{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:37:35Z","timestamp":1792553855669,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human cytomegalovirus (HCMV) can cause poor outcomes in solid organ transplant (SOT) recipients; moreover, it is associated with cardiovascular diseases (CVD) in the general population. Accordingly, anti-HCMV immunoglobulin G (IgG) seroepidemiology may be useful in identifying the risk of post-SOT HCMV infection or disease as well as immunosenescence or CVD. However, HCMV seroprevalence and titre have not been fully evaluated with regard to age distribution or compared between SOT recipients and healthy individuals in South Korea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively retrieved all unduplicated anti-HCMV IgG results of individuals aged &gt;\u20091\u2009year evaluated between July 2006 and November 2017 at Severance Hospital in Seoul. The cohort, excluding haematopoietic stem cell transplant recipients and subjects with equivocal values, included 2184 SOT recipients and 3015 healthy transplant donors. All IgG results in the SOT recipients were measured during the pre-transplant period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall IgG seroprevalence and titres were significantly higher among SOT recipients than among healthy donors (98.7% vs. 88.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, and 64.7\u2009\u00b1\u200944.3 vs. 49.8\u2009\u00b1\u200920.6 arbitrary units\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively). The lowest seropositive rate in the SOT group was observed in recipients aged between 11 and 15\u2009years (70.6%). The frequency of seropositivity among adults aged \u226541\u2009years increased to \u226590% in SOT recipients and healthy donors. Age was independently associated with higher HCMV seroprevalence (41\u201360\u2009years, OR, 76.4, 95% CI, 24.5\u2013238.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; \u2265 61\u2009years, OR, 4.4, 95% CI, 1.3\u201314.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, compared to \u226440\u2009years). The healthy donor group had an independently low HCMV seropositive rate (OR, 0.1, 95% CI, 0.1\u20130.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HCMV seropositivity was the lowest among school-aged children and adolescents. IgG testing revealed an intermediate serostatus risk of post-transplant HCMV infection and disease for most adult SOT recipients in South Korea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-019-4607-x","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T10:27:31Z","timestamp":1573208851000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Human cytomegalovirus seroprevalence and titres in solid organ transplant recipients and transplant donors in Seoul, South Korea"],"prefix":"10.1186","volume":"19","author":[{"given":"Yeonju","family":"La","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Eun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seul Gi","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4278-5198","authenticated-orcid":false,"given":"Sang Hoon","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Goo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"issue":"8","key":"4607_CR1","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1111\/ajt.13791","volume":"16","author":"H Kaminski","year":"2016","unstructured":"Kaminski H, Fishman JA. 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