{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:21:29Z","timestamp":1793118089146,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Guangxi Natural Science Foundation","award":["2016GXNSFAA380297"],"award-info":[{"award-number":["2016GXNSFAA380297"]}]},{"name":"the Talents Highland of Emergency and Medical Rescue of Guangxi Province in China","award":["GXJZ201605"],"award-info":[{"award-number":["GXJZ201605"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To investigate the clinical features of septic pulmonary embolism (SPE) cases and prognostic factors for in-hospital mortality in China.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective analysis was conducted of SPE patients hospitalized between January 2007 and June 2018 in the Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 98 patients with SPE were identified. All patients had bilateral multiple peripheral nodules on chest computed tomography. The most common pathogen found in blood culture was <jats:italic>Staphylococcus aureus<\/jats:italic> (10\/33, 30.3%). Transthoracic echocardiography was performed in 39 patients and 20 showed vegetations. Bronchoscopy was performed in 24 patients. Bronchoalveolar lavage fluid (BALF) was obtained from 15 patients (62.5%) and showed predominantly polymorphonuclear cell infiltration (52%, range of 48%~\u200963%). Four patients received transbronchial lung biopsy, and histopathological examinations revealed suppurative pneumonia and organizing pneumonia. The in-hospital mortality rate was 19.4%. Age (odds ratio [OR] 1.100; 95% confidence interval [CI] 1.035\u20131.169), hypotension (OR 7.260; 95% CI 1.126\u201346.804) and ineffective or delay of empirical antimicrobial therapy (OR 7.341; 95% CI 1.145\u201347.045) were found to be independent risk factors for in-hospital mortality, whereas drainage treatment was found to be a protective factor (OR 0.33; 95% CI 0.002\u20130.677).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>SPE cases presented with nonspecific clinical manifestations and radiologic features. Blood cultures and bronchoscopy are important measures for early diagnosis and differential diagnosis. There is relationship between primary infection sites and the type of pathogen. Maintaining normal blood pressure and providing timely and appropriate initial antimicrobial therapy for effective control of the infection could improve prognosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-019-4672-1","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T17:02:58Z","timestamp":1577466178000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Septic pulmonary embolism in China: clinical features and analysis of prognostic factors for mortality in 98 cases"],"prefix":"10.1186","volume":"19","author":[{"given":"Jing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-li","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-qi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-ye","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-liang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"issue":"6","key":"4672_CR1","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.2214\/ajr.174.6.1741499","volume":"174","author":"SE Rossi","year":"2000","unstructured":"Rossi SE, Goodman PC, Franquet T. Nonthrombotic pulmonary emboli. AJR Am J Roentgenol. 2000;174(6):1499\u2013508.","journal-title":"AJR Am J Roentgenol"},{"issue":"9","key":"4672_CR2","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/S1726-4901(08)70146-1","volume":"71","author":"PW Yang","year":"2008","unstructured":"Yang PW, Lin HD, Wang LM. Pyogenic liver abscess associated with septic pulmonary embolism. J Chin Med Assoc. 2008;71(9):442\u20137.","journal-title":"J Chin Med Assoc"},{"issue":"1","key":"4672_CR3","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1378\/chest.128.1.162","volume":"128","author":"RJ Cook","year":"2005","unstructured":"Cook RJ, Ashton RW, Aughenbaugh GL, Ryu JH. Septic pulmonary embolism: presenting features and clinical course of 14 patients. Chest. 