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This clinical trial study aimed to evaluate the effect of a last resort therapy with topical 0.09%<jats:italic>sodium chlorosum<\/jats:italic>on LCL in Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty Iranian patients (12 women and 8 men) with LCL refractory to treatment were included in this salvage study. A magistral preparation of<jats:italic>sodium chlorosum<\/jats:italic>(10\u2009mM NaClO<jats:sub>2<\/jats:sub>in amphiphilic basic cream) was applied twice daily to the lesions for 6\u2009weeks and continued up to 12\u2009weeks in patients who showed a clinical response within the first 6\u2009weeks. Responders were followed up for a maximum of 1 year. Lesions were photographed during weekly visits. Disappearance of erythema and indurated lesions were rated as complete clinical response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with a mean age of 28.6 (\u00b124.3) and with an ACL proven lesion history of 3.8 (\u00b11.4) years were treated for an average of 7.9 (\u00b11.8) weeks. At the end of the treatment period (12th week), a complete response was observed in 9 of 20 patients (45%). During the one-year follow-up period, LCL lesions recurred in 4 of these 9 patients (with one patient showing only a tiny lesion) and one case lost to follow up whereas the other four remained completely lesion-free. Mild temporary side-effects such as erythema and itching were seen in 4 of 20 patients (20%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical<jats:italic>sodium chlorosum<\/jats:italic>showed promising therapeutic results and can be considered as safe, painless, and relatively effective treatment for LCL, an ethical prerequisite for a two-armed controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>This study was registered in Iranian registry of clinical trials on 2019-02-02 with registration number<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/irct.ir\/trial\/36799\">IRCT20190114042356N1<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12879-019-4518-x","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T15:03:13Z","timestamp":1574953393000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Salvage therapy with Sodium chlorosum (formerly DAC N-055) for cases of refractory lupoid cutaneous leishmaniasis: results from a compassionate use study with 0.09% Sodium chlorosum in amphiphilic basic cream"],"prefix":"10.1186","volume":"19","author":[{"given":"Sara","family":"Molkara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaheh","family":"Poursoltani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt-Wilhelm","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Maleki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Khamesipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bogdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-3144","authenticated-orcid":false,"given":"Vahid Mashayekhi","family":"Goyonlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"4518_CR1","volume-title":"WHO technical report series 949: control of the leishmaniases, report of a meeting of the WHO expert committee on the control of Leishmaniases, Geneva, 22\u201326 March 2010","author":"World Health Organization","year":"2010","unstructured":"World Health Organization. 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All participants signed the informed consent form after reading the information sheet before including them in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed written consent for the publication of details and pictures was obtained from the patient. Consent form can be made available to the editor on request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"KWS is President of the NGO WM e. V., which donated the 0.09% <i>sodium chlorosum<\/i> basic cream. The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1005"}}