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The relation between its presence in the genitourinary tract and manifested clinical symptoms of STD patients remains an open question. In this study, a complex epidemiological investigation of GBS isolates from a venerology clinic was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ninety-six\u00a0GBS isolates were serotyped and their genetic relatedness determined by PFGE. MLST was also performed for a subset of 20 isolates. The antibiotic susceptibility was tested with agar dilution. Surface proteins and the ST-17 hypervirulent clone was detected by PCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The serotype prevalence was the following: V (29.2%), III (27.1%), Ia (22.9%), IV (10.4%), II (5.2%) and Ib (4.2%). A strong association was demonstrated between surface protein genes and serotypes. All isolates were fully susceptible to penicillin, but erythromycin and clindamycin resistance was high (41.7 and 35.4%, respectively), and 8 phenotypically macrolide sensitive isolates carried the <jats:italic>ermB<\/jats:italic> gene.<\/jats:p>\n                <jats:p>21.9% of all strains belonged to the hypervirulent ST17 clone, most being of serotype III and all were <jats:italic>rib<\/jats:italic> +. We found a few serotype IV isolates belonging to several STs and one serotype V\/ST110 strain, containing a 44-bp deletion in the <jats:italic>atr<\/jats:italic> allele.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The presence of silent <jats:italic>ermB<\/jats:italic> genes is of worry, as their expression upon macrolide exposure could lead to unforeseen therapeutic failure, while clindamycin is used for intrapartum antibiotic prophylaxis, in case of penicillin allergy. The other alarming result is the high prevalence of ST17 among these strains from STD patients, who could be sources of further infections.<\/jats:p>\n                <jats:p>This is the first report from Hungary providing both serotyping and genotyping data of GBS isolates. These results could be helpful for vaccine production as the major vaccine candidates are capsular antigens or surface proteins.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-019-4626-7","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T18:03:12Z","timestamp":1574964192000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["High prevalence of group B streptococcus ST17 hypervirulent clone among non-pregnant patients from a Hungarian venereology clinic"],"prefix":"10.1186","volume":"19","author":[{"given":"Szilvia","family":"Kardos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienn","family":"T\u00f3thp\u00e1l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Laub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Krist\u00f3f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Ostorh\u00e1zi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Rozgonyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-2288","authenticated-orcid":false,"given":"Orsolya","family":"Dobay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"issue":"9146","key":"4626_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(98)07128-1","volume":"353","author":"A Schuchat","year":"1999","unstructured":"Schuchat A. 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Patients were aware during their routine check-up performed by the Clinic that some of their samples might be used for further research. These bacteria are not part of the patients (like e.g. a tissue biopsy), and were not specifically collected for the study. Furthermore, when studying these bacteria, the isolates were used anonymously, we were not aware of the patients personal data except for age and gender and would not be able to identify them. Therefore, no consent was required.All permissions have been obtained from the Dermatology, Dermatooncology and Venerology Clinic of the Semmelweis University, including the use and publications of their data.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1009"}}