2005;128(1):162\u20136.","journal-title":"Chest."},{"key":"4672_CR4","doi-asserted-by":"publisher","first-page":"28","DOI":"10.2174\/1874306401408010028","volume":"8","author":"U Goswami","year":"2014","unstructured":"Goswami U, Brenes JA, Punjabi GV, LeClaire MM, Williams DN. Associations and outcomes of septic pulmonary embolism. Open Respir Med J. 2014;8:28\u201333.","journal-title":"Open Respir Med J"},{"issue":"12","key":"4672_CR5","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1001\/archinte.1992.00400240050008","volume":"152","author":"AJ Mansur","year":"1992","unstructured":"Mansur AJ, Grinberg M, da Luz PL, Bellotti G. The complications of infective endocarditis. A reappraisal in the 1980s. Arch Intern Med. 1992;152(12):2428\u201332.","journal-title":"Arch Intern Med"},{"issue":"3","key":"4672_CR6","first-page":"230","volume":"54","author":"SJ Lee","year":"2007","unstructured":"Lee SJ, Cha SI, Kim CH, Park JY, Jung TH, Jeon KN, Kim GW. Septic pulmonary embolism in Korea: microbiology, clinicoradiologic features, and treatment outcome. J Inf Secur. 2007;54(3):230\u20134.","journal-title":"J Inf Secur"},{"issue":"2","key":"4672_CR7","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/j.1440-1843.2012.02278.x","volume":"18","author":"T Hatani","year":"2013","unstructured":"Hatani T, Takemura M, Inoue D, Takamatsu K, Ishitoko M, Itotani R, Suzuki S, Matsumoto M, Sakuramoto M, Fukui M. Septic pulmonary embolism due to periodontal disease. Respirology. 2013;18(2):308\u201312.","journal-title":"Respirology"},{"issue":"5","key":"4672_CR8","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/S0022-5223(19)41311-1","volume":"75","author":"JC MacMillan","year":"1978","unstructured":"MacMillan JC, Milstein SH, Samson PC. Clinical spectrum of septic pulmonary embolism and infarction. J Thorac Cardiovasc Surg. 1978;75(5):670\u20139.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"4672_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0167-5273(84)90242-0","volume":"6","author":"IP Panidis","year":"1984","unstructured":"Panidis IP, Kotler MN, Mintz GS, Ross J, Weber J. Clinical and echocardiographic correlations in right heart endocarditis. Int J Cardiol. 1984;6(1):17\u201334.","journal-title":"Int J Cardiol"},{"issue":"Suppl 2","key":"4672_CR10","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1086\/511159","volume":"44","author":"LA Mandell","year":"2007","unstructured":"Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM Jr, Musher DM, Niederman MS, et al. Infectious diseases society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis :Official Publ Infect Dis Soc Ame. 2007;44(Suppl 2):S27\u201372.","journal-title":"Clin Infect Dis :Official Publ Infect Dis Soc Ame"},{"issue":"18","key":"4672_CR11","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1001\/jama.279.18.1452","volume":"279","author":"EA Halm","year":"1998","unstructured":"Halm EA, Fine MJ, Marrie TJ, Coley CM, Kapoor WN, Obrosky DS, Singer DE. Time to clinical stability in patients hospitalized with community-acquired pneumonia: implications for practice guidelines. Jama. 1998;279(18):1452\u20137.","journal-title":"Jama"},{"issue":"12","key":"4672_CR12","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1086\/426028","volume":"39","author":"R Menendez","year":"2004","unstructured":"Menendez R, Torres A. Rodriguez de Castro F, Zalacain R, Aspa J, Martin Villasclaras JJ, Borderias L, Benitez Moya JM, Ruiz-Manzano J, Blanquer J et al: reaching stability in community-acquired pneumonia: the effects of the severity of disease, treatment, and the characteristics of patients. Clin Infect Dis : Official Publ Infect Dis Soc Am. 2004;39(12):1783\u201390.","journal-title":"Clin Infect Dis : Official Publ Infect Dis Soc Am"},{"issue":"1","key":"4672_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rmed.2013.10.012","volume":"108","author":"R Ye","year":"2014","unstructured":"Ye R, Zhao L, Wang C, Wu X, Yan H. Clinical characteristics of septic pulmonary embolism in adults: a systematic review. Respir Med. 2014;108(1):1\u20138.","journal-title":"Respir Med"},{"issue":"8","key":"4672_CR14","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.jiac.2016.05.008","volume":"22","author":"HG Oh","year":"2016","unstructured":"Oh HG, Cha SI, Shin KM, Lim JK, Kim HJ, Yoo SS, Lee J, Lee SY, Kim CH, Park JY. Risk factors for mortality in patients with septic pulmonary embolism. J Infect Chemother : Official J Japan Soc Chemother. 