{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:35:09Z","timestamp":1787063709712,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China Mega-Project for Infectious Disease","award":["2017ZX10302301-004 and 2017ZX10104001"],"award-info":[{"award-number":["2017ZX10302301-004 and 2017ZX10104001"]}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["A2017143"],"award-info":[{"award-number":["A2017143"]}]},{"name":"Shenzhen Science and Technology Innovation Committee","award":["JCYJ20160428152017475"],"award-info":[{"award-number":["JCYJ20160428152017475"]}]},{"DOI":"10.13039\/501100014173","name":"Health and Family Planning Commission of Shenzhen Municipality","doi-asserted-by":"crossref","award":["201602009"],"award-info":[{"award-number":["201602009"]}],"id":[{"id":"10.13039\/501100014173","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12879-019-4162-5","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T10:02:33Z","timestamp":1561543353000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The etiology of acute meningitis and encephalitis syndromes in a sentinel pediatric hospital, Shenzhen, China"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5060-7116","authenticated-orcid":false,"given":"Hongwei","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuer","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxuan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"issue":"5","key":"4162_CR1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S1473-3099(10)70048-7","volume":"10","author":"K Edmond","year":"2010","unstructured":"Edmond K, Clark A, Korczak VS, Sanderson C, Griffiths UK, Rudan I. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10(5):317\u201328.","journal-title":"Lancet Infect Dis"},{"issue":"21","key":"4162_CR2","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1056\/NEJMoa1005384","volume":"364","author":"MC Thigpen","year":"2011","unstructured":"Thigpen MC, Whitney CG, Messonnier NE, Zell ER, Lynfield R, Hadler JL, Harrison LH, Farley MM, Reingold A, Bennett NM, et al. Bacterial meningitis in the United States, 1998-2007. N Engl J Med. 2011;364(21):2016\u201325.","journal-title":"N Engl J Med"},{"issue":"1","key":"4162_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3201\/eid2001.120375","volume":"20","author":"Y Li","year":"2014","unstructured":"Li Y, Yin Z, Shao Z, Li M, Liang X, Sandhu HS, Hadler SC, Li J, Sun Y, Li J, et al. Population-based surveillance for bacterial meningitis in China, September 2006-December 2009. Emerg Infect Dis. 2014;20(1):61\u20139.","journal-title":"Emerg Infect Dis"},{"issue":"12","key":"4162_CR4","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S1473-3099(10)70222-X","volume":"10","author":"J Granerod","year":"2010","unstructured":"Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh AL, Morgan D, Cunningham R, Zuckerman M, Mutton KJ, Solomon T, et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010;10(12):835\u201344.","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"4162_CR5","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/rmv.1710","volume":"22","author":"Y Zheng","year":"2012","unstructured":"Zheng Y, Li M, Wang H, Liang G. Japanese encephalitis and Japanese encephalitis virus in mainland China. Rev Med Virol. 2012;22(5):301\u201322.","journal-title":"Rev Med Virol"},{"issue":"5","key":"4162_CR6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.7883\/yoken.JJID.2009.331","volume":"62","author":"H Wang","year":"2009","unstructured":"Wang H, Li Y, Liang X, Liang G. Japanese encephalitis in mainland China. Jpn J Infect Dis. 2009;62(5):331\u20136.","journal-title":"Jpn J Infect Dis"},{"issue":"8","key":"4162_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003015","volume":"8","author":"X Gao","year":"2014","unstructured":"Gao X, Li X, Li M, Fu S, Wang H, Lu Z, Cao Y, He Y, Zhu W, Zhang T, et al. Vaccine strategies for the control and prevention of Japanese encephalitis in mainland China, 1951-2011. PLoS Negl Trop Dis. 2014;8(8):e3015.","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"4162_CR8","first-page":"429","volume":"76","author":"J Li","year":"2018","unstructured":"Li J, Shao Z, Liu G, Bai X, Borrow R, Chen M, Guo Q, Han Y, Li Y, Taha MK, et al. Meningococcal disease and control in China: findings and updates from the global meningococcal initiative (GMI). J Inf Secur. 