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But the relationship between IL-27 and MPP was unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ninety-eight patients with MPP\u2009&lt;\u200914\u2009years old were enrolled in this study and divided into groups by severity (mild cases and severe cases), infection types (\n                      <jats:italic>MP<\/jats:italic>\n                      single infection group and\n                      <jats:italic>MP<\/jats:italic>\n                      mixed infection group) and DNA loads (low\n                      <jats:italic>MP<\/jats:italic>\n                      DNA loads group and high\n                      <jats:italic>MP<\/jats:italic>\n                      DNA loads group), respectively. Fifteen children with foreign bodies in bronchus were also enrolled as control. IL-6\u2009s and IL-27\u2009s in bronchoalveolar lavage fluids (BALFs) from these children were measured by ELISA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were significant differences in IL-6\u2009s of BALFs from patients between mild cases and severe cases,\n                      <jats:italic>MP<\/jats:italic>\n                      single infection group and\n                      <jats:italic>MP<\/jats:italic>\n                      mixed infection group, and low\n                      <jats:italic>MP<\/jats:italic>\n                      DNA loads group and high\n                      <jats:italic>MP<\/jats:italic>\n                      DNA loads group, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Compared with IL-6\u2009s of BALFs from control, IL-6\u2009s in BALFs from the 6 patient groups were significantly higher (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). IL-27\u2009s in BALFs from\n                      <jats:italic>MP<\/jats:italic>\n                      mixed infection group were significantly lower than those from\n                      <jats:italic>MP<\/jats:italic>\n                      single infection group and control (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      IL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not related to\n                      <jats:italic>MP<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-020-05017-3","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T08:03:48Z","timestamp":1589184228000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The clinical significance of IL-6\u2009s and IL-27\u2009s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia"],"prefix":"10.1186","volume":"20","author":[{"given":"Jie","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"5017_CR1","doi-asserted-by":"publisher","first-page":"e0195288","DOI":"10.1371\/journal.pone.0195288","volume":"13","author":"MJ Sondergaard","year":"2018","unstructured":"Sondergaard MJ, Friis MB, Hansen DS, Jorgensen IM. 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