2016;22(8):553\u20138.","journal-title":"J Infect Chemother : Official J Japan Soc Chemother"},{"issue":"1","key":"4672_CR15","first-page":"105","volume":"144","author":"GL Griffith","year":"1977","unstructured":"Griffith GL, Maull KI, Sachatello CR. Septic pulmonary embolization. Surg Gynecol Obstet. 1977;144(1):105\u20138.","journal-title":"Surg Gynecol Obstet"},{"issue":"5","key":"4672_CR16","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1086\/590932","volume":"47","author":"SS Lee","year":"2008","unstructured":"Lee SS, Chen YS, Tsai HC, Wann SR, Lin HH, Huang CK, Liu YC. Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess. Clin Infect Dis. 2008;47(5):642\u201350.","journal-title":"Clin Infect Dis"},{"issue":"6","key":"4672_CR17","doi-asserted-by":"publisher","first-page":"400","DOI":"10.6061\/clinics\/2015(06)03","volume":"70","author":"DW Chou","year":"2015","unstructured":"Chou DW, Wu SL, Chung KM, Han SC. Septic pulmonary embolism caused by a Klebsiella pneumoniae liver abscess: clinical characteristics, imaging findings, and clinical courses. Clin (Sao Paulo). 2015;70(6):400\u20137.","journal-title":"Clin (Sao Paulo)"},{"issue":"3","key":"4672_CR18","first-page":"285","volume":"72","author":"MM Wahidi","year":"2005","unstructured":"Wahidi MM, Rocha AT, Hollingsworth JW, Govert JA, Feller-Kopman D, Ernst A. Contraindications and safety of transbronchial lung biopsy via flexible bronchoscopy. A survey of pulmonologists and review of the literature. Respir; Int Rev Thorac Dis. 2005;72(3):285\u201395.","journal-title":"Respir; Int Rev Thorac Dis"},{"issue":"5","key":"4672_CR19","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.ultrasmedbio.2018.01.016","volume":"44","author":"YQ Guo","year":"2018","unstructured":"Guo YQ, Liao XH, Li ZX, Chen YY, Wang SD, Wang JH, Liao XS, Luo Y. Ultrasound-guided percutaneous needle biopsy for peripheral pulmonary lesions: diagnostic accuracy and influencing factors. Ultrasound Med Biol. 2018;44(5):1003\u201311.","journal-title":"Ultrasound Med Biol"},{"issue":"1","key":"4672_CR20","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1148\/radiol.13131265","volume":"271","author":"SM Lee","year":"2014","unstructured":"Lee SM, Park CM, Lee KH, Bahn YE, Kim JI, Goo JM. C-arm cone-beam CT-guided percutaneous transthoracic needle biopsy of lung nodules: clinical experience in 1108 patients. Radiology. 2014;271(1):291\u2013300.","journal-title":"Radiology."},{"issue":"6","key":"4672_CR21","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1378\/chest.06-2506","volume":"131","author":"M Yoshikawa","year":"2007","unstructured":"Yoshikawa M, Sukoh N, Yamazaki K, Kanazawa K, Fukumoto S, Harada M, Kikuchi E, Munakata M, Nishimura M, Isobe H. Diagnostic value of endobronchial ultrasonography with a guide sheath for peripheral pulmonary lesions without X-ray fluoroscopy. Chest. 2007;131(6):1788\u201393.","journal-title":"Chest"},{"issue":"1","key":"4672_CR22","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.lungcan.2013.04.004","volume":"81","author":"L Fuso","year":"2013","unstructured":"Fuso L, Varone F, Magnini D, Baldi F, Rindi G, Pagliari G, Inchingolo R, Smargiassi A. Role of ultrasound-guided transbronchial biopsy in the diagnosis of peripheral pulmonary lesions. Lung cancer (Amsterdam, Netherlands). 