2018;76(5):429\u201337.","journal-title":"J Inf Secur"},{"issue":"8","key":"4162_CR9","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.vaccine.2014.10.072","volume":"33","author":"J Li","year":"2015","unstructured":"Li J, Li Y, Shao Z, Li L, Yin Z, Ning G, Xu L, Luo H. Prevalence of meningococcal meningitis in China from 2005 to 2010. Vaccine. 2015;33(8):1092\u20137.","journal-title":"Vaccine"},{"issue":"12","key":"4162_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144366","volume":"10","author":"Y Xie","year":"2015","unstructured":"Xie Y, Tan Y, Chongsuvivatwong V, Wu X, Bi F, Hadler SC, Jiraphongsa C, Sornsrivichai V, Lin M, Quan Y. A population-based acute meningitis and encephalitis syndromes surveillance in Guangxi, China, may 2007-June 2012. PLoS One. 2015;10(12):e0144366.","journal-title":"PLoS One"},{"issue":"6","key":"4162_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020675","volume":"6","author":"CT Sacchi","year":"2011","unstructured":"Sacchi CT, Fukasawa LO, Goncalves MG, Salgado MM, Shutt KA, Carvalhanas TR, Ribeiro AF, Kemp B, Gorla MC, Albernaz RK, et al. Incorporation of real-time PCR into routine public health surveillance of culture negative bacterial meningitis in Sao Paulo, Brazil. PLoS One. 2011;6(6):e20675.","journal-title":"PLoS One"},{"issue":"2","key":"4162_CR12","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s10156-009-0670-3","volume":"15","author":"N Chiba","year":"2009","unstructured":"Chiba N, Murayama SY, Morozumi M, Nakayama E, Okada T, Iwata S, Sunakawa K, Ubukata K. Rapid detection of eight causative pathogens for the diagnosis of bacterial meningitis by real-time PCR. J Infect Chemother. 2009;15(2):92\u20138.","journal-title":"J Infect Chemother"},{"issue":"12","key":"4162_CR13","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1097\/01.inf.0000190030.75892.78","volume":"24","author":"SK Saha","year":"2005","unstructured":"Saha SK, Darmstadt GL, Yamanaka N, Billal DS, Nasreen T, Islam M, Hamer DH. Rapid diagnosis of pneumococcal meningitis: implications for treatment and measuring disease burden. Pediatr Infect Dis J. 2005;24(12):1093\u20138.","journal-title":"Pediatr Infect Dis J"},{"issue":"11","key":"4162_CR14","first-page":"874","volume":"10","author":"Y Qin","year":"2016","unstructured":"Qin Y, Mei S, Xie X, Kong D, Tang X. Analysis of the epidemiological characteristics of epidemic cerebrospinal meningitis in Shenzhen during 2005-2015. J Dis Monitor Control. 2016;10(11):874\u20135 (in Chinese).","journal-title":"J Dis Monitor Control"},{"issue":"1","key":"4162_CR15","first-page":"64","volume":"16","author":"L Xu","year":"2009","unstructured":"Xu L, Xie J, Li Y. Analysis on epidemic characteristics of epidemic encephalitis B in Baoan District of Shenzhen. Pract Prev Med. 2009;16(1):64\u20135 (in Chinese).","journal-title":"Pract Prev Med"},{"key":"4162_CR16","first-page":"012","volume":"6","author":"S Z-j","year":"2007","unstructured":"Z-j S, Xu L, Gao Y. Epidemiologic trend of serogroup switching of Neisseria meningitidis strains in China [J]. Chin J Vaccines Immunization. 2007;6:012 (in Chinese).","journal-title":"Chin J Vaccines Immunization"},{"issue":"9","key":"4162_CR17","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.3201\/eid1909.130160","volume":"19","author":"H Zhou","year":"2013","unstructured":"Zhou H, Liu W, Xu L, Deng L, Deng Q, Zhuo J, Shao Z. Spread of Neisseria meningitidis serogroup W clone, China. Emerg Infect Dis. 2013;19(9):1496\u20139.","journal-title":"Emerg Infect Dis"},{"key":"4162_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1471-2334-6-25","volume":"6","author":"CS Chiou","year":"2006","unstructured":"Chiou CS, Liao JC, Liao TL, Li CC, Chou CY, Chang HL, Yao SM, Lee YS. Molecular epidemiology and emergence of worldwide epidemic clones of Neisseria meningitidis in Taiwan. BMC Infect Dis. 2006;6:25.","journal-title":"BMC Infect Dis"},{"issue":"10","key":"4162_CR19","doi-asserted-by":"publisher","first-page":"e150","DOI":"10.1093\/cid\/ciu514","volume":"59","author":"IO Okike","year":"2014","unstructured":"Okike IO, Johnson AP, Henderson KL, Blackburn RM, Muller-Pebody B, Ladhani SN, Anthony M, Ninis N, Heath PT, neoMen Study G. Incidence, etiology, and outcome of bacterial meningitis in infants aged <90 days in the United Kingdom and Republic of Ireland: prospective, enhanced, national population-based surveillance. Clin Infect Dis. 2014;59(10):e150\u20137.","journal-title":"Clin Infect Dis"},{"issue":"9405","key":"4162_CR20","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0140-6736(03)15389-5","volume":"363","author":"PT Heath","year":"2004","unstructured":"Heath PT, Balfour G, Weisner AM, Efstratiou A, Lamagni TL, Tighe H, O'Connell LA, Cafferkey M, Verlander NQ, Nicoll A, et al. Group B streptococcal disease in UK and Irish infants younger than 90 days. Lancet. 