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We developed and validated a scoring system to identify cancer patients harboring ESBL-PE at the National Institute of Cancer of Colombia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed medical records of 1695 cancer patients. Derivation phase included 710 patients admitted between 2013 to 2015, ESBL-PE positive culture (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009265) paired by month and hospitalization ward with Non-ESBL-PE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009445). A crude and weighted score was developed by conditional logistic regression. The model was evaluated in a Validation cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009985) with the same eligibility criteria between 2016 to 2017.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The score was based on eight variables (reported with Odds Ratio and 95% confidence interval): Hospitalization \u22657\u2009days (5.39 [2.46\u201311.80]), Hospitalization during the previous year (4, 87 [2.99\u20137.93]), immunosuppressive therapy during the previous 3\u2009months (2.97 [1.44\u20136.08]), Neutropenia (1.90 [1.12\u20133.24]), Exposure to Betalactams during previous month (1.61 [1.06\u20132.42]), Invasive devices (1.51 [1.012\u20132.25]), Neoplasia in remission (2.78 [1.25\u20131.17]), No chemotherapy during the previous 3\u2009months (1.90 [1.22\u20132.97]). The model demonstrated an acceptable discriminatory capacity in the Derivation phase, but poor in the Validation phase (Recipient Operating Characteristic Curve: 0.68 and 0.55 respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cancer patients have a high prevalence of risk factors for ESBL-PE infection. The scoring system did not adequately discriminate patients with ESBL-PE. In a high-risk population, other strategies should be sought to identify patients at risk of resistant ESBL-PE infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-020-05280-4","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T06:03:45Z","timestamp":1596175425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and validation of a scoring system for predicting cancer patients at risk of extended-spectrum b-lactamase-producing Enterobacteriaceae infections"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5641-2392","authenticated-orcid":false,"given":"Alvaro J.","family":"Mart\u00ednez-Valencia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"G\u00f3mez Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita M.","family":"Monta\u00f1ez Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherin","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"S\u00e1nchez Pedraza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leydy P.","family":"Jim\u00e9nez Cetina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C.","family":"G\u00f3mez Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia I.","family":"Cuervo Maldonado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"5280_CR1","first-page":"7","volume-title":"WHO | Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. 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Written informed consent was not required. The procedures followed were in accordance with the ethical standards set by the institutional ethics committee and that of the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"558"}}