2013;81(1):60\u20134.","journal-title":"Lung cancer (Amsterdam, Netherlands)"},{"key":"4672_CR23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2334-10-17","volume":"10","author":"J Galvez-Acebal","year":"2010","unstructured":"Galvez-Acebal J, Rodriguez-Bano J, Martinez-Marcos FJ, Reguera JM, Plata A, Ruiz J, Marquez M, Lomas JM, de la Torre-Lima J, Hidalgo-Tenorio C, et al. Prognostic factors in left-sided endocarditis: results from the Andalusian multicenter cohort. BMC Infect Dis. 2010;10:17.","journal-title":"BMC Infect Dis"},{"issue":"6","key":"4672_CR24","first-page":"1060","volume":"54","author":"C Ferrera","year":"2018","unstructured":"Ferrera C, Vilacosta I, Fernandez C, Lopez J, Sarria C, Olmos C, Carnero-Alcazar M, Vivas D, Di Stefano S, Saez C, et al. Early surgery for acute-onset infective endocarditis. Eur J Cardiothorac Surg. 2018;54(6):1060\u20136.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"1","key":"4672_CR25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1378\/chest.118.1.146","volume":"118","author":"EH Ibrahim","year":"2000","unstructured":"Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118(1):146\u201355.","journal-title":"Chest"},{"issue":"5","key":"4672_CR26","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1378\/chest.09-0087","volume":"136","author":"A Kumar","year":"2009","unstructured":"Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, Dodek P, Wood G, Simon D, Peters C, et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 2009;136(5):1237\u201348.","journal-title":"Chest"},{"issue":"11","key":"4672_CR27","doi-asserted-by":"publisher","first-page":"4851","DOI":"10.1128\/AAC.00627-10","volume":"54","author":"M Paul","year":"2010","unstructured":"Paul M, Shani V, Muchtar E, Kariv G, Robenshtok E, Leibovici L. Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis. Antimicrob Agents Chemother. 2010;54(11):4851\u201363.","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"4672_CR28","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1097\/CCM.0000000000000330","volume":"42","author":"R Ferrer","year":"2014","unstructured":"Ferrer R, Martin-Loeches I, Phillips G, Osborn TM, Townsend S, Dellinger RP, Artigas A, Schorr C, Levy MM. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med. 2014;42(8):1749\u201355.","journal-title":"Crit Care Med"},{"issue":"10","key":"4672_CR29","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001891","volume":"44","author":"Y Shirakura","year":"2016","unstructured":"Shirakura Y, Kuriyama A. Timing of antibiotic Administration in Sepsis and Septic Shock: the impact that a meta-analysis does not depict. Crit Care Med. 2016;44(10):e1004.","journal-title":"Crit Care Med"},{"issue":"5","key":"4672_CR30","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s15010-013-0428-9","volume":"41","author":"AJ Kaasch","year":"2013","unstructured":"Kaasch AJ, Rieg S, Kuetscher J, Brodt HR, Widmann T, Herrmann M, Meyer C, Welte T, Kern P, Haars U, et al. Delay in the administration of appropriate antimicrobial therapy in Staphylococcus aureus bloodstream infection: a prospective multicenter hospital-based cohort study. Infect. 2013;41(5):979\u201385.","journal-title":"Infect"},{"issue":"1","key":"4672_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/599376","volume":"49","author":"LA Mermel","year":"2009","unstructured":"Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, Raad II, Rijnders BJ, Sherertz RJ, Warren DK. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49(1):1\u201345.","journal-title":"Clin Infect Dis"},{"issue":"5","key":"4672_CR32","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/cid\/ciw504","volume":"63","author":"AC Kalil","year":"2016","unstructured":"Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, Napolitano LM, O'Grady NP, Bartlett JG, Carratala J, et al. Executive summary: Management of Adults with Hospital-acquired and Ventilator-associated Pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):575\u201382.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"4672_CR33","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1089\/sur.2009.9930","volume":"11","author":"JS Solomkin","year":"2010","unstructured":"Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ, O'Neill PJ, Chow AW, Dellinger EP, Eachempati SR, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the surgical infection society and the Infectious Diseases Society of America. Surg Infect. 