2004;363(9405):292\u20134.","journal-title":"Lancet"},{"issue":"2","key":"4162_CR21","first-page":"2939","volume":"8","author":"J Zhang","year":"2015","unstructured":"Zhang J, Zhao R, Dong Y, Zheng Y. Invasive group B streptococcal infection in infants in Shenzhen, China. Int J Clin Exp Med. 2015;8(2):2939\u201343.","journal-title":"Int J Clin Exp Med"},{"issue":"6","key":"4162_CR22","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3346\/jkms.2010.25.6.895","volume":"25","author":"HK Cho","year":"2010","unstructured":"Cho HK, Lee H, Kang JH, Kim KN, Kim DS, Kim YK, Kim JS, Kim JH, Kim CH, Kim HM, et al. The causative organisms of bacterial meningitis in Korean children in 1996-2005. J Korean Med Sci. 2010;25(6):895\u20139.","journal-title":"J Korean Med Sci"},{"issue":"11","key":"4162_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027333","volume":"6","author":"Y Chen","year":"2011","unstructured":"Chen Y, Deng W, Wang SM, Mo QM, Jia H, Wang Q, Li SG, Li X, Yao BD, Liu CJ, et al. Burden of pneumonia and meningitis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review. PLoS One. 2011;6(11):e27333.","journal-title":"PLoS One"},{"issue":"6","key":"4162_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067507","volume":"8","author":"X Ma","year":"2013","unstructured":"Ma X, Zhao R, Ma Z, Yao K, Yu S, Zheng Y, Yang Y. Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates causing invasive diseases from Shenzhen Children's hospital. PLoS One. 2013;8(6):e67507.","journal-title":"PLoS One"},{"issue":"49","key":"4162_CR25","doi-asserted-by":"publisher","first-page":"9127","DOI":"10.1016\/j.vaccine.2011.09.112","volume":"29","author":"E Miller","year":"2011","unstructured":"Miller E, Andrews NJ, Waight PA, Slack MP, George RC. Effectiveness of the new serotypes in the 13-valent pneumococcal conjugate vaccine. Vaccine. 2011;29(49):9127\u201331.","journal-title":"Vaccine"},{"issue":"7","key":"4162_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000674","volume":"2","author":"AG Michos","year":"2007","unstructured":"Michos AG, Syriopoulou VP, Hadjichristodoulou C, Daikos GL, Lagona E, Douridas P, Mostrou G, Theodoridou M. Aseptic meningitis in children: analysis of 506 cases. PLoS One. 2007;2(7):e674.","journal-title":"PLoS One"},{"issue":"4","key":"4162_CR27","doi-asserted-by":"publisher","first-page":"623-629.e1","DOI":"10.1016\/j.jpeds.2010.04.020","volume":"157","author":"Laurent Abel","year":"2010","unstructured":"Abel L, Plancoulaine S, Jouanguy E, Zhang SY, Mahfoufi N, Nicolas N, Sancho-Shimizu V, Alcais A, Guo Y, Cardon A et al: Age-dependent Mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood. J Pediatr 2010, 157(4):623\u2013629, 629 e621.","journal-title":"The Journal of Pediatrics"},{"issue":"9305","key":"4162_CR28","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(02)07681-X","volume":"359","author":"RJ Whitley","year":"2002","unstructured":"Whitley RJ, Gnann JW. Viral encephalitis: familiar infections and emerging pathogens. Lancet. 2002;359(9305):507\u201313.","journal-title":"Lancet"},{"issue":"Pt 10","key":"4162_CR29","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1099\/jmm.0.2008\/000935-0","volume":"57","author":"C Azzari","year":"2008","unstructured":"Azzari C, Moriondo M, Indolfi G, Massai C, Becciolini L, de Martino M, Resti M. Molecular detection methods and serotyping performed directly on clinical samples improve diagnostic sensitivity and reveal increased incidence of invasive disease by Streptococcus pneumoniae in Italian children. J Med Microbiol. 2008;57(Pt 10):1205\u201312.","journal-title":"J Med Microbiol"},{"issue":"10","key":"4162_CR30","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.3168\/jds.S0022-0302(05)73036-8","volume":"88","author":"BE Gillespie","year":"2005","unstructured":"Gillespie BE, Oliver SP. Simultaneous detection of mastitis pathogens, Staphylococcus aureus, Streptococcus uberis, and Streptococcus agalactiae by multiplex real-time polymerase chain reaction. J Dairy Sci. 2005;88(10):3510\u20138.","journal-title":"J Dairy Sci"},{"issue":"17","key":"4162_CR31","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1128\/AEM.02337-10","volume":"77","author":"AF Maheux","year":"2011","unstructured":"Maheux AF, Bissonnette L, Boissinot M, Bernier JL, Huppe V, Picard FJ, Berube E, Bergeron MG. Rapid concentration and molecular enrichment approach for sensitive detection of Escherichia coli and Shigella species in potable water samples. Appl Environ Microbiol. 