{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:17:58Z","timestamp":1768969078247,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2013 Research and Development and Popularization and Application of the Technology of Special Financial Foundation of Guangdong in China","award":["2013-401"],"award-info":[{"award-number":["2013-401"]}]},{"name":"Natural Science Foundation of the Xinjiang Uygur Autonomous Region","award":["2017D01C006"],"award-info":[{"award-number":["2017D01C006"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12879-019-4130-0","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T11:02:40Z","timestamp":1560510160000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Potential circulating biomarkers of circulating chemokines CCL5, MIP-1\u03b2 and HA as for early detection of cirrhosis related to chronic HBV (hepatitis B virus) infection"],"prefix":"10.1186","volume":"19","author":[{"given":"Liangshan","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"issue":"1","key":"4130_CR1","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1186\/s12879-018-3473-2","volume":"18","author":"H Van Tong","year":"2018","unstructured":"Van Tong H, Van Ba N, Hoan NX, Binh MT, Quyen DT, Son HA, Van Luong H, Quyet D, Meyer CG, Song LH, Toan NL, Velavan TP. Soluble fibrinogen-like protein 2 levels in patients with hepatitis B virus-related liver diseases. BMC Infect Dis. 2018;18(1):553.","journal-title":"BMC Infect Dis"},{"issue":"9930","key":"4130_CR2","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","volume":"383","author":"EA Tsochatzis","year":"2014","unstructured":"Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383(9930):1749\u201361.","journal-title":"Lancet."},{"issue":"Suppl 1","key":"4130_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/liv.13682","volume":"38","author":"P Marcellin","year":"2018","unstructured":"Marcellin P, Kutala BK. Liver diseases: a major, neglected global public health problem requiring urgent actions and large-scale screening. Liver Int. 2018;38(Suppl 1):2\u20136.","journal-title":"Liver Int"},{"issue":"1","key":"4130_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.diii.2013.08.009","volume":"95","author":"A Dohan","year":"2014","unstructured":"Dohan A, Guerrache Y, Boudiaf M, Gavini JP, Kaci R, Soyer P. Transjugular liver biopsy: indications, technique and results. Diagn Interv Imaging. 2014;95(1):11\u20135.","journal-title":"Diagn Interv Imaging"},{"issue":"3","key":"4130_CR5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.mayocp.2015.11.015","volume":"91","author":"JH Boyum","year":"2016","unstructured":"Boyum JH, Atwell TD, Schmit GD, Poterucha JJ, Schleck CD, Harmsen WS, Kamath PS. Incidence and risk factors for adverse events related to image-guided liver biopsy. Mayo Clin Proc. 2016;91(3):329\u201335.","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"4130_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1177\/1756283X16681707","volume":"10","author":"H Ou","year":"2017","unstructured":"Ou H, Cai S, Liu Y, Xia M, Peng J. A noninvasive diagnostic model to assess nonalcoholic hepatic steatosis in patients with chronic hepatitis B. Ther Adv Gastroenterol. 2017;10(2):207\u201317.","journal-title":"Ther Adv Gastroenterol"},{"issue":"7","key":"4130_CR7","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/jvh.12682","volume":"24","author":"MY Zhu","year":"2017","unstructured":"Zhu MY, Zou X, Li Q, Yu DM, Yang ZT, Huang D, Chen J, Gong QM, Zhang DH, Zhang Y, Chen L, Chen PZ, Zhang XX. A novel noninvasive algorithm for the assessment of liver fibrosis in patients with chronic hepatitis B virus infection. J Viral Hepat. 2017;24(7):589\u201398.","journal-title":"J Viral Hepat"},{"issue":"6","key":"4130_CR8","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1002\/hep.27389","volume":"60","author":"BK Kim","year":"2014","unstructured":"Kim BK, Kim HS, Yoo EJ, Oh EJ, Park JY, Kim DY, Ahn SH, Han KH, Kim SU, Park YN. Risk assessment of clinical outcomes in Asian patients with chronic hepatitis B using enhance dliver fibrosis test. Hepatology. 2014;60(6):1911\u20139.","journal-title":"Hepatology."},{"issue":"7","key":"4130_CR9","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1053\/j.gastro.2011.02.058","volume":"140","author":"J Vergniol","year":"2011","unstructured":"Vergniol J, Foucher J, Terrebonne E, Bernard PH, le Bail B, Merrouche W, Couzigou P, de Ledinghen V. Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C. Gastroenterology. 2011;140(7):1970\u20139.","journal-title":"Gastroenterology."},{"issue":"2","key":"4130_CR10","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/path.3029","volume":"226","author":"FR Balkwill","year":"2012","unstructured":"Balkwill FR. The chemokine system and cancer. J Pathol. 2012;226(2):148\u201357.","journal-title":"J Pathol"},{"issue":"3","key":"4130_CR11","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.cyto.2012.07.017","volume":"60","author":"JW Jang","year":"2012","unstructured":"Jang JW, Oh BS, Kwon JH, You CR, Chung KW, Kay CS, Jung HS. Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma. Cytokine. 2012;60(3):686\u201393.","journal-title":"Cytokine."},{"issue":"5","key":"4130_CR12","doi-asserted-by":"publisher","first-page":"e0154815","DOI":"10.1371\/journal.pone.0154815","volume":"11","author":"H Xue","year":"2016","unstructured":"Xue H, Lin F, Tan H, Zhu ZQ, Zhang ZY, Zhao L. Overrepresentation of IL-10-expressing B cells suppresses cytotoxic CD4+ T cell activity in HBV-induced hepatocellular carcinoma. PLoS One. 2016;11(5):e0154815.","journal-title":"PLoS One"},{"issue":"5","key":"4130_CR13","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1152\/ajpgi.00215.2003","volume":"285","author":"RF Schwabe","year":"2003","unstructured":"Schwabe RF, Bataller R, Brenner DA. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol. 2003;285(5):949\u201358.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"4130_CR14","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.jhep.2016.12.011","volume":"66","author":"A Mohs","year":"2017","unstructured":"Mohs A, Kuttkat N, Rei\u00dfing J, Zimmermann HW, Sonntag R, Proudfoot A, Youssef SA, de Bruin A, Cubero FJ, Trautwein C. Functional role of CCL5\/RANTES for HCC progression during chronic liver disease. J Hepatol. 2017;66(4):743\u201353.","journal-title":"J Hepatol"},{"issue":"7","key":"4130_CR15","first-page":"1858","volume":"119","author":"E Seki","year":"2009","unstructured":"Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009;119(7):1858\u201370.","journal-title":"J Clin Invest"},{"issue":"4","key":"4130_CR16","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1159\/000374097","volume":"33","author":"L Castera","year":"2015","unstructured":"Castera L. Noninvasive assessment of liver fibrosis. Dig Dis. 2015;33(4):498\u2013503.","journal-title":"Dig Dis"},{"issue":"3","key":"4130_CR17","doi-asserted-by":"publisher","first-page":"668","DOI":"10.7863\/ultra.15.12004","volume":"35","author":"E Karagoz","year":"2016","unstructured":"Karagoz E, Ozturker C, Sivrioglu AK. Noninvasive evaluation of liver fibrosis: is acoustic radiation force impulse a useful tool for evaluating liver fibrosis in patients with chronic hepatitis B and C? J Ultrasound Med. 2016;35(3):668.","journal-title":"J Ultrasound Med"},{"issue":"1","key":"4130_CR18","first-page":"33","volume":"12","author":"C Lucero","year":"2016","unstructured":"Lucero C, Brown RJ. Noninvasive measures of liver fibrosis and severity of liver disease. Gastroenterol Hepatol (NY). 2016;12(1):33\u201340.","journal-title":"Gastroenterol Hepatol (NY)"},{"issue":"7","key":"4130_CR19","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1007\/s11255-015-1017-x","volume":"47","author":"OH Or\u0103\u015fan","year":"2015","unstructured":"Or\u0103\u015fan OH, Sava M, Iancu M, Cozma A, Saplon\u0163ai-Pop A, Sarlea \u0162\u0103rmure S, Lungoci C, Or\u0103\u015fan RA, Patiu IM, Dumitra\u015fcu DL. Serum hyaluronic acid in chronic viral hepatitis B and C: a biomarker for assessing liver fibrosis in chronic hemodialysis patients. Int Urol Nephrol. 2015;47(7):1209\u201317.","journal-title":"Int Urol Nephrol"},{"issue":"2","key":"4130_CR20","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/hep.22650","volume":"49","author":"DH Crawford","year":"2009","unstructured":"Crawford DH, Murphy TL, Ramm LE, Fletcher LM, Clouston AD, Anderson GJ, Subramaniam VN, Powell LW, Ramm GA. Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis. Hepatology. 2009;49(2):418\u201325.","journal-title":"Hepatology."