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The present study aims to investigate the species distribution, specimen type and susceptibilities of <jats:italic>Enterococcal<\/jats:italic> species collected from Nanjing Drum Tower Hospital from 2013 to 2018. Additionally, distribution of VRE and prevalence of <jats:italic>van<\/jats:italic> gene among VRE isolates were also analyzed.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The susceptibilities of 3913 <jats:italic>Enterococcus<\/jats:italic> isolates were retrospectively investigated. Among these strains, 60 VRE strains were further anazlyed in this study. The minimum inhibitory concentrations (MICs) of the VRE strains towards vancomycin, teicoplanin and linezolid were determined by E-test. Polymerase chain reaction (PCR) and DNA sequencing were used to investigate the prevalence of <jats:italic>van<\/jats:italic> genes among VRE. Furthermore, the sequence types (STs) of VRE strains were explored by multi-locus sequence typing (MLST).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among the 3913 <jats:italic>enterococci<\/jats:italic> isolates, <jats:italic>Enterococcus faecalis<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20091870, 47.8%) and <jats:italic>Enterococcus faecium<\/jats:italic> (1738, 44.4%) were the main isolates. These <jats:italic>Enterococcus<\/jats:italic> strains were mainly isolated from urine (<jats:italic>n<\/jats:italic>\u2009=\u20091673, 42.8%), followed by secretions (<jats:italic>n<\/jats:italic>\u2009=\u2009583, 14.9%) and ascites (<jats:italic>n<\/jats:italic>\u2009=\u2009554, 14.2%). VRE displayed a decreasing trend year by year. Molecular analysis revealed that 49 out of 60 VRE isolates carried <jats:italic>vanA<\/jats:italic> gene, 10 carried <jats:italic>vanM<\/jats:italic>, and 1 carried both <jats:italic>vanA<\/jats:italic> and <jats:italic>vanM<\/jats:italic> genes. Sixteen distinct STs were identified among the 58 VREM, with ST78 (<jats:italic>n<\/jats:italic>\u2009=\u200916), ST192 (<jats:italic>n<\/jats:italic>\u2009=\u20098) and ST570 (<jats:italic>n<\/jats:italic>\u2009=\u20097) being the most dominant ones.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p><jats:italic>E. faecalis<\/jats:italic> and <jats:italic>E. faecium<\/jats:italic> were the major <jats:italic>enterococci<\/jats:italic> strains which are the main pathogens of urinary traction infections; <jats:italic>vanA<\/jats:italic> and <jats:italic>vanM<\/jats:italic> were the main determinants conferring resistance to vancomycin; ST78, ST192 and ST570 were the leading STs of VREM which displayed a decreasing trend of prevalence year by year.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12879-020-05078-4","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T15:03:39Z","timestamp":1591715019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Characterization of clinical enterococci isolates, focusing on the vancomycin-resistant enterococci in a tertiary hospital in China: based on the data from 2013 to 2018"],"prefix":"10.1186","volume":"20","author":[{"given":"Wanqing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunni","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"issue":"4","key":"5078_CR1","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.idc.2016.07.009","volume":"30","author":"K Reyes","year":"2016","unstructured":"Reyes K, Bardossy AC, Zervos M. 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