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A total of 407 consecutive patients who were admitted with infective endocarditis were included. The clinical characteristics and the risk factors related to the prognosis of infective endocarditis during this period were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 407 patients with infective endocarditis were included, the average age was 48\u2009\u00b1\u200916\u2009years old with an increasing trend and in-hospital mortality rate was 10.6% and one-year mortality rate was 11.3%. Among patients with underlying heart disease, congenital heart disease was the most common (25.8%), followed by rheumatic heart disease (17.0%) which showed a decreased trend during this period (P\u2009&lt;\u20090.001). There were 222(54.5%) patients with positive blood cultures results and\n                      <jats:italic>Streptococci<\/jats:italic>\n                      (24.6%) was the main pathogens with an increasing trend. There were 403 patients (99%) with surgical indications, but only 235 patients (57.7%) received surgical treatment. Hemodialysis (P\u2009=\u20090.041, OR\u2009=\u20094.697, 95% CI 1.068\u201320.665), pulmonary hypertension (P\u2009=\u20090.001, OR\u2009=\u20095.308, 95% CI 2.034\u201313.852), Pitt score\u2009\u2265\u20094 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001, OR\u2009=\u200928.594, 95% CI 5.561\u2013148.173) and vegetation length&gt;30\u2009mm (P\u2009=\u20090.011, OR\u2009=\u200913.754, 95% CI 1.832\u2013103.250) were independent risk factors for in-hospital mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      There were no significant changes in the overall incidence of infective endocarditis, but the clinical features of infective endocarditis had slightly changed during the past ten years.\n                      <jats:italic>Streptococci<\/jats:italic>\n                      infective endocarditis was still the predominant. Patients with hemodialysis, pulmonary hypertension, Pitt score\u2009\u2265\u20094 and vegetation length&gt;30\u2009mm had an worse in-hospital outcome.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-020-05153-w","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T07:02:59Z","timestamp":1592463779000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Epidemiology and risk factors of infective endocarditis in a tertiary hospital in China from 2007 to 2016"],"prefix":"10.1186","volume":"20","author":[{"given":"Zhenzhu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshui","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"issue":"1","key":"5153_CR1","doi-asserted-by":"publisher","first-page":"E107","DOI":"10.1016\/j.crvasa.2015.12.004","volume":"58","author":"K Linhartova","year":"2016","unstructured":"Linhartova K, Benes J, Gregor P. 2015 ESC guidelines for the management of infective endocarditis. 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The consent to participate was waived by our institutional review board since this study was retrospective data collection. The patient information used in this study was anonymised before its use.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"428"}}