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Cumulative IE incidence was 5.67\/1000 admissions. The most common pathogens were viridans group streptococci (VGS) (39.7%), methicillin-sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> (MSSA) (13.1%), and beta-hemolytic streptococci (11.5%) in NVE; and, MSSA (20.3%), VGS (20.3%), and <jats:italic>Enterococcus<\/jats:italic> spp. (16.9%) in prosthetic valve (PVE) or device-related IE (DRIE). Overall in-hospital mortality was 18.4%. Mortality was significantly higher in PVE\/DRIE than in NVE (26.8% vs. 16.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.047). End-stage renal disease (ESRD) (aOR: 9.43, 95% CI: 2.36\u201337.70), diabetes mellitus (DM) (aOR: 2.81, 95% CI: 1.06\u20137.49), neurological complication (aOR: 14.16, 95% CI: 5.11\u201339.22), congestive heart failure (aOR: 4.32, 95% CI: 1.91\u20139.75), hospital-acquired infection (aOR: 3.78, 95% CI: 1.66\u20138.57), renal complication (aOR: 3.12, 95%CI: 1.32\u20137.37), and other complication during admission (aOR: 3.28, 95% CI: 1.41\u20137.61) were independently associated with mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The incidence of IE, and the mortality rate among those diagnosed with IE are both increasing in Thailand \u2013 particularly among those with PVE or DRIE. End-stage renal disease, diabetes mellitus, and development of IE-related complications during admission were found to be independent predictors of mortality.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-019-4689-5","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T15:02:50Z","timestamp":1576681370000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cumulative incidence and mortality of infective endocarditis in Siriraj hospital\u2013Thailand: a 10-year retrospective study"],"prefix":"10.1186","volume":"19","author":[{"given":"Taksaon","family":"Angsutararux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-4877","authenticated-orcid":false,"given":"Nasikarn","family":"Angkasekwinai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"issue":"12","key":"4689_CR1","doi-asserted-by":"publisher","first-page":"e82665","DOI":"10.1371\/journal.pone.0082665","volume":"8","author":"L Slipczuk","year":"2013","unstructured":"Slipczuk L, Codolosa JN, Davila CD, Romero-Corral A, Yun J, Pressman GS, et al. 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A waiver of informed consent was approved by SIRB since the study involved no more than minimal risk to the subject and the waiver is not adversely affect the rights of the subject. The permission from Siriraj Information Technology Department (SiIT) is required for secondary use of electronic health record.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare no personal or professional conflicts of interest, and no financial support from the companies that produce and\/or distribute the drugs, devices, or materials described in this report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1062"}}