{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:34:27Z","timestamp":1788266067744,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"post-doctoral research start-up fund in Heilongjiang Province","award":["LBH-Q16156"],"award-info":[{"award-number":["LBH-Q16156"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12879-019-4081-5","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T07:41:25Z","timestamp":1558510885000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Epidemiological characteristics, clinical manifestations and laboratory findings in 850 patients with brucellosis in Heilongjiang Province, China"],"prefix":"10.1186","volume":"19","author":[{"given":"Wenhui","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"issue":"6","key":"4081_CR1","doi-asserted-by":"publisher","first-page":"e469","DOI":"10.1016\/j.ijid.2009.06.031","volume":"14","author":"T Buzgan","year":"2010","unstructured":"Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O. Akdeniz clinical manifestations and complications in 1028 cases of brucellosis: a retrospe- ctive evaluation and review of the literature. Int J Infect Dis. 2010;14(6):e469\u201378.","journal-title":"Int J Infect Dis"},{"key":"4081_CR2","unstructured":"Zhang JH, Yin F, Zhang T, Yang C, Zhang XY, Feng ZJ, Li XS. Spatial analysis on human brucellosis incidence in mainland China: 2004-2010. BMJ Open. 2014;(4, 4):e004470."},{"issue":"2","key":"4081_CR3","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3201\/eid2302.151710","volume":"23","author":"SJ Lai","year":"2017","unstructured":"Lai SJ, Zhou H, Xiong WY, Gilbert M, Huang ZJ, Yu JX, et al. Changing epidemiology of human brucellosis, China, 1955-2014. Emerg Infect Dis. 2017;23(2):184\u201394.","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"4081_CR4","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1186\/1471-2334-13-547","volume":"13","author":"YJ Li","year":"2013","unstructured":"Li YJ, Li XL, Liang S, Fang LQ, Cao WC. Epidemiological features and risk factors associated with the spatial and temporal distribution of human brucellosis in China. BMC Infect Dis. 2013;13(1):547.","journal-title":"BMC Infect Dis"},{"issue":"7","key":"4081_CR5","first-page":"475","volume":"24","author":"YW Wang","year":"2009","unstructured":"Wang YW, Sun H. Brucellosis epidemics situation and the countermeasures and suggestions in China. Disease Surveillance. 2009;24(7):475\u20137.","journal-title":"Disease Surveillance"},{"key":"4081_CR6","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/j.ejim.2018.03.004","volume":"51","author":"WL Kong","year":"2018","unstructured":"Kong WL. Brucellosis infection increasing in southern China. Eur J Intern Med. 2018;51:e16\u20138.","journal-title":"Eur J Intern Med"},{"key":"4081_CR7","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S1473-3099(07)70286-4","volume":"7","author":"MP Franco","year":"2007","unstructured":"Franco MP, Mulder M, Gilman RH, Smits HL. Human brucellosis. Lancet Infect Dis. 2007;7:775\u201386.","journal-title":"Lancet Infect Dis"},{"key":"4081_CR8","first-page":"2669","volume-title":"Brucella species. Principles and practice of infectious diseases","author":"EJ Young","year":"2005","unstructured":"Young EJ. Brucella species. Principles and practice of infectious diseases. 6th ed. Philadelphia: Churchill Livingstone; 2005. p. 2669\u201372.","edition":"6"},{"key":"4081_CR9","first-page":"323","volume":"06","author":"Ministry of health of the People\u2019s Republic of China","year":"2012","unstructured":"Ministry of health of the People\u2019s Republic of China. Brucellosis guidelines. Infectious Disease Information. 2012;06:323\u20134,359.","journal-title":"Infectious Disease Information"},{"key":"4081_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-196102000-00001","volume":"40","author":"RG Petersdorf","year":"1961","unstructured":"Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore). 