{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:17:19Z","timestamp":1780719439130,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12879-019-4348-x","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T13:02:38Z","timestamp":1565701358000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical benefits of FilmArray meningitis-encephalitis PCR assay in partially-treated bacterial meningitis in Israel"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-6623","authenticated-orcid":false,"given":"Yair","family":"Mina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered","family":"Schechner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Savion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna","family":"Yahav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efraim","family":"Bilavsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Sorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Ben-Zvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"issue":"18","key":"4348_CR1","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1056\/NEJMoa040845","volume":"351","author":"D van de Beek","year":"2004","unstructured":"van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351(18):1849\u201359.","journal-title":"N Engl J Med"},{"issue":"9854","key":"4348_CR2","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/S0140-6736(12)61187-8","volume":"380","author":"PB McIntyre","year":"2012","unstructured":"McIntyre PB, O'Brien KL, Greenwood B, van de Beek D. Effect of vaccines on bacterial meningitis worldwide. Lancet. 2012;380(9854):1703\u201311.","journal-title":"Lancet."},{"issue":"21","key":"4348_CR3","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1056\/NEJMoa1005384","volume":"364","author":"MC Thigpen","year":"2011","unstructured":"Thigpen MC, Whitney CG, Messonnier NE, Zell ER, Lynfield R, Hadler JL, et al. Bacterial meningitis in the United States, 1998-2007. N Engl J Med. 2011;364(21):2016\u201325.","journal-title":"N Engl J Med"},{"issue":"4","key":"4348_CR4","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S1473-3099(13)70332-3","volume":"14","author":"IO Okike","year":"2014","unstructured":"Okike IO, Ribeiro S, Ramsay ME, Heath PT, Sharland M, Ladhani SN. Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study. Lancet Infect Dis. 2014;14(4):301\u20137.","journal-title":"Lancet Infect Dis"},{"issue":"36","key":"4348_CR5","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.1016\/j.vaccine.2017.05.059","volume":"36","author":"S Ben-Shimol","year":"2018","unstructured":"Ben-Shimol S, Givon-Lavi N, Grisaru-Soen G, Megged O, Greenberg D, Dagan R, et al. Comparative incidence dynamics and serotypes of meningitis, bacteremic pneumonia and other-IPD in young children in the PCV era: insights from Israeli surveillance studies. Vaccine. 2018;36(36):5477\u201384.","journal-title":"Vaccine."},{"issue":"9","key":"4348_CR6","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1086\/425368","volume":"39","author":"AR Tunkel","year":"2004","unstructured":"Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39(9):1267\u201384.","journal-title":"Clin Infect Dis"},{"issue":"Suppl 3","key":"4348_CR7","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1016\/j.cmi.2016.01.007","volume":"22","author":"D van de Beek","year":"2016","unstructured":"van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, et al. ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect. 2016;22(Suppl 3):S37\u201362.","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"4348_CR8","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.bjm.2016.06.014","volume":"48","author":"EO Baspinar","year":"2017","unstructured":"Baspinar EO, Dayan S, Bekcibasi M, Tekin R, Ayaz C, Deveci O, et al. Comparison of culture and PCR methods in the diagnosis of bacterial meningitis. Braz J Microbiol. 2017;48(2):232\u20136.","journal-title":"Braz J Microbiol"},{"issue":"5","key":"4348_CR9","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1542\/peds.108.5.1169","volume":"108","author":"JT Kanegaye","year":"2001","unstructured":"Kanegaye JT, Soliemanzadeh P, Bradley JS. Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment. Pediatrics. 2001;108(5):1169\u201374.","journal-title":"Pediatrics."},{"issue":"3","key":"4348_CR10","first-page":"193","volume":"7","author":"V Bohr","year":"1983","unstructured":"Bohr V, Rasmussen N, Hansen B, Kjersem H, Jessen O, Johnsen N, et al. 875 cases of bacterial meningitis: diagnostic procedures and the impact of preadmission antibiotic therapy. Part III of a three-part series. J Inf Secur. 1983;7(3):193\u2013202.","journal-title":"J Inf Secur"},{"issue":"4","key":"4348_CR11","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1542\/peds.2007-3275","volume":"122","author":"LE Nigrovic","year":"2008","unstructured":"Nigrovic LE, Malley R, Macias CG, Kanegaye JT, Moro-Sutherland DM, Schremmer RD, et al. Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. Pediatrics. 2008;122(4):726\u201330.","journal-title":"Pediatrics."},{"issue":"3","key":"4348_CR12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1128\/CMR.00070-09","volume":"23","author":"MC Brouwer","year":"2010","unstructured":"Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev. 2010;23(3):467\u201392.","journal-title":"Clin Microbiol Rev"},{"issue":"5","key":"4348_CR13","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1128\/JCM.00469-14","volume":"52","author":"T Meyer","year":"2014","unstructured":"Meyer T, Franke G, Polywka SK, Lutgehetmann M, Gbadamosi J, Magnus T, et al. Improved detection of bacterial central nervous system infections by use of a broad-range PCR assay. J Clin Microbiol. 