, immune indices, and quality of life in HIV+ patients. Medicine & Science in Sports & Exercise; 1998."},{"issue":"12","key":"3960_CR76","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1519\/JSC.0000000000001454","volume":"30","author":"RE Pedro","year":"2016","unstructured":"Pedro RE, Guariglia DA, Okuno NM, Deminice R, Peres SB, Moraes SM. Effects of 16 weeks of concurrent training on resting heart rate variability and cardiorespiratory fitness in people living with HIV\/aids using antiretroviral therapy: a randomized clinical trial. J Strength Cond Res. 2016;30(12):3494\u2013502.","journal-title":"J Strength Cond Res"},{"issue":"1","key":"3960_CR77","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1089\/aid.2007.0023","volume":"24","author":"E Mutimura","year":"2008","unstructured":"Mutimura E, Crowther NJ, Cade TW, Yarasheski KE, Stewart A. Exercise training reduces central adiposity and improves metabolic indices in HAART-treated HIV-positive subjects in Rwanda: a randomized controlled trial. AIDS Res Hum Retrovir. 2008;24(1):15\u201323.","journal-title":"AIDS Res Hum Retrovir"},{"issue":"2","key":"3960_CR78","first-page":"e52","volume":"66","author":"M Tr\u00f8seid","year":"2014","unstructured":"Tr\u00f8seid M, Ditlevsen S, Hvid T, Gerstoft J, Gr\u00f8ndahl T, Pedersen BK, Nielsen SD, Lindegaard B. Reduced trunk fat and triglycerides after strength training are associated with reduced LPS levels in HIV-infected individuals. JAIDS. 2014;66(2):e52\u20134.","journal-title":"JAIDS"},{"issue":"10","key":"3960_CR79","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.1210\/jc.2007-2733","volume":"93","author":"B Lindegaard","year":"2008","unstructured":"Lindegaard B, Hansen T, Hvid T, Van Hall G, Plomgaard P, Ditlevsen S, Gerstoft J, Pedersen BK. The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy. J Clin Endocrinol Metab. 2008;93(10):3860\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"3960_CR80","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1123\/jpah.2015-0540","volume":"13","author":"HR Zanetti","year":"2016","unstructured":"Zanetti HR, da Cruz LG, Louren\u00e7o CL, Ribeiro GC, de Jesus Leite MA, Neves FF, Silva-Vergara ML, Mendes EL. Nonlinear resistance training enhances the lipid profile and reduces inflammation marker in people living with HIV: a randomized clinical trial. J Phys Act Health. 2016;13(7):765\u201370.","journal-title":"J Phys Act Health"},{"issue":"3","key":"3960_CR81","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/1559827614538750","volume":"10","author":"Jason R. Jaggers","year":"2014","unstructured":"Jaggers JR, Hand GA. Health benefits of exercise for people living with HIV: A review of the literature. American journal of lifestyle medicine. 2016;10(3):184\u201392.\u00a0 https:\/\/doi.org\/10.1177\/1559827614538750 . Accessed Dec 2017.","journal-title":"American Journal of Lifestyle Medicine"},{"key":"3960_CR82","doi-asserted-by":"publisher","unstructured":"Nixon\u00a0\u00a0S, O'Brien\u00a0\u00a0K, Glazier\u00a0\u00a0R, Tynan\u00a0\u00a0AM. Aerobic exercise interventions for adults living with HIV\/AIDS. Cochrane Database of Systematic Reviews. 2005. Issue 2. Art. No.: CD001796. https:\/\/doi.org\/10.1002\/14651858.CD001796.pub2 .","DOI":"10.1002\/14651858.CD001796.pub2"},{"key":"3960_CR83","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1249\/01.MSS.0000142404.28165.9B","volume":"36","author":"K Brien","year":"2004","unstructured":"Brien K, Nixon S, Tynan AM, Glazier RH. Effectiveness of aerobic exercise in adults living with HIV\/AIDS: systematic review. Med Sci Sports Exerc. 2004;36:1659\u201366.","journal-title":"Med Sci Sports Exerc"},{"key":"3960_CR84","doi-asserted-by":"publisher","unstructured":"O'Brien\u00a0\u00a0K, Nixon\u00a0\u00a0S, Tynan\u00a0\u00a0AM, Glazier\u00a0\u00a0R. Aerobic exercise interventions for adults living with HIV\/AIDS. Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No.: CD001796. https:\/\/doi.org\/10.1002\/14651858.CD001796.pub3 .","DOI":"10.1002\/14651858.CD001796.pub3"},{"issue":"1","key":"3960_CR85","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12879-016-1478-2","volume":"16","author":"KK O\u2019Brien","year":"2016","unstructured":"O\u2019Brien KK, Tynan AM, Nixon SA, Glazier RH. Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane collaboration protocol. BMC Infect Dis. 2016;16(1):182.","journal-title":"BMC Infect Dis"},{"issue":"4","key":"3960_CR86","first-page":"626","volume":"2","author":"V Anandh","year":"2014","unstructured":"Anandh V, Peter I, Alagesan J, Rajendran K. Effect of progressive resistance training on functional capacity, quality of life and CD4 count in people with HIV\/AIDS. Int J Physiother Res. 2014;2(4):626\u201330.","journal-title":"Int J Physiother Res"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-3960-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-019-3960-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-3960-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T15:41:18Z","timestamp":1607442078000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-019-3960-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,29]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3960"],"URL":"https:\/\/doi.org\/10.1186\/s12879-019-3960-0","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,29]]},"assertion":[{"value":"29 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the University of Nigeria Health Research Ethics Committee on certificate number - \u2013NHREC\/05\/01\/2008B.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"359"}}