},{"issue":"4","key":"4130_CR21","doi-asserted-by":"publisher","first-page":"e0152757","DOI":"10.1371\/journal.pone.0152757","volume":"11","author":"Z Zhang","year":"2016","unstructured":"Zhang Z, Wang G, Kang K, Wu G, Wang P. The diagnostic accuracy and clinical utility of three noninvasive models for predicting liver fibrosis in patients with HBV infection. PLoS One. 2016;11(4):e0152757.","journal-title":"PLoS One"},{"issue":"4","key":"4130_CR22","doi-asserted-by":"publisher","first-page":"271","DOI":"10.14218\/JCTH.2015.00024","volume":"3","author":"T Lan","year":"2015","unstructured":"Lan T, Chang L, Wu L, Yuan YF. IL-6 plays a crucial role in HBV infection. J Clin Transl Hepatol. 2015;3(4):271\u20136.","journal-title":"J Clin Transl Hepatol"},{"issue":"5","key":"4130_CR23","doi-asserted-by":"publisher","first-page":"6343","DOI":"10.1007\/s13277-015-4520-x","volume":"37","author":"A Tan","year":"2016","unstructured":"Tan A, Gao Y, Yao Z, Su S, Jiang Y, Xie Y, Xian X, Mo Z. Genetic variants in IL12 influence both hepatitis B virus clearance and HBV-related hepatocellular carcinoma development in a Chinese male population. Tumour Biol. 2016;37(5):6343\u20138.","journal-title":"Tumour Biol"},{"key":"4130_CR24","doi-asserted-by":"publisher","unstructured":"Peng MW, Lu SQ, Liu J, Dong CY. Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma. Genet Mol Res. 2016;15(1). \n                    https:\/\/doi.org\/10.4238\/gmr.15017984\n                    \n                  .","DOI":"10.4238\/gmr.15017984"},{"key":"4130_CR25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.trsl.2016.08.006","volume":"180","author":"BH Li","year":"2016","unstructured":"Li BH, He FP, Yang X, Chen YW, Fan JG. Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress. Transl Res. 2016;180:103\u201317.","journal-title":"Transl Res"},{"issue":"2","key":"4130_CR26","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.canlet.2008.03.018","volume":"267","author":"G Soria","year":"2008","unstructured":"Soria G, Ben-Baruch A. The inflammatory chemokines CCL2 and CCL5 in breast cancer. Cancer Lett. 2008;267(2):271\u201385.","journal-title":"Cancer Lett"},{"issue":"9","key":"4130_CR27","doi-asserted-by":"publisher","first-page":"4149","DOI":"10.4049\/jimmunol.1101883","volume":"188","author":"MJ Chenoweth","year":"2012","unstructured":"Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA. IL-15 can signal via IL-15Ralpha, JNK, and NF-kappaB to drive RANTES production by myeloid cells. J Immunol. 2012;188(9):4149\u201357.","journal-title":"J Immunol"},{"issue":"4","key":"4130_CR28","first-page":"678","volume":"6","author":"MK Stock","year":"2013","unstructured":"Stock MK, Hammerich L, do ONT, Berres ML, Alsamman M, Heinrichs D, Nellen A, Trautwein C, Tacke F, Wasmuth HE, Sahin H. Met-CCL5 modifies monocyte subpopulations during liver fibrosis regression. Int J Clin Exp Pathol. 2013;6(4):678\u201385.","journal-title":"Int J Clin Exp Pathol"},{"issue":"6","key":"4130_CR29","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1053\/jhep.2003.09022","volume":"38","author":"P Bedossa","year":"2003","unstructured":"Bedossa P, Dargere D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology. 2003;38(6):1449\u201357.","journal-title":"Hepatology."}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4130-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-019-4130-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4130-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T23:07:22Z","timestamp":1592003242000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-019-4130-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,14]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["4130"],"URL":"https:\/\/doi.org\/10.1186\/s12879-019-4130-0","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,14]]},"assertion":[{"value":"10 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Informed written consent was received from all participants after detailed explanation of the study at the time of blood sampling. All experiments were performed in accordance with relevant guidelines and regulations of the Ethical Committee of Guangdong Second Provincial General Hospital (No. 2014-KYLLh-066).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors disclosed any actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"523"}}