2014;52(5):1751\u20133.","journal-title":"J Clin Microbiol"},{"issue":"9","key":"4348_CR14","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s10096-007-0350-0","volume":"26","author":"E Van Gastel","year":"2007","unstructured":"Van Gastel E, Bruynseels P, Verstrepen W, Mertens A. Evaluation of a real-time polymerase chain reaction assay for the diagnosis of pneumococcal and meningococcal meningitis in a tertiary care hospital. Eur J Clin Microbiol Infect Dis. 2007;26(9):651\u20133.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"4348_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1086\/426436","volume":"40","author":"I Parent du Chatelet","year":"2005","unstructured":"Parent du Chatelet I, Traore Y, Gessner BD, Antignac A, Naccro B, Njanpop-Lafourcade BM, et al. Bacterial meningitis in Burkina Faso: surveillance using field-based polymerase chain reaction testing. Clin Infect Dis. 2005;40(1):17\u201325.","journal-title":"Clin Infect Dis"},{"issue":"5","key":"4348_CR16","first-page":"385","volume":"67","author":"E Heinsbroek","year":"2013","unstructured":"Heinsbroek E, Ladhani S, Gray S, Guiver M, Kaczmarski E, Borrow R, et al. Added value of PCR-testing for confirmation of invasive meningococcal disease in England. J Inf Secur. 2013;67(5):385\u201390.","journal-title":"J Inf Secur"},{"issue":"2","key":"4348_CR17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.diagmicrobio.2008.10.008","volume":"63","author":"C Munoz-Almagro","year":"2009","unstructured":"Munoz-Almagro C, Rodriguez-Plata MT, Marin S, Esteva C, Esteban E, Gene A, et al. Polymerase chain reaction for diagnosis and serogrouping of meningococcal disease in children. Diagn Microbiol Infect Dis. 2009;63(2):148\u201354.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"9","key":"4348_CR18","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1128\/JCM.00730-16","volume":"54","author":"AL Leber","year":"2016","unstructured":"Leber AL, Everhart K, Balada-Llasat JM, Cullison J, Daly J, Holt S, et al. Multicenter evaluation of BioFire FilmArray meningitis\/encephalitis panel for detection of Bacteria, viruses, and yeast in cerebrospinal fluid specimens. J Clin Microbiol. 2016;54(9):2251\u201361.","journal-title":"J Clin Microbiol"},{"issue":"4","key":"4348_CR19","first-page":"225","volume":"12","author":"O Waisbourd-Zinman","year":"2010","unstructured":"Waisbourd-Zinman O, Bilavsky E, Tirosh N, Samra Z, Amir J. Penicillin and ceftriaxone susceptibility of Streptococcus pneumoniae isolated from cerebrospinal fluid of children with meningitis hospitalized in a tertiary hospital in Israel. Isr Med Assoc J. 2010;12(4):225\u20138.","journal-title":"Isr Med Assoc J"},{"key":"4348_CR20","doi-asserted-by":"crossref","unstructured":"Leber AL. Clinical microbiology procedures handbook. 4th edition. ed. Washington, DC: ASM Press; 2016. 3 volumes p.","DOI":"10.1128\/9781555818814"},{"issue":"4","key":"4348_CR21","doi-asserted-by":"publisher","first-page":"e01927","DOI":"10.1128\/JCM.01927-17","volume":"56","author":"Rachael M. Liesman","year":"2018","unstructured":"Liesman RM, Strasburg AP, Heitman AK, Theel ES, Patel R, Binnicker MJ. Evaluation of a commercial multiplex molecular panel for diagnosis of infectious meningitis and encephalitis. J Clin Microbiol. 2018;56(4).","journal-title":"Journal of Clinical Microbiology"},{"key":"4348_CR22","doi-asserted-by":"crossref","unstructured":"Soucek DK, Dumkow LE, VanLangen KM, Jameson AP. Cost justification of the BioFire FilmArray meningitis\/encephalitis panel versus standard of Care for Diagnosing Meningitis in a community hospital. J Pharm Pract. 2017; 897190017737697.","DOI":"10.1177\/0897190017737697"},{"key":"4348_CR23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12941-016-0137-1","volume":"15","author":"SH Wootton","year":"2016","unstructured":"Wootton SH, Aguilera E, Salazar L, Hemmert AC, Hasbun R. Enhancing pathogen identification in patients with meningitis and a negative gram stain using the BioFire FilmArray((R)) meningitis\/encephalitis panel. Ann Clin Microbiol Antimicrob. 2016;15:26.","journal-title":"Ann Clin Microbiol Antimicrob"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4348-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-019-4348-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4348-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T15:43:38Z","timestamp":1664120618000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-019-4348-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["4348"],"URL":"https:\/\/doi.org\/10.1186\/s12879-019-4348-x","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,13]]},"assertion":[{"value":"28 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved and retrospectively registered by the Tel-Aviv Sourasky Medical Center (0378\u201317-TLV, 10\/17\/2017) and Rabin Medical Center (0270\u201318-RMC, 11\/11\/2018) Ethics committees and conforms to recognized standards. Due to the retrospective nature of the study, informed consent was determined to be unnecessary.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Author AA received travel grants from the bioMerieux company.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"713"}}