2011;77(17):6199\u2013207.","journal-title":"Appl Environ Microbiol"},{"issue":"4","key":"4162_CR32","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1128\/JCM.39.4.1553-1558.2001","volume":"39","author":"CE Corless","year":"2001","unstructured":"Corless CE, Guiver M, Borrow R, Edwards-Jones V, Fox AJ, Kaczmarski EB. Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR. J Clin Microbiol. 2001;39(4):1553\u20138.","journal-title":"J Clin Microbiol"},{"issue":"5","key":"4162_CR33","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.resmic.2007.02.008","volume":"158","author":"G Flekna","year":"2007","unstructured":"Flekna G, Stefanic P, Wagner M, Smulders FJ, Mozina SS, Hein I. Insufficient differentiation of live and dead campylobacter jejuni and listeria monocytogenes cells by ethidium monoazide (EMA) compromises EMA\/real-time PCR. Res Microbiol. 2007;158(5):405\u201312.","journal-title":"Res Microbiol"},{"issue":"3","key":"4162_CR34","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1002\/jmv.20291","volume":"75","author":"K Uchida","year":"2005","unstructured":"Uchida K, Shinohara M, Shimada S, Segawa Y, Doi R, Gotoh A, Hondo R. Rapid and sensitive detection of mumps virus RNA directly from clinical samples by real-time PCR. J Med Virol. 2005;75(3):470\u20134.","journal-title":"J Med Virol"},{"issue":"7","key":"4162_CR35","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1128\/JCM.38.7.2638-2642.2000","volume":"38","author":"HH Kessler","year":"2000","unstructured":"Kessler HH, Muhlbauer G, Rinner B, Stelzl E, Berger A, Dorr HW, Santner B, Marth E, Rabenau H. Detection of herpes simplex virus DNA by real-time PCR. J Clin Microbiol. 2000;38(7):2638\u201342.","journal-title":"J Clin Microbiol"},{"issue":"1\u20132","key":"4162_CR36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jviromet.2005.02.001","volume":"126","author":"K Shirato","year":"2005","unstructured":"Shirato K, Miyoshi H, Kariwa H, Takashima I. Detection of West Nile virus and Japanese encephalitis virus using real-time PCR with a probe common to both viruses. J Virol Methods. 2005;126(1\u20132):119\u201325.","journal-title":"J Virol Methods"},{"key":"4162_CR37","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/1743-422X-6-95","volume":"6","author":"MA Piqueur","year":"2009","unstructured":"Piqueur MA, Verstrepen WA, Bruynseels P, Mertens AH. Improvement of a real-time RT-PCR assay for the detection of enterovirus RNA. Virol J. 2009;6:95.","journal-title":"Virol J"},{"issue":"2","key":"4162_CR38","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/jmv.10382","volume":"70","author":"A Heim","year":"2003","unstructured":"Heim A, Ebnet C, Harste G, Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR. J Med Virol. 2003;70(2):228\u201339.","journal-title":"J Med Virol"},{"issue":"4","key":"4162_CR39","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1128\/JCM.41.4.1565-1568.2003","volume":"41","author":"M Weidmann","year":"2003","unstructured":"Weidmann M, Meyer-Konig U, Hufert FT. Rapid detection of herpes simplex virus and varicella-zoster virus infections by real-time PCR. J Clin Microbiol. 2003;41(4):1565\u20138.","journal-title":"J Clin Microbiol"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4162-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-019-4162-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4162-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T15:48:41Z","timestamp":1694965721000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-019-4162-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["4162"],"URL":"https:\/\/doi.org\/10.1186\/s12879-019-4162-5","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]},"assertion":[{"value":"14 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All aspects of the study were performed in accordance with national ethics regulations and approved by the Ethics Committee of Shenzhen Children\u2019s Hospital and Futian District Center for Disease Control and Prevention. Written consent was obtained from children\u2019s parents or guardians.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"560"}}