2010;11(1):79\u2013109.","journal-title":"Surg Infect"},{"issue":"2","key":"4672_CR34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/cid\/ciu444","volume":"59","author":"DL Stevens","year":"2014","unstructured":"Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014;59(2):147\u201359.","journal-title":"Clin Infect Dis"},{"issue":"3","key":"4672_CR35","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","volume":"43","author":"A Rhodes","year":"2017","unstructured":"Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, et al. Surviving Sepsis campaign: international guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304\u201377.","journal-title":"Intensive Care Med"},{"issue":"4","key":"4672_CR36","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.ccc.2009.08.001","volume":"25","author":"JC Marshall","year":"2009","unstructured":"Marshall JC. al Naqbi a: principles of source control in the management of sepsis. Crit Care Clin. 2009;25(4):753\u201368 viii-ix.","journal-title":"Crit Care Clin"},{"issue":"Suppl 1","key":"4672_CR37","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1007\/PL00003797","volume":"27","author":"MF Jimenez","year":"2001","unstructured":"Jimenez MF, Marshall JC. Source control in the management of sepsis. Intensive Care Med. 2001;27(Suppl 1):S49\u201362.","journal-title":"Intensive Care Med"},{"issue":"7","key":"4672_CR38","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1111\/apt.13764","volume":"44","author":"CJ Karvellas","year":"2016","unstructured":"Karvellas CJ, Abraldes JG, Zepeda-Gomez S, Moffat DC, Mirzanejad Y, Vazquez-Grande G, Esfahani EK, Kumar A. The impact of delayed biliary decompression and anti-microbial therapy in 260 patients with cholangitis-associated septic shock. Aliment Pharmacol Ther. 2016;44(7):755\u201366.","journal-title":"Aliment Pharmacol Ther"},{"key":"4672_CR39","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ijid.2014.11.007","volume":"30","author":"S Simsek-Yavuz","year":"2015","unstructured":"Simsek-Yavuz S, Sensoy A, Kasikcioglu H, Ceken S, Deniz D, Yavuz A, Kocak F, Midilli K, Eren M, Yekeler I. Infective endocarditis in Turkey: aetiology, clinical features, and analysis of risk factors for mortality in 325 cases. Int J Infect Dis. 2015;30:106\u201314.","journal-title":"Int J Infect Dis"},{"issue":"2","key":"4672_CR40","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1086\/321811","volume":"33","author":"HM Blumberg","year":"2001","unstructured":"Blumberg HM, Jarvis WR, Soucie JM, Edwards JE, Patterson JE, Pfaller MA, Rangel-Frausto MS, Rinaldi MG, Saiman L, Wiblin RT, et al. Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. The National Epidemiology of mycosis survey. Clin Infect Dis. 2001;33(2):177\u201386.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"4672_CR41","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1590\/S0037-86822008000100005","volume":"41","author":"JC Franca","year":"2008","unstructured":"Franca JC, Ribeiro CE. Queiroz-Telles F: [Candidemia in a Brazilian tertiary care hospital: incidence, frequency of different species, risk factors and antifungal susceptibility]. Rev Soc Bras Med Trop. 2008;41(1):23\u20138.","journal-title":"Rev Soc Bras Med Trop"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4672-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12879-019-4672-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-019-4672-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:08:07Z","timestamp":1608941287000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-019-4672-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["4672"],"URL":"https:\/\/doi.org\/10.1186\/s12879-019-4672-1","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"10 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the ethics committee of The First Affiliated Hospital of Guangxi Medical University, Nanning. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors report no conflicts of interest in this work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1082"}}