{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:53:51Z","timestamp":1762005231632,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p><jats:italic>Stenotrophomonas maltophilia<\/jats:italic>-induced pulmonary haemorrhage is considered a fatal infection among haematological patients. The outcome can be explained by the patients\u2019 immunity status and late diagnosis and treatment.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>We present the rare case of successful outcome in a 61-year-old female who developed alveolar haemorrhage and acute respiratory distress syndrome 8 days after a chemotherapy session for her acute lymphoblastic leukaemia, in the context of secondary bone marrow aplasia. <jats:italic>Stenotrophomonas maltophilia<\/jats:italic> was isolated in sputum culture. The patient benefitted from early empirical treatment with colistin followed by trimethoprim\/sulfamethoxazole, according to the antibiogram. Despite a severe initial clinical presentation in need of mechanical ventilation, neuromuscular blocking agents infusion, and ventilation in prone position, the patient had a favourable outcome and was discharged from intensive care after 26\u2009days.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p><jats:italic>Stenotrophomonas maltophilia<\/jats:italic> severe pneumonia complicated with pulmonary haemorrhage is not always fatal in haematological patients. Empirical treatment of multidrug-resistant <jats:italic>Stenotrophomonas maltophilia<\/jats:italic> in an immunocompromised haematological patient presenting with hemoptysis should be taken into consideration.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12879-020-05378-9","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T14:03:16Z","timestamp":1599746596000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia \u2013 case report"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0216-1380","authenticated-orcid":false,"given":"Stefan","family":"Andrei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Ghiaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Brezeanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Martac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Nicolau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Coriu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Droc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"issue":"1","key":"5378_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1128\/CMR.00019-11","volume":"25","author":"JS Brooke","year":"2012","unstructured":"Brooke JS. Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clin Microbiol Rev. 2012;25(1):2\u201341.","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"5378_CR2","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00277-014-2028-x","volume":"93","author":"M Mori","year":"2014","unstructured":"Mori M, Tsunemine H, Imada K, Ito K, Kodaka T, Takahashi T. Life-threatening hemorrhagic pneumonia caused by Stenotrophomonas maltophilia in the treatment of hematologic diseases. Ann Hematol. 2014;93(6):901\u201311.","journal-title":"Ann Hematol"},{"issue":"5","key":"5378_CR3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3855\/jidc.5463","volume":"9","author":"N Guzoglu","year":"2015","unstructured":"Guzoglu N, Demirkol FN, Aliefendioglu D. Haemorrhagic pneumonia caused by Stenotrophomonas maltophilia in two newborns. 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Respir Med Case Rep. 2016;19:12\u20134.","journal-title":"Respir Med Case Rep"},{"issue":"2","key":"5378_CR8","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2169\/internalmedicine.3358-19","volume":"59","author":"W Imoto","year":"2020","unstructured":"Imoto W, Yamada K, Yamairi K, Shibata W, Namikawa H, Yukawa S, et al. Clinical characteristics of rapidly progressive fatal hemorrhagic pneumonia caused by Stenotrophomonas maltophilia. Intern Med. 2020;59(2):193\u20138.","journal-title":"Intern Med"},{"key":"5378_CR9","first-page":"232","volume":"4","author":"KA Al-Anazi","year":"2014","unstructured":"Al-Anazi KA, Al-Jasser AM. Infections caused by Stenotrophomonas maltophilia in recipients of hematopoietic stem cell transplantation. Front Oncol. 2014;4:232.","journal-title":"Front Oncol"},{"key":"5378_CR10","first-page":"1","volume":"6","author":"M Gajdacs","year":"2019","unstructured":"Gajdacs M, Urban E. Prevalence and antibiotic resistance of Stenotrophomonas maltophilia in respiratory tract samples: a 10-year epidemiological snapshot. Health Serv Res Manag Epidemiol. 2019;6:1\u20139.","journal-title":"Health Serv Res Manag Epidemiol"},{"key":"5378_CR11","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1183\/09031936.00150611","volume":"40","author":"D Mokart","year":"2012","unstructured":"Mokart D, van Craenenbroeck T, Lambert J, Textoris J, Brun JP, Sannini A, et al. Prognosis of acute respiratory distress syndrome in neutropenic cancer patients. Eur Respir J. 2012;40:169\u201376.","journal-title":"Eur Respir J"},{"issue":"6","key":"5378_CR12","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1097\/CCM.0000000000004322","volume":"48","author":"V Lemiale","year":"2020","unstructured":"Lemiale V, Pons S, Mirouse A, Tudesq JJ, Hourmant Y, Mokart D, et al. Sepsis and SepticShock in Patients WithMalignancies: A Groupe de Recherche Respiratoire en R\u00e9animation Onco-H\u00e9matologique Study. Crit Care Med. 2020;48(6):822\u20139.","journal-title":"Crit Care Med"},{"issue":"12","key":"5378_CR13","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1007\/s00134-002-1528-7","volume":"28","author":"M Darmon","year":"2002","unstructured":"Darmon M, Azoulay E, Alberti C. FieuxF, Moreau D, Le gall JR, et al. impact of neutropenia duration on short-term mortality in Neutropenic critically ill Cancer patients. 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