{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:18:18Z","timestamp":1792444698497,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science & Technology Commission","doi-asserted-by":"crossref","award":["Z171100001017081"],"award-info":[{"award-number":["Z171100001017081"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The incidence of necrotizing pneumonia (NP) caused by\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      (MP) is increasing. We analyzed the clinical characteristics and the risk factors for NP caused by MP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective observational study was conducted in 37 patients with NP caused by MP (NP group) and 74 patients diagnosed with lobar\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      pneumonia with no necrosis (control group) who were admitted to our hospital between January 2013 and December 2017. The clinical manifestations, laboratory data, imaging findings, treatments and outcomes were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportion of females, the incidence of pleural effusion, fever duration, hospitalization days, white blood cell count, neutrophil ratio, D-dimer level and use of other types of antibiotics were higher in the NP group than in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The control group exhibited a greater use of low molecular weight heparin (LMWH) than the NP group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). According to the multivariate logistic regression analysis, a white blood cell count &gt;\u200912.3\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L (Odds ratio, OR\u2009=\u20096.412), a neutrophil ratio\u2009&gt;\u200973.9% (OR\u2009=\u20096.081) and D-dimer level\u2009&gt;\u20091367.5\u2009ng\/mL (OR\u2009=\u20098.501) were risk factors for pulmonary necrosis caused by MP. Furthermore, the use of LMWH (OR\u2009=\u20090.074) reduced the risk of pulmonary necrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      NP is a rare complication of severe\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      pneumonia (SMPP), and although the clinical course is longer than common MP infection, the necrotic area is absorbed gradually. In patients with SMPP presenting with lobar consolidation, a white blood cell count &gt;\u200912.3\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L, a neutrophil ratio\u2009&gt;\u200973.9% and D-dimer level\u2009&gt;\u20091367.5\u2009ng\/mL are risk factors for pulmonary necrosis, and the use of LMWH reduces the risk of pulmonary necrosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-020-05110-7","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T13:05:12Z","timestamp":1591103112000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["The clinical characteristics and risk factors for necrotizing pneumonia caused by Mycoplasma pneumoniae in children"],"prefix":"10.1186","volume":"20","author":[{"given":"Baoying","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"issue":"12","key":"5110_CR1","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1093\/cid\/cis784","volume":"55","author":"T Okada","year":"2012","unstructured":"Okada T, Morozumi M, Tajima T, et al. 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