1961;40:1\u201330.","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"4081_CR11","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1093\/cid\/cis980","volume":"56","author":"YF Wang","year":"2013","unstructured":"Wang YF, Zhang WY, Ke YH, Zhen Q, Yuan XT, Zou W, et al. Human brucellosis, a heterogeneouly distributed, delayed, and misdiagnosed disease in China. Clin Infect Dis. 2013;56(5):750\u20131.","journal-title":"Clin Infect Dis"},{"issue":"1\u20134","key":"4081_CR12","first-page":"165","volume":"90","author":"DQ Shang","year":"2002","unstructured":"Shang DQ, Xiao DL, Yin J. Epidemiology and control of brucellosis in China. Vet Microbiol. 2002;90(1\u20134):165\u201382.","journal-title":"Vet Microbiol"},{"key":"4081_CR13","first-page":"5712920","volume":"2018","author":"RJ Zheng","year":"2018","unstructured":"Zheng RJ, Xie SS, Lu XB, Sun LH, Zhou Y, Zhang YX, Wang K. A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. Biomed Res Int. 2018;2018:5712920.","journal-title":"Biomed Res Int"},{"key":"4081_CR14","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1186\/1471-2334-13-514","volume":"13","author":"Y Chen","year":"2013","unstructured":"Chen Y, Ke YH, Wang YF, Yuan XT, Zhou XY, Jiang H, et al. Changes of predominant species\/ biovars and sequence types of Brucella isolates, Inner Mongolia, China. BMC Infect Dis. 2013;13:514.","journal-title":"BMC Infect Dis"},{"issue":"6","key":"4081_CR15","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1017\/S0950268804002833","volume":"132","author":"MR Hasanjani Roushan","year":"2004","unstructured":"Hasanjani Roushan MR, Mohrez M, Smailnejad Gangi SM, Soleimani Amiri MJ, Hajiahmadi M. Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, northern Iran. Epidemiol Infect. 2004;132(6):1109\u201314.","journal-title":"Epidemiol Infect"},{"issue":"11","key":"4081_CR16","doi-asserted-by":"publisher","first-page":"624","DOI":"10.11622\/smedj.2015163","volume":"57","author":"E Kazak","year":"2016","unstructured":"Kazak E, Akal\u0131n H, Y\u0131lmaz E, Heper Y, M\u0131st\u0131k R, S\u0131n\u0131rta\u015f M. Brucellosis: a retrospective evaluation of 164 cases. Singap Med J. 2016;57(11):624\u20139.","journal-title":"Singap Med J"},{"issue":"1","key":"4081_CR17","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000331588","volume":"21","author":"G Mermut","year":"2012","unstructured":"Mermut G, \u00d6zgen\u00e7 O, Avc\u0131 M, Olut AI, \u00d6ktem E, Gen\u00e7 VE. Clinical, diagnostic and therapeutic approaches to complications of brucellosis: an experience of 12 years. Med Princ Pract. 2012;21(1):46\u201350.","journal-title":"Med Princ Pract"},{"issue":"2","key":"4081_CR18","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/clinids\/21.2.283","volume":"21","author":"EJ Young","year":"1995","unstructured":"Young EJ. An overview of human brucellosis. Clin Infect Dis. 1995;21(2):283\u20139.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"4081_CR19","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1542\/pir.2017-0126","volume":"39","author":"ER Harrison","year":"2018","unstructured":"Harrison ER, Posada R. Brucellosis. Pediatr Rev. 2018;39(4):222\u20134.","journal-title":"Pediatr Rev"},{"issue":"1","key":"4081_CR20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/S1413-8670(11)70140-4","volume":"15","author":"C Nurgul","year":"2011","unstructured":"Nurgul C, RecaiT IE, Asuman I, Derya E, Hulya T, et al. Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region. Braz J Infect Dis. 2011;15(1):52\u20139.","journal-title":"Braz J Infect Dis"},{"issue":"1","key":"4081_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1378\/chest.13-0240","volume":"145","author":"H Erdem","year":"2014","unstructured":"Erdem H, Inan A, Elaldi N, Recep T, Serda G, Cigdem AH, et al. Respiratory system involvement in Brucellosis, the results of the Kardelen study. Chest. 