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T. marneffei<\/jats:italic> usually causes invasive and disseminated infections, including fungemia. <jats:italic>T. marneffei<\/jats:italic> oro-pharyngo-laryngitis is an unusual manifestation of talaromycosis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 52-year-old Thai woman had been diagnosed anti-IFN\u0263 autoantibodies for 4\u2009years. She had a sore throat, odynophagia, and hoarseness for 3\u2009weeks. She also had febrile symptoms and lost 5\u2009kg in weight. Physical examination revealed marked swelling and hyperemia of both sides of the tonsils, the uvula and palatal arches including a swelling of the epiglottis, and arytenoid. The right tonsillar biopsy exhibited a few intracellular oval and elongated yeast-like organisms with some central transverse septum seen, which subsequently grew a few colonies of <jats:italic>T. marneffei<\/jats:italic> on fungal cultures. The patient received amphotericin B deoxycholate 45\u2009mg\/dayfor 1\u2009weeks, followed by oral itraconazole 400\u2009mg\/day for several months. Her symptoms completely resolved without complication.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In patients with anti-IFN-\u0263 autoantibodies, <jats:italic>T. marneffei<\/jats:italic> can rarely cause a local infection involving oropharynx and larynx. Fungal culture and pathological examination are warranted for diagnosis <jats:italic>T<\/jats:italic>. <jats:italic>marneffei<\/jats:italic> oro-pharyngo-laryngitis. This condition requires a long term antifungal therapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12879-019-4650-7","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T14:02:43Z","timestamp":1575554563000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis"],"prefix":"10.1186","volume":"19","author":[{"given":"Thanyarak","family":"Wongkamhla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piriyaporn","family":"Chongtrakool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-156X","authenticated-orcid":false,"given":"Anupop","family":"Jitmuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"issue":"1","key":"4650_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1128\/CMR.19.1.95-110.2006","volume":"19","author":"N Vanittanakom","year":"2006","unstructured":"Vanittanakom N, Cooper CR Jr, Fisher MC, Sirisanthana T. 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