{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:26Z","timestamp":1790617226893,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Invasive infections with <jats:italic>Candida krusei<\/jats:italic> are uncommon and rarely complicated by spondylitis. Previous described cases were solely treated with antimycotic therapy, despite guidelines recommending surgical interventions.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>We describe a case of <jats:italic>C. krusei<\/jats:italic> spondylitis in a patient treated with chemotherapy for acute myeloid leukemia. After induction chemotherapy, the patient developed a candidemia, which was treated with micafungin. One month after the candidemia, the patient was admitted with severe lumbar pain. Spondylitis of the L4 and L5 vertebra was diagnosed on MR-imaging, with signs suggesting an atypical infection. The patient was treated with anidulafungin combined with voriconazole. Despite maximal conservative management symptoms gradually worsened eventually requiring surgical intervention.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In contrast to previous case reports, antimycotic treatment alone could be insufficient in treating <jats:italic>C. krusei<\/jats:italic> spondylitis.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12879-020-05451-3","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T08:03:04Z","timestamp":1602144184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Case report: Candida krusei spondylitis in an immunocompromised patient"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-7969","authenticated-orcid":false,"given":"Audrey J. C.","family":"Overgaauw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"de Leeuw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne P.","family":"Stoof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost C. J.","family":"Bot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eef J.","family":"Hendriks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"5451_CR1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s15010-019-01294-6","volume":"47","author":"N McLeod","year":"2019","unstructured":"McLeod N, Fisher M, Lasala PR. Vertebral osteomyelitis due to Candida species. Infection. 2019;47:475\u20138.","journal-title":"Infection"},{"issue":"Suppl 3","key":"5451_CR2","first-page":"iii11","volume":"65","author":"T Gouliouris","year":"2010","unstructured":"Gouliouris T, Aliyu SH, Brown NM. Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother. 2010;65(Suppl 3):iii11\u201324.","journal-title":"J Antimicrob Chemother"},{"key":"5451_CR3","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1128\/JCM.44.5.1912-1914.2006","volume":"44","author":"J Peman","year":"2006","unstructured":"Peman J, Jarque I, Bosch M, et al. Spondylodiscitis caused by Candida krusei: case report and susceptibility patterns. J Clin Microbiol. 2006;44:1912\u20134.","journal-title":"J Clin Microbiol"},{"key":"5451_CR4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/13693780701552996","volume":"46","author":"A Schilling","year":"2008","unstructured":"Schilling A, Seibold M, Mansmann V, Gleissner B. Successfully treated Candida krusei infection of the lumbar spine with combined caspofungin\/posaconazole therapy. Med Mycol. 2008;46:79\u201383.","journal-title":"Med Mycol"},{"key":"5451_CR5","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1093\/jac\/dkq053","volume":"65","author":"MA Slavin","year":"2010","unstructured":"Slavin MA, Sorrell TC, Marriott D, et al. Candidaemia in adult cancer patients: risks for fluconazole-resistant isolates and death. J Antimicrob Chemother. 2010;65:1042\u201351.","journal-title":"J Antimicrob Chemother"},{"key":"5451_CR6","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ1194","volume":"62","author":"PG Pappas","year":"2016","unstructured":"Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of Candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62:e1\u201350.","journal-title":"Clin Infect Dis"},{"key":"5451_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ijid.2018.01.003","volume":"68","author":"M Gagliano","year":"2018","unstructured":"Gagliano M, Marchiani C, Bandini G, et al. A rare case of Candida glabrata spondylodiscitis: case report and literature review. Int J Infect Dis. 2018;68:31\u20135.","journal-title":"Int J Infect Dis"},{"key":"5451_CR8","doi-asserted-by":"crossref","unstructured":"Kaldau NC, Brorson S, Jensen PE, et al. Bilateral polymicrobial osteomyelitis with Candida tropicalis and Candida krusei: a case report and an updated literature review. Int J Infect Dis. 2012;16(1):e16\u201322.","DOI":"10.1016\/j.ijid.2011.10.001"},{"key":"5451_CR9","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1128\/JCM.01915-07","volume":"46","author":"MA Pfaller","year":"2008","unstructured":"Pfaller MA, Diekema DJ, Gibbs DL, et al. Candida krusei, a multidrug-resistant opportunistic fungal pathogen: geographic and temporal trends from the ARTEMIS DISK antifungal surveillance program, 2001 to 2005. J Clin Microbiol. 2008;46:515\u201321.","journal-title":"J Clin Microbiol"},{"key":"5451_CR10","doi-asserted-by":"publisher","first-page":"872","DOI":"10.2214\/AJR.12.10344","volume":"201","author":"SW Lee","year":"2013","unstructured":"Lee SW, Lee SH, Chung HW, Kim MJ, Seo MJ, Shin MJ. Candida spondylitis: comparison of MRI findings with bacterial and tuberculous causes. 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A copy of the signed, written informed consent for publication form is available for review by the editor.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None of the authors have competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"739"}}