2014;145(1):87\u201394.","journal-title":"Chest."},{"issue":"5","key":"4081_CR22","doi-asserted-by":"publisher","first-page":"e0005577","DOI":"10.1371\/journal.pntd.0005577","volume":"11","author":"B Jia","year":"2017","unstructured":"Jia B, Zhang FB, Lu Y, Zhang WB, Li J, Zhang YX, et al. The clinical features of 590 patients with brucellosis in Xinjiang, China with the emphasis on the treatment of complications. PLoS Negl Trop Dis. 2017;11(5):e0005577.","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"4081_CR23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1258\/004947506775598752","volume":"36","author":"OF Kokoglu","year":"2006","unstructured":"Kokoglu OF, HosogluS GMF, Ayaz C, Akallln S, Buyukbese MA, et al. Clinical and laboratory features of brucellosis in two university hospitals in Southeast Turkey. Trop Dr. 2006;36(1):49\u201351.","journal-title":"Trop Dr"},{"key":"4081_CR24","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1056\/NEJMra050570","volume":"352","author":"G Pappas","year":"2005","unstructured":"Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005;352:2325\u201336.","journal-title":"N Engl J Med"},{"issue":"12","key":"4081_CR25","doi-asserted-by":"publisher","first-page":"e1929","DOI":"10.1371\/journal.pntd.0001929","volume":"6","author":"AS Dean","year":"2012","unstructured":"Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. Clinical manifestations of human brucellosis: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2012;6(12):e1929.","journal-title":"PLoS Negl Trop Dis"},{"key":"4081_CR26","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cgh.2006.08.010","volume":"5","author":"N Akritidis","year":"2007","unstructured":"Akritidis N, Tzivras M, Delladetsima I, Stefanaki S, Moutsopoulos HM, Pappas G. The liver in brucellosis. Clin Gastroenterol Hepatol. 2007;5:1109\u201312.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"4081_CR27","first-page":"803","volume":"26","author":"M Karakukcu","year":"2004","unstructured":"Karakukcu M, Patiroglu T, Ozdemir MA, Gunes T, Gumus H, Karakukcu C, et al. Pancytopenia, a rare hematologic manifestation of brucellosis in children. Pediatr Hematol Oncol. 2004;26:803\u20136.","journal-title":"Pediatr Hematol Oncol"},{"key":"4081_CR28","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3855\/jidc.43","volume":"3","author":"A Erbay","year":"2009","unstructured":"Erbay A, Bodur H, Akinci E, Ba\u015ftu\u011f A, Cevik MA. Brucellosis mimicking enteric fever. J Infect Dev Ctries. 2009;3:239\u201340.","journal-title":"J Infect Dev Ctries"},{"issue":"10","key":"4081_CR29","first-page":"19491","volume":"8","author":"PF Jiao","year":"2015","unstructured":"Jiao PF, Chu WL, Ren GF, Hou JN, Li YM, Xing LH. Expression of eosinophils be beneficial to early clinical diagnosis of brucellosis. Int J Clin Exp Med. 2015;8(10):19491\u20135.","journal-title":"Int J Clin Exp Med"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4081-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-019-4081-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4081-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T23:06:05Z","timestamp":1589843165000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-019-4081-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,20]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["4081"],"URL":"https:\/\/doi.org\/10.1186\/s12879-019-4081-5","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,20]]},"assertion":[{"value":"11 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the ethics committee of the First Affiliated Hospital of Harbin Medical University. Due to the retrospective nature of the study, the need for informed consent was waived. Access to case data was approved by the medical record departments of the First Affiliated Hospital of Harbin Medical University and the Second Hospital of Daqing.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"439"}}