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The most frequently isolated relevant microorganisms were <jats:italic>Enterobacterales<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u2009439, 59.3%), <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u200992, 12.4%), <jats:italic>Streptococcus pneumoniae<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u200934, 4.6%), <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u200932, 4.3%), <jats:italic>Streptococcus pyogenes<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u200916, 2.2%), <jats:italic>Enterococcus faecalis<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u200918, 2.4%), and <jats:italic>Enterococcus faecium<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u200912, 1.6%). Antimicrobial susceptibility testing revealed a high proportion of resistance against ampicillin-sulbactam in <jats:italic>Enterobacterales<\/jats:italic> (42.2%). The rate of methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> was low (0.4%).<\/jats:p>\n                <jats:p>Piperacillin-tazobactam therapy provided coverage for 83.2% of all relevant pathogens using conventional breakpoints. Application of the new European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommendations increased the percentage of susceptible isolates to high-dose piperacillin-tazobactam to 92.8% (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Broad-spectrum carbapenems would only cover an additional 4.8%. The addition of vancomycin or linezolid extended coverage by just 1.7%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Using an ureidopenicillin-beta-lactamase inhibitor combination at the high dose suggested by the new EUCAST recommendations provided nearly 93% coverage for relevant pathogens in patients with suspected bloodstream infection in our cohort. This might offer a safe option to reduce the empiric use of carbapenems. Our data support the absence of a general need for glycopeptides or oxazolidinones in empiric treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12879-019-4721-9","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T20:02:17Z","timestamp":1577736137000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Antimicrobial resistance of bacteraemia in the emergency department of a German university hospital (2013\u20132018): potential carbapenem-sparing empiric treatment options in light of the new EUCAST recommendations"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8293-5832","authenticated-orcid":false,"given":"Kathrin","family":"Rothe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Wantia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph D.","family":"Spinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Lahmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Waschulzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland M.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk H.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juri","family":"Katchanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"issue":"5","key":"4721_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.jemermed.2016.07.003","volume":"51","author":"B Long","year":"2016","unstructured":"Long B, Koyfman A. 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